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Tytuł:
Argeting neurons overcoming extra and intracellular barriers with biomaterial-based vectors to promote neuroprotection and neuroregeneration
Autorzy:
Pêgo, A. P.
Powiązania:
https://bibliotekanauki.pl/articles/284333.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
neurons
biomaterials
regeneration
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 7
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Increased neurogenesis after ACEA and levetiracetam treatment in mouse pilocarpine model of epilepsy
Autorzy:
Zagaja, Mirosław
Szewczyk, Aleksandra
Haratym-Maj, Agnieszka
Rola, Radosław
Maj, Maciej
Łuszczki, Jarogniew J.
Anders-Mach, Marta
Powiązania:
https://bibliotekanauki.pl/articles/972512.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
neurogenesis
neurons
astrocytes
pilocarpine
ACEA
Levetiracetam
Opis:
Introduction and objectives. The aim of the study was to asses the impact of long-term therapy with the second generation antiepileptic drug levetiracetam (LEV) with arachidonyl-2’-chloroethylamide (ACEA), a highly selective cannabinoid CB1 receptor agoniston the process of neurogenesis in a mouse pilocarpine model of epilepsy (PILO). Additionally, a relationship was established between the treatment with ACEA in combination with LEV, and hippocampal neurogenesis in mouse PILO brain. Materials and method. All experiments were performed on adolescent male CB57/BL mice injected i.p. with LEV (10 mg/kg), ACEA (10 mg/kg) and PMSF (30 mg/kg) (phenylmethylsulfonyl fluoride — a substance protecting ACEA against degradation by the fatty-acid amidohydrolase), pilocarpine (PILO, a single dose 290 mg/kg) and methylscopolamine (30 min before PILO to stop the peripheral cholinergic effects of the pilocarpine, 1 mg/kg). The process of neurogenesis was evaluated after10 days treatment with LEV and ACEA. Results. Obtained results indicated that the combinations of ACEA+PMSF+LEV and ACEA +PMSF increased the total number of total newborn cells compared to the control. Moreover, ACEA+PMSF administered alone and in combination with LEV had a significant impact on neurogenesis increasing the total number of newborn neurons compared to the control group. Neither LEV nor PMSF had a significant impact on the number of proliferating cells and newborn neurons when compared to the control PILO group. In turn, LEV administered alone decreased significantly the number of astrocytes. However, ACEA+PMSF has demonstrated significant increase of astrocytes compare to control mice. Conclusions. These data provide substantial evidence that the combination of LEV+ACEA significantly increases the level of newborn neurons in the PILO dentate subgranular zone.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2017, 11, 2; 136-141
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunohistochemical characterization of nerve elements in porcine intrinsic laryngeal ganglia
Autorzy:
Sienkiewicz, W.
Klimczuk, M.
Gulbinowicz-Gowkielewicz, M.
Lepiarczyk, E.
Kaleczyc, J.
Powiązania:
https://bibliotekanauki.pl/articles/16539221.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
larynx
intrinsic neurons
pig
immunohistochemistry
biologically active substances
Opis:
The present study investigated the chemical coding of neurons and nerve fibres in local laryngeal ganglia in pigs (n=5) using double-labelling immunohistochemistry. Virtually all the neurons were cholinergic in nature (ChAT- or VAChT-positive). Only very solitary, small nerve cells (presumably representing interneurons) stained intensely for adrenergic marker, DβH. Many neurons also contained immunoreactivity for NOS (91%), VIP (62.7%), NPY (24.7%), galanin (10%), SP (1.3%) and CGRP (5.3%). No neurons expressing somatostatin or Leu-enkephalin were observed. Nearly all the neuronal somata were densely supplied with varicose cholinergic nerve terminals, which presumably represented preganglionic axons, and some of them were also closely apposed with CGRP- and/or SP-positive varicose nerve endings, which were putative collaterals of extrinsic primary sensory fibres. In conclusion, this study has revealed that intrinsic neurons in the porcine larynx, like in many other mammalian species studied, should be classified as parasympathetic cholinergic neurons expressing biologically active substances, predominantly NOS and VIP. Furthermore, they are likely to receive inputs from not only preganglionic neurons but also primary sensory nerve cells. Finally, it appears that the information on the occurrence of the local laryngeal ganglia should be regularly included in textbooks dealing with the cranial portion of the parasympathetic nervous system in mammals.
