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Wyświetlanie 1-15 z 324
Tytuł:
Therapeutic options in the treatment of open angle glaucoma and their use in accordance with the latest guidelines
Autorzy:
Misiuk-Hojło, Marta
Tomczyk-Socha, Martyna
Powiązania:
https://bibliotekanauki.pl/articles/51789554.pdf
Data publikacji:
2024-03-31
Wydawca:
Medical Education
Tematy:
glaucoma
pharmacological therapy
glaucoma drugs
combined drugs
Opis:
Glaucoma is an optic neuropathy characterized by typical damage of the optic nerve with gradual atrophy of retinal ganglion cells and visual field defects. The goal of glaucoma therapy is to reduce intraocular pressure and reduce daily pressure fluctuations. Currently, in the treatment of primary open-angle glaucoma in Poland, we use four groups of drugs: β-adrenergic receptor antagonists, prostaglandin analogues, α-adrenergic receptor agonists and carbonic anhydrase inhibitors. First-line drugs, according to the guidelines of the Polish Ophthalmological Society, are prostaglandin analogues/prostamide. When considering the addition of a second drug to prostaglandins, brimonidine lowers intraocular pressure more strongly than dorzolamide or brinzolamide, similarly as timolol does. Drug containing two active substances are as effective as substances administered in two separate drops, therefore it is advantageous to use combined drug instead of using two different drugs.
Źródło:
OphthaTherapy; 2024, 11, 1; 7-13
2353-7175
2543-9987
Pojawia się w:
OphthaTherapy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Monitoring risk behaviour in adolescent pupils regarding consumption of psychoactive substances
Autorzy:
Wojtyła-Buciora, Paulina
Klimberg, Aneta
Kapka-Skrzypczak, Lucyna Kapka-Skrzypczak
Diatczyk, Jarosław
Urbaniak, Monika
Ulatowska-Szostak, Ewa
Bołdowski, Tomasz
Wojtyła, Andrzej
Marcinkowski, Jerzy T.
Powiązania:
https://bibliotekanauki.pl/articles/989849.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
drugs/narcotics
designer drugs (dds)/legal highs
adolescents/youth
Opis:
Introduction. Taking psychoactive substances constitutes a significant problem for Public Health, particularly in preventing drug abuse and addiction. Objectives. To estimate the amount and incidence of drug consumption in middle and high school pupils, including the circumstances in which drug taking first started, and to determine pupils’ knowledge about the consequences of taking psychoactive substances and designer drugs (DDs). Materials and methods. A randomised study was conducted throughout Poland on 9,360 pupils attending middle school (junior high school) in 2009 and 7,971 pupils from middle and high school pupils in 2011. The survey consisted of a questionnaire devised by the Chief Sanitary Inspectorate (GIS) and the replies obtained were subject to the relevant statistical analyses. Results. Drug taking was found to have increased between 2009–2011, especially among those attending high school; proportionally rising from 4% – 11%. The numbers who had ever taken designer drugs were 3% for middle school pupils and 4% from high school. Conclusions. 1) Adolescent drug consumption has increased, particularly in those of older age and in boys. 2) Despite the only brief interval for which designer drugs were legal, they have gained high popularity among the young. 3) Adolescents have insufficient knowledge about the dangers of using DDs. 4) Faced with the growing threat of a dynamic designer drug market, appropriate counter-measures in education and prevention are therefore necessary.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
New applications of FeMOF as drug delivery system for theophylline
Autorzy:
Strzempek, W.
Gil, B.
Menaszek, E.
Powiązania:
https://bibliotekanauki.pl/articles/285613.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
theophylline
drugs
MOF
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 106
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Potential of electrospinning technique to drug delivery system
Autorzy:
Dzierzkowska, E.
Stodolak-Zych, E.
Powiązania:
https://bibliotekanauki.pl/articles/284071.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
electrospinning
drugs
fibers
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 119
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Halloysite nanotubes as potential carrier for gentamicin
Autorzy:
Stodolak-Zych, E.
Skóra, K.
Rapacz-Kmita, A.
Mikołajczyk, M.
Gajek, M.
Bućko, M. M.
Powiązania:
https://bibliotekanauki.pl/articles/284115.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
nanotubes
gentamicin
drugs
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 93
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Multi-parametric SPR – in vitro characterization method for biopharmaceuticals and drug delivery systems
Autorzy:
Sadowski, J. W.
Granqvist, N.
Jokinen, A.
