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Wyświetlanie 1-4 z 4
Tytuł:
Analysis of post-blasting source mechanisms of mininginduced seismic events in Rudna copper mine, Poland
Autorzy:
Caputa, A.
Talaga, A.
Rudziński, Ł.
Powiązania:
https://bibliotekanauki.pl/articles/100792.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Śląski. Wydział Nauk o Ziemi
Tematy:
source mechanism
blasting
foci
analiza
mechanizm
górnictwo
zdarzenia sejsmiczne
kopalnia miedzi Rudna
Polska
Opis:
The exploitation of georesources by underground mining can be responsible for seismic activity in areas considered aseismic. Since strong seismic events are connected with rockburst hazard, it is a continuous requirement to reduce seismic risk. One of the most effective methods to do so is blasting in potentially hazardous mining panels. In this way, small to moderate tremors are provoked and stress accumulation is substantially reduced. In this paper we present an analysis of post-blasting events using Full Moment Tensor (MT) inversion at the Rudna mine, Poland, underground seismic network. In addition, we describe the problems we faced when analyzing seismic signals. Our studies show that focal mechanisms for events that occurred after blasts exhibit common features in the MT solution. The strong isotropic and small Double Couple (DC) component of the MT, indicate that these events were provoked by detonations. On the other hand, post-blasting MT is considerably different than the MT obtained for strong mining events. We believe that seismological analysis of provoked and unprovoked events can be a very useful tool in confirming the effectiveness of blasting in seismic hazard reduction in mining areas.
Źródło:
Contemporary Trends in Geoscience; 2015, 4, 1; 26-38
2299-8179
Pojawia się w:
Contemporary Trends in Geoscience
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Concerted control of DNA double strand break repair and cell cycle progression in X-irradiated mammalian cells
Autorzy:
Sochanowicz, B.
Szumiel, I.
Powiązania:
https://bibliotekanauki.pl/articles/148697.pdf
Data publikacji:
2005
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
ATM kinase
DNA double strand break repair
RAD50
cell cycle arrest
repair foci
BRCT domain
Opis:
Upon examination of cell cycle regulation in a damaged cell, relations were discovered of the cell cycle control mechanisms with a complicated web of signalling pathways, eventually called the genome surveillance system. After infliction of DNA double strand breaks (DSB), the signalling is initiated by sensor proteins and transducer protein kinase ATM. This kinase phosphorylates downstream effector proteins, such as checkpoint kinases CHK1 and CHK2, which initiate the pathways leading to cell cycle arrest. In contrast with the older model of linear transmission of signals in a certain sequence, it is now accepted that the damage signalling system is branched and contains feedback loops. DSB's presence is signalled by sensor proteins (MRE11-RAD50-nibrin complex, MRN) to ATM and the signal is amplified through adaptor proteins, MDC1/NFBD1 or 53BP1 (Tp53 binding protein). MRN contains a forkheadassociated (FHA) domain and BRCA1 carboxyl-terminal (BRCT) domain. The combination of the FHA/BRCT domains has a crucial role for the binding of nibrin to the H2AX histone, assembling the components of repair foci. These domains also are important for interaction of other proteins localised in the foci. For example, MDC1/NFBD1 contains a FHA domain and two BRCT domains which are involved in protein interactions. The signal generated at DSBs is amplified and transduced to recruit components of DNA repair systems. In a concerted way with the sequential recruitment of components of repair foci, activation of transcription of genes takes place, that is necessary for blocking progression through the cell cycle, for DNA repair or apoptosis.
Źródło:
Nukleonika; 2005, 50, 4; 129-138
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Inhibition of poly(ADP-ribose) polymerase activity affects its subcellular localization and DNA strand break rejoining
Autorzy:
Ryabokon, Nadezhda
Cieślar-Pobuda, Artur
Rzeszowska-Wolny, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1040571.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
DNA strand break rejoining
efficiency of PARP inhibition
PARP foci
poly(ADP-ribose) polymerase (PARP)
PARP inhibitors
Opis:
Poly(ADP-ribose) polymerase (PARP) plays a crucial role in DNA repair. Modulation of its activity by stimulation or inhibition is considered as a potentially important strategy in clinical practice, especially to sensitize tumor cells to chemo- and radiotherapy through inhibition of DNA repair. Here we studied the effect of the three PARP inhibitors, 5-iodo-6-amino-benzopyrone (INH2BP), 1,5-isoquinolinediol (1,5-dihydroxyisoquinolinediol (1,5-IQD) and 8-hydroxy-2-methylquinazolin-4-[3H]one (NU1025), and for two of them the efficiency in slowing the rejoining of DNA strand breaks induced by H2O2 was compared. Inhibition of PARP changed its intranuclear localization markedly; cells exposed to the inhibitor NU1025 showed a significant tendency to accumulate PARP in large foci, whereas in untreated cells its distribution was more uniform. The speed and efficiency of rejoining of H2O2-induced DNA strand breaks were lower in cells incubated with a PARP inhibitor, and the kinetics of rejoining were modulated in a different manner by each inhibitor. At a concentration of 100 µM the efficiency of the inhibitors could be ranked in the order NU1025 > IQD > INH2BP. The two first compounds were able to decrease the overall PARP activity below the level detected in control cells, while INH2BP showed up to 40% PARP activity after exposure to H2O2.
Źródło:
Acta Biochimica Polonica; 2009, 56, 2; 243-248
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
DNA damage in subpopulations of human lymphocytes irradiated with doses in the range of 0-1 Gy of X-radiation
Autorzy:
Wojewódzka, M.
Machaj, E. K.
Goździk, A.
Iwaneńko, T.
Ołdak, T.
Kruszewski, M.
Pojda, Z.
Powiązania:
https://bibliotekanauki.pl/articles/147760.pdf
Data publikacji:
2008
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
alkaline comet assay
biodosimetry
micronucleus test
histone gammaH2AX foci immunofluorescence assay
T lymphocytes
B lymphocytes
ionizing radiation
DNA damage
Opis:
We compared three methods usually applied in biological dosimetry for estimation of radiation-induced DNA damage in human T and B lymphocytes: alkaline comet assay, micronucleus (MN) test and formation of histone gamma-H2AX foci. Human peripheral blood lymphocytes were fractionated using T cells and B cells isolation kits. Cells were irradiated with doses in the range of 0-1 Gy of X-rays. Induction of DNA damage was assessed by the standard alkaline comet assay, MN test and histone gammaH2AX foci immunofluorescence assay. Notwithstanding different end-points measured by the applied methods, all tests revealed a similar induction of DNA damage in B lymphocytes as compared with T lymphocytes. The results indicated that all three tests detect DNA damage with similar sensitivity, the lowest dose being approximately 0.3 Gy. The difference between irradiated and control cells was expressed as the ratio of the value obtained for irradiated cells (1 Gy) to that for control cells. The highest ratio was obtained for formation of gammaH2AX foci and was 6.2 for T and 13.8 for B lymphocytes, whereas those for comet assay and micronucleus test were 3.5; 3.6 and 5.6; 4.8, respectively.
Źródło:
Nukleonika; 2008, 53, 4; 145-149
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-4 z 4

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