Źródło:
Polish Journal of Veterinary Sciences; 2022, 25, 2; 325-334
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dispersal and immunohistochemical characteristics of neurons in the stem of the porcine vagus nerve
Autorzy:
Sienkiewicz, W.
Klimczuk, M.
Majewska, M.
Kaleczyc, J.
Powiązania:
https://bibliotekanauki.pl/articles/16647386.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
vagus nerve
intravagal neurons
neurotransmitter markers
immunohistochemistry
pig
Opis:
The present study investigated the distribution and chemical properties of nerve cell bodies within the trunk of the vagus nerve in juvenile female pigs (n=4) using double-labelling immunofluorescence. The neurons appeared mostly as single cells or formed streaks of cells or small ganglia. Many of the perikarya were cholinergic (VAChT-positive; VAChT+) or adrenergic (DβH+) in nature and no SP+ or CGRP+ neurons were encountered. There were no distinct left-right differences regarding the number and chemical coding of the neuronal somata, however, these characteristics significantly varied between particular nerve segments investigated. The vagosympathetic trunks, and thoracic and abdominal segments of the vagus nerve contained on average (the numerical values represent the means for both the left and right corresponding nerve segments) 142, 236, and 111 PGP 9.5-positive neurons, respectively. Proportions of cholinergic and adrenergic neurons were as follows: 0% and 100%, 54.2% and 33.2%, and 52.8% and 35.4%, respectively. Relatively many neurons in the thoracic and abdominal segments stained also for NOS (39.2% and 39.9%, respectively). It remains to be determined whether the porcine intravagal neurons represent a developmental relic, or whether they have any specific functional significance.
Źródło:
Polish Journal of Veterinary Sciences; 2022, 25, 4; 617-619
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dense Wireless Network Inspired by the Nervous System
Autorzy:
Kułacz, Łukasz
Kliks, Adrian
Powiązania:
https://bibliotekanauki.pl/articles/226424.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
dense wireless network
nervous system
neurons
glial cells
Opis:
This work presents concepts of the use of algorithms inspired by the functions and properties of the nervous system in dense wireless networks. In particular, selected features of the brain consisting of a large number of nerve connections were analyzed, which is why they are a good model for a dense network. In addition, the action of a selected cells from the nervous system (such as neuron, microglia or astrocyte) as well as phenomena observed in it (e.g. neuroplasticity) are presented.
Źródło:
International Journal of Electronics and Telecommunications; 2020, 66, 1; 93-98
2300-1933
Pojawia się w:
International Journal of Electronics and Telecommunications
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Can we build theories of understanding on the basis of mirror neurons?
Autorzy:
Pacholik-Żuromska, Anita
Powiązania:
https://bibliotekanauki.pl/articles/18687746.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
mirror neurons
understanding
intentionality
self-reflection
concepts
self-knowledge
Opis:
The discovery of mirror neurons and the characterization of their response properties is certainly an important achievement in neurophysiology and cognitive neuroscience. The reference to the role of mirror neurons in ‘reading’ the intentions of other creatures and in the learning process fulfils an explanatory function in understanding many cognitive phenomena beginning from imitating, towards understanding, and finishing with complex social interactions. The focus of this paper is to review selected approaches to the role of mirror neurons in mental activity as understanding, and to conclude with some possible implications for researches on mirror neurons for philosophical theories of understanding.
