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Wyświetlanie 1-8 z 8
Tytuł:
Single dose of green tea extract decreases lipid digestion and absorption from a test meal in humans
Autorzy:
Walkowiak, Jarosław
Bajerska, Joanna
Kargulewicz, Angelika
Lisowska, Aleksandra
Siedlerski, Gwidon
Szczapa, Tomasz
Kobelska-Dubiel, Natalia
Grzymisławski, Marian
Powiązania:
https://bibliotekanauki.pl/articles/1039556.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
green tea
digestion
absorption
mixed triglyceride breath test
Opis:
Background & Aims: Green tea is known worldwide for its high content of polyphenolic compounds and multifactorial beneficial effects on human health. The role of green tea as an inhibitor of lipid hydrolysis is widely discussed. The aim of the study was to assess the influence of green tea extract on lipid digestion and absorption. Methods: The study comprised 32 healthy volunteers aged 23 to 30 years with normal exocrine pancreatic function. In all subjects 13C-labelled mixed triglyceride breath test was performed twice with and without green tea extract ingestion. Cumulative percentage dose recovery was considered to reflect digestion and absorption of lipids. Values are expressed as medians and 1st-3rd quartile distribution. Results: In all subjects, cumulative percentage dose recovery values were normal in a placebo test (36.8% <30.1-43.3%>). These results were significantly higher (p=0.021) than those obtained in green tea extract test (28.8% <23.1-37.2%>). Results of six tests with GTE were abnormal. Conclusions: Single dose of green tea extract taken with a test meal decreases lipid digestion and absorption in humans.
Źródło:
Acta Biochimica Polonica; 2013, 60, 3; 481-483
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Surface-active agents from the group of polyoxyethylated glycerol esters of fatty acids. Part IV. Equilibrium micellar solubilization of selected lipophilic therapeutic agents (BCS class II and III) in aqueous solutions of products of catalytic oxyethylation of triglyceride fractions extracted from pharmacopoeial lard (Adeps suillus PP XI) of nTE≥50
Autorzy:
Marczyński, Zbigniew
Kołodziejczyk, Michał K.
Nachajski, Michał J.
Zgoda, Marian M.
Powiązania:
https://bibliotekanauki.pl/articles/895709.pdf
Data publikacji:
2019-08-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
valsartan
gemfibrozil
micellar solubilization
products of triglyceride fraction ethoxylation
loratadine
Opis:
Summary: Preformulation studies were carried out to estimate the solubilization capacity of products of catalytic oxyethylation of triglyceride fractions extracted from the pharmacopoeial lard (Adeps suillus, PP XI). There were determined basic viscosity ([ɳ], Mɳ) and hydrodynamic (Ro, Robs., Ω) values of micellar solutions of oxyethylated derivatives as well as their surface activity - . Critical micellar concentration (cmc) was used to calculate the thermopotential for the formation of micelles (∆ ). Model studies on micellar solubilization of gemfibrozil, loratadine and valsartan from the solid body surface (phase boundary) were performed under equilibrium conditions at the surfactant concentration of cexp>>cmc. The amount of dissolved lipophilic therapeutic agents with qualitative and quantitative involvement of micellar solubilization was determined by spectrophotometric (UV) method - cǀsǀ (mg/100mL) as well as by calculating the solubilization indices - n|s| (mol / mol). The research study has identified structures of oxyethylated derivatives of triglyceride fractions which selectively and effectively solubilize gemfibrozil, loratadine and valsartan from the solid surface in the equilibrium system. The obtained results are a technological inspiration to create a model form of the drug (tablet) with continuous dispersion of lipophilic therapeutic agents (gemfibrozil, loratadine and valsartan), obtained on the basis of the liquefied surfactant structure. Key words: micellar solubilization, products of triglyceride fraction ethoxylation, gemfibrozil, loratadine, valsartan
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 4; 707-714
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hypolipidemic action of rutin on triton WR-1339-induced hyperlipidemia in rats
Autorzy:
Livingston Raja, N.R.
Nair, A.R.
Senthilpandian, S.
Ravi, V.
