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Tytuł:
The aging process and function of endocrine glands
Proces starzenia a czynność gruczołów wydzielania wewnętrznego
Autorzy:
Kazimierczak, Aleksandra E.
Powiązania:
https://bibliotekanauki.pl/articles/1036028.pdf
Data publikacji:
2017
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
aging
somatopause
thyroid hormones
parathyroid glands hormones
adrenal gland hormones
starzenie
somatopauza
hormony tarczycy
hormony przytarczyc
hormony nadnerczy
Opis:
Population aging is becoming the biggest medical challenge of the 21st century. The body of elderly people shows a decreased ability to adapt to changing environmental and intracorporeal conditions. Aging is a process that is complex and stretches over a considerable length of time. As we get older our bodies progressively change, including the endocrine system. The changes are not unidirectional and do not affect all the endocrine glands to the same degree. The secretion of some hormones becomes impaired, while the secretion of other ones increases. There are also some hormones whose secretion does not change. The frequent concomitance of chronic diseases and taking many medications makes it difficult to interpret the results of studies on changes in hormone secretion in elderly people. This paper focuses on aging-related changes in the secretion of growth hormone, thyroid hormones, parathyroid and adrenal hormones.
Starzenie społeczeństw staje się największym wyzwaniem medycznym XXI w. Organizm osób w podeszłym wieku wykazuje obniżoną umiejętność przystosowywania się do zmiennych warunków środowiska zewnętrznego i wewnętrznego. Starzenie to proces złożony i znacznie rozciągnięty w czasie. Wraz z wiekiem dochodzi do postępujących zmian w ustroju, w tym do zmian w układzie endokrynnym. Zmiany te nie są jednokierunkowe i nie dotyczą w równym stopniu wszystkich gruczołów dokrewnych. Wydzielanie części hormonów ulega upośledzeniu, innych zwiększa się, są również takie, których wydzielanie nie ulega zmianie. Ze względu na częste współistnienie chorób przewlekłych i przyjmowanie wielu leków interpretacja wyników badań dotyczących zmian hormonalnych u osób w wieku podeszłym jest trudna. W niniejszym opracowaniu uwagę skupiono na zmianach związanych z wiekiem w wydzielaniu hormonu wzrostu, hormonów tarczycy, przytarczyc i nadnerczy.
Źródło:
Annales Academiae Medicae Silesiensis; 2017, 71; 282-296
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of the Psychological and Hormonal Parameters in Paragliding
Autorzy:
Çalık, Deniz Sinem
Gürsoy, Recep
Saruhan, Ercan
Powiązania:
https://bibliotekanauki.pl/articles/1627250.pdf
Data publikacji:
2021-09-10
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
paragliding
hormones
risk
anxiety
Opis:
Background. Paragliding is an extreme sport performed by gliding from a mountain at high altitude into the air. The authors aimed to determine the differences between the levels of adrenaline, cortisol, and insulin before and after the flight of tandem pilots and passengers flying for the first time, and to determine the relationship between these hormones and death anxiety and risk-taking levels. Materials and methods. The study included 12 experienced male pilots and 15 male passengers flying for the first time. Heart rate and blood pressure were measured after the participants had filled in Personal Information Form, DOSPERT Risk-Taking Scale and Death Anxiety Scale before the flight. Blood samples were taken before and after the flight to determine adrenaline, cortisol, and insulin levels. Results. Adrenaline and cortisol levels, as well as heart rate, increased significantly after the flight, while insulin levels decreased significantly in the passenger group (p < 0.05). There were no statistically significant differences in the pilot group. Conclusions. The experience factor plays an important role in the positive effect of paragliding flight on cortisol, adrenaline, insulin, and various physiological parameters, as well as mediates the adaptation of the organism to unusual situations. The human organism adapts physiologically and hormonally to the flying action. One of the striking results of the study was that cortisol levels were at the upper limit of normal values in the passenger group after the flight.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2021, 34, 2; 15-23
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of creatine hydrochloride supplementation on physical performance and hormonal changes in soldiers
Autorzy:
Tayebi, Mohammad Milad
Yousefpour, Mitra
Ghahari, Laya
Powiązania:
https://bibliotekanauki.pl/articles/1932984.pdf
Data publikacji:
2021-05-19
Wydawca:
PPHU Projack Jacek Wąsik
Tematy:
creatine
performance
HCl
hormones
Opis:
Purpose: The aim of this study was to examine the effects of 2 weeks of creatine hydrochloride (CrHCl) supplementation on physical performance and hormonal changes in army soldiers. Materials: Eighteen male army soldiers were randomly assigned in a double-blind fashion to either a CrHCl (n=9) or placebo (Pl) (n=9) groups. CrHCl group costumed 3g of creatine per day, whereas Pl group was given dextrose. Before and after supplementation period, the subjects performed a battery of performance tests including one repletion maximum (1RM) of bench press and back squat, vertical jump (VJ) and Wingate anaerobic test. In addition, blood samples were obtained to determine changes in testosterone and cortisol concentrations per and post supplementation. Results: There were significant increases in VJ, peak and mean power, and 1RM back squat test following the 2 weeks of CrHCl supplementation (p < 0.05) without any significant change for the Pl group. In addition significant changes were observed in testosterone and cortisol concentrations from before to after supplementation in CrHCl group (p < 0.05) and compared with Pl group (p=0.001). Conclusions: In conclusion, the present study indicates that CrHCl supplementation can improve VJ, power performance, 1RM back squat and hormonal changes in army soldiers.