Źródło:
Internetowy Magazyn Filozoficzny Hybris; 2015, 28, 1; 141-157
1689-4286
Pojawia się w:
Internetowy Magazyn Filozoficzny Hybris
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Neuroplasticity and Microglia Functions Applied in Dense Wireless Networks
Autorzy:
Kułacz, Łukasz
Kliks, Adrian
Powiązania:
https://bibliotekanauki.pl/articles/308840.pdf
Data publikacji:
2019
Wydawca:
Instytut Łączności - Państwowy Instytut Badawczy
Tematy:
ad-hoc network
brain inspired communication
glial cells
neurons
Opis:
This paper presents developments in the area of brain-inspired wireless communications relied upon in dense wireless networks. Classic approaches to network design are complemented, firstly, by the neuroplasticity feature enabling to add the learning ability to the network. Secondly, the microglia ability enabling to repair a network with damaged neurons is considered. When combined, these two functionalities guarantee a certain level of fault-tolerance and self-repair of the network. This work is inspired primarily by observations of extremely energy efficient functions of the brain, and of the role that microglia cells play in the active immune defense system. The concept is verified by computer simulations, where messages are transferred through a dense wireless network based on the assumption of minimized energy consumption. Simulation encompasses three different network topologies which show the impact that the location of microglia nodes and their quantity exerts on network performance. Based on the results achieved, some algorithm improvements and potential future work directions have been identified.
Źródło:
Journal of Telecommunications and Information Technology; 2019, 1; 39-46
1509-4553
1899-8852
Pojawia się w:
Journal of Telecommunications and Information Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Enteric neuronal development in canine small intestine – an immunohistochemical study
Autorzy:
Serzysko, T.
Skwarek, A.
Chudziak, E.
Malina, M.
Kaleczyc, J.
Sienkiewicz, W.
Powiązania:
https://bibliotekanauki.pl/articles/2087175.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
dog
fetus
small intestine
enteric nervous system
development
neurons
immunohistochemistry
Źródło:
Polish Journal of Veterinary Sciences; 2021, 24, 2; 293-301
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of NucleoCounter for the comprehensive assessment of murine cultured neurons during infection with Equine Herpesvirus type 1 (EHV-1)
Autorzy:
Chodkowski, M.
Serafińska, I.
Brzezicka, J.
Bańbura, M.W.
Cymerys, J.
Powiązania:
https://bibliotekanauki.pl/articles/2087859.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
NucleoCounter NC-3000
viability
cell cycle
apoptosis
neurons
EHV-1
Źródło:
Polish Journal of Veterinary Sciences; 2017, 4; 831-834
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Perception-based reasoning: evaluation systems
Autorzy:
Rutkowska, D.
Powiązania:
https://bibliotekanauki.pl/articles/1931577.pdf
Data publikacji:
2003
Wydawca:
Politechnika Gdańska
Tematy:
fuzzy sets
perception-based systems
fuzzy neurons
neural networks
artificial intelligence
Opis:
A perception-based interpretation of evaluation systems is proposed in this paper. Thus, a perception-based approach to create intelligent systems is considered. The evaluation systems can be employed eg. in order to assess student exams, as well as to other applications. Evaluation marks used in these systems are given as perceptions expressed by words. The words play the role of labels of perceptions, and are represented by fuzzy sets. This means that the idea of perception-based systems, introduced by Zadeh, is applied. Various algorithms of overall assessment are suggested in this paper. Overall evaluation is produced as an aggregation of component evaluation marks. Systems of this kind can be obtained using fuzzy neurons, so fuzzy neural networks are also mentioned as a method of perception-based reasoning. The usefulness in artificial intelligence of both fuzzy sets and neural networks, and especially a combination of these, is shown.
Źródło:
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2003, 7, 1; 131-145
1428-6394
Pojawia się w:
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Poeta zmysłów
A poet of the sence
Autorzy:
Łapiński, Zdzisław
Powiązania:
https://bibliotekanauki.pl/articles/16729485.pdf
Data publikacji:
2020-05-05
Wydawca:
Katolicki Uniwersytet Lubelski Jana Pawła II. Towarzystwo Naukowe KUL
Tematy:
ucieleśnienie
zmysły
neurony lustrzane
symulacja
alegoria
incarnation
senses
mirror neurons
simulation
allegory
Opis:
The article is an attempt to explain sensual depictions that are constantly present in Norwid’s works – albeit they are sometimes hidden – by means of cognitivistic categories. On the example of two texts two different ways are shown, in which these depictions are used by the poet. A fragment from the drama Cleopatra and Caesar illustrates Norwid’s technique of realistic description, and the poem Fate – the technique of allegory.
