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Wyświetlanie 1-4 z 4
Tytuł:
Optymalizacja własności oraz analiza technologii wykonania funkcjonalnego ostrza z materiałów łączonych wybuchowo
Optimization of Properties and Analysis of the Technology of Making a Functional Blade from Explosively Bonded Materials
Autorzy:
Długosz, Jakub
Kała, Paulina
Pabich, Bartłomiej
Lisiecki, Łukasz
Lipiński, Tomasz
Nowacki, Krzysztof
Powiązania:
https://bibliotekanauki.pl/chapters/28328117.pdf
Data publikacji:
2023-12-14
Wydawca:
Politechnika Częstochowska. Wydawnictwo Politechniki Częstochowskiej
Tematy:
nawęglanie
obróbka cieplna
ostrza
spajanie wybuchowe
blades
carburizing
explosive bonding
heat treatment
Opis:
W rozdziale przedstawiono prace nad wykorzystaniem materiałów spajanych wybuchowo do zastosowań w produkcji noży. Badaniom poddano bi-metal wytworzony poprzez połączenie miedzi i stali za pomocą energii wybuchu. Omówiono podstawowe zastosowanie zgrzewania wybuchowego. Przeanalizowano przebieg badań i operacji, takich jak: badanie mikrostruktury połączenia, nawęglanie, badanie składu chemicznego stali po nawęglaniu, zmianę mikrostruktury stali oraz dobór i przeprowadzenie procesów obróbki cieplnej. Opisano wyniki badania mikrostruktury nawęglonej i hartowanej stali. Zaprezentowano wykonane ostrze. W końcowej części rozdziału sformułowano wnioski dotyczące przeprowadzonych badań.
The chapter presents a research on the use of explosively bonded materials for applications in the production of blades. Bimetal produced by combining copper and steel with the use of explosion energy was subjected to the investigation. The basic application of explosive welding was discussed. The course of a series of tests and operations was analyzed, such as: examination of the joint microstructure, carburizing, analysis of the chemical composition of the steel after carburizing, change of the steel microstructure as well as the selection and implementation of heat treatment processes. The results of the study of the microstructure of carburized and hardened steel are described. In the final part of the article the finished blade and some conclusions were presented.
Źródło:
Potencjał innowacyjny w inżynierii materiałowej i zarządzaniu produkcją; 106-115
9788371939457
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anticancer activity of new molecular hybrids combining 1,4-naphthalenedione motif with phosphonic acid moiety in hepatocellular carcinoma HepG2 cells
Autorzy:
Długosz, Angelika
Gach, Katarzyna
Szymański, Jacek
Modranka, Jakub
Janecki, Tomasz
Janecka, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1038683.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
MTT test
apoptosis
real-time PCR
flow cytometry
Opis:
Structural motifs found in naturally occurring compounds are frequently used by researchers to develop novel synthetic drug candidates. Some of these new agents are hybrid molecules which are designed through a concept of combining more than one functional element. In this report, anticancer activity of new synthetic molecular hybrids, substituted 3-diethoxyphosphorylnaphtho[2,3-b]furan-4,9-diones and 3-diethoxyphosphorylbenzo[f]indole-4,9-diones, which integrate natural 1,4-naphtalenedione scaffold, present in several anticancer agents, with pharmacophoric phosphonate moiety, were tested against hepatocellular cell line HepG2. Cytotoxicity was examined using MTT assay. Two most potent compounds, furandione 8a and benzoindoldione 12a, which reduced the number of viable HepG2 cells with the IC50 values of 4.13 µM and 5.9 µM, respectively, were selected for further research. These compounds decreased the mRNA expression levels of several genes: Bcl-2, angiogenic vascular endothelial growth factor (VEGF), c-Fos, caspase-8 and increased the expression of Bax, caspase-3 and -9, c-Jun, p21, p53, as determined by quantitative real-time PCR. The ability of these compounds to induce apoptosis and DNA damage was studied by flow cytometry. The obtained data showed that the new compounds inhibited cell viability by increasing apoptosis and decreasing angiogenesis. Compound 8a was a much stronger apoptosis inducer as compared with 12a and strongly activated the intrinsic pathway of apoptosis, associated with the loss of mitochondrial membrane potential and changes in Bax/Bcl-2 ratio. These findings show that the synthetic hybrids combining 1,4-naphthalenedione system and phosphonic acid moiety display potential to be further explored in the development of new anticancer agents.