Źródło:
Physical Activity Review; 2021, 1, 9; 93-99
2300-5076
Pojawia się w:
Physical Activity Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Phenomenon of ageing – a process or a state
Autorzy:
Klusek, Jolanta
Klusek, Justyna
Powiązania:
https://bibliotekanauki.pl/articles/472562.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie
Tematy:
ageing
cell
brain
hormones
Źródło:
Annales Universitatis Paedagogicae Cracoviensis. Studia ad Didacticam Biologiae Pertinentia; 2016, VI; 42-51
2083-7267
2450-3487
Pojawia się w:
Annales Universitatis Paedagogicae Cracoviensis. Studia ad Didacticam Biologiae Pertinentia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Changes in the concentrations of thyroid hormones in dairy sheep
Autorzy:
Flis, Z.
Molik, E.
Powiązania:
https://bibliotekanauki.pl/articles/2119543.pdf
Data publikacji:
2021
Wydawca:
Polskie Towarzystwo Zootechniczne
Tematy:
sheep
thyroid hormones
lactation
milk
Opis:
The aim of the research was to determine the changes in the concentrations of thyroid hormones (T3 and T4) in sheep during lactation. The experiment was conducted on 20 Polish Longwool ewes. Milking was begun after the lambs were weaned, on the 57th day of lactation. Sheep were milked twice a day (8:00 a.m. and 6:00 p.m.) until dry. The milk yield of each ewe was checked every 10 days. For determination of thyroid hormones, blood was collected every 28 days beginning at sunset, every 20 minutes for 6 hours. The average milk yield of the sheep was determined based on the individual yields on test days. The highest (P ≤ 0,01) milk yield was obtained in the first month of milking, i.e. April (0,48 ± 0,018 l). Milk yield decreased as lactation progressed. The concentration of hormone T3 was significantly higher (P ≤ 0,01) in the first and third months of lactation (0,72 ± 0,02 ng/ml in April and 0,74 ± 0,02 ng/ml in June) than in September (0,55 ± 0,01 ng/ml). The T3 concentration decreased in successive months of lactation. In contrast, the concentration of the T4 hormone increased with the progression of lactation. Significantly (P ≤ 0,01) the lowest concentration of T4 was found in the first and second month of milking (51,7 ± 9,8 ng/ml, 48,8 ± 7,4 ng/ml). The highest T4 concentration in lactating sheep was noted in August (60,55 ± 10 ng/ml). The research showed that the secretion of T3 decreases with milk yield, while secretion of T4 shows an upward trend as lactation progresses. Therefore thyroid hormones modulate secretion of milk in sheep.
Źródło:
Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego; 2021, 17, 1; 7-12
1733-7305
Pojawia się w:
Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of sucralose on thyroid gland function
Wpływ sukralozy na stan funkcjonalny gruczołu tarczycy
Autorzy:
Oliynyk, O.
Powiązania:
https://bibliotekanauki.pl/articles/2048845.pdf
Data publikacji:
2021
Wydawca:
Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:
thyroid hormones
thyroid gland
sucralose
Opis:
Background. Recently, an increasing number of scientific studies have reported on the adverse effects of sweeteners on the body. The aim of this work was to study the effect of sucralose on the production of thyroid hormones. Material and methods. The study involved 30 women (average age 24.5±5.2 years) who considered themselves to be healthy. Blood levels of free and total triiodothyronine, free and total thyroxine, as well as thyroid-stimulating hormone were determined. The women were then prescribed sucralose for a month, taken daily at a dose of 15 mg/kg. At the end of this period, levels of thyroid hormones were measured again. Results. After the sucralose regimen, free and total triiodothyronine and total thyroxine were found to be 2.0, 1.58 and 1.46 times lower, respectively, than before sucralose intake (P<0.001). Conclusions. Given that sucralose affects the production of thyroid hormones, it can be concluded that sucralose is not a biologically inert compound.
