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    Wyświetlanie 1-13 z 13
    Tytuł:
    Genetic algorithm combined with a local search method for identifying susceptibility genes
    Autorzy:
    Yang, C -H.
    Moi, S. -H.
    Lin, Y. -D.
    Chuang, L. -Y.
    Powiązania:
    https://bibliotekanauki.pl/articles/91586.pdf
    Data publikacji:
    2016
    Wydawca:
    Społeczna Akademia Nauk w Łodzi. Polskie Towarzystwo Sieci Neuronowych
    Tematy:
    genetic algorithms
    identifying susceptibility genes
    local search algorithm
    Opis:
    Detecting genetic association models between single nucleotide polymorphisms (SNPs) in various disease-related genes can help to understand susceptibility to disease. Statistical tools have been widely used to detect significant genetic association models, according to their related statistical values, including odds ratio (OR), chi-square test (χ2), p-value, etc. However, the high number of computations entailed in such operations may limit the capacity of such statistical tools to detect high-order genetic associations. In this study, we propose lsGA algorithm, a genetic algorithm based on local search method, to detect significant genetic association models amongst large numbers of SNP combinations. We used two disease models to simulate the large data sets considering the minor allele frequency (MAF), number of SNPs, and number of samples. The three-order epistasis models were evaluated by chi-square test (χ2) to evaluate the significance (P-value < 0.05). Analysis results showed that lsGA provided higher chi-square test values than that of GA. Simple linear regression indicated that lsGA provides a significant advantage over GA, providing the highest β values and significant p-value.
    Źródło:
    Journal of Artificial Intelligence and Soft Computing Research; 2016, 6, 3; 203-212
    2083-2567
    2449-6499
    Pojawia się w:
    Journal of Artificial Intelligence and Soft Computing Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Coopetition in international maritime shipping
    Autorzy:
    Lin, D. Y.
    Huang, C. C.
    Powiązania:
    https://bibliotekanauki.pl/articles/259566.pdf
    Data publikacji:
    2013
    Wydawca:
    Politechnika Gdańska. Wydział Inżynierii Mechanicznej i Okrętownictwa
    Tematy:
    coopetition
    maritime freight
    international shipping
    Jacobi approach
    Backward Induction
    Opis:
    The increasingly competitive nature of maritime freight transport has stimulated carriers to improve efficiency and lower costs. The industry has gradually matured, and it has recently become the case that the larger a carrier is, the more competitive advantage it has. Therefore, carriers form strategic alliances to collaborate with each other so that they can reduce their operational costs due to economies of scale. At the same time, such alliances allow carriers to improve the quality of their service by increasing their network coverage. Although carriers collaborate to improve their operational efficiency, they compete with each other simultaneously. In other words, a game of coopetition among carriers has developed in international maritime freight transport in recent years. In this study, we propose a theoretical framework for characterizing coopetition in international maritime shipping and investigating how carriers can manage their business models. Empirical studies, together with salient analytical results, are presented and discussed.
    Źródło:
    Polish Maritime Research; 2013, S 1; 5-12
    1233-2585
    Pojawia się w:
    Polish Maritime Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    SFRs-based numerical simulation for the reliability of highly-coupled DFTS
    Metoda symulacji numerycznej oparta na pojęciu zakresów uszkodzeń sekwencyjnych służąca do obliczania niezawodności układów modelowanych metodą silnie sprzężonych dynamicznych drzew błędów
    Autorzy:
    Ge, D.
    Li, D.
    Lin, M.
    Yang, Y.-H.
    Powiązania:
    https://bibliotekanauki.pl/articles/300798.pdf
    Data publikacji:
    2015
    Wydawca:
    Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
    Tematy:
    highly-coupled DFTs
    sequence failure region
    arbitrary distributions
    numerical simulation
    silnie sprzężone dynamiczne drzewo błędów
    zakres uszkodzeń sekwencyjnych
    arbitralnie przyjęty rozkład
    symulacja numeryczna
    Opis:
    The failure behaviors of many real-life systems are very complex and sequence-dependent, and can be modeled by highly-coupled dynamic fault trees (DFTs). Existing approaches for solving DFTs, such as Markov state-space-based or inclusion-exclusion based methods all have their disadvantages. They either suffer from the problem of state space explosion or are subjected to the combination explosion. Additionally, Markov-based approaches become unavailable when components follow non-exponential time-to-failure distributions which prevail in real-life systems. To overcome shortcomings of the methods mentioned above, SFRs (Sequence Failure Regions)-Based numerical simulation approach is first proposed. The proposed method is applicable for a generalized cut sequence as well as highly-coupled DFTs modeling non-repairable systems with arbitrary time-to-failure distributed components. The results of the validation example indicate the reasonability of our proposed approach.
