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Tytuł:
Determination of polymorphism of IS-1311 sequence in Mycobacterium avium subspecies paratuberculosis strains isolated from milk samples
Autorzy:
Szteyn, J.
Bednarko-Młynarczyk, E.
K. Liedke
Wiszniewska-Łaszczych, A.
Wojtacka, J.
Powiązania:
https://bibliotekanauki.pl/articles/2087864.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Mycobacterium avium subsp. paratuberculosis
milk
IS-1311 polymorphism
Źródło:
Polish Journal of Veterinary Sciences; 2017, 4; 827-829
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Silver nanoparticles in isotactic polypropylene. Part II. Molecular modelling of polypropylene chains arrangement on the surface of silver nanoparticles
Nanocząstki srebra w izotaktycznym polipropylenie. Cz. II. Modelowanie ułożenia łańcuchów polipropylenu na powierzchni nanocząstek srebra
Autorzy:
Hybiak, D.
Chmielewska, S.
Garbarczyk, J.
Powiązania:
https://bibliotekanauki.pl/articles/947446.pdf
Data publikacji:
2015
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Chemii Przemysłowej
Tematy:
polymorphism
epitaxy
molecular modelling
polimorfizm
epitaksja
modelowanie molekularne
Opis:
Molecular modelling (MM) was used to explain the mechanism of formation of polymorphic form of isotactic polypropylene (iPP) at the surface of the silver nanoparticles (nAg). Geometrical optimization of iPP chains and unit cell of Ag systems was made with the use of MM+force field in vacuum. According to the results, the arrangement of methyl groups in the (110) contact plane implies a lateral packing of helices with a periodicity α ≈ 19 Å, which is a characteristic feature of the complicated packing of helices in β iPP. Partial charges calculated on the basis of the hybrid potential BLYP revealed the possibility of electrostatic interactions between hydrogens from methyl groups and silver atoms at the edge of unit cell. Analysis of the optimized iPP/Ag system confirmed that the formation of the polymorphic β iPP can be explained by the epitaxial mechanism.
W celu wyjaśnienia mechanizmu tworzenia się formy β izotaktycznego polipropylenu (iPP) na powierzchni nanocząstek srebra (nAg) wykorzystano modelowanie molekularne (MM). Wykonano optymalizacje geometryczne układów iPP z nAg przy użyciu pola siłowego MM+ w próżni. Stwierdzono, że ustawienie grup metylowych w płaszczyźnie kontaktu (110) ujawnia boczne upakowanie helis z okresowością α ≈ 19 Å. Jest to cecha charakterystyczna dla upakowania helis w formie β iPP. Wyniki obliczeń ładunków cząstkowych przy użyciu potencjału hybrydowego BLYP wskazują na możliwość występowania oddziaływań elektrostatycznych między wodorami z grup metylowych łańcuchów iPP i atomami srebra leżącymi na krawędziach komórki elementarnej. Analiza optymalizowanych układów potwierdziła, że oddziaływanie atomów srebra z makrocząsteczką iPP może się przyczyniać do tworzenia polimorficznej formy β na drodze mechanizmu epitaksjalnego.