Wprowadzenie. W ostatnim czasie coraz więcej badań naukowych porusza kwestię szkodliwego wpływu słodzików na organizm. Celem niniejszej pracy było przebadanie związku sukralozy z produkcją hormonów tarczycowych. Materiał i metody. Badanie objęło 30 kobiet (średnia wieku 24,5±5,2 roku), które określiły siebie jako zdrowe. Ustalono poziomy wolnej i całkowitej trijodotyroniny, wolnej i całkowitej tyroksyny oraz hormonu stymulującego hormon tarczycy we krwi. Następnie zalecono pacjentkom przyjmowanie sukralozy codziennie przez miesiąc (w dawce 15 mg/kg). Po tym okresie ponownie zbadano wartości hormonów tarczycy. Wyniki. Po reżimie dawkowania sukralozy, zaobserwowano znaczący spadek wolnej i całkowitej trijodotoroniny oraz całkowitej tyroksyny o odpowiednio 2,0, 1,58 i 1,46 (P<0,001). Wnioski. Wziąwszy pod uwagę fakt, iż sukraloza wpływa na produkcję hormonów tarczycy, można stwierdzić, że nie jest ona związkiem biologicznie obojętnym.
Źródło:
Health Problems of Civilization; 2021, 15, 1; 12-16
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Serotonin in Tetrahymena – How Does It Work?
Autorzy:
Csaba, György
Powiązania:
https://bibliotekanauki.pl/articles/763501.pdf
Data publikacji:
2010
Wydawca:
Uniwersytet Jagielloński. Wydawnictwo Uniwersytetu Jagiellońskiego
Tematy:
Tetrahymena, serotonin, Protozoan hormones, enzyme blockers
Opis:
Presence, uptake and production of serotonin and its effect on the production of other hormones were studied using immunocytochemical flow cytometric method. In a serotonin (10–12 M) containing medium up to 15 min. serotonin level does not elevate in the cells, but after 30 min. there is a significant elevation which remains till 4 h. In cells starved in salt solution the elevation is higher which calls attention to the effect of (starvation) stress. Using four enzyme blockers tryptophane hydroxylase inhibitor PCPA decreased (in serotonincontaining medium) and MAO B blocker deprenyl increased serotonin content, while serotonin reuptake inhibitor fluoxetine and MAO-A blocker clorgyline were ineffective. Extremely low concentrations of serotonin (10–15 M in case of histamine and 10–18 M in case of ACTH and T3) in the milieu was sufficient for increasing hormone (ACTH, T3, histamine) levels inside the cells. In conclusion; serotonin can be taken up by the cells and can be produced by induction, as Tetrahymena has enzymes for building it up and decomposing it. For synthesizing serotonin; basic molecules from outside are not needed. Serotonin in a minute amount can induce production of different hormones.
Źródło:
Acta Protozoologica; 2010, 49, 2
1689-0027
Pojawia się w:
Acta Protozoologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Tips for optimizing organ preservation solutions
Autorzy:
Ostróżka-Cieślik, Aneta
Dolińska, Barbara
Ryszka, Florian
Powiązania:
https://bibliotekanauki.pl/articles/1038517.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
organ transplantation
preservation solution
hormones
micronutrients
Opis:
Organ injury during ischemia is one of the clinical problems of today's transplantation. It occurs during warm ischemia time (WIT) when the blood flow is cut off and during cold ischemia when a graft is chilled in situ until the circulation is restored to the recipient organism. Fast cooling of the organ slows down metabolism and activates intracellular enzymes, which minimizes the effects of warm ischemia. Unfortunately, hypothermia also results in inhibition of ATP synthesis, cell swelling and intracellular acidity. That is why research is continually being conducted to develop new fluids for rinsing and storing organs, as well as to optimize the composition of those that are already in use, which will allow for longer and more effective graft storage and restoration of their optimal functions after transplantation. This article provides current information on rinsing and storage fluids available on the global market. It also discusses tips for the fluid modifications with hormones and micronutrients.