Powiązania:
https://bibliotekanauki.pl/articles/285101.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
drugs
SPR
biopharmaceuticals
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 120
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Selenium containing hydroxyapatite granules as drug carriers for risedronate
Autorzy:
Kolmas, J.
Pajor, K.
Pajchel, Ł.
Olędzka, E.
Sobczak, M.
Powiązania:
https://bibliotekanauki.pl/articles/285367.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
hydroxyapatite
drugs
biomaterials
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 70
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chitosan based drug delivery systems
Autorzy:
Piegat, A
Goszczyńska, A.
Niemczyk, A.
Powiązania:
https://bibliotekanauki.pl/articles/285591.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
drugs
polymeric materials
chitosan
Opis:
One of the research area in which polymeric materials are intensively explored, deals with the controlled drug delivery systems (DDSs), allowing for drugs distribution directly to the desired site of biological activity. The morphology of polymeric colloidal drug carriers can be described as a construction of a core-shell type. Depending on the chemical or physical bonds providing stability of those systems and the type of interactions between the drug and the polymer, among polymeric DDSs the following morphological structures can be distinguished: micelles, dendrimers, liposomes, niosomes, polymerosomes and micro- and nanocapsules [1]. The main advantages of those systems are the preparation of particles with desired size (diameter from nano to micrometers) during their synthesis / formation and high specific surface area, which can be modified by the appropriate chemical composition of the surface improving the efficiency of a drug delivery. Chitosan is biopolymer derived from chitin, that is characterised by biodegradability, biocompatibility, mucoadhesion and antimicrobial activity [2,3]. Taking into account the overall advantages of this polymer and the possibility of modification due to the accessible functional groups i.e. hydroxyl and amine, chemically modified chitosan is one of the most promising biomaterials for DDS. In order to obtain micelle structures by selfassemby in aqueous environment several hydrophobically modified chitosan derivatives, such as – stearic acid-modified chitosan [4], palmitic anhydridemodified chitosan [5], linolenic acid-modified chitosan [6], have been synthesized. The micelles prepared by these derivatives in the aqueous medium contain internal hydrophobic moieties as drug reservoir and external hydrophilic chitosan chains as surrounding shell. The above mentioned micellar systems allow encapsulation of hydrophobic antitumor drugs e.g. doxorubicin or paclitaxel due to the compatibility between the hydrophobic core and hydrophobic drug affecting the drug loading and regulate drug release. Another important group of chitosan based micro- and nanoparticles are those dedicated for gastric infection treatment. The use of chitosan in this specific application is mainly related with the mucoadhesive properties of chitosan resulted from the electrostatic interactions between its positively charged free amine groups and the negatively charged gastric mucins at the acidic stomach pH. Several problems such as high solubility of chitosan under stomach acidic conditions, low retention time and difficulty in crossing the mucus barrier have been observed in those systems [7]. Therefore various crosslinking methods e.g. with glutaraldehyde [8], genipin [9] or sodium triphosphate pentabasic (TPP) solution [10] were investigated in order to minimize these problems. The nanotechnological production of the polymeric drug carriers, as well as the disadvantages of already developed chitosan based drug delivery systems induce the NANOENCAP project concept on the development and characterization of new dendrimeric micelles polymeric systems, with rigidly defined chemical structure, allowing the encapsulation of several drugs and their controlled release, and thus forming the so-called multidrug therapy systems. To provide the biocompatibility of new polymeric materials the monomer / reactant with proven biocompatibility or naturally occurring in the human body are chosen. According to the assumptions of the project the amphiphilic character of the proposed multi-functional polymeric drug delivery systems is going to enable the encapsulation of at least two drugs, matching latest trends in the research on DDS models in multi-therapy. As an exemplary multi-drug therapy in this project, the combine therapy of peptic ulcer disease was chosen. In this work we would like to present the short review of chitosan based drug delivery systems and the concept of the project as well as preliminary studies on new chitosan derivatives and the possibility of synthesis new micellar structures.
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 27
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Carbon nanopowders in technology drug form
Autorzy:
Skibska, B.
Bodek, K. H.
Powiązania:
https://bibliotekanauki.pl/articles/285643.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
carbon nanopowders
drugs
biotechnology
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 81
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sonochemical synthesis of drug molecules nanoparticles: towards controlled drug release
Autorzy:
Chytrosz, P.
Golda-Cepa, M.
Kotarba, A.