Źródło:
Polimery; 2015, 60, 11-12; 700-704
0032-2725
Pojawia się w:
Polimery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Genetic diversity in populations of Slovak Spotted cattle based on single nucleotide polymorphisms analyses
Autorzy:
Moravčíková, Nina
Trakovická, Anna
Navrátilová, Alica
Powiązania:
https://bibliotekanauki.pl/articles/1039494.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cattle
growth hormone
leptin
leptin receptor
polymorphism
Opis:
The aim of this study was to identify SNPs in leptin (LEP), leptin receptor (LEPR) and growth hormone (GH) genes in order to analyze genetic diversity of Slovak Spotted cattle. The total numbers of blood samples were taken from 353 Slovak Spotted cows originating from four farms. Genomic DNA was isolated by phenol-chloroform extraction method and analyzed by PCR-RFLP method. After digestion with restriction, enzymes were detected in whole population of cow's alleles with frequency: LEP/Sau3AI A 0.84 and B 0.16 (±0.0152); LEPR/BseGI C 0.95 and T 0.05 (±0.0089) and GH/AluI L 0.70 and V 0.30 (±0.0188). Based on the observed vs. expected genotypes frequencies populations across loci were in Hardy-Weinberg equilibrium (P\>0.05). Predominant for SNP LEP/Sau3AI was AA genotype (0.70), for SNP LEPR/T945M CC genotype (0.91), and LL genotype (0.48) was most frequent for SNP GH/AluI. The observed heterozygosity of SNPs across populations was also transferred to the low or median polymorphic information content 0.24 (He 0.28), 0.08 (He 0.09) and 0.33 (He 0.47) for LEP, LEPR and GH genes, respectively. Within genetic variability estimating negative values of fixation indexes FIS (-0.09-0.05) and FIT (-0.07-0.03) indicating heterozygote excess were observed. The value of FST indexes (0.018-0.023) shows very low levels of genetic differentiation in allele frequencies of loci among evaluated subpopulations. The low values of genetic distances (0.0018-0.0159) indicated high genetic relatedness among animals in subpopulations caused probably by common ancestry used in breeding program at farms.
Źródło:
Acta Biochimica Polonica; 2013, 60, 4; 807-810
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sequence analysis of human cytomegalovirus US28 gene in low-passage clinical isolates from children and AIDS patients
Autorzy:
He, Rong
Xia, Chang
Ruan, Qiang
Qi, Ying
Ma, Yan-Ping
Ji, Yao-Hua
Guo, Jin-Jin
Powiązania:
https://bibliotekanauki.pl/articles/1039923.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
chemokine receptors
cytomegalovirus
genetic polymorphism
US28
Opis:
Human cytomegalovirus (HCMV) is often a dangerous opportunistic pathogen that causes significant morbidity and mortality in newborn children and immunocompromised patients. The different symptoms and tissue tropisms of HCMV infection may result from genetic polymorphism. This study investigated the sequence variability of the HCMV US28 ORF, which shows sequence homology to the G protein-coupled receptor. HCMV isolated from suspected pediatric cases and isolates from AIDS patients were compared in order to examine the possible associations between polymorphisms and pathogenesis. Seventy children with suspected congenital HCMV infection, who suffered from jaundice (47), megacolon (10), and microcephaly (13), and 17 AIDS patients, were studied. Mutation was prevalent among the sequences of US28, with a focus on the two ends of US28. The important functional groups of US28 are highly conserved. An unrooted tree showed that all sequences from suspected congenitally infected infants and AIDS patients were divided into three groups. Comparison showed that most of the sequences (12/17) from pediatric patients were included in the first group (G1), whereas most of the sequences (11/17) from AIDS patients were included in the third group (G3). The specific high mutation sites in US28 from children were located at the C terminus of the protein, whereas those from AIDS patients were located at the N terminus. We demonstrated the existence of polymorphisms among the US28 genes of clinical isolates of HCMV from infants with suspected congenital infection. Comparison of US28 sequences from AIDS patients with those from children showed that both sequences have their own specific high mutation points.
Źródło:
Acta Biochimica Polonica; 2011, 58, 2; 231-236
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Development of microsatellite markers for horse-chestnut (Aesculus hippocastanum), their polymorphism in natural Greek populations, and cross-amplification in related species
Autorzy:
Walas, L.
Iszkulo, G.
Barina, Z.
Dering, M.
Powiązania:
https://bibliotekanauki.pl/articles/2078223.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Instytut Dendrologii PAN
Tematy:
Tertiary relict
endemic species
cross-amplification
polymorphism
Opis:
New nuclear microsatellite markers (SSRs) were developed for Aesculus hippocastanum, a relict tree species from the Balkan Peninsula. The development of microsatellites was done using the Illumina MiSeq PE300 platform. Out of a set of 500 SSRs designed, a subset of 13 loci was tested using 290 individuals from seven natural populations. Twelve species-specific loci were polymorphic. The number of alleles per locus ranged from 2 to 17 and expected heterozygosity from 0.089 to 0.800 with a mean value of 0.484. The population of Kalampaka had the lowest value of allelic richness (2.63) and gene diversity in comparison to the remaining populations. STRUCTURE analysis confirmed isolation of population Mariolata from the southern edge of the species range and genetic similarity among populations from the Pindos Mts. Additionally, the utility of new SSRs in 29 individuals from nine other Aesculus taxa was tested. Eleven markers gave polymorphic products for all tested species. For 24 individuals, a high-quality product was obtained for each marker. Results confirmed the utility of specific markers for future population genetics studies.
