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Tytuł:
Malignant transformation of the salivary gland pleomorphic adenoma in myoepithelial carcinoma – the report of two cases
Autorzy:
Szabelska, Paulina
Rzepakowska, Anna
Szczepankiewicz, Benedykt
Niemczyk, Elżbieta
Osuch-Wójcikiewicz, Ewa
Niemczyk, Kazimierz
Powiązania:
https://bibliotekanauki.pl/articles/1399613.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
salivary gland tumors
carcinoma ex pleomorphic adenoma
pleomorphic adenoma
myoepithelial carcinoma
Opis:
A multiform adenoma is the most commonly diagnosed benign tumor of the salivary glands. In the majority of patients, surgical resection of the tumor with the adequate surrounding tissue of salivary gland allows for complete recovery. A small percentage of the cases is a recurring pleomorphic adenoma. Even more rarely the diagnosis of carcinoma ex pleomorphic adenoma is made. The study presents two clinical cases of the malignant transformation of pleomorphic adenoma into the myoepithelial carcinoma. The surgical treatment and additional radiotherapy were performed in both cases.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2019, 8, 1; 53-58
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The comorbidity of papillary thyroid carcinoma and the primary hyperparathyroidism
Autorzy:
Podlasek, Robert
Bednarczyk, Grzegorz
Świder, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/454749.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
thyroid carcinoma
primary hyperparathyroidism parathyroid adenoma
Opis:
Introduction. The prevalence of papillary thyroid carcinoma (PTC) in patients with primary hyperparathyroidism (PHPT) is low, it can be estimated around 2 to 4%. For unknown reasons it is higher than the prevalence of PTC in the overall population. The authors analyse the comorbidity of PTC with PHPT on patients treated in their institution. Material and method. The analysis covered medical records of 885 patients subject to the thyroid resection procedure and 95 patients operated for PHPT, the procedures were performed in years 2005-2014. Results. In the above-mentioned period there were 121 patients operated due to a malignant thyroid tumour and there were 95 patients that had surgery for PHPT. There were 4 cases of comorbidity of PHPT with papillary thyroid cancer. Prevalence of PTC at the patients with PHPT was 4.2%. In two out of the four cases, both diseases were diagnosed prior to the procedure and the single appropriate surgery i.e. total thyroidectomy and excision of parathyroid adenoma was performed. In the other two cases false positive localisation of parathyroid adenoma occurred due to metastatic cancerous lesions in cervical lymph nodes. The diagnosis of PTC was made postoperatively based on surgical specimen examination. Second surgical procedure appropriate for this diagnosis was necessary in both cases. Conclusions. The comorbidity of PHPT and PTC is clinically important and should be taken into account in the case of patients with PHPT and thyroid tumours. There is the possibility of false positive localization of parathyroid adenoma in the case of metastatic cancerous lesions in cervical lymph nodes
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 2; 103-108
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Primary hyperparathyroidism on the example of a 33-year-old female patient with parathyroid adenoma
Autorzy:
Łach, Jarosław
Dyaczyński, Michał
Buczkowski, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1391700.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
parathyroid hyperactivity
parathyroid adenoma
kidney stones
Opis:
Parathyroid hyperactivity is the state of over-production and PTH secretion [1]. The most common cause of primary hyperparathyroidism is parathyriod adenoma - about 80% of cases, the remaining are parathyroid hyperplasia around 15%cases [2] [3], and in 1-5% of cases, cancer [2] [3] [4] [5]. The disease is diagnosed inabout 40 people in 100,000 [5] [6] [3] [7]. The most common cause of adenoma is the mutation in gene MEN 1. Less than 5% of cases are chronichyperparathyroidism, which is a component of the MEN 1 MEN 2a endocrine adenocarcinoma syndrome [1]. Excess PTH in the body leads to increased mobilization of calcium from the bones, and henceincreased osteolysis, what also increases the absorption of calcium from thedigestive system, as well as an increased amount of phosphate excretion in the urine. Clinical picture of the disease is multiform and often runs in a latent form. Most often the diseaseoccurs in the form of osteoporosis, chronic recurrent kidney stones, and is also commonpyelonephritis on the basis of urolithiasis. The disease may be accompanied by: dysphagia, abdominal pain, metallic taste in the mouth, persistent constipation. In addition, from the systemnervous: dizziness and headaches, disturbances of consciousness. Arrhythmia the form of additional contractions and paroxysmal tachycardia. Osteolysis, osteoporosis and pathological fractures [1]. The purpose of this article is to bring closer to the reader case of 33 years old woman with primary hyperparathyroidism on the adenoma.
