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Wyświetlanie 1-15 z 29
Tytuł:
Deuterium isotope effects in oxidation of dopamine by tyramine oxidase
Autorzy:
Pająk, M.
Byszewska, W.
Kańska, M.
Powiązania:
https://bibliotekanauki.pl/articles/147724.pdf
Data publikacji:
2013
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
deuterium
dopamine (DA)
isotope effects
oxidation
tyramine oxidase
Opis:
We report the studies on the mechanism of oxidation of dopamine (DA) to 3’,4’-dihydroxyphenylacetaldehyde (DOPAL) by enzyme tyramine oxidase (EC 1.4.3.6) using kinetic isotope effects (KIE) and solvent isotope effects (SIE) methods. For kinetic studies, the selectively deuterium labelled isotopologues of dopamine, i.e., [(1R)-2H]-, and [(1S)- -2H]-DA were used. The numerical values of KIE’s for the (1R)- and (1S)-isotopologues of dopamine in the enzymatic oxidation of DA to DOPAL were determined using the non competitive spectrophotometric method. Also, the SIE’s for this reaction carried out in heavy water were obtained spectrophotometrically. Some mechanistic details of enzymatic oxidation of DA to DOPAL were discussed.
Źródło:
Nukleonika; 2013, 58, 2; 255-259
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Deuterium isotope effects in oxidation of dopamine and norepinephrine catalyzed by horseradish peroxidase
Autorzy:
Byszewska, W.
Pająk, M.
Kańska, M.
Powiązania:
https://bibliotekanauki.pl/articles/146852.pdf
Data publikacji:
2013
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
deuterium
dopamine (DA)
norepinephrine
isotope effects
oxidation
peroxidase
Opis:
Deuterium kinetic isotope effects (KIE’s) in the reaction of oxidation of dopamine (DA) catalyzed by the enzyme horseradish peroxidase (HRP, EC 1.11.1.7) was determined using a non-competitive spectrophotometric method. For kinetic studies, the deuterium ring labelled isotopomer [2’,5’,6’-2H3]-dopamine was synthesized using acid catalyzed isotopic exchange between authentic dopamine and heavy water. Deuterium solvent isotope effects (SIE’s) for dopamine and norepinephrine were determined separately for the enzymatic oxidation carried out in the presence or absence of hydrogen peroxide. Some mechanistic details of enzymatic oxidation of dopamine and norepinephrine to corresponding catecholchromes catalyzed by HRP were discussed.
Źródło:
Nukleonika; 2013, 58, 4; 475-479
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of Fragment Molecular Orbital Method to investigate dopamine receptors
Autorzy:
Preikša, Jokūbas
Śliwa, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/93092.pdf
Data publikacji:
2019
Wydawca:
Państwowa Wyższa Szkoła Zawodowa w Tarnowie
Tematy:
Fragment Molecular Orbital
molecular dynamic
dopamine receptor
Fragment Molecular Orbital (FMO)
dynamika molekularna
receptor dopaminowy
Opis:
GPCRs are a vast family of seven-domain transmembrane proteins. This family includes dopamine receptors (D1, D2, D3, D4, and D5), which mediate the variety of dopamine-controlled physiological functions in the brain and periphery. Ligands of dopamine receptors are used for managing several neuropsychiatric disorders, including bipolar disorder, schizophrenia, anxiety, and Parkinson’s disease. Recent studies have revealed that dopamine receptors could be part of multiple signaling cascades, rather than of a single signaling pathway. For these targets, a variety of experimental and computational drug design techniques are utilized. In this work, dopamine receptors D2, D3, and D4 were investigated using molecular dynamic method as well as computational ab initio Fragment Molecular Orbital method (FMO), which can reveal atomistic details about ligand binding. The results provided useful insights into the significances of amino acid residues in ligand binding sites. Moreover, similarities and differences between active-sites of three studied types of receptors were examined.
