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Wyświetlanie 1-15 z 499
Tytuł:
Effects of fluoxetine on the anticonvulsant action of valproate and ethosuximide in mouse model of myoclonic convulsions
Autorzy:
Borowicz, K.K.
Piskorska, B.
Stepniak, B.
Czuczwar, S.J.
Powiązania:
https://bibliotekanauki.pl/articles/50030.pdf
Data publikacji:
2012
Wydawca:
Instytut Medycyny Wsi
Opis:
Depression is becoming a growing problem in rural areas. This psychiatric disorder often accompanies epilepsy. The aim of this study was to assess the influence of fluoxetine (FXT), a commonly used antidepressant, on the protective action of two conventional antiepileptic drugs: ethosuximide (ETX) and valproate (VPA), against pentylenetetrazole (PTZ)-induced convulsions in mice. Motor coordination and long-term memory deficits induced by FXT, antiepileptic drugs alone and in combinations with FXT were assessed in the chimney test and passive-avoidance task, respectively. Brain concentrations of ETX and VPA were measured by immunofluorescence. Obtained results indicate that FXT at the dose of 15 mg/kg (ip, 30 min before the test) significantly increased the threshold for clonic convulsions. The antidepressant drug at lower doses remained ineffective in this respect. Moreover, FXT at the highest subprotective dose (10 mg/kg, ip) markedly enhanced the anticonvulsant effects of VPA, but not of ETX, against PTZ-induced seizures. The interaction between FXT and VPA seems to be pharmacodynamic because the antidepressant drug did not alter the brain concentration of VPA. With regard to adverse effects, FXT, VPA, ETX, and the combinations of FXT with antiepileptic drugs, did not impair motor coordination and long-term memory in mice. In conclusion, the combination of FXT with VPA may be advantageous in the treatment of myoclonic epilepsy, and therefore it should be recommended for further study in clinical conditions.
Źródło:
Annals of Agricultural and Environmental Medicine; 2012, 19, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Exposure, symptoms and airway inflammation among sewage workers
Autorzy:
Heldal, K K
Madso, L.
Huser, P.O.
Eduard, W.
Powiązania:
https://bibliotekanauki.pl/articles/51884.pdf
Data publikacji:
2010
Wydawca:
Instytut Medycyny Wsi
Tematy:
environmental exposure
sewage
worker
worker exposure
biological agent
toxic gas
microbial degradation
health risk
risk factor
sewage dust
endotoxin
lung function
nitric oxide
exposure-response relationship
Źródło:
Annals of Agricultural and Environmental Medicine; 2010, 17, 2; 263-268
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sequence-based typing of Legionella pneumophila strains isolated from hospital water distribution systems as a complementary element of risk assessment of legionellosis in Poland
Autorzy:
Pancer, K.
Powiązania:
https://bibliotekanauki.pl/articles/52112.pdf
Data publikacji:
2013
Wydawca:
Instytut Medycyny Wsi
Opis:
Many factors affect the risk of Legionella infection, such as the design, construction and maintenance of water distribution systems, the presence of individuals who may be exposed and their vulnerability to infection, and the degree of water system colonization and properties of Legionella strains. For epidemiological investigations, two properties of the Legionella strains are usually determined: serotyping and genotyping (sequence-based typing, SBT). In Poland, data regarding legionellosis are fragmentary, despite the fact that this has been a notifiable disease since 2002. The number of reported cases is very low; moreover, the main method of diagnosis is serological examination (delayed diagnosis and cheaper methods), and only single cases of LD were confirmed by culture of bacteria. Therefore, after 10 years of mandatory reporting of the Legionella spp. infection in Poland, the real epidemiological situation is still unknown; however, risk assessment should be carried out, especially in hospitals. In the presented study, comparison of the sequence types of 111 isolated L. pneumophila strains (from hospital water systems) with those present in the EWGLI SBT data was undertaken for complex risk analysis as a complementary element. In total, strains of L. pneumophila belonging to 12 out of 19 STs determined in the presented study were previously reported to the EWGLI SBT database (ST1, ST42, ST59, ST81, ST87, ST114, ST152, ST191, ST371, ST421, ST461, ST520). Among these strains, only 7 STs were previously reported in the amount of ≥10 (mainly ST1, ST42, ST81). Analysis of EWGLI data were carried out and, proportionally, the highest percentage of hospital-acquired strains (clinical and environmental) was found for ST 81, ST421 and ST152, but the largest number was for ST1. Based on the EWGLI data and the presented results, it was found that persistent colonization of HWS of 3 hospitals by strains belonging to ST42, ST1, ST87 indicated an increased risk of legionellosis, especially ST42.