    Zachowania uszkodzeniowe wielu działających w rzeczywistości układów są bardzo złożone i zależą od sekwencji w jakiej występują uszkodzenia. Zachowania takie można modelować za pomocą silnie sprzężonych dynamicznych drzew błędów (DFT). Istniejące podejścia do rozwiązywania DFT, takie jak metody markowowskie oparte na pojęciu przestrzeni stanów i metody oparte na zasadzie włączeń i wyłączeń mają swoje ograniczenia:albo borykają się z problemem eksplozji przestrzeni stanów albo są narażone na eksplozję kombinatoryczną. Dodatkowo, podejścia markowowskie stają się niedostępne, gdy elementy składowe mają niewykładnicze rozkłady czasu do uszkodzenia, co ma miejsce w przeważającej części układów spotykanych w rzeczywistości. Aby przezwyciężyć mankamenty powyższych metod, zaproponowano metodę symulacji numerycznej opartą na pojęciu zakresów uszkodzeń sekwencyjnych (sequence failure regions, SFR). Proponowana metoda znajduje zastosowanie w modelowaniu systemów nienaprawialnych o elementach, które charakteryzuje arbitralnie przyjęty rozkład czasu do uszkodzenia. Metodę można stosować w modelowaniu opartym zarówno na uogólnionej sekwencji niezdatności (generalizedcut sequence), jak również silnie sprzężonych DFT. Wyniki uzyskane w przedstawionym przykładzie potwierdzają zasadność proponowanego przez nas podejścia.
    Źródło:
    Eksploatacja i Niezawodność; 2015, 17, 2; 199-206
    1507-2711
    Pojawia się w:
    Eksploatacja i Niezawodność
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Antioxidant activity and mechanism in flower of Hylocereus undatus (Haw.) Britt. et Rose
    Autorzy:
    Li, X.
    Gao, Y.
    Han, W.
    Lin, J.
    Hu, Q.
    Chen, D.
    Powiązania:
    https://bibliotekanauki.pl/articles/19838.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    Hylocereus undatus flower is commonly used as food or for medicinal purposes in south China. To study its antioxidant activity and mechanism we used antioxidant and chemical assays to compare two commercial samples from different locations (Shenjing, Qixing). The difference in antioxidant levels corresponded with differences in chemical content (including total phenolics, total flavonoids, kaempferol and quercetin) between Shenjing and Qixing. The antioxidant ability of H. undatus flower seems attributable to total phenolics (mainly total flavonoids). Kaempferol is one of the main bioactive components. H. undatus flower exerts its antioxidant effects through metal chelation and radical scavenging via hydrogen atom (H•) and electron (e) donation.
    Źródło:
    Acta Biologica Cracoviensia. Series Botanica; 2013, 55, 1
    0001-5296
    Pojawia się w:
    Acta Biologica Cracoviensia. Series Botanica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Study of flow softening mechanisms of a nickel-based superalloy with o phase
    Autorzy:
    Lin, Y. C.
    He, D.-G
    Chen, M. S.
    Chen, X.-M.
    Zhao, C.-Y.
    Ma, X.
    Powiązania:
    https://bibliotekanauki.pl/articles/958203.pdf
    Data publikacji:
    2016
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    alloys
    hot deformation
    flow softening behavior
    microstructural evolution
    Opis:
    The flow softening behaviors of a nickel-based superalloy with o phase are investigated by hot compression tests over wide ranges of deformation temperature and strain rate. Electron backscattered diffraction (EBSD). optical microscopy (OM), and scanning electron microscopy (SEM) are employed to study the flow softening mechanisms of the studied superalloy. It is found that the flow softening behaviors of the studied superalloy are sensitive to deformation temperature and strain rate. At high strain rate and low deformation temperature, the obvious flow softening behaviors occur. With the increase of deformation temperature or decrease of strain rate, the flow softening degree becomes weaken. At high strain rate (1s-1), the flow softening is mostly induced by the plastic deformation heating and flow localization. However, at low strain rate domains (0.001-0.01s-1), the effects of deformation heating on flow softening are slight. Moreover, the flow softening at low strain rates is mainly induced by the discontinuous dynamic recrystallization and the dissolution of 6 phase (Ni3Nb).
    Źródło:
    Archives of Metallurgy and Materials; 2016, 61, 3; 1537-1546
    1733-3490
    Pojawia się w:
    Archives of Metallurgy and Materials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of luteinizing hormone regulation of maturation and apoptosis, expression of LHR and FSHR in cumulus-oocyte complexes in Lanzhou fat-tailed sheep
    Autorzy:
    Wei, S.C.
    Deng, Y.Y.
    Lai, L.J.
    Liang, H.Q.
    Lin, G.Z.