Powiązania:
https://bibliotekanauki.pl/articles/286014.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
nanoparticles
drugs
sonochemical synthesis
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 69
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Charakterystyka wpływu narkotyków na ośrodkowy układ nerwowy
Autorzy:
Panas, Krystyna Teresa
Powiązania:
https://bibliotekanauki.pl/articles/2140999.pdf
Data publikacji:
2011
Wydawca:
Instytut Studiów Międzynarodowych i Edukacji Humanum
Tematy:
drugs addiction
nervous system
Opis:
Article covers the issues: Substances opóźniająco the central nervous system Substances stimulating the central nervous system Substances that cause disturbances in the central nervous system Escape from the daily concerns and environmental impact
Źródło:
Humanum. Międzynarodowe Studia Społeczno-Humanistyczne; 2011, 2(7); 253-263
1898-8431
Pojawia się w:
Humanum. Międzynarodowe Studia Społeczno-Humanistyczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Opinia prawna stanowiąca uzupełnienie opinii na temat obowiązku wprowadzenia przez Polskę do sprzedaży aptecznej bez recepty produktu leczniczego ellaOne
Legal opinion complementing the opinion on Poland’s obligation to allow sale in pharmacies of a medicinal product ellaOne without prescription
Autorzy:
Kondrat, Mariusz
Powiązania:
https://bibliotekanauki.pl/articles/2223418.pdf
Data publikacji:
2015
Wydawca:
Kancelaria Sejmu. Biuro Analiz Sejmowych
Tematy:
contraception
drugs
European Union
Opis:
The author provides an analysis of Poland’s obligations as a Member State of the European Union, relating to the implementation of Community law in so far as it concerns Ellaone contraceptive. He points out that Regulation 726/2004 does not regulate issues related to the marketing of medicinal products in a comprehensive manner. Directive 2001/83/EC of the European Parliament and of the Council, according to its Article 4 para. 4, does not affect the application of national legislation prohibiting or restricting the sale or use of medicinal products as contraceptives or abortifacients. In Poland, there is no legislation expressly establishing a ban or restrictions on marketing or application of this particular type of agents, and any possible national legislation introduced to implement the restrictions permitted under the Directive should not only aim at eliminating the effect of the decision of the European Commission amending marketing authorisation issued by a decision (2009) 4049 for “ellaOne – ulipristal acetate”, a medicinal product for human use, but should relate to this category of products.
Źródło:
Zeszyty Prawnicze BAS; 2015, 1(45); 100-106
1896-9852
2082-064X
Pojawia się w:
Zeszyty Prawnicze BAS
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Problem legalizacji narkotyków miękkich w Polsce na tle regulacji prawnych przyjętych w Republice Czeskiej oraz w Królestwie Niderlandów
The issue of legalizing soft drugs in Poland against the legal regulations adopted in the Czech Republic and in the Netherlands
Autorzy:
Fiedukowicz, Marcin
Powiązania:
https://bibliotekanauki.pl/articles/964942.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
drugs
criminalization
decriminalization
drugs possession
soft drugs
legalization
prohibition
narkotyki
kryminalizacja
dekryminalizacja
posiadanie narkotyków
narkotyki miękkie
legalizacja
prohibicja
Opis:
Celem niniejszej publikacji jest przybliżenie unormowań prawnych odnoszących się do problematyki legalizacji oraz dostępności narkotyków miękkich w Polsce. W oparciu o regulacje prawa międzynarodowego, a także najważniejsze akty prawa wewnątrzwspólnotowego wskazuje się na zasadnicze przyczyny, dla których depenalizacja zachowań polegających na posiadaniu bądź też wytwarzaniu tzw. soft drugs nie jest obecnie możliwa. Zestawienie przepisów karnych polskiej ustawy narkotykowej pozwala wytyczać pożądane kierunki zmian w polskim modelu prohibicyjnym. W tym kontekście autor prezentuje podstawowe założenia polityk antynarkotykowych przyjętych w Republice Czeskiej oraz w Królestwie Niderlandów, jako państw o mniej restrykcyjnym (radykalnym) podejściu do kwestii posiadania narkotyków. Podjęte rozważania pozwalają ostatecznie na sformułowanie odpowiedzi na pytanie: Czy zasadne jest zalegalizowanie chociażby tzw. „narkotyków miękkich”, czy też należy pozostawić obowiązujące unormowania prawne bez zmian, karząc zawsze i za każdy przejaw posiadania narkotyków i to bez względu na ich rodzaj?