Źródło:
Annals of Agricultural and Environmental Medicine; 2013, 20, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Urogenital Chlamydia trachomatis in the environment of soldiers from the Polish Special Forces
Autorzy:
Korzeniewski, K.
Powiązania:
https://bibliotekanauki.pl/articles/2082927.pdf
Data publikacji:
2019
Wydawca:
Instytut Medycyny Wsi
Tematy:
RT-PCR
Chlamydia trachomatis
Polish soldiers
Opis:
Introduction and objective. Urogenital Chlamydia trachomatis is one of the most common sexually transmitted bacterial pathogens. The aim of the study was to present the current occurrence of chlamydial infections among Polish soldiers, sexually-active men and women at reproductive age. Materials and method. The research involved 253 active duty soldiers from the Polish Special Forces, 237 men and 16 women aged 26–57, stationed in Warsaw between October – November 2016. The study participants were asked to fill a socio-demographic questionnaire and then subjected to diagnostic tests. These included a urine test for the presence of Chlamydia trachomatis DNA using the Real-Time PCR assay with fluorescently labeled markers and probes, complementary to plasmid DNA of the bacteria (DNA isolated from urine samples was used as matrix). Results. Chlamydia trachomatis infection was detected in two male soldiers, non-commissioned officers, at mean age 40.5 years (total: 38.0 years); reporting sexual contacts with 2–3 partners in the last 12 months (total: 141 soldiers – 1 partner, 66 – 2–3 partners, 46 – >4 partners), with no UTI symptoms. Conclusions. Among all the study participants, of whom more than 40% reported sexual contacts with 2–4 or more partners within the last 12 months, only 0.8% were found to be infected. The low prevalence of Chlamydia trachomatis infection can be associated with a regular or frequent use of STI prevention measures during casual sex, or having a single sexual partner.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 1; 51-54
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Increasing deaths from colorectal cancer in Poland - insights for optimising colorectal cancer screening in society and space
Autorzy:
Czaderny, K.
Powiązania:
https://bibliotekanauki.pl/articles/2082987.pdf
Data publikacji:
2019
Wydawca:
Instytut Medycyny Wsi
Tematy:
colorectal neoplasms
mortality
colonoscopy
mass screening
screening acceptance
self-selection
Opis:
Introduction and objective. With respect to the increasing numbers of deaths due to colorectal cancer in Poland, the aim of the study was to investigate socio-demographic characteristics which influence colorectal cancer screening acceptance and to assess spatial variation of colorectal cancer mortality. Materials and method. An age-period-cohort model was estimated to assess mortality trends in colorectal cancer in Poland. A geographical analysis was performed by spatial regression. Factors influencing participation in colorectal cancer screening were identified using structural equation modelling. Results. In 2014 in Poland, 6.4 thousand men and 5.0 thousand women died due to colorectal cancer. In total, by 2030 this number is expected to rise to nearly 14.4 thousand. Observed spatial clustering of age-adjusted colorectal cancer mortality is associated with spatial variation in tobacco use, employment in industry, and consumption of red meat. Patient- physician communication, advanced age, and healthy diet are the most important predictors of colorectal cancer screening acceptance. Tobacco and alcohol users are not more likely to participate in colorectal cancer screening, adjusting for other variables. Conclusions. Self-selection of patients who follow healthy diet means that individuals at higher risk of colorectal cancer are less likely to participate in colorectal cancer screening. Therefore, screening should be more targeted. According to the structural equation modelling results, the phenomenon of ‘no-show’ for screening can be mitigated by patient-physician communication. The inhabitants of the Greater Poland region are at the highest risk of dying due to colorectal cancer, which may have public health policy implications.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 1; 125-132
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An attempt to assess knowledge about tobacco dependence among students at the Medical University in Wroclaw
Autorzy:
Janik-Koncewicz, K.