Źródło:
Dendrobiology; 2021, 85; 105-116
1641-1307
Pojawia się w:
Dendrobiology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
THE POSSIBILITY OF USING X-RAY POWDER DIFFRACTION, INFRARED AND RAMAN SPECTROSCOPY IN THE STUDY OF THE IDENTIFICATION OF STRUCTURAL POLYMORPHS OF ACETAMINOPHEN
Autorzy:
Stasiłowicz, Anna
Mizera, Mikołaj
Tykarska, Ewa
Lewandowska, Kornelia
Miklaszewski, Andrzej
Cielecka-Piontek, Judyta
Powiązania:
https://bibliotekanauki.pl/articles/895486.pdf
Data publikacji:
2019-12-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
acetaminophen
PXRD
Raman
FT-IR
structural polymorphism
Opis:
Paracetamol (acetaminophen), a pain-killer with antipyretic properties, shows structural polymorphism. It occurs in three polymorphic forms: monoclinic, orthorhombic, and unstable form III. In the study, the commercially available samples of paracetamol (P1 and P2) were examined using X-ray powder diffraction, infrared, and Raman spectroscopy. Results demonstrated that all of the methods defined polymorphic forms of paracetamol in the samples. However, only Raman spectroscopy and PXRD methods detected impurities in the sample P1. These methods transpired to be more sensitive than the FT-IR method, which identified samples of paracetamol as one structural form (monoclinic polymorph). Moreover, the Raman spectroscopy identified impurities in the form P1 as changes in the crystalline form.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 6; 997-1004
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polimorficzność motywacji osób twórczych. Implikacje pedagogiczne
Autorzy:
Bartnicka-Michalska, Aneta
Powiązania:
https://bibliotekanauki.pl/articles/1789867.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Warszawski. Wydawnictwa Uniwersytetu Warszawskiego
Tematy:
interpreting artist
efficient personality
polymorphism of motivation
Opis:
In the article the hypothesis of motivational polymorphism in creativity is formulated and confirmed. The hypothesis assumes that activation of creative behaviour needs many different types of motivation, which are variations of one main motivation. The theoretical basis of this article rests on Józef Kozielecki’s concept of psychotransgressionism, which assumes that creative behaviour can be activated by three motivations: self-esteem motivation (hubristic), motivation of the meaning of life and motivation of self-efficiency. In this study on a sample of interpreting artists (N = 133), creative behaviour was measured using the STZ questionnaire (Strzałecki 2003). The motivational orientations were measured using the Polish adaptation of Power Motivation Scale (PMS) by Tokarz and Trzebińska (2011), the Polish adaptation of Life Attitude Profile questionnaire (LAP-R) by Klamut (2010) and the Polish adaptation of General Self- Efficacy Scale questionnaire (GSES) by Juczyński (2001). The results confirmed the hypothesis of a polymorphic nature of motivation in creative people. Educational implications of results are discussed.