Źródło:
Acta Biochimica Polonica; 2017, 64, 1; 41-48
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Radon intercomparison tests : Katowice, 2016
Autorzy:
Chałupnik, Stanisław
Skubacz, Krystian
Wysocka, Małgorzata
Mazur, Jadwiga
Bonczyk, Michał
Kozak, Krzysztof
Grządziel, Dominika
Urban, Paweł
Tchorz-Trzeciakiewicz, D.
Kozłowska, Beata
Walencik-Łata, Agata
Podstawczyńska, Agnieszka
Olszewski, Jerzy
Bartak, Jakub
Karpińska, Maria
Wołoszczuk, Katarzyna
Dohojda, Marek
Nowak, Jakub
Długosz-Lisiecka, Magdalena
Foerster, Elisabeth
Przylibski, Tadeusz A.
Powiązania:
https://bibliotekanauki.pl/articles/146183.pdf
Data publikacji:
2020
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
active monitors
passive monitors
Polish Radon Centre
proficiency test
radon
Opis:
At the beginning of the year 2016, the representatives of the Polish Radon Centre decided to organize proficiency tests (PTs) for measurements of radon gas and radon decay products in the air, involving radon monitors and laboratory passive techniques. The Silesian Centre for Environmental Radioactivity of the Central Mining Institute (GIG), Katowice, became responsible for the organization of the PT exercises. The main reason to choose that location was the radon chamber in GIG with a volume of 17 m3 , the biggest one in Poland. Accordingly, 13 participants from Poland plus one participant from Germany expressed their interest. The participants were invited to inform the organizers about what types of monitors and methods they would like to check during the tests. On this basis, the GIG team prepared the proposal for the schedule of exercises, such as the required level(s) of radon concentrations, the number and periods of tests, proposed potential alpha energy concentration (PAEC) levels and also the overall period of PT. The PT activity was performed between 6th and 17th June 2016. After assessment of the results, the agreement between radon monitors and other measurement methods was confirmed. In the case of PAEC monitors and methods of measurements, the results of PT exercises were consistent and confirmed the accuracy of the calibration procedures used by the participants. The results of the PAEC PTs will be published elsewhere; in this paper, only the results of radon intercomparison are described.
Źródło:
Nukleonika; 2020, 65, 2; 127-132
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
National comparison of methods for determination of radon in water
Autorzy:
Mazur, Jadwiga
Kozak, Krzysztof
Grządziel, Dominik
Guguła, Szymon
Mroczek, Mariusz
Kozłowska, Beata
Walencik-Łata, Agata
Podgórska, Zuzanna
Wołoszczuk, Katarzyna
Przylibski, Tadeusz A.
Kowalska, Agata
Domin, Elżbieta
Wysocka, Małgorzata
Chałupnik, Stanisław
Chmielewska, Izabela
Długosz-Lisiecka, Magdalena
Szajerski, Piotr
Chau, Nguyen Dinh
Krakowska, Paulina
Pliszczyński, Tomasz
Ośko, Jakub
Dymecka, Małgorzata
Mazurek, Daria
Powiązania:
https://bibliotekanauki.pl/articles/148272.pdf
Data publikacji:
2020
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
AlphaGUARD monitor
interlaboratory comparison
LSC method
radon in water
Z-score value
Opis:
The article describes three interlaboratory experiments concerning 222Rn determination in water samples. The first two experiments were carried out with the use of artificial radon waters prepared by the Laboratory of Radiometric Expertise (LER), Institute of Nuclear Physics, Polish Academy of Sciences in Kraków in 2014 and 2018. The third experiment was performed using natural environment waters collected in the vicinity of the former uranium mine in Kowary in 2016. Most of the institutions performing radon in water measurements in Poland were gathered in the Polish Radon Centre Network, and they participated in the experiments. The goal of these exercises was to evaluate different measurement techniques used routinely in Polish laboratories and the laboratories’ proficiency of radon in water measurements. In the experiment performed in 2018, the reference values of 222Rn concentration in water were calculated based on the method developed at LER. The participants’ results appeared to be worse for low radon concentration than for high radon concentrations. The conclusions drawn on that base indicated the weaknesses of the used methods and probably the sampling. The interlaboratory experiments, in term, can help to improve the participants’ skills and reliability of their results.
Źródło:
Nukleonika; 2020, 65, 2; 77-81
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-4 z 4

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