Źródło:
Polish Journal of Surgery; 2020, 92, 3; 55-61
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pleomorphic adenoma - the results of a retrospective analysis of 104 patients treated at the Clinical Department of Cranio-Maxillofacial Surgery, Clinic of Otolaryngology and Laryngologic Oncology of the Military Institute of Medicine
Autorzy:
Korba, Michał
Chloupek, Aldona
Dąbrowski, Jarosław
Piętka, Tomasz
Domański, Wojciech
Biernacka, Barbara
Leśniak, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/1398512.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
pleomorphic adenoma
tumor mixtus
parotid gland
parotidectomy
Opis:
Pleomorphic adenoma, also known as tumor mixtus, is one of the most common types of benign neoplasm of the salivary gland, which presents as a slow growing, painless tumor. Major salivary glands are the typical localization of this neoplasm. It rarely undergoes malignant transformation, however may recur locally post resection. In this study, we present the results of a retrospective analysis of 104 patients treated at the Clinical Department of Cranio-Maxillofacial Surgery, Clinic of Otolaryngology and Laryngologic Oncology of the Military Institute of Medicine between 2004 and 2015 due to pleomorphic adenoma. The study confirmed the parotid gland as the most common location of tumor mixtus. In some cases, the large size of the tumor and its location were the cause of life-threatening complications.
Źródło:
Polish Journal of Otolaryngology; 2017, 71, 4; 34-36
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mixed tumor of the parotid gland spreading into the cranial cavity
Autorzy:
Majszyk, Daniel
Osuch-Wójcikiewicz, Ewa
Czesak, Małgorzata
Niemczyk, Kazimierz
Powiązania:
https://bibliotekanauki.pl/articles/1400063.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
pleomorphic adenoma
benign mixed tumor
intracranial invasion
Opis:
Pleomorphic adenoma is benign tumor of the salivary glands. It is the most common neoplasm occurring in salivary glands. Although it is a benign tumor, it should be treated as a clinically uncertain. In about half of the cases a blurred boundary between the tumor tissue and the parotid parenchyma can be observed. This tumor metastasize distant, even without malignant transformation. Malignant transformation of adenoma observed in 3-5% of cases. The aim of this study was to present the case of 75-year-old patient with recurrent mixed tumor spreading by continuity to the cranial cavity.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2017, 6, 1; 21-25
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oxidative stress in proliferative lesions of parathyroid gland
Autorzy:
Deska, Mariusz
Romuk, Ewa
Segiet, Oliwia
Polczyk, Joanna
Buła, Grzegorz
Gawrychowski, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1392364.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
oxidative stress
primary hyperparathyroidism
parathyroid hyperplasia
parathyroid adenoma
Opis:
Background: Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders and defined as excessive secretion of parathormone. PHPT is a risk factor of several cardiovascular diseases, which could be caused by alterations in oxidant-antioxidant balance. Materials and methods: Blood serum collected from 52 consecutive patients with PHPT treated surgically constituted our study material, whereas 36 healthy volunteers were our control group. Oxidative stress was evaluated in both patients and control subjects by assessment of malondialdehyde (MDA) and lipid hydroperoxides (LHP). Antioxidants were evaluated by the measurement of superoxide dismutase (SOD), ceruloplasmin (CER), catalase (CAT), sulfhydryl (SH) groups, glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione transferase activity (GST) and glutathione reductase (GR). Moreover, total antioxidant capacity (TAC) and total oxidative status (TOS) were measured and oxidative stress index (OSI) was calculated. Results: OSI was increased in patients with PHPT when compared to normal controls, whereas TAC was lower in PHPT. The levels of CER, MnSOD, GR, SH groups and MDA were significantly decreased in PHPT. The levels of serum LHP, catalase and SOD were significantly higher in patients with PHPT than in healthy patients. The erythrocyte CAT activity and GST were significantly increased in patients after parathyroidectomy. The erythrocyte GR and GPx were up-regulated postoperatively, whereas SOD activity decreased. Conclusions: In PHPT there are several alterations in the balance between the production of reactive oxygen species and antioxidant defense system.