Zatonski, T.
Poltyn-Zaradna, K.
Zatonska, K.
Cedzynska, M.
Przewozniak, K.
Wojtyla, A.
Powiązania:
https://bibliotekanauki.pl/articles/50060.pdf
Data publikacji:
2012
Wydawca:
Instytut Medycyny Wsi
Opis:
Introduction: Tobacco smoking is still one of the greatest, avoidable, singular causes of death. Although students of medical faculties are expected to have solid knowledge about smoking hazards, a significant number of them still smoke. Aim: The aim of the study was to assess knowledge on tobacco dependence in a sample of students at the Medical University in Wroclaw. Material and methods: Between 2009-2011, non-compulsory lectures on the diagnosis and treatment of tobacco dependence were provided for 3rd to 6th year students of medicine at the Medical University in Wroclaw (170 students). The questionnaire contained 10 questions about smoking-related diseases and medicines used in tobacco dependence treatment. Results: 21% of students smoked cigarettes and 79% were never smokers. 36% of the study group was exposed to passive smoking at the university. Nearly 80% of survey respondents agreed with the statement that cigarette smoking can lead to psychological addiction as strong as drug addiction, but more than 12% of the respondents perceived smoking just as a strong habit. Only 6 out of 10 surveyed students recognised tobacco dependence as an illness classified in an international classification of diseases and health problems (ICD-10). The correct amount of the chemical substances to be found in tobacco smoke was known by 67.1% of all surveyed students. The vast majority of the surveyed students indicated correctly 2 brands of nicotine replacement therapy, but none of them could name even one chemical and corresponding trade name of the pharmaceutical with central effect. Conclusions: The level of knowledge about the diagnosis and treatment of tobacco dependence among the students of the Medical Faculty in Wroclaw Medical University is low, and requires improvement through educational activities at both facultative and compulsory study level. Special attention should be paid to pharmaceutical treatment of the tobacco dependence syndrome.
Źródło:
Annals of Agricultural and Environmental Medicine; 2012, 19, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Changes in population abundance of adult Dermacentor reticulatus (Acari: Amblyommidae) in long-term investigations in eastern Poland
Autorzy:
Buczek, A.
Bartosik, K.
Wisniowski, L.
Tomasiewicz, K.
Powiązania:
https://bibliotekanauki.pl/articles/50724.pdf
Data publikacji:
2013
Wydawca:
Instytut Medycyny Wsi
Tematy:
population change
abundance
adult
Dermacentor reticulatus
Acari
Amblyommidae
long-term investigation
tick
seasonal activity
sex ratio
climate condition
Polska
Opis:
Investigations into the abundance of adult D. reticulatus in relation to the effect of climatic conditions (temperature, humidity) on host-seeking behaviour were conducted during the autumn (September-October) and spring (May) activity peaks in 2008–2009 in eastern Poland (51°25’N). The study was conducted in the same habitat where similar examinations were performed in 1999–2000. A comparative analysis revealed that the abundance of D. reticulatus had almost doubled within 10 years. Analysis of data on the humidity and temperature conditions prevailing during tick collection, and on tick abundance in the respective study periods in 1999–2000 and 2008–2009, as well as absence of climatic changes over many years, indicate that the increase in the numbers of ticks may have been a result of a multitude of other factors, e.g. weather or environmental conditions favourable for ticks and their hosts. The substantial differences in D. reticulatus abundance observed during the autumn activity peak (an increase from 126 and 128.6 specimens per collection in 1999 and 2000, respectively, to 247.3 in 2008) demonstrate the considerable effect of the biotic and abiotic conditions prevailing during the development of young and adult stages on the abundance of this tick species. The activity of adult D. reticulatus ticks in the autumn was 2.7-fold higher in comparison to that observed during the spring collection; the difference was statistically significant (p<0.0001). Females dominated in both seasonal activity peaks. The ratio between females and males during the spring and autumn peaks was 3.31:1 and 1.05:1, respectively. The increase in the abundance of the D. reticulatus population implies a higher risk of transmission of tick-borne diseases in the study area, and the necessity to develop and implement effective prevention methods and tick control programmes.