Źródło:
Kwartalnik Pedagogiczny; 2015, 60(3 (237)); 34-52
0023-5938
Pojawia się w:
Kwartalnik Pedagogiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Revision of reciprocal action of mercury and selenium
Autorzy:
Kuraś, Renata
Janasik, Beata
Wąsowicz, Wojciech
Stanisławska, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/2162011.pdf
Data publikacji:
2018-10-23
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
gene expression
polymorphism
mercury
selenium
antagonism
interaction
Opis:
Diverse forms of mercury (Hg) have various effects on animals and humans because of a variety of routes of administration. Inorganic mercury (iHg) binds to thiol groups of proteins and enzymes in one’s body or is methylated by microorganisms. Organic form of Hg, contrary to the iHg, is more stable but may be demethylated to Hg2+ in the tissue of intestinal flora. Selenium (Se) also occurs in a variety of chemical forms in one’s body but both of these elements behave very differently from one another. Mercury binding to selenide or Se-containing ligands is a primary molecular mechanism that reduces toxicity of Hg. Complexes formed in such a way are irreversible, and thus, biologically inactive. Se deficiency in a human body may impair normal synthesis of selenoproteins and its expression because expression of mRNA may be potentially regulated by the Se status. This paper provides a comprehensive review concerning Hg–Se reciprocal action as a potential mechanism of protective action of Se against Hg toxicity as well as a potential detoxification mechanism. Although interactions between Hg–Se have been presented in numerous studies concerning animals and humans, we have focused mainly on animal models so as to understand molecular mechanisms responsible for antagonism better. The review also investigates what conclusions have been drawn by researchers with respect to the chemical species of Se and Hg (and their relationship) in biological systems as well as genetic variations and expression and/or activity of selenoproteins related to the thioredoxin (thioredoxin Trx/TrxR) system and glutathione metabolism. Int J Occup Med Environ Health 2018;31(5):575–592
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2018, 31, 5; 575-592
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of effect CAT -262C/T, SOD + 35A/C, GPx1 Pro197Leu polymorphisms in patients with ibd in the polish population
Autorzy:
Mrowicki, Jerzy
Mrowicka, Małgorzata
Majsterek, Ireneusz
Mik, Michał
Dziki, Adam
Dziki, Łukasz
Powiązania:
https://bibliotekanauki.pl/articles/1393718.pdf
Data publikacji:
2016
Wydawca:
Index Copernicus International
Tematy:
genetic polymorphism
antioxidant enzyme
inflammatory bowel disease
Opis:
Inflammatory bowel disease (IBD) are a heterogeneous group of disorders in the course dominated by chronic, recurrent gastrointestinal inflammation. It is believed that the activation of IBD occurs in patients with a genetic predisposition to their development. Chronic inflammation develops as a result of an excessive reaction of the immune system principally under the influence of environmental risk factors. Among them, it has been shown that the mechanism of oxidative stress is associated with the pathophysiology of inflammatory bowel disease, responsible for the commencement and progress of these diseases. The aim of the study was the relationship between single nucleotide polymorphisms (SNPs) of individual antioxidant enzymes, and the prevalence of inflammatory bowel disease that may be associated with increased levels of oxidative stress. Material and methods. A total of 111 IBD patients, including 65 patients with ulcerative colitis (UC) and 46 with Crohn’s disease (CD) and 125 healthy controls recruited from the Polish population, were genotyped for CAT -262C / T (rs1001179), SOD + 35A / C (rs2234694), GPx Pro 197 Leu polymorphisms. Genotyping of CAT, SOD, GPx gene polymorphism was performed by a RFLP-PCR. Results. The performed analysis of genetic polymorphisms of antioxidant enzymes showed that polymorphic variant of the CAT -262 C / T may have protective effects in patients with ulcerative colitis in the range of genotype C / T; OR = 0.49 (0.25-0.99), p = 0.044. Trend protective, but statistically unrelated, it was also observed for genotype T / T and T allele of the same polymorphism and genotypes and alleles + 35A / C SOD1 in UC as well as polymorphic variants CAT -262 C / T, Pro197Leu of GPx1, + 35A / C SOD1 in CD. The results were compared with a control group of potentially healthy individuals without such diseases. Conclusions. It has been shown that the polymorphism of antioxidant enzymes CAT gene -262 C / T may have protective effects in patients who are carriers of a genotype C / T at the UC. The potential protective effect without statistical relationships were also observed for other genotypes and alleles studied polymorphic variants of antioxidant enzymes in CD and CAT- 262C / T and + 35 A / C SOD1 in UC. Conducted our audit should be extended to more group of patients in order to assess whether or not to confirm the observed during analysis, the protective effect of CAT-262 C / T in ulcerative colitis and other trends observed for other polymorphic variants tested genes.