Źródło:
Studia Norwidiana; 2013, 31; 5-15
0860-0562
Pojawia się w:
Studia Norwidiana
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Does senile impairment of cholinergic system in rats concern only disturbances in cholinergic phenotype or the progressive degeneration of neuronal cell bodies?
Autorzy:
Niewiadomska, Grażyna
Wyrzykowska, Jolanta
Chechłacz, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/1044354.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cholinergic neurons morphology and phenotype
aging
nerve growth factor
plasticity
basal forebrain
Opis:
The trophic effect of continuous intraventricular infusion of nerve growth factor (NGF) on morphology of the basal forebrain (BF) cholinergic neurons was tested in 4- and 28-month-old male Wistar rats. All studies were conducted using behaviorally uncharacterized animals from the same breeding colony. Immunohistochemical procedure for choline acetyltransferase (ChAT) and p75NTR receptor has been applied to identify cholinergic cells in the structures of basal forebrain (BF). Using a quantitative image analyzer, morphometric and densitometric parameters of ChAT- and p75NTR-positive cells were measured immediately after cessation of NGF infusion. In 28-month-old non-treated rats the number of intensively ChAT-positive cells in all forebrain structures was reduced by 50-70% as compared with young animals. The remaining ChAT-positive cells appeared shrunken and the neuropil staining was markedly reduced. In contrast, the same neurons when stained for p75NTR were numerous and distinctly visible with perfect morphology. Analysis of Nissl stained sections also showed that 28-month-old rats did not display significant losses of neuronal cell bodies. NGF restored the number of intensely stained ChAT-positive cells to about 90% of that for young controls and caused a significant increase in size of those cells in 28-month-old rats as compared with the control, age-matched group. NGF did not influence the morphology of p75NTR-positive neurons, which were well labeled, irrespective of treatment and age of the rats. In 4-month-old rats, NGF infusion decreased the intensity of both ChAT and p75NTR immunostaining. These data provide some evidence for preservation of BF cholinergic neurons from atrophy during aging and indicate that senile impairment of the cholinergic system in rats concerns decrease in ChAT-protein expression rather than an acute degeneration of neuronal cell bodies. Treatment with NGF resulted in restoration of cholinergic phenotype in the BF neurons of aged rats. However, the present study also rises issue of possible detrimental effects of NGF in young normal animals.
Źródło:
Acta Biochimica Polonica; 2000, 47, 2; 313-330
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Neurophysiological changes in the afferent somatosensory system indices in the case of vertebrogenic spine pathology in miners
Autorzy:
Battakova, Sharbanu
Shraimanov, Bekkair
Powiązania:
https://bibliotekanauki.pl/articles/2179775.pdf
Data publikacji:
2013-04-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
miners
vertebral pathology
pain syndrome
Somatosensory Stimulated Potential (SSP)
pain reception
afferent neurons
Opis:
Objectives: The aim of the paper was to prove that job conditions impact the state of the afferent part of the somatosensory system in miners. Materials and Methods: Data analysis of the electrophysiological examination of the syndrome in 148 patients, aged from 28 to 55 years, with a mild, moderate and severe degree of the pain syndrome was performed. The control group included 28 people without any pain symptoms. The method used was that of somatosensory stimulated potential (SSP) with the potentials amplitude and latency main components taken into consideration. Results: It was proven that the true decrease of the somatosensory stimulated potential SSP N22 (p < 0.05) component amplitudes by 41%; N30 component amplitude tend to decrease by 26%. This proves that the true N22 (p < 0.01) component latency increase by 63.8% corresponds to afferent excitation wave conductibility under the pain syndrome of vertebral pathology through sensitivity pathways mainly in the posterior spinal cord columns and then, through the parts of the brain stem, involving the cerebral cortex, which is confirmed by the fact that the P38 and P46 components amplitudes tend to decrease. In addition to this, the proven N10–N13 (p < 0.05), N13–N20 (p < 0.05), N10–N20 (p < 0.05) intervals increases by 43.5–41.8–38.7%, respectively, correspond to the nervous impulse conductibility through the peripheral nervous system structures and allow to reveal the subclinical slowdown of impulse conductibility, which indicates that the conducting system is changed even under a mild pain syndrome. Conclusions: It was found that the data obtained allow for the better understanding of how the neuropathological pain syndrome under vertebral spine pathology is formed.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2013, 26, 2; 230-234
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
What can a mathematician do in neuroscience?