Źródło:
Polish Journal of Surgery; 2019, 91, 1; 29-34
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Przypadek gruczolaka oksyfilnego, wyjątkowo rzadkiego guza krtani, współistniejącego z rakiem płuca
Autorzy:
Kozakiewicz, J
Teodorowicz, E
Haczyńska-Partyka, A
Myrcik, G
Lange, D
Szwabowicz, M
Powiązania:
https://bibliotekanauki.pl/articles/1398874.pdf
Data publikacji:
2007
Wydawca:
Index Copernicus International
Tematy:
adenoma oxyphillicum
tumour of the larynx
lung cancer
Opis:
There was presented an exstremely rare case of adenoma oxyphillicum of the larynx coexisting with the lung carcinoma. Diagnostical and medical conduct was throughly analyzed. It consisted such matters as detailed graphical examination, spliting of larynx, and radiotherapy and chemiotherapy of lung cancer. The authors want to call attention to limited use fullness of competent lungs X-ray in a-p projection in recognizing the early stadium of lung cancer.
Źródło:
Polish Journal of Otolaryngology; 2007, 61, 3; 311-314
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Review and characteristics of 585 salivary gland neoplasms from a tertiary hospital registered in the Polish National Major Salivary Gland Benign Tumors Registry over a period of 5 years: a prospective study
Autorzy:
Piwowarczyk, Krzysztof
Bartkowiak, Ewelina
Klimza, Hanna
Greczka, Grażyna
Wierzbicka, Małgorzata
Powiązania:
https://bibliotekanauki.pl/articles/1397308.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
benign neoplasms
characteristics
pleomorphic adenoma
registry
salivary gland
surgery
Opis:
Introduction: A Polish National Major Salivary Gland Benign Tumors Registry (SGR) is a report of benign salivary gland neoplasms (SGNs) from 26 different centres in Poland, introduced in 2014. The aim of this study is to analyze demographic characteristics and clinico-pathological factors of benign SGNs treated in large tertiary institutions and to determine possible correlations between selected variables. Material and method: Analysis of 585 patients recorded in SGR and operated on for SGNs in the Department of Otolaryngology and Laryngological Surgery, University of Medical Sciences, Poznań, Poland, over a 5-year period. Patient age, sex, occupation, place of residence, tumor location, size, histology, recurrence, facial nerve function after surgery, wound healing, surgery procedure, availability of pre-operative imaging examinations, fine-needle aspiration cytology (FNAC) results were analyzed. Results: 338 females and 247 males with a mean age of 53 years were operated on. In total, 96.2% of tumors originated from the parotid and 3.8% from the submandibular gland. The most frequent primary tumor diameter was 2–4 cm (59.5%) followed by <2 cm (29.2%) and >4 cm (8.4%). Tumors of over 4 cm were frequently removed by partial superficial parotidectomy, while those under 2 cm – by extracapsullar dissection (ECD). Pleomorphic adenomas (PA) were predominant (58.8%), followed by Warthin’s tumor (WT) – 37.1%. Patients with WT were on average 13.3 years older than patients with PA. Discussion: This research can be helpful to better understand the clinico-pathological features of SGNs. Long-termin hospital-based analysis is important for subsequent metaanalyses and comparisons with other centers. The reasons why not all patients’ data are reported to the national SGR should be further precisely analyzed.
