- Tytuł:
-
Нейромедіаторні механізми когнітивних порушень в щурів при довготривалому пентиленететразоловому кіндлінзі
Neurotransmitter mechanisms of rats cognitive impairments in prolonged pentylenetetrazol-induced kindling - Autorzy:
-
Vastyanov, R. S.
Prishchepa, Ye. A. - Powiązania:
- https://bibliotekanauki.pl/articles/1032246.pdf
- Data publikacji:
- 2014
- Wydawca:
- Uniwersytet Kazimierza Wielkiego w Bydgoszczy
- Tematy:
-
pentylenetetrazol
kindling
noradrenergic and serotoninergic neurotransmitter systems
conditioned reflex
cognitive impairments - Opis:
- The data of experimental trials devoted to prolonged pentylenetetrazol (PTZ) kindling neurotransmitter mechanisms investigation are given. The authors studied the peculiarities of the conditioned reflex (CR) formation, its both preservation and inhibition in kindled rats in conditions of adrenergic and serotoninergic neurotransmitter systems activity modulation. The data obtained showed that kindled rats develop cognitive impairment as CR formation repression, inability of its saving and rapid inhibition. These impairments expression progresses in the chronic seizure activity model dynamics. Revealed mnestic disorders were found in kindling rats in case of both adrenergic and serotoninergic neurotransmitter systems activation that shows their pathogenetic importance in the context of prolonged PTZ-induced kindling.
- Źródło:
-
Journal of Health Sciences; 2014, 4, 6; 147-156
1429-9623 - Pojawia się w:
- Journal of Health Sciences
- Dostawca treści:
- Biblioteka Nauki
Artykuł