Autorzy:
Karbowski, Jan
Powiązania:
https://bibliotekanauki.pl/articles/748768.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Matematyczne
Tematy:
mózg, modelowanie systemu nerwowego, neurobiologia obliczeniowa, neurony, procesy mózgowe
Computational Neuroscience
Brain, Modeling, Neurons
Opis:
Mózg ssaków jest jednym z najbardziej złozonych obiektów we wszechswiecie. Jest odpowiedzialny za sterowanie wszystkimi aspektami zachowan zwierzecia i człowieka. Obecnie usprawiedliwione wydaje sie stwierdzenie, ze nasza wiedza na temat pracy mózgu i jego funkcjach jest dosc ograniczona. Neurobiologia obliczeniowa jest dyscyplina naukowa, która próbuje zrozumiec i opisac mózg w kategoriach modelowania matematycznego. W tej pracy zawarto przyjazny dla czytelnika przeglad zagadnien, który ma na celu wprowadzenie w ten stosunkowo nowy dla matematyków i fizyków obszar badawczy, pokazujac przykłady najnowszych trendów w tej dziedzinie. Artykuł omawia takze krótko przyszłe perspektywy dla budowy zintegrowanej teorii funkcji mózgu.
Mammalian brain is one of the most complex objects in the known universe, as it governs every aspect of animal’s and human behavior. It is fair to say that we have a very limited knowledge of how the brain operates and functions. Computational Neuroscience is a scientific discipline that attempts to understand and describe the brain in terms of mathematical modeling. This user-friendly review tries to introduce this relatively new field to mathematicians and physicists by showing examples of recent trends. It also discusses briefly future prospects for constructing an integrated theory of brain function.
Źródło:
Mathematica Applicanda; 2012, 40, 1
1730-2668
2299-4009
Pojawia się w:
Mathematica Applicanda
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Historia sztuki i medycyna
Art history and medicine
Autorzy:
Kędziora, Łukasz
Powiązania:
https://bibliotekanauki.pl/articles/1041322.pdf
Data publikacji:
2019-01-11
Wydawca:
Uniwersytet im. Adama Mickiewicza w Poznaniu
Tematy:
neuroesthetics
embodied simulation
mirror neurons
Zoe Leonard
Wilhelm Sasnal
art
medicine
art history
empathy
Opis:
The article Art history and medicine concerns selected aspects of the Medicine in art exhibition, taking place at the Museum of Contemporary Art in Kraków (MOCAK) between 22nd April and 22nd October 2016. The author discusses the issue of medicine with regard to its mechanisms that let us create and perceive art. This reflection includes a historical overview of the “medically-oriented” art research. Another significant aspect constitutes the attempt to explain by the tools associated with neuroaesthetics, why the viewers are likely to look at some drastic images created by artists with such willingness and involvement. The analysis refers to texts by D. Freedberg, V. Gallese, A. Damasio, P. Przybysz, and others. It also includes interpretations of the photohraph Seated anatomical model by Zoe Leonard, as well as the Medical Kit installation by Wilhelm Sasnal.
Źródło:
Poznańskie Studia Polonistyczne. Seria Literacka; 2018, 34; 341-356
1233-8680
2450-4947
Pojawia się w:
Poznańskie Studia Polonistyczne. Seria Literacka
Dostawca treści:
Biblioteka Nauki
Artykuł
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