Źródło:
Polish Journal of Otolaryngology; 2020, 74, 5; 1-6
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Giant pleomorphic adenoma of nasal cavities and paranasal sinuses
Autorzy:
Sroka, Paweł
Okła, Sławomir
Powiązania:
https://bibliotekanauki.pl/articles/1399797.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
Pleomorphic adenoma
minor salivary glands
paranasal sinuses
nasal cavity
Opis:
Pleomorphic adenoma is benign tumor of the salivary glands. It is the most common neoplazm both major and minor salivary glands. Only in 1% of cases pleomorphic adenoma occur in the sinonasal cavities. The histopalogical wiew of pleomorphic adenomas originating from small salivary glands is different in higher cellularity and lower stromal component than those from major salivary glands. It is a benign tumor but it should be treated as a clinically uncertain. Malignant transformation of pleomorphic adenoma can occur in 2-10% of cases, The aim of this study was to present he case of 37-year-old patient with giant pleomorphic adenoma of the sinonasal cavities causing extensive destruction of sinuses and orbits walls.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2018, 7, 3; 15-21
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The profile of ErbB/Her family genes copy number assessed by real-time PCR in parathyroid adenoma and hyperplasia associated with sporadic primary hyperparathyroidism
Autorzy:
Bednarz, Natalia
Błaut, Krzysztof
Sworczak, Krzysztof
Osęka, Tomasz
Bielawski, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1040637.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
parathyroid hyperplasia
hyperparathyroidism
parathyroid adenoma
ErbB/Her
quantitative real-time PCR
Opis:
Hyperparathyroidism (pHPT) is a relatively frequent endocrinopathy, however, the molecular mechanisms of its etiology remain poorly understood. This disorder is mainly associated with benign tumours (adenoma) and hyperplasia of the parathyroid, hence, the focus is directed also to genes that are likely to be involved in carcinogenesis. Among such genes are ErbB/Her family genes already used in diagnosis of other tumours (e.g., breast carcinoma) and reported also to play a role in development of endocrine lesions. So far, ErbB-1/Her-1/EGFR expression has been detected in pHPT-associated adenomas and hyperplasia as opposed to no expression in normal parathyroid tissue. Moreover, losses or gains of the fragments of chromosomes where ErbB/Her genes are located have been reported. In this study, the gene dosage of ErbB/Her family genes were determined for the first time in parathyroid adenomas, hyperplasia and morphologically unchanged tissue in order to establish their putative role in the development of the disease. Genomic DNA was isolated from 33 patients with sporadic hyperparathyroidism and the gene copy numbers were assessed using real-time PCR. The ErbB/Her genes' profile was unaltered in most of the examined samples. Two low-level amplifications of ErbB-1/Her-1/EGFR gene, two deletions of ErbB-2/Her-2, and six deletions of ErbB-4/Her-4 were found. The ErbB-3/Her-3 gene remained unaffected. No correlation with clinical parameters was found for any gene. Both the low number of alterations and a lack of their associations with clinical parameters exclude the prognostic value of the ErbB/Her genes family in parathyroid tumourigenesis. Nevertheless, the ErbB-4/Her-4 deletions seem to be interesting for further investigations, especially in the context of PTH secretion.