Źródło:
Acta Biochimica Polonica; 2018, 65, 1; 9-15
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Microbiome impact on metabolism and function of sex, thyroid, growth and parathyroid hormones
Autorzy:
Kunc, Michał
Gabrych, Anna
Witkowski, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1038795.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
microbiome
lipopolysaccharide
estrogens
thyroid hormones
growth hormone
Opis:
Commensal bacteria and their genes associated with host are known as microbiome. In recent years, microbial influence on host endocrine system has been under detailed investigation. The role of microbiome in the pathogenesis of insulin resistance and obesity, the function of hypothalamic-pituitary-adrenal axis and secretion of hormones regulating appetite is well described in world literature. In this article we discuss poorly reviewed issues: the microbiome role in modulation of non-peptide (sex and thyroid) and peptide (growth hormone and parathyroid hormone) functions. Understanding complex bidirectional relations between host endocrine system and bacteria is of fundamental importance to understanding microbial impact on host reproduction, risk of endocrine-related cancers, pathogenesis of non-thyroidal illness syndrome, growth failure in children and hormonal changes during chronic kidney disease. This article also highlights effects of dietary compounds on microbiome composition and bacterial enzymes activity, and thus host hormonal status.
Źródło:
Acta Biochimica Polonica; 2016, 63, 2; 189-201
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Real-time assessment of the superovulatory effect of FSH and eCG with laparoscopy at different seasons in Akkaraman ewes
Autorzy:
Şen, U.
Powiązania:
https://bibliotekanauki.pl/articles/2087326.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
superovulation
season
laparoscopy
plasma hormones
eCG
FSH
Źródło:
Polish Journal of Veterinary Sciences; 2020, 23, 2; 291-299
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A levels of endogenous gonadal hormones and their relationship with selected coronary artery disease risk factors among young women post myocardial infarction
Autorzy:
Ablewska, Urszula
Jankowski, Krzysztof
Rzewuska, Ewa
Liszewska-Pfejfer, Danuta
Hryniewiecki, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/1039893.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
myocardial infarction
gonadal hormones
risk factors
young women
Opis:
In recent decades a significant raise in the incidence of myocardial infarction among young women has been recorded. It is presumed that, apart from the classical risk factors, other reasons exist for premature atherosclerosis in young women, related to the homeostasis of gonadal hormones. The aim of the study was to analyze the levels of gonadal hormones (estradiol, progesterone, follicle-stimulating hormone, luteinizing hormone, testosterone and dehydroepiandrosterone) measured in the luteal phase, in 65 normally menstruating women post myocardial infarction (MI) and to investigate a possible relationship between the hormone profile and selected coronary artery disease (CAD) risk factors. The levels of gonadal hormones: estradiol, progesterone, follicle-stimulating hormone, luteinizing hormone, testosterone and dehydroepiandrosterone were measured in the luteal phase. All examined women had normal mean levels of gonadal hormones. In the post MI patients leading a sedentary life style, a significantly lower mean progesterone concentration was observed (16.29 ± 9.11 versus 29.43 ± 21.14 nmol/l, p < 0.05) and significantly higher mean testosterone concentration (2.34 ± 0.98 versus 1.76 ± 1.09 nmol/l, p < 0.05) when compared to patients from the same group, but leading a more active life. In obese post MI women (BMI ≥ 30 kg/m2) a lower mean concentration of progesterone was detected (18.02 ± 8.12 versus 26.16 ± 14.72 nmol/l, p < 0.05), than in slimmer patients from the same group. In post MI women with a positive family history for CAD, a significantly higher mean concentration of testosterone was detected (2.31 ± 1.22 versus 1.67 ± 0.74 nmol/l, p < 0.05) than in patients with no family history. The results suggest a correlation between levels of gonadal hormones and classical CAD risk factors.
Źródło:
Acta Biochimica Polonica; 2011, 58, 3; 385-389
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oznaczanie hormonów steroidowych w materiale biologicznym
Autorzy:
Kotłowska, A.
Szulfer, J.
Kamysz, W.
Powiązania:
https://bibliotekanauki.pl/articles/274307.pdf
Data publikacji:
2010
Wydawca:
Roble
Tematy:
oznaczanie hormonów steroidowych
hormony steroidowe
steroid hormones marking
Źródło:
LAB Laboratoria, Aparatura, Badania; 2010, 15, 4; 20-23
1427-5619
Pojawia się w:
LAB Laboratoria, Aparatura, Badania
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of rooting hormones on the juvenile stem cuttings of Annona muricata Linn. (Annonaceae)
Autorzy:
Dada, C. A.
Kayode, J.
Arowosegbe, S.