Powiązania:
https://bibliotekanauki.pl/articles/2098294.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Tematy:
rutin
flavonoids
triglyceride
atorvastatin
Triton WR-1339
hyperlipidemia
cholesterol
rat
Opis:
Introduction and objective. Hyperlipidemia is considered as a serious communal problem in developed countries, caused by an excess level of cholesterol in blood circulation. It leads to chronic illness and even death in human beings. As the currently available drugs cause unexpected side-effect, the aim of this study is to concentrate on naturally occurring flavonoids which can potentially provide defensive and therapeutic effects in atherosclerosis diseases, and investigate the hypolipidemic effect of rutin on Triton WR-1339 triggered hyperlipidemia in a rat blood sample. Materials and method. Rats were randomly prearranged into five different groups of five rats each. Group-I was the non-disease control and administered normal saline. Group-II was the atherogenic control, administered Triton WR 1339 (200 mg/kg BW). Group-III was standard and received Atorvastatin. The last two groups (IV, V) were tested (I&II) by administering administered Rutin (40 mg/kg, 80 mg/kg) orally. The test material (I&II) and the standard drug were administered for seven days. After the last dose, blood samples were collected and the lipid levels estimated in the blood samples. Results. Rats treated with rutin flavonoid at a dose of 40 mg/kg & 80mg/kg exhibited a reduction in Total Cholesterol, Triglycerides, Low Density Lipoprotein (LDL) and Very Low Density Lipoprotein (VLDL). Rutin also increases the High Density Lipoprotein (HDL), compared with control rats. Rutin treated rats exhibited dose-dependent hypolipidemic activity. The protection percentage of rutin against hyperlipidemia was observed as 41.89%, 55.57% whereas the atorvastatin treated group protection was observed at 60.63%. Conclusions. The results of the study revealed that rutin showed a significant hypolipidemic effectiveness on Triton WR- 1339 induced hyperlipidemia in rats.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2021, 15, 2; 51-55
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The association between cardiorespiratory fitness and metabolic syndrome diagnosis: A cross-sectional study in Indonesian middle-aged and older adults
Autorzy:
Arovah, Novita Intan
Heesch, Kristiann C.
Powiązania:
https://bibliotekanauki.pl/articles/1933084.pdf
Data publikacji:
2021-10-20
Wydawca:
PPHU Projack Jacek Wąsik
Tematy:
abdominal obesity
hyperglycaemia
triglyceride
high density of lipoprotein
hypertension
Opis:
Objectives: The roles of cardiorespiratory fitness (CF) in reducing cardiovascular disease (CVD) and allcause mortality risks are well established; however, little is known about the role of CF in reducing risk of metabolic syndrome (MetS), a cluster of CVD risk factors, particularly in Asian countries. This research examined associations between CF and MetS diagnosis and its five components in Indonesian middle-aged and older adults. Methods: This cross-sectional study included 161 participants (aged 63±8 years; 70% female). CF was assessed with a 6-minute walk test. MetS diagnosis and its components were assessed with the Adult Treatment Panel III. Logistic regression modelling was conducted to examine the relationships between CF and MetS diagnosis and its components, after adjustment for BMI and other confounders. BMI was categorized using cut-points for Asians. Results: In adjusted models, participants with low CF had a greater likelihood of being diagnosed with MetS than those with high CF (OR=4.79, 95%CI:2.17-10.62). They were also more likely to have low highdensity lipoprotein (OR=2.07, 95%CI:1.02-4.18) or hypertriglyceridemia (OR=2.37, 95%CI:1.15-4.86). There was also borderline significant findings that suggested that participants with low CF had greater likelihood of having abdominal obesity (OR=2.34, 95%CI:0.97-5.65, p=0.06) or hyperglycaemia (OR=2.07 95%CI:0.98-4.41, p=0.06). Conclusions: Low CF is associated with increased likelihood of being diagnosed with MetS. The adverse effects of low CF are mainly characterized by dyslipidaemia. Public health messages should emphasise the importance of improving CF for preventing MetS. Assessment of CF could be useful for targeting individuals most likely to benefit from intervention to prevent MetS.
Źródło:
Physical Activity Review; 2021, 2, 9; 101-110
2300-5076
Pojawia się w:
Physical Activity Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparison of triglyceride-glucose index and HOMA-IR as indicators of insulin resistance in obese women with subclinical hypothyroidism
Autorzy:
Onur Kirac, Cem
Sirikci, Vehbi
Avni Findikli, Huseyin
Powiązania:
https://bibliotekanauki.pl/articles/2216805.pdf
Data publikacji:
2022-12-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
HOMA-IR
insulin resistance
subclinical hypothyroidism
triglyceride-glucose index
Opis:
Introduction and aim. Thyroid hormones play an important role in glucose metabolism as in many metabolic events. The aim of our study is to evaluate the relationship between subclinical hypothyroidism (SCH) and insulin resistance, especially in obese women. Material and methods. Newly diagnosed SCH patients with body mass index (BMI) ≥30 who applied to our outpatient clinic between March 2021 and October 2021, and euthyroid obese women who applied for routine control were included in the study. In this study, we used homeostasis model assessment of insulin resistance (HOMA-IR) and triglyceride glucose (TyG) indexes, which are noninvasive, simple and useful methods for evaluating insulin sensitivity. Results. The study included 78 female patients between the ages of 19 and 64. A correlational analysis was performed between thyroid stimulating hormone (TSH) and HOMA-IR, TyG, and BMI. The results showed that TSH levels were positively correlated with HOMA-IR (R=0.297, p=0.008), TyG (R=0.316, p=0.005) and BMI (R=0.307, p=0.006). This relationship was stronger for TyG compared to the other variables. As another finding, BMI was positively correlated with HOMA-IR (R=0.359, p=0.001) and TyG (R=0.404, p<0.001). This relationship was stronger for TyG than HOMA-IR. Conclusion. These results show that patients with SCH are at risk of developing diseases that accompany insulin resistance, such as metabolic syndrome and cardiovascular disorders. The most important finding of our study is that the TyG index gives more significant results than HOMA-IR, especially in obese women.