Źródło:
Acta Biochimica Polonica; 2009, 56, 1; 83-88
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Results of screening in Lublin Province, Poland, for colorectal cancer and neoplastic polyps - the role of environmental factors
Autorzy:
Cichoż-Lach, Halina
Szumiło, Justyna
Celiński, Krzysztof
Kasztelan-Szczerbińska, Beata
Szczerbiński, Mariusz
Swatek, Jarosław
Wronecki, Lech
Wargocki, Janusz
Słomka, Maria
Powiązania:
https://bibliotekanauki.pl/articles/989962.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
neoplastic polyps of colon
advanced adenoma of colon
colorectal cancer screening
Opis:
Introduction and objective. Screening colonoscopy is a recommended tool, and the most sensitive and cost-effective method for reducing the incidence of colorectal cancer (CRC). Objective. The purpose of the study was to present the results of a 5-year screening for early detection of CRC carried out among the population of the central-eastern regions of Poland, primarily in Lublin Province. Materials and method. Screening colonoscopy was conducted in a group of 1,009 patients – 636 women and 373 men, aged 40–65 years. Results. Neoplastic polyps were found in 275 patients, advanced adenomas in 49 patients and adenocarcinoma in 13. 70.55% of neoplastic polyps was located in the distal colon, 18.9% in the proximal part and 10.55% in both regions, advanced adenomas in 79.59%, 8.16% and 12.25%, respectively. Adenocarcinoma was located in the proximal colon in 2 cases and in the distal region in 11 cases. Neoplastic polyps and advanced adenomas occurred significantly more frequently in smokers than in non-smokers. Neoplastic polyps were found statistically more frequent in males than in females, among the overweight and obese patients, than in subjects with normal BMI, and more frequently in the group of urban, compared to rural patients. However, the frequency of advanced adenomas and CRC was not statistically different in those groups. The incidence of CRC was statistically more frequent in males than in females. Smoking and male gender were significant risk factors for developing neoplastic polyps. Male gender seemed to predispose to CRC. Obesity was found to favour advanced adenomas. Conclusions. The results of screening found neoplastic polyps in every third person (mean) who did not have any symptoms suggestive of colon pathology. Advanced adenomas were found in 5% of the examined and CRC was detected in 1.29% of participants. Smoking, male gender and overweight were significant risk factors for developing neoplastic polyps. No correlation was found between gender and the location of neoplastic polyps and advanced adenomas in the colon.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 1
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Macroprolactinoma – ocena skuteczności leczenia chirurgicznego
Macroprolactinoma – evaluation of surgical treatment
Autorzy:
Beda-Maluga, Karolina
Janocha, Justyna
Świętosławski, Jacek
Winczyk, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1032614.pdf
Data publikacji:
2015
Wydawca:
Łódzkie Towarzystwo Naukowe
Tematy:
prolactinoma
gruczolak przysadki
leczenie operacyjne
niedoczynność przysadki
pituitary adenoma
surgical treatment
hypopituitarism
Opis:
Introduction: The first–line treatment of prolactinoma is pharmacotherapy with dopamine agonists. Surgery is performed rarely – if pharmacological treatment is ineffective (lack of normalization of blood prolactin (PRL) level and/or tumor reduction) and/or the patient does not tolerate the medication. The aim of our study was to assess the hormonal function of the pituitary in patients operated for prolactinoma. We analyzed both the efficacy of the treatment and the occurrence of hypopituitarism after surgery. Material and methods: The study group consisted of 26 patients after macroprolactinoma surgery hospitalized in the Department of Endocrinology, Chair of Endocrinology, Medical University of Lodz. The biochemical criterion of cure was the normalization of serum PRL concentration, measured in the morning, in a fasting state. The hormonal function of the pituitary was assessed on the basis of the levels of tropic hormones and adequate peripheral glands hormones. Results: The normalization of PRL concentration was achieved in 19 patients – in two after the surgery and in 17 as a result of post–operative therapy with dopamine agonists. Moreover, in 13/19 patients the imaging study showed the incomplete removal of adenoma, and in 14 patients hypopituitarism occurred. In seven patients, despite continued treatment with dopamine agonists after the surgery, PRL concentration still exceeded the reference values. Four of them had hypopituitarism. Conclusions: Treatment of macroprolactinoma remains a serious therapeutic problem because surgery in many cases does not lead to the removal of the entire tumor mass and quite often causes hypopituitarism. However, the use of postoperative medication with dopamine agonists significantly increases the chance of the normalization of PRL blood concentration and is necessary in majority of patients with macroprolactinoma.