    Gong, Z.D.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087862.pdf
    Data publikacji:
    2017
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    In vitro maturation
    apoptosis
    luteinizing hormone
    cumulus oocyte complexes
    Caspase-3
    receptor
    Źródło:
    Polish Journal of Veterinary Sciences; 2017, 4; 759-768
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    An application of feedback linearization to the tracking and almost disturbance decoupling control of nonlinear system with uncertainties
    Autorzy:
    Chen, C.-C.
    Huang, Y.-C
    Lin, W.-J.
    Shen, D.-C.
    Huang, L.-A.
    Powiązania:
    https://bibliotekanauki.pl/articles/970382.pdf
    Data publikacji:
    2007
    Wydawca:
    Polska Akademia Nauk. Instytut Badań Systemowych PAN
    Tematy:
    almost disturbance decoupling
    feedback linearizable
    differential geometry approach
    composite Lyapunov approach
    Opis:
    This paper studies the tracking and almost disturbance decoupling problem of nonlinear systems with uncertainties, based on the feedback linearization approach. The main contribution of this study is to construct a controller, under appropriate conditions, such that the resulting closed-loop system is valid for any initial condition and bounded tracking signal with the following characteristics: input-to-state stability with respect to disturbance inputs and almost disturbance decoupling, i.e., the influence of disturbances on the L2 norm of the output tracking error can be arbitrarily attenuated by changing some adjustable parameters. Two examples, which cannot be solved by the first paper on the almost disturbance decoupling problem, are proposed in this paper to exploit the fact that the tracking and the almost disturbance decoupling performances are easily achieved by the proposed approach. In order to demonstrate the practical applicability, the paper has investigated the AMIRA ball and beam system.
    Źródło:
    Control and Cybernetics; 2007, 36, 2; 385-403
    0324-8569
    Pojawia się w:
    Control and Cybernetics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Establishment of 5-Fluorouracil-resistant canine mammary tumor cell line
    Autorzy:
    Zhou, B.
    Zhang, D.
    Pei, S.M.
    Zhang, K.
    Du, H.C.
    Jin, Y.P.
    Lin, D.G.
    Powiązania:
    https://bibliotekanauki.pl/articles/30283.pdf
    Data publikacji:
    2017
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    Canine mammary tumors are the most common neoplasms in intact female dogs. The surgery cannot always solve the problem, chemotherapy are recommend to these patients. However, chemotherapy could always fail because of multidrug resistance (MDR). Through stepwise increasing 5-Fluorouracil (5-FU) concentration in the culture medium, a 5-FU-resistant canine mammary tumor cell line CMT7364/5-FU was established to disclose the molecular mechanism of the drug resistance. Cell morphology, cell sensitivity to drugs, growth curves, expression of proteins, and chemo-sensitivity in vivo were compared between the parental cell line and resistant cell line. As compared it to its parental cell line (CMT7364), CMT7364/5-FU showed different morphology, cross-resistant to other chemo-drugs and a prolonged population doubling time (PDT). The drug efflux pump proteins (ABCB1 and ABCG2) in CMT7364/5-FU were up-regulated. In vivo, the similar result revealed that CMT7364/5-FU cell line was more resistant to 5-FU. In conclusion, a 5-FU-resistant canine mammary tumor cell line (CMT7364/5-FU) was successfully established, it can serve as a good model for researching the mechanism of MDR and screening effective agents to reverse drug resistance.
    Źródło:
    Polish Journal of Veterinary Sciences; 2017, 20, 1
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Molecular cloning, bioinformation analysis and expression of the strictosidine synthase in Dendrobium officinale
    Autorzy:
    Zhu, Y.-F.
    Fan, H.-H.
    Li, D.-H.
    Jin, Q.
    Zhang, C.-M.
    Zhu, L.-Q.
    Song, C.
    Cai, Y.-P.
    Lin, Y.
    Powiązania:
    https://bibliotekanauki.pl/articles/12715947.pdf
    Data publikacji:
    2020
    Wydawca:
    Uniwersytet Przyrodniczy w Lublinie. Wydawnictwo Uniwersytetu Przyrodniczego w Lublinie
    Opis:
    The enzyme strictosidine synthase (STR, EC: 4.3.3.2) plays a key role in the biosynthetic pathway of terpenoid indole alkaloid (TIA). It catalyzes the condensation of the tryptamine and secologanin to form 3α(S)-strictosidine, which is the common precursor of all TIAs. In this paper, a STR gene designated as DoSTR (GenBank: KX068707) was first cloned and characterized from Dendrobium officinale with rapid amplified cDNA ends method (RACE). DoSTR has a length of 1380bp with 1179bp open reading frame encoding 392 amino acids. BlastP analyses showed that its amino acid sequence was classified into Str_synth superfamily. qRT-PCR showed that DoSTR was expressed in all tissues tested, with a significantly higher level in flower and the lowest in stem. Four different treatments with MeJA, SA, ABA and AgNO₃, respectively, could induce the DoSTR expression to a different extent. And the effect of MeJA was the most obvious and transcript level of DoSTR induced by MeJA was 20.7 times greater than that of control at 48 hours after treatment. Furthermore, it was found that DoSTR was localized in vacuole through transient expression in tobacco. The characterization and expression of DoSTR can help in further studying the role of DoSTR in the biosynthesis of TIAs in D. officinale. This study may throw light on the alkaloid biosynthesis pathway of D. officinale.