Powiązania:
https://bibliotekanauki.pl/articles/1077472.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Annona muricata
Juvenile Stem Cuttings
Medicinal plant
Rooting Hormones
Opis:
Annona muricata is a recognized medicinal plant species. Despite its usefulness, adequate attention has not been given to its propagation and cultivation. Therefore, this study investigates the effect of some rooting hormones on juvenile stem cuttings of Annona muricata. Uniform, healthy, single node leafy stem cuttings were obtained from eighty (80) uniformly growing seedlings. The cuttings were treated with 1mg/ml of Indole Acetic Acid (IAA), 1 mg/ml of Indole Butyric Acid (IBA), coconut water and distilled water as control, using the quick dip method. The percentage survival of the cuttings, percentage of die back, number of new roots formed per cutting, length of new roots formed, and number of new shoot were assessed after 60 days. Results obtained revealed that the species responded differently to the four treatments. Coconut water had the highest survivor percentage (100%) and IBA had the lowest (25%). Coconut water had the highest mean number of roots (5.25) and IBA had the least (1.75), but there was no significant difference between the values obtained from IBA and distilled water. IAA had the highest mean value (1.80) for new shoots, while IBA had the least value and there was no significant difference between the values obtained from coconut water and distilled water. Significant differences, however, did abound in the root length. Coconut water had the highest mean root length value (4.70 cm), followed by distilled water (1.95 cm), while IBA had 1.55 cm and IAA had the least value (0.80 cm). Thus the use of coconut water might enhance the development of stem cuttings of Annona muricata.
Źródło:
World News of Natural Sciences; 2019, 23; 336-342
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Treatment of symptomatic oral lichen planus: a literature review
Autorzy:
Borba Filla, Jessica
Fontanelli, Andressa Fontanelli
Brown, Michelle Antonette
Naval Machado, Maria Angela
Powiązania:
https://bibliotekanauki.pl/articles/1401758.pdf
Data publikacji:
2016
Wydawca:
Index Copernicus International
Tematy:
administration
Topical; Lichen Planus; Mouth mucosa
Adrenal Cortex Hormones
Opis:
Lichen planus (LP) is a relatively common chronic inflammatory mucocutaneous disease. The aetiology is un-known, but appears to be mediated by the immune system. Emotional factors such as stress and anxiety are as-sociated with oral lichen planus (OLP). It affects a higher percentage of middle-aged females. Erosive/ulcerative lesions are accompanied by symptoms such as severe pain and burning sensation, which vary according to the de-gree of inflammation. The main treatment of symptomatic OLP includes the use of topical corticosteroid drugs. Al-ternative treatments include immunosuppressants, retinoids, laser therapy, photodynamic therapy, aloe vera and green tea. The objective of this literature review was to describe the effective treatments for symptomatic OLP le-sions. It was concluded that topical therapy is the most widely used treatment for symptomatic lesions of OLP. Clo-betasol propionate mouthwash was the most used anti-inflammatory drug even though it has the same efficacy as other treatments. There is no stipulated duration of topical treatment for clobetasol propionate and should be used until the complete remission of the symptoms.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2016, 5, 1; 30-35
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The HPV16 E2 transcriptional regulator mode of action depends on the physical state of the viral genome
Autorzy:
Schmidt, Marcin
Olejnik, Agnieszka
Goździcka-Józefiak, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1041324.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
E2
chromatin
transcription
HPV
retinol
steroid hormones
LCR
Opis:
Human papillomavirus (HPV) infection is a major risk factor for the development of cervical cancer. The HPV-induced immortalization of epithelial cell usually requires integration of the viral DNA into the host cell genome. The integration event causes disruption of the E2 gene and this is followed by overexpression of the E6 and E7 oncoproteins. The E2 protein is a transcription factor that regulates expression of the E6 and E7 oncoproteins by binding to four sites within the viral long control region. We used an in vitro cell culture model to explore the role of the E2 protein in the transcriptional control of the HPV16 long control region. Employing transient and stable transfection experiments we simulated the episomal and integrated states of the viral genome, respectively. We show that the E2 protein up-regulates E6/E7 transcription from episomal DNA but represses it in the case of integrated DNA. The activator function of the E2 protein seems to counteract the repressive chromatin structure formed over episomal DNA. Steroid hormones and retinol also modulate oncogene transcription differently depending on the physical structure of the viral DNA. Our data suggest regulatory mechanisms involving interactions between the E2 protein and nuclear hormone receptors.
Źródło:
Acta Biochimica Polonica; 2005, 52, 4; 823-832
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
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