Wstęp: Leczeniem z wyboru prolactinoma jest farmakoterapia z zastosowaniem agonistów receptorów dopaminergicznych. Zabieg chirurgiczny wykonuje się dość rzadko – w przypadku braku skuteczności leczenia farmakologicznego (normalizacji stężenia prolaktyny (ang. prolactin – PRL) i/lub zmniejszenia masy nowotworu) i/lub złej tolerancji leków. Celem naszej pracy była ocena czynności hormonalnej przysadki u chorych operowanych z powodu prolactinoma. Analizie poddano zarówno skuteczność leczenia, jak i wystąpienie po zabiegu niedoczynności przysadki. Materiał i metody: Grupę badaną stanowiło 26 pacjentów po operacji macroprolactinoma hospitalizowanych w Klinice Endokrynologii Katedry Endokrynologii Uniwersytetu Medycznego w Łodzi. Za biochemiczne kryterium wyleczenia przyjęto normalizację stężenia PRL w surowicy krwi oznaczonej na czczo w godzinach porannych. Czynność wydzielniczą przysadki oceniono na podstawie stężeń hormonów tropowych i odpowiednich hormonów gruczołów obwodowych. Wyniki: Normalizację stężenia PRL uzyskano u 19 pacjentów – w tym u dwóch po samej operacji, a u 17 dodatkowo w wyniku pooperacyjnej farmakoterapii agonistami dopaminy. Ponadto u 13/19 osób w badaniu obrazowym stwierdzono niecałkowite usunięcie gruczolaka, a u 14 chorych odnotowano niedoczynność przysadki. U siedmiu pacjentów, mimo kontynuacji leczenia agonistami dopaminy po operacji, stężenie PRL nadal przekraczało granice wartości referencyjnych. U czterech z nich stwierdzono niedoczynność przysadki. Wnioski: Leczenie makrogruczolaków prolaktynowych przysadki stanowi nadal poważny problem terapeutyczny, bowiem zabieg chirurgiczny w wielu przypadkach nie pozwala na usunięcie całej masy nowotworu i dość często powoduje niedoczynność przysadki. Jednakże, zastosowanie pooperacyjnej farmakoterapii agonistami dopaminy znacznie zwiększa szansę na normalizację stężenia PRL we krwi i jest niezbędne u większości pacjentów z macroprolactinoma.
Źródło:
Folia Medica Lodziensia; 2015, 42, 1; 75-87
0071-6731
Pojawia się w:
Folia Medica Lodziensia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pleomorphic adenoma of the nasal cavity – a case report
Gruczolak wielopostaciowy jamy nosowej – opis przypadku
Autorzy:
Frączek, Anna
Szczygielska, Julia
Majszyk, Daniel
Niemczyk, Kazimierz
Powiązania:
https://bibliotekanauki.pl/articles/1399249.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
benign tumors
nasal cavity
pleomorphic adenoma
gruczolak wielopostaciowy
jama nosowa
nowotwór łagodny
Opis:
Introduction: Pleomorphic adenoma is a benign tumor which occurs most commonly in the major salivary glands. It is very rare in the nasal cavity and may be misdiagnosed because of its uncharacteristic clinical and histopathological manifestation. Case report: A case of a 42-year-old patient with pleomorphic adenoma on the lateral nasal wall has been presented. The tumor was accidentally found during FESS and septorhinoplasty. Initially, based on the histopathological examination of the obtained sample, there was a suspicion of adenoid cystic carcinoma. Later, the neoplasm was completely removed by the open septorhinoplasty and histopathological re-examination showed features of pleomorphic adenoma. Long term followup was necessary due to the potential risk of local recurrence.
