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    Wyświetlanie 1-8 z 8
    Tytuł:
    Biobankowanie ludzkiego materiału biologicznego dla celów naukowych w Polsce i w Europie
    Autorzy:
    Łukasz, Kozera,
    Dominik, Strapagiel,
    Joanna, Gleńska-Olender,
    Anna, Chrościcka,
    Katarzyna, Ferdyn,
    Jarosław, Skokowski,
    Leszek, Kalinowski,
    Jakub, Pawlikowski,
    Błażej, Marciniak,
    Markus, Pasterk,
    Agnieszka, Matera-Witkiewicz,
    Małgorzata, Lewandowska-Szumieł,
    Michał, Piast,
    Małgorzata, Witoń,
    Powiązania:
    https://bibliotekanauki.pl/articles/902739.pdf
    Data publikacji:
    2018-06-22
    Wydawca:
    Uniwersytet Warszawski. Wydawnictwa Uniwersytetu Warszawskiego
    Tematy:
    Consortium of Polish Biobanks
    BBMRI
    data protection
    Konsorcjum Polskich Biobanków
    rejestr biobanków
    ochrona danych
    Opis:
    Biobanks are one of the 10 Ideas Changing the World Right now – according to Time Magazine (2009). Samples and data deposition have become an increasing. trend in the world. Europe has invested a lot of money into infrastructures responsible for collection and storage of human biological samples. Poland, a country with a population of over 38.5 million people has just started investing funds into this powerful and indispensable tool for scientific research. Consortium of Polish Biobanks named as BBMRI.pl consisting of seven well-established biobanks developed a project for the Creation of the Polish Biobanking Network in order to organise our infrastructures according to world-recognized standards. The main tasks include: creation of Consortium of Polish Biobanks, development of IT solutions coherent with pan European needs, development of quality assurance tools, establishment of the Biobanking National Node, development of quality control programme and analysis of Ethical, Legal and Social Implications of research using human samples. Results of this project will increase Poland’s position in the international research arena of biomedicine, make our biorepositories open for international collaboration and in the future will contribute to the development of personalized medicine.
    Źródło:
    Studia Iuridica; 2018, 73; 13-28
    0137-4346
    Pojawia się w:
    Studia Iuridica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Endothelial NADH/NADPH-dependent enzymatic sources of superoxide production: relationship to endothelial dysfunction.
    Autorzy:
    Kalinowski, Leszek
    Malinski, Tadeusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1043282.pdf
    Data publikacji:
    2004
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    peroxynitrite
    endothelial dysfunction
    NAD(P)H oxidase
    nitric oxide
    superoxide
    eNOS
    Opis:
    There is growing evidence that endothelial dysfunction, which is often defined as the decreased endothelial-derived nitric oxide (NO) bioavailability, is a crucial factor leading to vascular disease states such as hypertension, diabetes, atherosclerosis, heart failure and cigarette smoking. This is due to the fact that the lack of NO in endothelium-dependent vascular disorders contributes to impaired vascular relaxation, platelet aggregation, increased vascular smooth muscle proliferation, and enhanced leukocyte adhesion to the endothelium. During the last several years, it has become clear that reduction of NO bioavailability in the endothelium-impaired function disorders is associated with an increase in endothelial production of superoxide (O2̇̄). Because O2̇̄ rapidly scavenges NO within the endothelium, a reduction of bioactive NO might occur despite an increased NO generation. Among many enzymatic systems that are capable of producing O2̇̄, NAD(P)H oxidase and uncoupled endothelial NO synthase (eNOS) apparently are the main sources of O2̇̄ in the endothelial cells. It seems that O2̇̄ generated by NAD(P)H oxidase may trigger eNOS uncoupling and contribute to the endothelial balance between NO and O2̇̄. That is maintained at diverse levels.