Źródło:
Polish Journal of Surgery; 2016, 88, 6; 565-575
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
DNA polymorphism in locus D1S80 in Poland. DNA profiling and detection of new alleles by heteroduplex formation between alleles of the same size
Autorzy:
Kwiatkowska, J
Dziechciowska, K
Lisiecka, D
Slomski, R
Powiązania:
https://bibliotekanauki.pl/articles/2046677.pdf
Data publikacji:
1997
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
DNA sequence
polymorphism
Polska
hybridization
Polish population
heteroduplex formation
DNA polymorphism
same size
polymerase chain reaction
allele
distribution
Opis:
We have analysed allele distribution at the highly polymorphic variable number of tandem repeats (VNTR) locus D1S80 (pMCT118) in the Polish population using the, polymerase chain reaction (PCR) technique. Characteristics of the D1S80 locus makes it a very useful marker for population genetic research, genetic linkage studies and forensic identification of individuals. During our routine application of the D1S80 marker to paternity testing in several cases of homozygosity detected by polyacrylamide gel electrophoresis, heteroduplex formation for alleles 18 and 24 was also observed. Direct sequencing of PCR products revealed that alleles 18 and 24 of locus D1S80 actually represent a mixture composed of different sequences. Our observations indicate that identification of some 18 and 24 VNTR alleles based only on size estimated in electrophoretic analyses could lead to errors in paternity testing and DNA profiling.
Źródło:
Journal of Applied Genetics; 1997, 38, 3; 335-341
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Doubled haploids as a material for biotechnological manipulation and as a modern tool for breeding oilseed rape (Brassica napus L.)
Autorzy:
Cegielska-Taras, T.
Szala, L.
Matuszczak, M.
Babula-Skowronska, D.
Mikolajczyk, K.
Poplawska, W.
Sosnowska, K.
Hernacki, B.
Olejnik, A.
Bartkowiak-Broda, I.
Powiązania:
https://bibliotekanauki.pl/articles/80477.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Brassica napus
oilseed rape
doubled haploid
marker-assisted selection
gene mapping
transformation
breeding
amplified fragment length polymorphism
random amplified polymorphic DNA
restriction fragment length polymorphism
recombinant inbred line
single nucleotide polymorphism
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2015, 96, 1
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The angiotensin converting enzyme gene i/d polymorphism in Polish rowers
Autorzy:
Jastrzębski, Zbigniew
Leońska-Duniec, Agata
Kolbowicz, Marek
Tomiak, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/1055139.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
ACE I/D polymorphism
athlete status
rowers
sport genetics
Opis:
Angiotensin converting enzyme gene (ACE) is the most frequently investigated genetic marker in the context of genetic conditioning of athletic predispositions. The product of the gene is a key component of the renin-angiotensin system (RAS) and the kallikrein-kinin system (KKS), mainly responsible for the regulation of blood pressure. The main aim of the study was to determine the possible interaction between the ACE I/D polymorphism and endurance athlete status in a group of Polish rowers in comparison with sedentary individuals. 121 male Polish rowers, members of academic sports clubs, and 115 unrelated volunteers, were recruited for the study. The PCR amplification of the insertion (I) or deletion (D) fragment of the ACE gene was performed. Compared with control group, the frequency of the I allele differ significantly from that found in rowers (57.4% vs. 44.3%; P=0.013) and the ACE genotype frequency amongst the whole cohort of rowers (30.6% II, 53.7% ID, 15.7% DD) was also different from expected values (control group 19.1% II, 50.4% ID, 30.4% DD; P=0.017). Our investigation confirms a positive association of the I allele of the ACE gene with endurance athlete status in a group of Polish rowers.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2014, 5, 1; 77-82
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of the G/C polymorphism in the 5-untranslated region of the RAD51 gene in breast cancer.
