- Tytuł:
- Evaluation of physicochemical properties of solid dispersions of bcs class ii substances with chitosan
- Autorzy:
-
Grimling, Bożena
Górniak, Agata
Meler, Jan
Pluta, Janusz - Powiązania:
- https://bibliotekanauki.pl/articles/1035366.pdf
- Data publikacji:
- 2012
- Wydawca:
- Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
- Tematy:
-
DSC studies
chitosan
dissolution
fenofibrate
solid state lyophilisation - Opis:
- The BCS class II includes drugs with low solubility and high permeability. The substances require modification to increase their solubility in the upper part of the digestive system. Fenofibrate is an example of this class drugs. The aim of the study was to investigate the effect of chitosan on the solubility of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions using a method of the solvent evaporation by means of freeze-drying at the drug to polymer ratio of 3:7,5:5,7:3. The study revealed a multi-fold increase (from 33 to 57 times) in fenofibrat solubility in the presence of chitosan, which increased with duration of the study and with increasing percentage of the polymer in formulations. DSC examination revealed a possible physical interaction between the drug and the polymer. The degree of lowering of temperature and increased heat effects is correlated with increased solubility of the drug in all the formulations. DSC studies confirmed that fenofibrate is present in solid dispersions in a crystalline form.
- Źródło:
-
Progress on Chemistry and Application of Chitin and its Derivatives; 2012, 17; 87-94
1896-5644 - Pojawia się w:
- Progress on Chemistry and Application of Chitin and its Derivatives
- Dostawca treści:
- Biblioteka Nauki
Artykuł