Źródło:
Science, Technology and Innovation; 2019, 6, 3; 24-32
2544-9125
Pojawia się w:
Science, Technology and Innovation
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The circulatory levels of Serotonin and Dopamine and physical fitness factors in active and inactive men addicted to opium during rehabilitation
Autorzy:
Arazi, Hamid
Mollazadeh, Rahim
Dadvand, Seyedeh Shiva
Davaran, Maryam
Powiązania:
https://bibliotekanauki.pl/articles/1031952.pdf
Data publikacji:
2016
Wydawca:
PPHU Projack Jacek Wąsik
Tematy:
Addiction
Dopamine
Exercise
Opium
Serotonin
Opis:
Addiction to drugs is one of the significant problems in many countries. Opium is a kind of drug that its use goes back to many years ago. Dopamine and serotonin are neurotransmitters involved in the process of addiction. As a result, this study aimed to investigate the blood levels of serotonin, dopamine and physical fitness factors in active and inactive men addicted to opium during their rehabilitation period. This study is a descriptive and Causal after the occurrence. A total of 34 men addicted to opium referring to rehabilitation center had been admitted voluntarily as samples were available in the study. According to a questionnaire answered by them, 16 of them did exercise during their rehabilitation period (active group) and 18 of them did not do any physical activity during this period (inactive group). 5 cc of peripheral blood samples were obtained from both groups and were tested their aerobic capacity, muscular endurance, flexibility, body composition, blood pressure and heart rate. Statistical analysis showed that blood levels of serotonin and dopamine in active group were significantly more than inactive group (p<0.05). In addition, the active group compared with the inactive group had low body fat percent, more muscular endurance, more flexibility, and low resting heart rate (p<0.05). According to the findings, we can conclude that low physical activity but as regular walking can affect blood levels of serotonin and dopamine, and health-related fitness factors of addicted men and as a non-drug treatment is helpful.
Źródło:
Physical Activity Review; 2016, 4; 1-8
2300-5076
Pojawia się w:
Physical Activity Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bradykinin B2 receptor and dopamine D2 receptor cooperatively contribute to the regulation of neutrophil adhesion to endothelial cells
Autorzy:
Niewiarowska-Sendo, Anna
Łabędź-Masłowska, Anna
Kozik, Andrzej
Guevara-Lora, Ibeth
Powiązania:
https://bibliotekanauki.pl/articles/1038361.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
bradykinin
bradykinin receptor
dopamine receptor
endothelial cells
neutrophil adhesion
Opis:
Leukocyte adhesion to the vascular endothelium contributes to many immunological and inflammatory disorders. These processes have been shown to be mediated by bradykinin receptor type 2 (B2R) and dopamine receptor type 2 (D2R). In a previous study, we reported the formation of a B2R-D2R heterodimer, possibly altering cellular functions. Hence, in the present study, we examined the effect of co-activation of endothelial cells with B2R and D2R agonists on the interaction of these cells with neutrophils. Bradykinin, the main B2R agonist, significantly increased cell adhesion, and this effect was reversed when the endothelial cells were additionally co-treated with a selective D2R agonist, sumanirole. These results were dependent on the incubation time, showing an opposite tendency after prolonged stimulation. Significant changes in the expression of adhesion proteins, such as E-selectin and intercellular adhesion molecule 1 in endothelial cells were observed. Additionally, the cells preincubated with tumor necrosis factor-α showed decreased cell adhesion and IL-8 release after long incubation with both agonists. The modulation of cell adhesion by D2R and B2R seem to be mediated via STAT3 phosphorylation. In summary, this study demonstrated a protective role of D2R in neutrophil-endothelial cell adhesion induced by bradykinin, especially in cytokine-stimulated endothelial cells.
Źródło:
Acta Biochimica Polonica; 2018, 65, 3; 367-375
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cortical localization of dopamine D4 receptors in the rat brain - immunocytochemical study
Autorzy:
Wedzony, K.
Chocyk, A.
Mackowiak, M.
Fijal, K.
Czyrak, A.
Powiązania:
https://bibliotekanauki.pl/articles/69855.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
prefrontal cortex
neuroleptic drug
brain
cortical localization
immunocytochemistry
polyclonal antibody
dopamine D4 receptor
rat
neurofilament H
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 2
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of dopamine D2 receptor in the behavioral effects of imipramine - study with the use of antisense oligonucleotides
Autorzy:
Dziedzicka-Wasylewska, M.
Kolasiewicz, W.
Rogoz, Z.
Margas, W.
Maj, J.