Źródło:
European Journal of Clinical and Experimental Medicine; 2022, 4; 412-416
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of Role of Job Components and Individual Parameters on the Raised Blood Pressure in a Noisy Industry
Autorzy:
Abbasi, Milad
Farhang-Dehghan, Somayeh
Yazdanirad, Saeid
Mehri, Ahmad
Kolahdouzi, Malihe
Fallah Madvari, Rohollah
Akbarzadeh, Arash
Ghaljahi, Maryam
Powiązania:
https://bibliotekanauki.pl/articles/177433.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
noise exposure
noise annoyance
noise sensitivity
triglyceride
cholesterol
raised blond pressure
Opis:
The present study aimed to determine the role of job components and individual parameters on the raised blood pressure among male workers of textile industry who were exposed to continuous high noise level. Information of all eligible subjects including demographic and individual characteristics, medical history and job characteristics were obtained by direct interview and referring to the medical records. All blood pressure measurements were done using mercury sphygmomanometer in the morning before work. The 8-hours equivalent A-weighted sound pressure level, the level of blood cholesterol and triglyceride, and noise annoyance was determined for each worker. As the result of weighted regression in path analysis (direct effect), only the work shift did not have a significant effect on blood pressure among the studiem variables. It can be seen that variables including the level of triglyceride, cholesterol, and noise exposure have the most direct effects on blood pressure. The results of total effects showed that variables, including using the hearing protection device, age, work experience and visibility of sound source, did not have a significant effect on blood pressure. The results of this study indicate that occupational noise exposure alone and combined with other job components and individual parameters is associated with raised blond pressure. However, noise exposure was probably a stronger stressor for increased blood pressure.
Źródło:
Archives of Acoustics; 2019, 44, 3; 575-584
0137-5075
Pojawia się w:
Archives of Acoustics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of high fructose intake on renal morphology and renal function in rats
Autorzy:
Manitius, J
Baines, A.D.
Roszkiewicz, A.
Powiązania:
https://bibliotekanauki.pl/articles/68957.pdf
Data publikacji:
1995
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
glucose
insulin
renal morphology
rat
urine
blood pressure
renal function
fructose feeding
lipid
mesangial cell
kidney
triglyceride
cholesterol
glomerular filtration
Źródło:
Journal of Physiology and Pharmacology; 1995, 46, 2
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of thyroxin induction on enzymatic and biochemical levels in albino rats
Autorzy:
Hanchinalmath, J.V.
Shivasharanappa, K.
Roopa, T.S.
Saisundeep, Y.
Powiązania:
https://bibliotekanauki.pl/articles/11503.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
thyroxine
alpha-amylase
enzymatic level
biochemical level
albino rat
rat
kidney
liver
blood serum
creatine phosphokinase activity
cholesterol
citric acid
triglyceride
Opis:
The albino Wistar rats were used to investigate the effect of thyroxine administration on the activity of citric acid, α-Amylase, creatine phosphokinase (CPK), creatinine, cholesterol and triglycerides level in blood serum and citric acid in liver and kidney. Two groups of rats were taken for the experiment. One group was injected subcutaneously with 200 μl of thyroxine/50 g of body weight, the other group served as control. The animals were vivisected with anesthesia after intervals of 24, 48, 72 and 96 hours α-Amylase and CPK levels in blood; citric acid level in liver and kidney of control and thyroxine treated rats. The results showed that the α-Amylase activity remained unaltered (100 g/h/l) throughout the experiment. However, citric acid level found to be 460 mg in the liver and 415 mg in kidney of control rats. The values slightly increased to 480 and 680 mg in respective tissues of thyroxine treated animals for 24 hr. The values decreased in 48 and 72 hours of treatment. Further the values found to be increased after 96 hours of treatment. Although the thyroxine treatment altered citric acid, Creatinine, Cholesterol, Triglycerides and CPK levels in the tissues, the serum α-Amylase was not influenced by the thyroxine. The study suggests that the thyroxine acts as a regulator all the above parameters in the cellular level.
Źródło:
International Letters of Natural Sciences; 2014, 08, 2
2300-9675
Pojawia się w:
International Letters of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-8 z 8

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