    Źródło:
    Acta Biochimica Polonica; 2004, 51, 2; 459-469
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Inflammatory response to a marathon run in amateur athletes
    Autorzy:
    Kaleta-Duss, Anna Maria
    Lewicka-Potocka, Zuzanna
    Dąbrowska-Kugacka, Alicja
    Raczak, Grzegorz
    Siekierzycka, Anna
    Woźniak, Marcin
    Kalinowski, Leszek
    Lewicka, Ewa Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1197575.pdf
    Data publikacji:
    2021-05-26
    Wydawca:
    Gdański Uniwersytet Medyczny
    Tematy:
    neopterin
    endothelin-1
    pentraxin-3
    marathon
    amateur runners
    Opis:
    Background: While moderate physical exercise has positive effects on the cardiovascular system, the data regarding intensive endurance sports is biased with studies suggesting that the inflammatory response to strenuous exercise may act proarrhythmogenic. In amateurs, the effects of intensive endurance exercise on the cardiovascular system have not been studied. Analysis of the effects of a marathon on the kinetics of inflammatory biomarkers may bring new insights into this issue. Material and methods: We studied the effect of a marathon on the kinetics of inflammatory biomarkers: Endothelin-1 (ET-1), Pentraxin-3 (PTX-3), Neopterin and Interleukin-6 (IL-6) in the population of 35 amateur male marathoners. The study was divided into 3 stages: two weeks prior to the marathon (S1), at the finish line (S2) and two weeks after (S3). Blood analyses for biomarkers were performed at each stage. Results: The concentrations of ET-1 (3.20 ± 0.90 vs. 1.30 ±0.34 pg/ml, p <0,001), PTX-3 (441.09 ± 295.64 vs. 279.99 ± 125.68 pg/ml, p < 0,001), Neopterin (9.97 ± 2.17 vs. 8.36 ± 2.68 nmol/l, p < 0,05) and IL-6 (32.5 ± 13.90 vs. 0.97 ± 0.77 pg/ml, p < 0,001) were significantly higher at S2 compared to S1. Conclusions: Running a marathon causes an acute rise in concentrations of inflammatory biomarkers. Further research is needed on the long-term effects of intensive endurance exercise on the cardiovascular system.
    Źródło:
    European Journal of Translational and Clinical Medicine; 2021, 4, 1; 43-49
    2657-3148
    2657-3156
    Pojawia się w:
    European Journal of Translational and Clinical Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evolution Of The Results Of 1500 Liver Transplantations Performed In The Department Of General, Transplant And Liver Surgery Medical University Of Warsaw
    Autorzy:
    Krawczyk, Marek
    Grąt, Michał
    Grąt, Karolina
    Wronka, Karolina
    Krasnodębski, Maciej
    Stypułkowski, Jan
    Masior, Łukasz
    Hołówko, Wacław
    Ligocka, Joanna
    Nyckowski, Paweł
    Wróblewski, Tadeusz
    Paluszkiewicz, Rafał
    Patkowski, Waldemar
    Zieniewicz, Krzysztof
    Pączek, Leszek
    Milkiewicz, Piotr
    Ołdakowska-Jedynak, Urszula
    Najnigier, Bogusław
    Dudek, Krzysztof
    Remiszewski, Piotr
    Grzelak, Ireneusz
    Kornasiewicz, Oskar
    Kotulski, Marcin
    Smoter, Piotr
    Grodzicki, Mariusz
    Korba, Michał
    Kalinowski, Piotr
    Skalski, Michał
    Zając, Krzysztof
    Stankiewicz, Rafał
    Przybysz, Marta
    Cieślak, Bartosz
    Nazarewski, Łukasz
    Nowosad, Małgorzata
    Kobryń, Konrad
    Wasilewicz, Michał
    Raszeja-Wyszomirska, Joanna
    Piwowarska, Jolanta
    Giercuszkiewicz, Dorota
    Sańko-Resmer, Joanna
    Rejowski, Sławomir
    Szydłowska-Jakimiuk, Monika
    Górnicka, Barbara
    Wróblewska-Ziarkiewicz, Bogna
    Mazurkiewicz, Michał
    Niewiński, Grzegorz
    Pawlak, Jacek
    Pacho, Ryszard
    Powiązania:
    https://bibliotekanauki.pl/articles/1395614.pdf
    Data publikacji:
    2015-05-01
    Wydawca:
    Index Copernicus International
    Tematy:
    liver transplantation
    survival
    outcomes
    donors
    center experience
    center volume
    Opis:
    Liver transplantation is a well-established treatment of patients with end-stage liver disease and selected liver tumors. Remarkable progress has been made over the last years concerning nearly all of its aspects. The aim of this study was to evaluate the evolution of long-term outcomes after liver transplantations performed in the Department of General, Transplant and Liver Surgery (Medical University of Warsaw). Material and methods. Data of 1500 liver transplantations performed between 1989 and 2014 were retrospectively analyzed. Transplantations were divided into 3 groups: group 1 including first 500 operations, group 2 including subsequent 500, and group 3 comprising the most recent 500. Five year overall and graft survival were set as outcome measures. Results. Increased number of transplantations performed at the site was associated with increased age of the recipients (p<0.001) and donors (p<0.001), increased rate of male recipients (p<0.001), and increased rate of piggyback operations (p<0.001), and decreased MELD (p<0.001), as well as decreased blood (p=0.006) and plasma (p<0.001) transfusions. Overall survival was 71.6% at 5 years in group 1, 74.5% at 5 years in group 2, and 85% at 2.9 years in group 3 (p=0.008). Improvement of overall survival was particularly observed for primary transplantations (p=0.004). Increased graft survival rates did not reach the level of significance (p=0.136). Conclusions. Long-term outcomes after liver transplantations performed in the Department of General, Transplant and Liver Surgery are comparable to those achieved in the largest transplant centers worldwide and are continuously improving despite increasing recipient age and wider utilization of organs procured from older donors.
