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    Wyświetlanie 1-5 z 5
    Tytuł:
    Militarische Planungen in der Zwischenkriegszeit
    Autorzy:
    Messerschmidt, Manfred.
    Powiązania:
    Menetekel: das gesicht des zweiten Weltkrieges: Nürnberger Gespräch zum 50. Jahrestag der Entfesselung des zweiten Weltkrieges / hrsg. Peter Schönlein, Jörg Wollenberg, Jerzy Wyrozumski Kraków, 1991 S. 39-64
    Współwytwórcy:
    Schönlein, Peter. Redakcja
    Wollenberg, Jörg. Redakcja
    Wyrozumski, Jerzy (1930-2018). Redakcja
    Dostawca treści:
    Bibliografia CBW
    Artykuł
    Tytuł:
    Pain and mobility improvement and MDA plasma levels in degenerative osteoarthritis, low back pain, and rheumatoid arthritis after infrared A-irradiation
    Autorzy:
    Siems, Werner
    Bresgen, Nikolaus
    Brenke, Rainer
    Siems, Renate
    Kitzing, Manfred
    Harting, Heike
    Eckl, Peter
    Powiązania:
    https://bibliotekanauki.pl/articles/1040373.pdf
    Data publikacji:
    2010
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    rheumatoid arthritis
    infrared
    malondialdehyde (MDA)
    lipid peroxidation
    pain
    osteoarthritis
    Opis:
    Infrared (IR)-A irradiation can be useful in back and musculoskeletal pain therapy. In this study joint and vertebral column pain and mobility were measured during two weeks of IR-A irradiation treatment of patients suffering from degenerative osteoarthritis of hip and knee, low back pain, or rheumatoid arthritis. Additionally, before and after IR-A treatment MDA serum levels were measured to check if MDA variations accompany changes in pain intensity and mobility. Two-hundred and seven patients were divided into verum groups getting IR-irradiation, placebo groups getting visible, but not IR irradiation, and groups getting no irradiation. In osteoarthritis significant pain reduction according to Visual Analogue Scale and mobility improvements occurred in the verum group. Even though beneficial mean value changes occurred in the placebo group, the improvements in the placebo and No Irradiation groups were without statistical significance. In low back pain, pain and mobility improvements (by 35-40%) in the verum group were found, too. A delayed (2nd week) mobility improvement in rheumatoid arthritis was seen. However, pain relief was seen immediately. In patients suffering from low back pain or rheumatoid arthritis, the pain and mobility improvements were accompanied by significant changes of MDA serum levels. However, MDA appears not a sensitive biofactor for changes of the pain intensity in degenerative osteoarthritis. Nevertheless, unaffected or lowered MDA levels during intensive IR-A therapy argue against previous reports on free radical formation upon infrared. In conclusion, rapid beneficial effects of IR-A towards musculoskeletal pain and joint mobility loss were demonstrated.
    Źródło:
    Acta Biochimica Polonica; 2010, 57, 3; 313-319
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    In Vitro Chemo-Sensitivity Assay Guided Chemotherapy is Associated with Prolonged Overall Survival in Cancer Patients
    Autorzy:
    Udelnow, Andrej
    Schönfelder, Manfred
    Würl, Peter
    Halloul, Zuhir
    Meyer, Frank
    Lippert, Hans
    Mroczkowski, Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/1396300.pdf
    Data publikacji:
    2013-06-01
    Wydawca:
    Index Copernicus International
    Tematy:
    chemo-sensivity in vitro
    survival prediction
    chemotherapy
    drug sensivity
    cancer
    Opis:
    The overall survival (OS) of patients suffering From various tumour entities was correlated with the results of in vitro-chemosensitivity assay (CSA) of the in vivo applied drugs. Material and methods. Tumour specimen (n=611) were dissected in 514 patients and incubated for primary tumour cell culture. The histocytological regression assay was performed 5 days after adding chemotherapeutic substances to the cell cultures. n=329 patients undergoing chemotherapy were included in the in vitro/in vivo associations. OS was assessed and in vitro response groups compared using survival analysis. Furthermore Cox-regression analysis was performed on OS including CSA, age, TNM classification and treatment course. Results. The growth rate of the primary was 73-96% depending on tumour entity. The in-vitro response rate varied with histology and drugs (e.g. 8-18% for methotrexate and 33-83% for epirubicine). OS was significantly prolonged for patients treated with in vitro effective drugs compared to empiric therapy (log-rank-test, p=0.0435). Cox-regression revealed that application of in vitro effective drugs, residual tumour and postoperative radiotherapy determined the death risk independently. Conclusions. When patients were treated with drugs effective in our CSA, OS was significantly prolonged compared to empiric therapy. CSA guided chemotherapy should be compared to empiric treatment by a prospective randomized trial.
    Źródło:
    Polish Journal of Surgery; 2013, 85, 6; 340-347
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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