    Źródło:
    Acta Scientiarum Polonorum. Hortorum Cultus; 2020, 19, 3; 111-124
    1644-0692
    Pojawia się w:
    Acta Scientiarum Polonorum. Hortorum Cultus
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A new mechanism for data visualization with TSK-type preprocessed collaborative fuzzy rule based system
    Autorzy:
    Prasad, M.
    Liu, Y.-T.
    Li, D.-L.
    Lin, C. -T.
    Shah, R. R.
    Kaiwartya, O. P.
    Powiązania:
    https://bibliotekanauki.pl/articles/91743.pdf
    Data publikacji:
    2017
    Wydawca:
    Społeczna Akademia Nauk w Łodzi. Polskie Towarzystwo Sieci Neuronowych
    Tematy:
    fuzzy interference system
    collaborative clustering
    fuzzy logic
    big data
    data visualization
    Opis:
    A novel data knowledge representation with the combination of structure learning ability of preprocessed collaborative fuzzy clustering and fuzzy expert knowledge of TakagiSugeno-Kang type model is presented in this paper. The proposed method divides a huge dataset into two or more subsets of dataset. The subsets of dataset interact with each other through a collaborative mechanism in order to find some similar properties within eachother. The proposed method is useful in dealing with big data issues since it divides a huge dataset into subsets of dataset and finds common features among the subsets. The salient feature of the proposed method is that it uses a small subset of dataset and some common features instead of using the entire dataset and all the features. Before interactions among subsets of the dataset, the proposed method applies a mapping technique for granules of data and centroid of clusters. The proposed method uses information of only half or less/more than the half of the data patterns for the training process, and it provides an accurate and robust model, whereas the other existing methods use the entire information of the data patterns. Simulation results show the proposed method performs better than existing methods on some benchmark problems.
    Źródło:
    Journal of Artificial Intelligence and Soft Computing Research; 2017, 7, 1; 33-46
    2083-2567
    2449-6499
    Pojawia się w:
    Journal of Artificial Intelligence and Soft Computing Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Development of Hydrophobic Surgical Forceps using Powder Injection Molding and Surface Treatment
    Autorzy:
    Park, D. Y.
    Park, B. R.
    Gal, C. W.
    Lin, D.
    Han, J. S.
    Jeong, M.-S.
    Bollina, R.
    Hwang, W.
    Park, S. J.
    Powiązania:
    https://bibliotekanauki.pl/articles/352093.pdf
    Data publikacji:
    2018
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    powder injection molding
    hydrophobic
    debinding
    sintering
    surface treatment
    Opis:
    Hydrophobic surgical forceps of end-effectors for laparoscopic operations or minimally invasive surgery were developed through powder injection molding (PIM) and surface treatment. Processing conditions for mixing, debinding, and sintering were investigated to produce defect-free components. An optimum solid loading was determined by torque rheometry experiments. The optimized processing conditions for debinding and sintering were designed through the measurement of weight loss and shrinkage behavior by thermogravimetric analysis and dilatometry experiments. After producing the surgical forceps based on the optimized processing conditions via PIM, surface treatment was carried out to generate the hydrophobic structure on the surface.
    Źródło:
    Archives of Metallurgy and Materials; 2018, 63, 1; 473-480
    1733-3490
    Pojawia się w:
    Archives of Metallurgy and Materials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Isolation and sequence analysis of the complete VP2 gene of canine parvovirus from Chinese domestic pets and determination of the pathogenesis of these circulating strains in beagles
    Autorzy:
    Chen, M.R.
    Guo, X.Y.
    Wang, Z.Y.
    Jiang, Y.T.
    Yuan, W.F.
    Xin, T.
    Hou, S.H.
    Song, T.Q.
    Lin, W.D.
    Zhu, H.F.
    Jia, H.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087542.pdf
    Data publikacji:
    2019
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    canine parvovirus
    molecular epidemiology
    phylogenetic analysis
    pathogenesis
    Źródło:
    Polish Journal of Veterinary Sciences; 2019, 2; 287-296
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-13 z 13

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