    Źródło:
    Polish Journal of Surgery; 2015, 87, 5; 221-230
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    1000 Liver Transplantations at the Department of General, Transplant and Liver Surgery, Medical University of Warsaw - Analysis of Indications and Results
    Autorzy:
    Krawczyk, Marek
    Grąt, Michał
    Barski, Krzysztof
    Ligocka, Joanna
    Antczak, Arkadiusz
    Kornasiewicz, Oskar
    Skalski, Michał
    Patkowski, Waldemar
    Nyckowski, Paweł
    Zieniewicz, Krzysztof
    Grzelak, Ireneusz
    Pawlak, Jacek
    Alsharabi, Abdulsalam
    Wróblewski, Tadeusz
    Paluszkiewicz, Rafał
    Najnigier, Bogusław
    Dudek, Krzysztof
    Remiszewski, Piotr
    Smoter, Piotr
    Grodzicki, Mariusz
    Korba, Michał
    Kotulski, Marcin
    Cieślak, Bartosz
    Kalinowski, Piotr
    Gierej, Piotr
    Frączek, Mariusz
    Rdzanek, Łukasz
    Stankiewicz, Rafał
    Kobryń, Konrad
    Nazarewski, Łukasz
    Leonowicz, Dorota
    Urban-Lechowicz, Magdalena
    Skwarek, Anna
    Giercuszkiewicz, Dorota
    Paczkowska, Agata
    Piwowarska, Jolanta
    Gelo, Remigiusz
    Andruszkiewicz, Paweł
    Brudkowska, Anna
    Andrzejewska, Renata
    Niewiński, Grzegorz
    Kilińska, Beata
    Zarzycka, Aleksandra
    Nowak, Robert
    Kosiński, Cezary
    Korta, Teresa
    Ołdakowska-Jedynak, Urszula
    Sańko-Resmer, Joanna
    Foroncewicz, Bartosz
    Ziółkowski, Jacek
    Mucha, Krzysztof
    Senatorski, Grzegorz
    Pączek, Leszek
    Habior, Andrzej
    Lechowicz, Robert
    Polański, Sławomir
    Leowska, Elżbieta
    Pacho, Ryszard
    Andrzejewska, Małgorzata
    Rowiński, Olgierd
    Kozieł, Sławomir
    Żurakowski, Jerzy
    Ziarkiewicz-Wróblewska, Bogna
    Górnicka, Barbara
    Hevelke, Piotr
    Michałowicz, Bogdan
    Karwowski, Andrzej
    Szczerbań, Jerzy
    Powiązania:
    https://bibliotekanauki.pl/articles/1396689.pdf
    Data publikacji:
    2012-06-01
    Wydawca:
    Index Copernicus International
    Tematy:
    liver transplantation
    indications
    results
    mortality
    Opis:
    The aim of the study was to analyze indications and results of the first one thousand liver transplantations at Chair and Clinic of General, Transplantation and Liver Surgery, Medical University of Warsaw.Material and methods. Data from 1000 transplantations (944 patients) performed at Chair and Clinic of General, Transplantation and Liver Surgery between 1994 and 2011 were analyzed retrospectively. These included 943 first transplantations and 55 retransplantations and 2 re-retransplantations. Frequency of particular indications for first transplantation and retransplantations was established. Perioperative mortality was defined as death within 30 days after the transplantation. Kaplan-Meier survival analysis was used to estimate 5-year patient and graft survival.Results. The most common indications for first transplantation included: liver failure caused by hepatitis C infection (27.8%) and hepatitis B infection (18%) and alcoholic liver disease (17.7%). Early (< 6 months) and late (> 6 months) retransplantations were dominated by hepatic artery thrombosis (54.3%) and recurrence of the underlying disease (45%). Perioperative mortality rate was 8.9% for first transplantations and 34.5% for retransplantations. Five-year patient and graft survival rate was 74.3% and 71%, respectively, after first transplantations and 54.7% and 52.9%, respectively, after retransplantations.Conclusions. Development of liver transplantation program provided more than 1000 transplantations and excellent long-term results. Liver failure caused by hepatitis C and B infections remains the most common cause of liver transplantation and structure of other indications is consistent with European data.
    Źródło:
    Polish Journal of Surgery; 2012, 84, 6; 304-312
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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