Wstęp: Gruczolak wielopostaciowy jest nowotworem łagodnym występującym najczęściej w śliniankach przyusznych. Bardzo rzadko pojawia się on w jamie nosa, co w połączeniu z jego niecharakterystycznym obrazem klinicznym i histopatologicznym stwarza ryzyko postawienia błędnego rozpoznania. Opis przypadku: Przedstawiono przypadek 42-letniego pacjenta z gruczolakiem wielopostaciowym na bocznej ścianie nosa. Guz został wykryty przypadkowo podczas endoskopowej operacji zatok i septoplastyki, a na podstawie badania histopatologicznego pobranego wycinka początkowo wysunięto przypuszczenie raka gruczołowo-torbielowatego. Guz został doszczętnie usunięty z dostępu do septorynoplastyki otwartej. W ponownym badaniu histopatologicznym wykazano cechy gruczolaka wielopostaciowego. Ze względu na ryzyko wznowy miejscowej, pacjent pozostał pod opieką poradni laryngologicznej.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2020, 9, 3; 47-51
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Guz z komórek zrębu i sznurów płciowych z pierścieniowatymi kanalikami współistniejący z gruczolakorakiem szyjki macicy i brodawczakiem wewnątrzprzewodowym piersi u pacjentki z zespołem Peutza–Jeghersa – opis przypadku
Simultaneous sex cord stromal tumor with annular tubules, adenocarcinoma of the cervix and intraductal papilloma of the breast in a patient with Peutz–Jeghers syndrome: a case report
Autorzy:
Takmaz, Ozguc
Iyibozkurt, Cem
Powiązania:
https://bibliotekanauki.pl/articles/1030332.pdf
Data publikacji:
2015
Wydawca:
Medical Communications
Tematy:
Peutz–Jeghers
adenoma malignum
ovarian tumor
gruczolak złośliwy
guz jajnika
zespół peutza–jeghersa
Opis:
Peutz–Jeghers syndrome was first described by a Dutch physician, Jan Peutz, in 1921. It is an inherited syndrome characterized by intestinal hamartomatous polyps, which can cause obstruction, and mucocutaneous hyperpigmentation. This rare syndrome brings a 15-fold increase in the risk of intestinal as well as gynecologic tumors, especially ovarian cancer. We present a 49-year-old women with a huge adnexal mass and already diagnosed Peutz–Jeghers syndrome. Although the sampling of the endometrium, which was done before the surgery, was normal, cervical adenocarcinoma (adenoma malignum) was diagnosed after the operation, and complementary radical trachelectomy was conducted to complete the therapy. In conclusion, Peutz–Jeghers syndrome patients are at an increased risk of genital tract tumors. It should be kept in mind that a clinical examination could be insufficient to diagnose all the tumoral components of the disease.
Zespół Peutza–Jeghersa jako pierwszy opisał holenderski lekarz Jan Peutz w 1921 roku. Ten dziedziczny zespół charakteryzuje się obecnością polipów hamartomatycznych, które mogą powodować niedrożność jelit, oraz hiperpigmentacją skóry i błon śluzowych. To rzadkie schorzenie powoduje 15-krotny wzrost ryzyka wystąpienia guzów jelita oraz nowotworów ginekologicznych, szczególnie raka jajnika. Poniżej przedstawiamy przypadek 49-letniej pacjentki z olbrzymią zmianą w obrębie przydatków, u której wcześniej zdiagnozowano zespół Peutza–Jeghersa. Chociaż przeprowadzona przed operacją biopsja endometrium nie wykazała zmian wewnątrz macicy, po zabiegu zdiagnozowano gruczolakoraka szyjki macicy, a leczenie uzupełniono zabiegiem radykalnej trachelektomii. Podsumowując, pacjentki z zespołem Peutza–Jeghersa znajdują się w grupie zwiększonego ryzyka wystąpienia nowotworów narządów rodnych. Należy pamiętać, że badanie kliniczne może nie być wystarczające do wykrycia wszystkich guzowych elementów tej choroby.
