- Tytuł:
- Differential effects of various soy isoflavone dietary supplements (nutraceuticals) on bacterial growth and human fibroblast viability
- Autorzy:
-
Pierzynowska, Karolina
Rzeszótko, Agata
Blendowska, Aleksandra
Wieczerzak, Ewa
Rodziewicz-Motowidło, Sylwia
Piotrowska, Ewa
Węgrzyn, Grzegorz - Powiązania:
- https://bibliotekanauki.pl/articles/1038411.pdf
- Data publikacji:
- 2018
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
genistein
soy isoflavone extracts
anti-menopausal dietary supplements
bacterial growth
viability of human cells - Opis:
- Flavonoids, polyphenolic compounds present in many food products, affect growth of different bacterial species when tested as purified or synthetic substances. They can also influence gene expression in human cells, like fibroblasts. Here, we asked if soy isoflavone extracts, commonly used in many products sold as anti-menopausal dietary supplements, influence bacterial growth similarly to a synthetic isoflavone, genistein. Four commercially available products were tested in amounts corresponding to genistein concentrations causing inhibition of growth of Vibrio harveyi (a model bacterium sensitive to this isoflavone) and Escherichia coli (a model bacterium resistant to genistein). Differential effects of various extracts on V. harveyi and E. coli growth, from stimulation, to no changes, to inhibition, were observed. Moreover, contrary to genistein, the tested extracts caused a decrease (to different extent) in viability of human dermal fibroblasts. These results indicate that effects of various soy isoflavone extracts on bacterial growth and viability of human cells are different, despite similar declared composition of the commercially available products.
- Źródło:
-
Acta Biochimica Polonica; 2018, 65, 2; 325-332
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł