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Tytuł:
Wybrane metody leczenia osteoarthritis, prezentacja z wykorzystaniem modeli zwierzęcych
Autorzy:
Kozera, Aleksandra
Krać, Katarzyna
Powiązania:
https://bibliotekanauki.pl/chapters/2201290.pdf
Data publikacji:
2022
Wydawca:
Akademia Bialska im. Jana Pawła II
Tematy:
Osteoarthritis
Opis:
Osteoarthritis (OA), czyli zwyrodnieniowa choroba stawów jest najczęstszym schorzeniem stawów u ludzi. Badania nad patogenezą zwyrodnienia chrząstki oraz potencjalnymi postępowaniami terapeutycznymi są możliwe dzięki wykorzystywaniu modeli zwierzęcych, u których OA jest wywoływane w celach eksperymentalnych, lub występuje naturalnie. Najpowszechniejszymi gatunkami wykorzystywanymi do badań są kawie domowe, myszy, szczury, konie oraz psy. Stosowane obecnie terapie przy użyciu nowoczesnych preparatów oraz biomateriałów zostały opracowane z wykorzystaniem powyższych gatunków.
Źródło:
Koła naukowe - szkołą twórczego działania. Edycja ósma; 21-32
9788364881923
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Current concepts of articular cartilage repair
Autorzy:
Mierzwiński, M.
Ficek, K.
Powiązania:
https://bibliotekanauki.pl/articles/285520.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
cartilage
osteoarthritis
implantation
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 115
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stigmasterol blocks cartilage degradation in rabbit model of osteoarthritis
Autorzy:
Chen, Wei-Ping
Yu, Chong
Hu, Peng-Fei
Bao, Jia-Peng
Tang, Jing-Li
Wu, Li-Dong
Powiązania:
https://bibliotekanauki.pl/articles/1039645.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
matrix metalloproteinases
stigmasterol
osteoarthritis
Opis:
Stigmasterol has been shown exihbit anti-osteoarthritic properties in vitro studies. However, the in vivo effects of stigmasterol on cartilage are still unclear. This study investigated the anti-osteoarthritic properties of stigmasterol on cartilage degradation in a rabbit model of osteoarthritis (OA). Twenty rabbits underwent bilateral anterior cruciate ligament transection (ACLT) to induce OA. Five rabbits were used as normal control. Two weeks after operation, the rabbits were randomly divided into two groups. Each group of 10 rabbits received intra-articular injection with 0.3 ml of stigmasterol in left knees and vehicle in right knees, once weekly. Group 1 was killed 6 weeks after ACLT and 2 were sacrificed 9 weeks after ACLT. The knee joints were assessed by gross morphology, histology and gene expression analysis. We found that expression of genes encoding matrix metalloproteinases (MMPs) was significantly higher while tissue inhibitors of metalloproteinase (TIMP)-1 was significantly lower in the both joints of the two OA groups compared to normal contrals. Stigmasterol reduced the cartilage degradation as assessed by histological analysis and markedly suppressed MMPs expression both in group 1 and group 2. Our results suggest that stigmasterol may be considered as a possible therapeutical agent in the treatment of OA.
Źródło:
Acta Biochimica Polonica; 2012, 59, 4; 537-541
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
New approaches in the ortobiological therapy
Autorzy:
Ficek, K.
Rajca, J.
Racut, A.
Powiązania:
https://bibliotekanauki.pl/articles/284390.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
diseases
ortobiological therapy
osteoarthritis
Opis:
Osteoarthritis is the most frequently reported and the most onerous disease in middle-aged and elderly people. Degenerative changes constitute a heterogeneous set of pathological transformations of the structure and function of the elements forming the joint, which is the result of factors disturbing their balance. The loss of joint cartilage mass with its insufficient rebuilding or transformation of subchondral bone and other soft tissue structures is characteristic for this disease [1-3]. Nowadays, in addition to the development of invasive surgical methods aimed at cartilage reconstruction, it is possible to use ortobiological therapy in parallel, taking into account the careful qualification for this type of treatment. Ortobiological therapies use the vital potential of the unique tissue that is blood. The expected effects of ortobiological treatment in osteoarthritis is joint cartilage regeneration and acceleration of healing [1,2,4]. The effectiveness of each therapy depends on a number of factors that affect its results not only during or after its application, but also before the start of treatment. Therefore, it is important to properly prepare the tissues for the planned therapy. Targeted physical activity, taking into account the correctness of its performance is extremely important in the preparation of the tissue base for the application of autologous preparations. Physical exercises, preceding the application of injection within the musculoskeletal system, improve the effectiveness of ortobiological treatment. The combination of ortobiological therapy and subsequent physiotherapy support the rehabilitation process, leading to the achievement of the best possible end results [5-7]. The platelet rich plasma (PRP) is a more and more commonly used method of ortobiological therapy. Platelet rich plasma is a source of growth factors that is used to improve the function of tissues by remodeling their morphology and improving metabolism. This therapy distinguishes itself from conventional means of influencing tissue and contributes to establishing a new therapeutic direction in the treatment of osteoarthritis [8]. Another therapy used in ortobiology is autologous conditioned serum (Orthokine®). This modern method of treating inflammation and degenerative joints strengthen the integrity of joint cartilage by introducing antiinflammatory cytokines into the body. In addition, a significant increase in the concentration of growth factors during conditioning using Orthokine® has been demonstrated. These factors stimulate tissue repair and regeneration processes by migrating cells to the site of damage, their multiplication, differentiation and the formation of new blood vessels [9-11]. One of the methods used to treat osteoarthritis is stem cell therapy. The purpose of these cells is to replace the dead cells and rebuild the tissue. Due to the fact that stem cells present in the human body, as the body ages, they lose their ability to intensively regenerate, the method of stem cell proliferation is used for therapeutic purposes. Properly prepared stem cells are injected precisely to the affected area. Stem cell therapy is a method that is constantly improved both in the selection of the source of cells and the method of their preparation in order to isolate and concentrate the cells. The research carried out in this direction is aimed at optimizing the therapy and, consequently, effective assistance to patients with osteoarthritis [12]. An important problem associated with osteoarthritis is the occurrence of degenerative cysts. They appear due to the formation of bloody strokes and the conduct of destructive processes in the subchondral bone. Ongoing work on surgical methods to prevent the rapid progression of the disease. Currently, tissue scaffolds are used to fill defects. These are the resorbable material that fills the tissue defect, and through their structure they allow for the migration of cells and overgrowth of tissues, and thus its reconstruction [13-15]. In order to improve the properties of materials, research is conducted on hybrid implants that would combine individual therapies. The possibility of comprehensive treatment, consisting in filling cavities with an implant, with the use of an ortobiological preparation in the scaffolding space, will allow bone tissue remodeling to proceed under optimal conditions [16].
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 75
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Histological changes following the administration of two different chondroitin sulfate products in experimental osteoarthritis models in rats
Autorzy:
Nosivets, Dmitriy
Montell, Eulalia
Opryshko, Valentine
Powiązania:
https://bibliotekanauki.pl/articles/2040156.pdf
Data publikacji:
2021-03-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
chondroitin sulfate
chondroprotection
osteoarthritis
Opis:
Introduction. Osteoarthritis (OA) is generally a progressive disease that affects synovial joints, resulting in abnormalities to articular cartilage subchondral bone, synovium, and adjacent soft tissues. Aim. The purpose of this work was to examine the histological changes in knee cartilage and bone following the administration of two different chondroitin sulfate products in two experimental OA models in rats. Material and methods. OA was induced in rats by either a single injection of mono-iodoacetate or four once-weekly injections of dexamethasone. 70 adult rats were included: 30 received mono-iodoacetate, 30 received dexamethasone and the 10 remaining controls received no injection. Samples of knee bone and cartilage were then analyzed histologically. Results. Animals with OA that received CS had significantly less inflammation, improved motor activity, and better analgesia compared with those that did not receive CS, with little difference between products. Histologically, both products reduced the signs of OA and resulted in the activation of regenerative processes of cartilage and bone and stimulation of proliferation and formation of amorphous material. Conclusion. These results substantiate the importance of using high-quality pharmaceutical-grade CS to ensure optimal efficacy and safety of the final product in patients with OA
Źródło:
European Journal of Clinical and Experimental Medicine; 2021, 1; 23-32
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molecular correlates of joint pain intensity in osteoarthritis
Autorzy:
Mlost, J.
Bryk, M.
Chwastek, J.
Korostynski, M.
Starowicz, K.
Powiązania:
https://bibliotekanauki.pl/articles/283966.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
osteoarthritis
pathology
knee cartilage
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 107
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Quality of life of osteoarthritis patients in the aspect of analgesic treatment
Autorzy:
Niczyporuk, M.
Kłossowska, J.
Kleszczewska, E.
Shpakou, A.
Knaś, M.
Powiązania:
https://bibliotekanauki.pl/articles/1918857.pdf
Data publikacji:
2019-08-26
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Osteoarthritis
analgesics
quality of life
Opis:
Introduction: Osteoarthritis an inflammatory process in the synovial membrane. These changes cause pain and joint deformities. Pharmacists can assess patients’ quality of life, which can be a good criterion for assessing analgesics treatment effectiveness and prevent the growing phenomenon of polypharmacy and self-treatment. Purpose: To answer these questions: 1) Is there a relationship between the quality of life of patients with osteoarthritis taking analgesics and those with osteoarthritis taking analgesics and implemented rehabilitation? 2) Do patients using analgesics practice polypharmacy? 3) Are patients with osteoarthritis the main consumers of painkillers? and 4) Does the use of analgesics affect the health-related quality of life of patients with osteoarthritis? Materials and methods: The study was conducted on 240 people who were divided into three groups: osteoarthritis, reference (generally healthy, occasionally taking analgesics), and control (generally healthy, no intake of analgesics). To assess the rise in analgesics consumption by patients with osteoarthritis and the phenomenon of polypharmacy, an original questionnaire was used. Results: There is a relationship between the quality of life of patients with osteoarthritis taking analgesics. Statistical analysis showed that in the years 2013-2015 the purchase of prescription analgesics and without a prescription systematically, significantly increased. Conclusions: Patients using analgesics unknowingly practice polypharmacy. In Ars Medica Pharmacies, analgesics purchases by patients with osteoarthritis grew significantly in the analyzed period, but they are not the main analgesics consumers. Use of analgesics by patients with osteoarthritis improves their health-related quality of life.
Źródło:
Progress in Health Sciences; 2019, 1; 36-44
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Personality correlates in the tendency to incur debt in patients with and without osteoarthritis
Autorzy:
Łukasiewicz, Jacek
Stencel, Marcin
Raczkowski, Adam
Cwynar, Andrzej
Cwynar, Wiktor
Saran, Tomasz
Mazur, Anna
Powiązania:
https://bibliotekanauki.pl/articles/454971.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
life on credit
osteoarthritis
personality
Opis:
Introduction. Osteoarthritis is the most common disease of the musculoskeletal system. Osteoarthritis progresses slowly, but with time it results in movement disability and chronic pain. Its progression is also significantly associated with personality functioning and the ability to make rational life choices regarding various aspects of human life, including the economic sphere. Aim. The aim of the research was to determine how personality correlates with a tendency towards indebtedness between patients with and without osteoarthritis. Material and methods. The researched sample consisted of two groups - 50 patients diagnosed with osteoarthritis hospitalized in the Department of General and Neuro Rehabilitation in the Institute of Rural Health in Lublin and 50 healthy people. The KOS-B Questionnaire, the IVE Questionnaire, the SES Scale, the SPP-25 Scale, the Delta Questionnaire and the APSZ questionnaire were used in the research. Results. In the group of patients with osteoarthritis, the leading correlates of indebtedness are: assessment of the stress situation related to the current economic situation seen as a threat, and perceiving it as harm or loss. In the healthy group, the leading correlates of incurring financial liabilities are impulsiveness, self-esteem, assessment of the stress situation related to the current economic situation seen as a threat, openness to new experiences and sense of humor, empathy, and the need for social approval. Conclusion. In the group of patients with osteoarthritis, the factor conducive to incurring financial liabilities is the assessment of the stressful situation related to the current economic situation seen as a threat, while perceiving it as harm or loss leads to abandoning reliance on credit. In the healthy group, the factors that favor this type of activity are impulsiveness, self-esteem, the assessment of the stress situation related to the current economic situation seen as a threat and the need for social approval; the factors protecting against indebtedness in healthy persons are openness to new experiences and sense of humor as well as empathy.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 1; 26-32
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of Integrated Therapeutic Exercises on Pain and Disability in Medial Knee Osteoarthritis
Autorzy:
Raghav, Sumit
Singh, Anshika
Mani, Suresh
Srivastava, Anirudh
Kumar, Mukul
Powiązania:
https://bibliotekanauki.pl/articles/28761968.pdf
Data publikacji:
2023
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
knee osteoarthritis
integrated exercises
pain
disability
Opis:
The purpose of this study was to compare the effect of quadriceps isometric exercises along with hip abductors isometric exercises as integrated exercise with quadriceps exercises in reducing pain, disability in medial knee osteoarthritis. The Total of 54 patients (both male and female) were recruited in this study but on the basis of inclusion and exclusion criteria, only 32 were included in this study. Womac index was opted as outcome measures to collect the data of pain, disability and functional limitation. Participants were randomly assigned to integrated exercise group; (n = 16) (mean age 52) who performed exercises [Quadriceps isometric along with hip abductor isometric exercises] and quadriceps isometric exercises group (n = 16) (mean age 49) performed for 3 weeks. 32 patients were analyzed and the effect of integrated exercises [Quadriceps isometric along with hip abductor isometric exercises] showed a statistically significant difference in pain, disability and functional limitation (p < 0.000). Total duration to collect the pre and post data of pain, disability and functional limitation was 3 weeks. 3 weeks of exercise protocol was effective in both groups in terms of reducing pain and disability but integrated exercises were found to be more effective than quadriceps exercise in improving the pain, disability and functional limitation over the time at the level of significance.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2023, 44; 55-62
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparative efficacy of kneading massage and pulsed mode ultrasound in the management of chronic knee osteoarthritis
Autorzy:
O. Ojoawo, Adesola
Abiodun Fatai, Wasiu
Powiązania:
https://bibliotekanauki.pl/articles/2040133.pdf
Data publikacji:
2020-12-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
kneading massage
knee osteoarthritis
pulsed ultrasounds
Opis:
Introduction. Osteoarthritis of the knee is the most common presentation of osteoarthritis with prevalence between 12% and 35% of general population and is considered the leading cause of musculoskeletal disability in the elderly population worldwide. Aim. The study compared efficacy of kneading massage and pulsed ultrasound on pain, joint stiffness and difficulty in knee osteoarthritis (KOA). Material and methods. Fifty subjects with radiological evidence of KOA participated in the study. They were randomly allocated into kneading massage group (KMG) (25) and Ultrasound group (USG) (25). KMG received kneading massage for 7 minutes while USG received pulsed mode ultrasound for 15 minutes. Treatment was twice in a week for six weeks. Pain intensity (PI), joint stiffness and difficulty were assessed pre, 3rd and 6th weeks of treatment session with semantic differential scale and WOMAC. The data were analyzed using descriptive and inferential statistics, alpha level was set at 0.05 Results. There was a significant difference in present PI (F=11.45,P=0.001) and stiffness (F= 11.32, P=0.003) in USG. There was a significant reduction in PI (F=7.95, P=0.001) and joint stiffness (F=8.86, P=0.003) in KMG. At the 6th week, there was a significant differences in PI (t=12.23,P=0.000) and stiffness (t=8.08, P=0.000) when USG (3.00+0.4, vs 7.14+ 1.49) was compared with KMG (3.16+0.5 vs 7.50+1.5). Conclusion. Ultrasound (US) and kneading massage (KM) reduced PI and joint stiffness of KOA effectively; however US reduced PI than KM while KM reduces joint stiffness than US.
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 4; 275-280
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of the quality of life of patients with osteoarthritis
Autorzy:
Niczyporuk, M.
Kłossowska, J.
Kleszczewska, E.
Shpakou, A.
Knaś, M.
Powiązania:
https://bibliotekanauki.pl/articles/1918782.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
uality of life
osteoarthritis
chronic diseas
Opis:
Purpose: The tools for measuring objective quality of life include research regarding the conditions of a successful life and life satisfaction. Osteoarthritis (OA) is characterized by progressive degradation and loss of articular cartilage as well as abnormal bone growth and remodeling, located directly under the cartilage. The aim of this study is to answer the question on which level OA patients perceive their quality of life dependent on health. Material and methods: The Polish version of the HAQ questionnaire, assessing the quality of life over the past week, was used for overall assessment of quality of life. The Polish version of the AIMS-2 questionnaire was used as a specific questionnaire for assessing the health status of patients with osteoarthritis. Surveys were conducted in a group of 240 people. Results: The quality of life dependent on health is significantly reduced in the group of healthy people who take painkillers sporadically because of other reasons and in the OA pateints group compared to the control group, the same as in the OA pateints group compared to the group of healthy people who take painkillers sporadically for other reasons. Conclusions: According to the answers from the questionnaire, patients with OA seek different forms of improving their quality of life. It is important to change their lifestyle (weight reduction, using a bench-mounted bike, walking stick or walking frame), reducing the surface area of the joints, reducing the defective position of the limb axis. Exercises that increase muscle mass and exercises to improve joint mobility should be introduced. It is advisable to refer the OA patient for physical therapy and/or balneotherapy.
Źródło:
Progress in Health Sciences; 2018, 8(2); 1-9
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
miRNA-146a-5p is upregulated in serum and cartilage samples of patients with osteoarthritis
Autorzy:
Skrzypa, Marzena
Szala, Dariusz
Gablo, Natalia
Czech, Joanna
Pajak, Justyna
Kopanska, Marta
Trzeciak, Mateusz
Gargasz, Krzysztof
Snela, Sławomir
Zawlik, Izabela
Powiązania:
https://bibliotekanauki.pl/articles/1391948.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
circulating microRNA
osteoarthritis
serum
cartilage
biomarker
Opis:
Introduction: Osteoarthritis (OA) is a widely prevalent joint disease leading to motor disability and pain. Appropriate indicators for identifying patients at risk for this progressive disease, identifying molecular events for detecting early phases of the disease, or biomarkers to screen for treatment responses, however, are lacking. Micro RNAs (miRNAs), which play crucial roles in OA, could be potential biomarkers of OA. Because circulating miRNA levels reflect the disease state, they may be useful for OA screening and as diagnostic tools, reducing the need for invasive procedures and minimizing the cost of current diagnostic methods. Materials and methods: The expression levels of 18 microRNAs (let-7e-5p, miR-21-5p, miR-93-5p, miR-101-3p, miR-103a-3p, miR-130a-3p miR-146a-5p, miR-16-5p, miR-193b-3p miR-199a-3p, miR-210-3p, miR-222-3p, miR-22-3p, miR-27a-3p, miR-27b-3p, miR-335-5p, miR-454-3p, and miR-98-5p) were analyzed by quantitative real-time polymerase chain reaction in the cartilage tissues and serum samples of 28 OA patients and were compared to those of 2 healthy controls. Results: Expression of microRNA-146a-5p was significantly upregulated in the cartilage (p=0.006) and serum (p=0.002) of OA patients. The expression levels of miR-146a-5p in the serum were positively correlated with those in the cartilage (Pearson correlation coefficient R=0.32; p=0.002). Conclusion: miR-146a-5p was significantly overexpressed in patients with OA, both in the articular cartilage tissue and serum, with a positive correlation between the levels in both types of samples. Therefore, the miR-146a-5p serum level could reflect the molecular processes in the cartilage, suggesting its clinical utility as a biomarker for OA management. Implementing noninvasive biomarker using serum miRNAs involves the analysis of the misregulated miRNAs linked to the cartilage pathology.
Źródło:
Polish Journal of Surgery; 2019, 91, 3; 1-5
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Excessive tensile strain induced the change in chondrocyte phenot
Autorzy:
Zhong, D.
Chen, X.
Luo, Z.-P.
Powiązania:
https://bibliotekanauki.pl/articles/306533.pdf
Data publikacji:
2018
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
osteoartroza
fenotyp
chondrocyt
osteoarthritis
phenotype
chondrocytes
tensile strain
Opis:
Chondrocyte extracellular matrix type II collagen and proteoglycans ensure an important compression-bearing structure in synovial joint. However, much more type I collagen is generated in osteoarthritis, which implies the presence of abnormal tensile strain in cartilage. We hypothesize that tensile stress influences chondrocyte phenotype at the cellular level, leading to potential osteoarthritis. Methods: Chondrocytes were stimulated with cyclic excessive tensile (10%) or mild tensile or compressive strain (5%) at 0.5 Hz, 3 h per day for 3 days. Chondrocyte morphology and matrix proteoglycans level was separately determined by Rhodamine phalloidin and toluidine blue staining. The expression of cartilage marker molecules was measured using quantitative reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assays. Results: Chondrocytes demonstrated significant fibroblastic morphology, reduced proliferation and increased apoptosis following exposure to 10% tensile strain. The 10% tensile strain group induced the lowest matrix proteoglycans level. It observably reduced the expression of COL2A1, Acan and SOX9, and increased COL1A1 expression level. The 5% tensile (5% compression) group, maintained the chondrocyte phenotype. Conclusions: The findings identified the effects of different magnitudes of tensile stress on chondrocyte phenotype compared to compressive strain. Further studies on cartilage biomechanical micro-environment might benefit from this study.
Źródło:
Acta of Bioengineering and Biomechanics; 2018, 20, 2; 3-10
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Leczenie, diagnostyka i profilaktyka stawu biodrowego w chorobie zwyrodnieniowej
Treatment, diagnosis and prevention of hip replacement for osteoarthritis
Autorzy:
Nalazek, Anna
Kamińska, Ewa
Kaźmierczak, Urszula
Trela, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1032509.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Kazimierza Wielkiego w Bydgoszczy
Tematy:
choroba zwyrodnieniowa stawu biodrowego
osteoarthritis of the hip
Opis:
Chorobę zwyrodnieniową stawów charakteryzuje stała progresja zmian patologicznych. Nie można mówić o wyleczeniu tych zmian, jedynie o zahamowaniu, przeciwdziałaniu dalszemu zużyciu powierzchni stawowych i działaniu przeciwbólowym (leczenie zachowawcze i i operacyjne).
Osteoarthritis is characterized by the constant progression of pathological changes. You can't talk about disinfecting these changes, only stem, further consumption of articular surfaces and analgesic action (conservative treatment and operational).
Źródło:
Journal of Health Sciences; 2014, 4, 1; 333-338
1429-9623
Pojawia się w:
Journal of Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of the function of the knee after rehabilitation in patients with gonarthrosis - the KOOS scale
Autorzy:
Krawczyk – Suszek, Marlena
Martowska, Blanka
Cygan, Natalia
Mierzwińska, Aleksandra
Maciejewski, Ryszard
Bednarski, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1071322.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
KOOS scale
Osteoarthritis (OA)
VAS scale
knee
rehabilitation
Opis:
Osteoarthritis (OA) of the knee joints is nowadays a significant medical and economic problem in the world. The percentage of people diagnosed with degeneration of the knee joint is increasing rapidly. Not only does it cause negative social consequences, but also generates large treatment costs. The treatment consists in taking preventative measures and educating patients, as well as pharmacological therapy, physiotherapy and, as a last resort – surgery. Suitable and comprehensive measures can decrease symptoms of gonarthrosis. The research was conducted among 110 patients diagnosed with OA of the knee joints in one of the rehabilitation clinics in Podkarpacie voivodeship. A self-construction questionnaire, the KOOS scale and the VAS scale were the research tools. The respondents were informed about the anonymity of the survey. The research was carried out twice before and after the rehabilitation. Among the respondents, the highest percentage of people with gonarthrosis involved women (74.5%). Overweight and obesity were important factors correlating with the occurrence of gonarthrosis. The cryotherapy (66.4%), exercise in relief (42.7%), followed by laser therapy, magnetronics and individual exercises were considered the most helpful treatments. Electrotherapy and massage were considered as the least effective. Having analysed the result of the KOOS questionnaire and the VAS scale provided to the patients before and after the treatment, the positive effects of physiotherapy have been noted. The patients have noticed improvement in daily activities, quality of life, severity of symptoms and pain relief (p <0.05). The research indicates that physiotherapy is an effective measure, therefore it should be included in the treatment of patients diagnosed with OA.
Źródło:
World Scientific News; 2019, 122; 1-11
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 63

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