Powiązania:
https://bibliotekanauki.pl/articles/70213.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
antisense oligonucleotide
locomotor activity
drug
mRNA
dopamine D2 receptor
limbic forebrain
antidepressant drug
imipramine
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 3
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Znaczenie dopaminy w regulacji stanów snu i czuwania
The role of dopamine in the control of sleep-wake states
Autorzy:
Orzeł-Gryglewska, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/1192573.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Przyrodników im. Kopernika
Opis:
Sen i czuwanie regulowane są przez szereg neurotransmiterów i neuromodulatorów ośrodkowego układu nerwowego. W pracy przedstawiono fakty przemawiające za udziałem dopaminergicznego układu mezostriatalnego i mezokortykolimbicznego w regulacji snu i czuwania. Omówiono wpływ dopaminy, jej agonistów i transportera dopaminowego na stan czuwania i snu, zaburzenia snu towarzyszące dysfunkcjom układu dopaminergicznego oraz rolę dopaminy w śnie REM i indukcji marzeń sennych. Przedstawiono także propozycję modelu uwzględniającego udział dróg mezolimbicznych w systemie generacji hipokampalnego rytmu theta, który jest jedną z kryterialnych cech snu REM.
Sleep and wakefulness are regulated by a number of neurotransmitters and neuromodulators of the central nervous system. This paper presents the facts supporting the role of the dopaminergic mesocorticolimbic and mesostriatal systems in the regulation of sleep and wakefulness. The effects of dopamine, its agonists and dopamine transporter on wakefulness, sleep, sleep disorders and the role of dopamine in the induction of REM sleep and dreams are discussed. Mesolimbic pathways are included in a suggested model of generation of hippocampal theta rhythm, which is one of the criterial features of REM sleep.
Źródło:
Kosmos; 2014, 63, 2; 189-200
0023-4249
Pojawia się w:
Kosmos
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effects of increased inspired oxygen with and without dopamine on lung and diaphragm hydrogen peroxide and apoptosis following hemorrhagic shock
Autorzy:
Mach, W.J.
Thimmesch, A.R.
Slusser, J.G.
Clancy, R.L.
Pierce, J.D.
Powiązania:
https://bibliotekanauki.pl/articles/3448.pdf
Data publikacji:
2010
Wydawca:
Instytut Medycyny Wsi
Tematy:
reactive oxygen species
dopamine
lung
hydrogen peroxide
apoptosis
hemorrhagic shock
DNA damage
hemodynamics
acid-base balance
hyperoxia
Źródło:
Journal of Pre-Clinical and Clinical Research; 2010, 04, 1
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Era dopaminy – jak znaleźć równowagę w czasach obfitości. Anna Lembke. Dopamine Nation: Finding Balance in the Age of Indulgence. New York: Dutton, 2021. 304 ss. ISBN: 9781-52-474672-8.
The Age of Dopamine — How to Find a Balance in Times of Abundance. Anna Lembke. Dopamine Nation: Finding Balance in the Age of Indulgence. New York: Dutton, 2021. 304 ss. ISBN: 9781-52-474672-8.
Autorzy:
Sikora, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/31232008.pdf
Data publikacji:
2022
Wydawca:
Katolicki Uniwersytet Lubelski Jana Pawła II. Towarzystwo Naukowe KUL
Źródło:
Roczniki Filozoficzne; 2022, 70, 3; 505-511
0035-7685
Pojawia się w:
Roczniki Filozoficzne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Affording Our Culture: “Smart” Technology and the Prospects for Creative Democracy
Autorzy:
Solymosi, Tibor
Powiązania:
https://bibliotekanauki.pl/articles/451283.pdf
Data publikacji:
2018-12-28
Wydawca:
Uniwersytet Warszawski. Wydział Filozofii
Tematy:
digital devices
social media
democracy
neuropragmatism
dopamine
affordances
neuroscience
Opis:
John Dewey, as Sidney Hook characterized him, was the philosopher of science and freedom. Dewey, as Larry Hickman has demonstrated, was also a philosopher of technology. And, as most people familiar with Dewey know, he was a philosopher of education and democracy. The complex of technology, science, freedom, education and democracy requires re-examination, not only because of our contemporary cultural political situation but also because of our growing insights into the human condition thanks to the technosciences of life, especially human life. Dewey’s philosophical method of reconstruction, equipped with insights from evolutionary neuroscience and ecological psychology, offers means of reconceiving and thus reevaluating our conception of tools and technology within our cultural context. I begin to take up Mark Tschaepe’s challenge to neuropragmatism to counter what he calls “dopamine democracy” – Plato’s critique of democracy resurrected in neural garb coupled with a critical examination of how social media and other so-called “smart” technologies undermine healthy democratic life. Central to this neuropragmatist approach are cultural affordances – opportunities for action humans have created initially for specific purposes and later retrofitted for other ends-in-view. Dewey’s reconstruction – as method as well as the reconstruction of technology, science, freedom, education and democracy as an entangled complex – is thus imagined as our best strategy for achieving the culture of creative democracy.