The aim of this publication is to bring closer legal regulations referring to issues of legalization and availability of soft drugs in Poland. Basing on regulations of the international law as well as on the most important acts of the intra-Community law fundamental reasons are indicated for which depenalization of behaviours such as the possession or production of the so-called soft drugs is not at present possible. Comparing regulations of penalties of the Polish drug act allows setting necessary guidelines for changes to the Polish prohibition model. In this context the author is presenting fundamental assumptions of the anti-drug policies adopted in the Netherlands and Czech Republic as the states with a less restrictive (radical) approach to the issue of drug possession. The considerations undertaken allow finally formulating an answer to a question: Is it reasonable to legalize at least the so-called ‘soft drugs’ or should the binding legal regulations be maintained without changes, punishing always and for every manifestation of drug possession and irrespectively of a type of drugs?
Źródło:
Acta Universitatis Lodziensis. Folia Iuridica; 2016, 76
0208-6069
2450-2782
Pojawia się w:
Acta Universitatis Lodziensis. Folia Iuridica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Correlation between relative rates of hospital treatment or death due to ischaemic heart disease (IHD) and of IHD-related medication among socio-occupational and economic activities groups in Denmark, 1996–2005
Autorzy:
Hannerz, Harald
Dalhoff, Kim
Burr, Hermann
Latza, Ute
Powiązania:
https://bibliotekanauki.pl/articles/2178871.pdf
Data publikacji:
2014-08-06
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
pccupational epidemiology
heart therapeutic drugs
anti-hypertensive drugs
lipid modifying agents
Opis:
Objective: The aim of the present work was to establish whether or not prescribed medication is a usable risk indicator for work‑related ischaemic heart disease (IHD), in Denmark. Material and Methods: Weighted Spearman rank correlation coefficients (rho) were used to evaluate the agreement between Standardised Hazard Ratios (SHR) for hospital treatment or death due to IHD and SHR for purchase of prescriptions for medicine that may prevent IHD from (re)occurring, among socio-occupational and economic activities groups in Denmark. The SHR were based on a 10-year prospective follow-up of 2 million people in Danish national registers 1996–2005. Results: We found approximately 7 times more cases of medicine usage (N = 411 651) than we did for hospital treatment or death (N = 55 684). The correlations between the 2 types of SHR were strong (rho = 0.94 for the socio-occupational groups; rho = 0.74 for the economic activities groups). We observed, however, one markedly contradictive result; the industrial group entitled ‘general practitioner, dentists etc.’ was associated both with significantly high rates of medicine usage (SHR = 1.15, 95% CI: 1.12–1.19) and significantly low rates of hospital treatment or death due to IHD (SHR = 0.80, 95% CI: 0.71–0.91). Conclusion: Apart from a few caveats, the strong correlations obtained in the present study signify that purchase of a prescription for IHD-related medication is a usable risk indicator for IHD in the working population of Denmark. The usage of medicine data in addition to or instead of the use of death or hospital data in epidemiological studies on work-related IHD risk will bring about a tremendous increase in statistical power.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2014, 27, 4; 536-546
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Liposomal drug delivery, a novel approach: PLARosomes.
Autorzy:
Kozubek, Arkadiusz
Gubernator, Jerzy
Przeworska, Ewa
Stasiuk, Maria
Powiązania:
https://bibliotekanauki.pl/articles/1044303.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
drugs
liposomes
vesicles
amphiphiles
Opis:
Almost from the time of their rediscovery in the 60's and the demonstration of their entrapment potential, liposomal vesicles have drawn attention of researchers as potential carriers of various bioactive molecules that could be used for therapeutic applications in humans and animals. Several commercial liposome-based drugs have already been discovered, registered and introduced with great success on the pharmaceutical market. However, further studies, focusing on the elaboration of more efficient and stable amphiphile-based vesicular (or non-viral) drug carriers are still under investigation. In this review we present the achievements of our group in this field. We have discovered that natural amphiphilic dihydroxyphenols and their semisynthetic derivatives are promising additives to liposomal lipid compositions. The presence of these compounds in lipid composition enhances liposomal drug encapsulation, reduces the amount of the lipid carrier necessary for efficient entrapment of anthracycline drugs by a factor of two, stabilizes liposomal formulation of the drug (both in suspension and in a lyophilized powder), does not influence liposomal fate in the blood circulation system and benefits from other biological activities of their resorcinolic lipid modifiers.
Źródło:
Acta Biochimica Polonica; 2000, 47, 3; 639-649
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 324

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