Autorzy:
Blasiak, Janusz
Przybyłowska, Karolina
Czechowska, Agnieszka
Zadrożny, Marek
Pertyński, Tomasz
Rykała, Jan
Kołacińska, Agnieszka
Morawiec, Zbigniew
Drzewoski, Józef
Powiązania:
https://bibliotekanauki.pl/articles/1043672.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
genetic polymorphism
RAD51 gene
RFLP-PCR
breast cancer
Opis:
The breast cancer suppressor proteins BRCA1 and BRCA2 interact with RAD51, a protein essential for maintaining genomic stability by playing a central role in homology-dependent recombinational repair of the DNA double-strand breaks. Therefore, genetic variability in the RAD51 gene may contribute to the appearance and/or progression of breast cancer. A single nucleotide polymorphism in the 5'- untranslated region of RAD51 (a G to C substitution at position 135, the G/C polymorphism) is reported to modulate breast cancer risk. We investigated the distribution of genotypes and frequency of alleles of the G/C polymorphism in breast cancer. Tumor tissues were obtained from postmenopausal women with node-negative and node-positive breast carcinoma with uniform tumor size. Blood samples from age matched healthy women served as control. The G/C polymorphism was determined by PCR-based MvaI restriction fragment length polymorphism. The distribution of the genotypes of the G/C polymorphism did not differ significantly (P >0.05) from those predicted by the Hardy-Weinberg distribution. There were no differences in the genotype distribution and allele frequencies between node-positive and node-negative patients. There were no significant differences between distributions of the genotypes in subgroups assigned to histological grades according to Scarf-Bloom-Richardson criteria and the distribution predicted by Hardy-Weinberg equilibrium (P >0.05). Our study implies that the G/C polymorphism of the RAD51 gene may not be directly involved in the development and/or progression of breast cancer and so it may not be useful as an independent marker in this disease.
Źródło:
Acta Biochimica Polonica; 2003, 50, 1; 249-253
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Transferrin receptor levels and polymorphism of its gene in age-related macular degeneration
Autorzy:
Wysokinski, Daniel
Danisz, Katarzyna
Pawlowska, Elzbieta
Dorecka, Mariola
Romaniuk, Dorota
Robaszkiewicz, Jacek
Szaflik, Marta
Szaflik, Jerzy
Blasiak, Janusz
Szaflik, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1039085.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
AMD
gene polymorphism
iron
oxidative stress
TFRC
transferrin receptor
Opis:
The aim of the present study was to investigate the association of age related macular degeneration (AMD) risk with some aspects of iron homeostasis: iron concentration in serum, level of soluble transferrin receptor (sTfR), and transferrin receptor (TFRC) genetic variability. Four hundred and ninety one AMD patients and 171 controls were enrolled in the study. Restriction fragment length polymorphism PCR was employed to genotype polymorphisms of the TFRC gene, and colorimetric assays were used to determine the level of iron and sTfR. Multiple logistic regression was applied for all genotype/allele-related analyses and the ANOVA test for iron and sTfR serum level comparison. We found that the genotypes and alleles of the c.-253G > A polymorphism of the TFRC gene were associated with AMD risk and this association was modulated by smoking status, AMD family history, living environment (rural/urban), body mass index and age. The levels of sTfR was higher in AMD patients than controls, whereas concentrations of iron did not differ in these two groups. No association was found between AMD occurrence and the p.Gly142Ser polymorphism of the TRFC gene. The results obtained suggest that transferrin receptor and variability of its gene may influence AMD risk.
Źródło:
Acta Biochimica Polonica; 2015, 62, 2; 177-184
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polymorphism of the porcine growth hormone gene and its linkage to microsatellites S0083 and S0090
Autorzy:
Korwin-Kossakowska, A
Pierzchala, M.
Kuryl, J.
Zwierzchowski, L.
Cymerowska-Prokopczyk, I.
Siadkowska, E.
Powiązania:
https://bibliotekanauki.pl/articles/2043894.pdf
Data publikacji:
1999
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
pig
gene
polymorphism
microsatellite
Sus scrofa
linkage
growth hormone
Źródło:
Journal of Applied Genetics; 1999, 40, 2; 85-91
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 31-45 z 216

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