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Wyszukujesz frazę "dissociation constant" wg kryterium: Temat

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    Wyświetlanie 1-3 z 3
    Tytuł:
    Chenodeoxycholic acid: A Physicochemical study
    Autorzy:
    Baluja, Shipra
    Bhesaniya, Kapil
    Powiązania:
    https://bibliotekanauki.pl/articles/1193963.pdf
    Data publikacji:
    2015
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Chenodeoxycholic acid
    Dissociation constant
    acoustical parameters
    thermal analysis
    Opis:
    Some physicochemical properties such as dissociation constant, acoustical parameters and thermal studies of acid are studied in methanol and 1,4-dioxane at 298.15 K. The dissociation constant of Chenodeoxycholic acid is evaluated in binary mixtures (of methanol / 1,4-dioxane + water) by two methods; half-integral and average methods. The acoustical properties have been evaluated from experimental data of density, viscosity and ultrasonic velocity. It is observed that in both the solvents, strong solute-solvent interactions exist. Thermal degradation of Chenodeoxycholic acid is found to be a single step process.
    Źródło:
    World Scientific News; 2015, 18; 115-127
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Investigations of selected properties of pharmacologically active compounds by chromatographic and potentiometric methods on the chrysin example
    Autorzy:
    Pusz, J.
    Zapała, W.
    Papciak, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/778249.pdf
    Data publikacji:
    2008
    Wydawca:
    Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
    Tematy:
    RP-HPLC
    model retencji
    chryzyna
    stała dysocjacji
    retention model
    chrysin
    dissociation constant
    Opis:
    The RP-TLC method was used to determine the dissociation constant of chrysin (5,7-dihydroxyflavone) in methanol-aqueous (1:1 v/v) solutions. In this method the pK value was quantified on the basis of retention data and a retention model. The accuracy of determining the model parameters was analysed using the following statistical criteria: the sum of the squared differences between the experimental and theoretical data, approximation of standard deviation, and the Fisher test. Besides, in this work the potentiometric method was used. Investigations were carried out at ionic strength I=0.1 at T= 298 K. The dissociation constant were determined using the Rossotti method as well as the numerical method based on the procedures of non-linear curve fitting using Microsoft Excel Solver and the user-defined function. It has been found that the differences in the evaluated pK values were relatively small and did not exceed 1.2%.
    Źródło:
    Polish Journal of Chemical Technology; 2008, 10, 1; 41-44
    1509-8117
    1899-4741
    Pojawia się w:
    Polish Journal of Chemical Technology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The comparative study of influence of lactic and glycolic acids copolymers type on properties of daunorubicin loaded nanoparticles and drug release
    Autorzy:
    Nikolskaya, E.
    Sokol, M.
    Faustova, M.
    Zhunina, O.
    Mollaev, M.
    Yabbarov, N.
    Tereshchenko, O.
    Popov, R.
    Severin, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/307136.pdf
    Data publikacji:
    2018
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    nanocząsteczki
    daunorubicyna
    PLGA
    uwalnianie kontrolowane
    stała dysocjacji
    nanoparticles
    daunorubicin
    controlled release
    MCF7/MCF7 Adr
    dissociation constant
    Opis:
    The aim of this study was to compare the physico-chemical and biological properties of polymeric nanoparticles obtained from poly(DL-lactide-co-glycolide) (PLGA) with different ratios of monomers loaded with daunorubicin (DNR). Methods: DNR-loaded nanoparticles (NPs) were prepared with use of modified simultaneous double-emulsion solvent evaporation/diffusion technique. NPs were characterized using dynamic light scattering, atomic force microscopy, transmission electron microscopy, scanning electron microscopy, and differential scanning calorimetry and Fourier transform infrared spectroscopy. Results: NPs with DNR were differing in size and zeta potential, depending on the type of polymer. The data obtained show that total content of DNR correlates with the values of the binding constant of DNR with polymers. The release of DNR from NPs proceeds predominantly for polymers with lower binding constants. The in vitro study of NPs on the MCF-7 cells showed similar activity of particles and substances while for the anthracycline-resistant MCF-7Adr cells the cytotoxicity of the nanoparticles was 3 to 7 times higher depending on the type of copolymer. Conclusions: PLGA DNR-loaded nanoparticles can be used to overcome multidrug resistance (MDR) as well as for reducing the frequency of DNR reception due to the prolonged effect, which allows maintaining the concentration of the drug at the required level. The usefulness of binding constant calculations for obtaining nanoparticles with the maximum drug loading was proven. The rate of drug administration and the frequency of administration can be calculated based on the DNR release profiles and release parameters that depend on polymer type.
    Źródło:
    Acta of Bioengineering and Biomechanics; 2018, 20, 1; 65-77
    1509-409X
    2450-6303
    Pojawia się w:
    Acta of Bioengineering and Biomechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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