Autor: Lasota, Ewa. - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Potrzeby w zakresie rehabilitacji medycznej nipełnosprawnych mieszkańców Bełchatowa
Autorzy:: Lasota, Ewa.
Czernicki, Jan.
Powiązania:: Przegląd Wojskowo-Medyczny 1999, z. 1, s. 171-178
Data publikacji:: 1999
Tematy:: Wojskowa Akademia Medyczna, Łódź badania naukowe
Akademie wojskowe badania naukowe Polska
Medycyna wojskowa badania naukowe Polska
Rehabilitacja medyczna
Niepełnosprawni Bełchatów(Polska)
Opis:: Ryc.; Tytuł także w jęz. angielskim; Bibliogr.
Dostawca treści:: Bibliografia CBW

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Skocz do pozycji: 2.

Tytuł:: Detection of cross-resistance between methotrexate and azoles in Candida albicans and Meyerozyma guilliermondii: an in vitro study
Autorzy:: Karuga, Filip Franciszek
Góralska, Katarzyna
Brzeziańska-Lasota, Ewa
Powiązania:: https://bibliotekanauki.pl/articles/11543398.pdf
Data publikacji:: 2021
Wydawca:: Polskie Towarzystwo Botaniczne
Tematy:: cross resistance
detection
methotrexate
azole
Candida albicans
Meyerozyma guilliermondii
drug resistance
fluconazole
Opis:: In recent years, there has been a rapid increase in the incidence of Candida infections. The different species of the genus Candida vary in their virulence abilities and susceptibility to antifungal agents, depending on several external factors. The result of such modifications may be cross-resistance, which is understood as an acquired resistance to a certain antimicrobial agent after exposure to another drug. The aim of this study was to determine the possibility of cross-resistance between fluconazole, voriconazole, itraconazole, and methotrexate in Candida albicans and Meyerozyma guilliermondii (syn. Candida guilliermondii). Fifteen strains of M. guilliermondii and eight strains of C. albicans, including the standard strains, were tested. For all strains, the minimum inhibitory concentrations (MICs) for fluconazole, voriconazole, and itraconazole were determined before and after stimulation with methotrexate. The median MICs in M. guilliermondii before and after stimulation were 9.333 and 64 mg/L (p = 0.005) for fluconazole; 0.917 and 1.667 mg/L (p = 0.001) for itraconazole, respectively. No significant change in MIC was observed for voriconazole. For C. albicans strains, the median MICs before and after stimulation were 0.917 and 64 mg/L (p = 0.012) for fluconazole; 0.344 and 1.135 mg/L (p = 0.018) for voriconazole, respectively. There was no significant change in MIC values for itraconazole. Thus, this study demonstrates the presence of cross-resistance between voriconazole, itraconazole, fluconazole, and methotrexate for the selected strains. Methotrexate exposure induces different responses when certain drugs are used for various species. Therefore, if a patient was previously exposed to methotrexate, there may be a higher risk of treatment failure with fluconazole than with other azoles such as voriconazole for fungemia caused by M. guilliermondii or itraconazole for C. albicans infection.
Źródło:: Acta Mycologica; 2021, 56, 1; 566
0001-625X
2353-074X
Pojawia się w:: Acta Mycologica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Analysis of molecular markers as IL-12, IL-22 and IFN-γ in correlation with a clinical course in patients with psoriasis
Autorzy:: Kutwin, Magdalena
Migdalska-Sęk, Monika
Brzeziańska-Lasota, Ewa
Zelga, Piotr
Woźniacka, Anna
Powiązania:: https://bibliotekanauki.pl/articles/2116535.pdf
Data publikacji:: 2020-09-17
Wydawca:: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:: psoriasis
disease activity
proinflammatory cytokines
skin disease
immunology
molecular markers
Opis:: ObjectivesAs a chronic, recurrent, immunologically mediated systemic disease and a common cause of dermatological problems, psoriasis is often a subject of scientific research. Skin changes located on the hands can cause difficulties and limitations in the performance of professional activities, especially manual ones. The main role in pathogenesis is played by immunological factors – improper functioning of the components of the immune system, among others, T lymphocytes and cytokines like interleukin-12 (IL-12), interleukin-22 (IL-22) and interferon gamma (IFN-γ).Material and MethodsThe obtained tissue and blood were destined for RNA isolation. The RNA was then subjected to a reverse transcription reaction. The relative gene expression level was evaluated by the real-time polymerase chain reaction for IL-12B, IL-22 and IFN-γ genes, and presented as the relative quantification (RQ) value, relative to the reference gene GAPDH. In addition, a correlation analysis of the expression level of selected genes with the clinical course of the disease, as assessed by the Psoriasis Area and Severity Index (PASI), the Body Surface Area (BSA) and the Dermatology Life Quality Index (DLQI) scores was performed.ResultsStatistical analysis confirmed a significant increase in RQ values for IL-12B, IL-22 and IFN-γ in the group of psoriatic patients vs. the control group. A positive correlation was also found between BSA and PASI and RQ for the IL-12B gene.ConclusionsIncreased expression levels of IL-12B, IL-22 and IFN-γ genes in psoriatic skin confirm that selected cytokines play an important role in the initiation and sustenance of psoriasis.
Źródło:: International Journal of Occupational Medicine and Environmental Health; 2020, 33, 5; 635-647
1232-1087
1896-494X
Pojawia się w:: International Journal of Occupational Medicine and Environmental Health
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Slope aspect and altitude effect on selected soil organic matter characteristics in Beskid Mountains forest soils
Autorzy:: Staszel, Karolina
Błońska, Ewa
Lasota, Jarosław
Powiązania:: https://bibliotekanauki.pl/articles/2040996.pdf
Data publikacji:: 2021
Wydawca:: Instytut Badawczy Leśnictwa
Tematy:: carbon stock
climatic factors
dehydrogenases activity
forest ecosystem
nitrogen stock
Opis:: In the era of dynamic climate change, it is important to have knowledge on the interactions between climatic factors and processes occurring in the soil environment. The present study aimed to determine how slope aspect and altitude above sea level influence carbon and nitrogen accumulation and dehydrogenases activity of forest soils. The study was conducted in the Beskid Żywiecki in the south-facing part of Poland. Soils of the same texture, with similar vegetation species composition, in different altitude variants (600, 800, 1000 and 1200 m above sea level) and different north-facing and south-facing slope aspect were selected for the study. For each height and slope aspect variant, samples were collected from the surface horizons of soils for further analyses. The basic chemical properties and dehydrogenases activity of the soil samples were determined. Carbon and nitrogen stocks in the surface horizons of the soils were calculated. The analyses confirmed the influence of location conditions on the carbon and nitrogen stocks in mountain forest soils. The stock of carbon and nitrogen increased with the height up to 1000 m a.s.l. In the soils at the highest altitude, the reserve of carbon and nitrogen decreased regardless of the slope aspect variant. There were no statistically significant differences in carbon and nitrogen stocks between slope aspect variant. The highest dehydrogenases activity was associated with the organic horizons of the soils at the lowest altitude in height gradient. In our study, higher dehydrogenases activity was observed in the north-facing slope soils, and this finding can be explained by more stable thermal conditions.
Źródło:: Folia Forestalia Polonica. Series A . Forestry; 2021, 63, 3; 214-224
0071-6677
Pojawia się w:: Folia Forestalia Polonica. Series A . Forestry
Dostawca treści:: Biblioteka Nauki

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