Źródło:
Annals of Agricultural and Environmental Medicine; 2013, 20, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Disturbance of posture in children with very low lead exposure, and modification by VDR FokI genotype
Autorzy:
Pawlas, N.
Broberg, K.
Skerfving, S.
Pawlas, K.
Powiązania:
https://bibliotekanauki.pl/articles/51353.pdf
Data publikacji:
2014
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2014, 21, 4
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of checklists for agricultural safety management
Autorzy:
Kim, H.
Rasanen, K.
Chae, H.
Lee, K.
Powiązania:
https://bibliotekanauki.pl/articles/2081898.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
checklist
agriculture
safety
management
Opis:
Introduction. The current health and safety management system under the Occupational Health and Safety Act has avoided agriculture in Korea. It is important to consider the various safety systems used in agricultural health and safety to develop effective regulations. Objective. The aims were to classify and review the items from various checklists using safety systems, such as design, training, etc., ultimately aimed at proposing directions for improving the health and safety of farmers. Materials and method. Among the retrieved checklists with Google, four were chosen for this study, based on criteria such as the Checklist developed by an international organization, as well as others. Each item on the checklist was categorized using criteria concerning safety systems, developed based on previous studies. Results. The total number of analyzed items was 573, which is 36 more than the actual number of checklist items (537). The proportion of items belonging to the training/procedures system was the highest (32.5%); the second-highest was for the mitigation system – 18.2%.; the third-largest proportion of items was maintenance/inspection – with 14.3%. Items related to the design and human factor systems were 8.2% and 5.6%, respectively. The safety system with the lowest proportion was the warning/notification system – 4.2% of the total items. The proportion of items that could not be classified into safety systems was found to be 16.1%. Conclusions. A large number of items belonging to the training/procedures system reported as occasionally not effective in prevention of injury were found in the checklists. It appears important to develop checklist items proposing the supplementation of various safety systems, rather than presenting items that are biased towards certain safety systems.
Źródło:
Annals of Agricultural and Environmental Medicine; 2018, 25, 3; 494-499
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chemopreventive properties of young green barley extracts in in vitro model of colon cancer
Autorzy:
Kawka, K.
Lemieszek, M.K.
Rzeski, W.
Powiązania:
https://bibliotekanauki.pl/articles/2082991.pdf
Data publikacji:
2019
Wydawca:
Instytut Medycyny Wsi
Tematy:
Hordeum vulgare
barley
colon cancer
chemoprevention
Opis:
Introduction and objective. Young green barley is the most valuable source of nutrients and bioactive substances. It has a broad spectrum of health-promoting properties such as antioxidant, anti-inflammatory, hypoglycaemic, anti-depressant, anti-atherosclerotic and anticancer. The presented study is an attempt to extend this knowledge with particular emphasis on the possibility of using green barley in colon cancer prevention. Materials and method. Extracts were prepared on the basis of two commercial products: ground dried barley grass (YGB INT) and powder of young green barley juice (YGB GW). Their influence on colon epithelial cells (CCD841 CoN) viability and proliferation were analyzed by LDH and MTT assays. Anticancer properties of extracts were screened on colon cancer cell lines (LS180, HT-29) by MTT and BrdU assays. Changes in cells morphology induced by extracts were investigated after May-Grünwald-Giemsa staining. Results. Tested extracts were not toxic against CCD841 CoN and did not affected their proliferation or morphology (LDH test, MTT test, microscopy observation). The MTT revealed that extracts significantly inhibited proliferation of colon cancer cells in a dose-dependent manner. Results of BrdU test confirmed antiproliferative properties of extracts, but opposite to MTT test, indicated YGB GW as a better anticancer agent. Light microscopy observation proved the data obtained from both MTT and BrdU tests and additionally suggested the ability of the extracts to induce necrosis in LS180 and HT-29 cells. Conclusions. The study demonstrated that YGB extracts specifically inhibit proliferation of colon cancer cells without any undesirable effect on colon epithelial cells. Obtained results will provide a rationele for the future development of dietary supplements which could be beneficial in colon cancer chemoprevention.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 1; 174-181
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 499

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