Źródło:
Current Gynecologic Oncology; 2015, 13, 3; 180-184
2451-0750
Pojawia się w:
Current Gynecologic Oncology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Retrospective analysis of the effectiveness of treatment of the pituitary micro adenomas in nulliparous women, taking into account the fractionation of prolactin and correction of the luteal phase deficiency
Autorzy:
Trushkevich, A. A.
Stepura, A. A.
Powiązania:
https://bibliotekanauki.pl/articles/1032199.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Kazimierza Wielkiego w Bydgoszczy
Tematy:
micro adenoma
luteal phase deficiency
reproductive function
микроаденома
недостаточность лютеиновой фазы
репродуктивная функция.
Opis:
Prolactin synthesizing pituitary body (PB) tumors are in the third flight among nervous systems neoplasms and constitute up to 17% of brain tumours. Prolactinoma is the most frequently met endocrine active tumour of PB, and it accounts for 30% of all adenomas. Manifesting sign of PB adenoma is the increase of prolactin level. The retrospective analysis of conservative treatment efficacy of micro adenomas in nulliparous women of the early reproductive age had been done. Molecular polymorthism of prolactin and correction of luteal phase deficiency was taken into account. Objective. To determine qualitative and quantitative context of lutein and, first of all, the level of its “little” fraction in the patients with micro adenomas of PB, determine the relation between clinical signs and data of hormonal examination, substantiate differentiated approach to the treatment of organic pathology of PB. Materials and Methods: 40 nulliparous women with micro adenoma of PB, aged 18 – 26 y.o. General clinical, gynecological, hormonal, ultra sound examinations and CT of brain have been. A prolonged therapy with microdoses of dostinex under the contol of prolactin fractions has been offered. Clinical effect was gained at 40% of cases and in 4 patients there was a complete recovery. The positive dynamics in the state of vision analyzer has been noted, as well as improvement of hormonal state, rehabilitation of reproductive function. High acceptability of the treatment has been registered.
Ретроспективный анализ эффективности лечения микроаденом гипофиза у нерожавших женщин с учетом фракционирования пролактина и коррекцией недостаточности лютеиновой фазы. А. А. Трушкевич, А. А. Степур (Крымский государственный медицинский университет им. С. И. Георгиевского, Симферополь). Пролактинсинтезирующие опухоли гипофиза занимают третье место среди новообразований нервной системы и до 17% опухолей головного мозга. Пролактинома -наиболее часто встречающаяся эндокринно активная опухоль гипофиза, на долю которой приходится до 30% всех аденом. Манифестирующим признаком аденом гипофиза является повышение уровня пролактина. Был проведен ретроспективный анализ эффективности консервативного лечения микроаденом гипофиза у нерожавших женщин раннего репродуктивного возраста с учетом молекулярного полиморфизма пролактина и коррекцией недостаточности лютеиновой фазы. Цель – определить качественный и количественный состав пролактина, прежде всего уровень фракции «little» у пациенток с микроаденомами гипофиза, установить взаимосвязь клинический проявлений и данных гормонального обследования, обосновать дифференцированный подход к лечению органической патологии гипофиза. Материалы и методы: 40 нерожавших женщин с микроаденомой гипофиза в возрасте 18-26 лет. Проведено общеклиническое, гинекологическое, гормональное, УЗисследование, КТ головного мозга. Предложена длительная терапия микродозами препарата достинекс под контролем фракции пролактина. Клинический эффект получен в 40% случаев, у 4 пациенток микроаденома излечена полностью. Отмечена положительная динамика в состоянии зрительного анализатора, улучшение гормонального статуса больных, реабилитация репродуктивной функции, хорошая переносимость терапии пациентками.
Źródło:
Journal of Health Sciences; 2014, 4, 7; 18-26
1429-9623
Pojawia się w:
Journal of Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
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