Źródło:
Eidos. A Journal for Philosophy of Culture; 2018, 2, 4(6); 46-69
2544-302X
Pojawia się w:
Eidos. A Journal for Philosophy of Culture
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Neurotransmitters detection using a fluorescence-based sensor with graphene quantum dots
Autorzy:
Baluta, S.
Cabaj, J.
Malecha, K.
Powiązania:
https://bibliotekanauki.pl/articles/175014.pdf
Data publikacji:
2017
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
sensor
dopamine
fluorescence
Förster resonance energy transfer
quantum dots
Opis:
In the paper, the development and performance of an optical sensor for detection of neurotransmitters (dopamine) is presented. The concentration of dopamine is measured basing on fluorescence quenching of graphene quantum dots. In the sensor, the dopamine molecules coat the graphene quantum dots surface – in result, the quenching of fluorescence occurs due to the Förster resonance energy transfer. The changes in fluorescence correspond to specific concentrations of the neurotransmitter in tested samples, so it is possible to accurately determine the concentration of dopamine in the sample.
Źródło:
Optica Applicata; 2017, 47, 2; 225-231
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
How to Handle Humility? Audaciously: A Response to Mark Tschaepe
Autorzy:
Solymosi, Tibor
Bywater, Bill
Powiązania:
https://bibliotekanauki.pl/articles/451557.pdf
Data publikacji:
2019-10-31
Wydawca:
Uniwersytet Warszawski. Wydział Filozofii
Tematy:
neuropragmatism
dopamine democracy
digital devices
social media
information and news
education
Opis:
We address Mark Tschaepe’s response to Tibor Solymosi, in which Tschaepe argues that neuropragmatism needs to be coupled with humility in order to redress “dopamine democracy,” Tschaepe’s term for our contemporary situation of smartphone addiction that undermines democracy. We reject Tschaepe’s distinction between humility and fallibility, arguing that audacious fallibility is all we need. We take the opportunity presented by Tschaepe’s constructive criticism of neuropragmatism to reassert some central themes of neuropragmatism. We close with discussion of Bywater’s method of apprenticeship, as an imaginative education for creative democracy, thereby rejecting Tschaepe’s claim that neuropragmatism lacks a pedagogical method.
Źródło:
Eidos. A Journal for Philosophy of Culture; 2019, 3, 3(9); 145-159
2544-302X
Pojawia się w:
Eidos. A Journal for Philosophy of Culture
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bulbospinal catecholamine neurones and sympathetic pattern generation
Autorzy:
Coote, J H
Lewis, D.I.
Powiązania:
https://bibliotekanauki.pl/articles/70075.pdf
Data publikacji:
1995
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
catecholamine neuron
sympathetic pattern generation
brain tissue
preganglionic neuron
dopamine
noradrenaline
cardiovascular system
rat
Źródło:
Journal of Physiology and Pharmacology; 1995, 46, 3
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fluorymetryczne oznaczanie dopaminy w moczu i tkankach
Fluorimetricheskoe opredelenie soderzhanija dofamina v moche i tkanjakh
Fluorimetric determination of dopamine in urine and tissues
Autorzy:
Maruchin, J.
Olesiński, J.
Powiązania:
https://bibliotekanauki.pl/articles/2188192.pdf
Data publikacji:
1981
Wydawca:
Polskie Towarzystwo Diagnostyki Laboratoryjnej
Źródło:
Diagnostyka Laboratoryjna; 1981, 17, 1; 49-56
0867-4043
Pojawia się w:
Diagnostyka Laboratoryjna
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 29

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