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Wyszukujesz frazę "ursolic acid" wg kryterium: Wszystkie pola

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    Wyświetlanie 1-7 z 7
    Tytuł:
    Evaluation of ursolic acid as the main component isolated from Catharanthus roseus against hyperglycemia
    Autorzy:
    Thanh Tam, N.
    Thien, D.D.
    Sung, T.V.
    Thi Hoang Anh, N.
    Thuy, T.T.
    Trung, K.H.
    Xuan, T.D.
    Khanh, T.D.
    Powiązania:
    https://bibliotekanauki.pl/articles/10779.pdf
    Data publikacji:
    2016
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Opis:
    Ursolic acid with large amount (0.67% of dried plant weight) along with 7 compounds, namely as spatozoate (1), kaurenoic acid (2), ursonic acid (3), 3-hydroxy-11-ursen-28,13-olide (4), ursolic acid (5), vindoline (6) and mixture of β-sitosterol and stigmasterol were isolated from dichloromethane and ethyl acetate extracts which have shown anti-glucosidase activity of the whole plant of C.roseus. Some isolated compounds and their derivatives were also tested for anti-glucosidase and cytotoxicity.Ursolic acid was examined for hypoglycemic activity in alloxan-induced diabetic mice with dose of 200 and 300 mg/kg/day, respectively. The results have shown that the blood glucose level were reduced by 45.75% and 51.31% to compare with the control group. This study has confirmed that the main component of Vietnamese C. roseus has had significant anti-hyperglycemia activity.
    Źródło:
    International Letters of Natural Sciences; 2016, 50
    2300-9675
    Pojawia się w:
    International Letters of Natural Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Leonurus cardiaca L. herb - a derived extract and an ursolic acid as the factors affecting the adhesion capacity of Staphylococcus aureus in the context of infective endocarditis
    Autorzy:
    Micota, Bartłomiej
    Sadowska, Beata
    Podsędek, Anna
    Redzynia, Małgorzata
    Różalska, Barbara
    Powiązania:
    https://bibliotekanauki.pl/articles/1039309.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    ECM
    Leonurus cardiaca
    ursolic acid
    Staphylococcus aureus
    Opis:
    The objective was an assessment of the impact of Leonurus cardiaca L. extract (LCE) and ursolic acid (UA) on the adhesive properties of Staphylococus aureus NCTC 8325 strain, expressing virulence factors important in the pathogenesis of infective endocarditis. The adhesion and biofilm formation of bacteria cultured in the presence of subinhibitory concentrations of LCE or UA on the abiotic surface or covered with fibrinogen, fibronectin or collagen, were evaluated. Inhibitory effects of LCE and UA on staphylococcal adherence to both types of surface were demonstrated. This, in the case of UA, resulted in a significant reduction of biofilm formation.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 2; 385-388
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Przeciwnowotworowe działanie roślinnych triterpenoidów: kwasu oleanolowego i ursolowego oraz ich pochodnych
    Antitumor activity of plant triterpenoids: oleanolic aicd, ursolic acid and their derivatives
    Autorzy:
    Chojnicka, Izabela
    Janiszowska, Wirginia
    Powiązania:
    https://bibliotekanauki.pl/articles/1197738.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Przyrodników im. Kopernika
    Opis:
    Oleanolic acid and ursolic acid occur widely in species of the /Magnoliopsydia/ class. They are classified as pentacyclic triterpenoids, which belong to a large group of compounds known as secondary metabolites. Glycoside derivatives of oleanolic and ursolic acids are saponins, so-called because of their ability to form in water a stable soapy foam. Oleanolic acid and ursolic acid as well as their derivatives reveal antioxidant, antimutagenic and cytotoxic activity. They prevent formation of cancer, inhibit tumor promotion, differentiation of cancer cells and angiogenesis. Therefore potentially they can be used in chemoprevention as well as in cancer therapy.
    Źródło:
    Kosmos; 2007, 56, 3-4; 335-341
    0023-4249
    Pojawia się w:
    Kosmos
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Distribution of triterpene acids and their derivatives in organs of cowberry (Vaccinium vitis-idaea L.) plant
    Autorzy:
    Szakiel, Anna
    Mroczek, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/1040859.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    ursolic acid
    triterpenoids
    Ericaceae
    allelopathic activity
    Vaccinium vitis-idaea L.
    cowberry
    oleanolic acid
    Opis:
    Wild berries of the genus Vaccinium have become increasingly popular in human health promotion due to their nutritional and medicinal properties. Some striking divergence of opinion about the content of triterpenoids in these plants still exists, meanwhile, this very large class of natural isoprenoids exhibits a wide range of biological activities and hence is of growing research interest. An investigation of triterpenoidal constituents from the cowberry (Vaccinium vitis-idaea L.) plant led to the isolation of two isomeric acids: oleanolic and ursolic and the occurrence of their derivatives in this plant was demonstrated for the first time. Free triterpene acids as well as small amounts of their bound forms (presumable glycosides and glycoside esters) occur in fruits and the vegetative part of the plant, however, in various amounts and different ratios. The total content of both acids was the highest in organs regarded as traditional herbal resources, namely fruits and leaves (1 and 0.6% of dry mass, respectively), whereas it was markedly lower in stems and rhizomes. However, the rhizomes were in turn the plant organ containing relatively the highest amount of the bound forms of both acids (0.01% of dry mass). Ursolic acid was dominant in the whole plant, but the ratio of oleanolic to ursolic acid was significantly different in individual organs, decreasing from the upper (fruits 1:2.4, leaves 1:2) to the lower (stems 1:3.5, rhizomes 1:5.2) parts of the plant. This pattern of distribution of triterpenoids in the plant may have an important physiological and ecological meaning.
    Źródło:
    Acta Biochimica Polonica; 2007, 54, 4; 733-740
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Permeation-enhancing properties of Nepeta cataria var. citriodora dry extract
    Właściwości suchego wyciągu z Nepeta cataria var. citriodora zwiększające zdolność przenikania
    Autorzy:
    Winnicki, A.M.
    Smieszek, J.M.
    Partyka, D.
    Modnicki, D.
    Powiązania:
    https://bibliotekanauki.pl/articles/71985.pdf
    Data publikacji:
    2013
    Wydawca:
    Instytut Włókien Naturalnych i Roślin Zielarskich
    Tematy:
    permeation-enhancing property
    Nepeta cataria var.citriodora
    dry extract
    progesterone
    lipophilic membrane
    solubility
    ursolic acid
    oleanolic acid
    Opis:
    This paper presents the research on permeation enhancing properties of Nepeta cataria var. citriodora (catnip) dry extract in comparison to oleanolic acid and ursolic acid. Progesterone was chosen as a model substance for permeation test. The hydrogels made of hydroxypropylmethylcellulose with progesterone, enhancers and ethanol were applied in the study. The in vitro progesterone penetration test was based on the method proposed by Fürst, using artificial lipophilic membranes which were made of colloxylin and dodecanol. Statistical analyses showed an increase in penetration of progesterone caused by catnip dry extract in comparison to ursolic acid and blank sample. HPLC assay was applied to study the effect of enhancers on progesterone physicochemical properties. The solubility of progesterone was tested in solvent systems corresponding to liquid phases of gels. The statistical increase in progesterone solubility was observed in the presence of dry extract in comparison to the result from ursolic acid-containing sample. The partition coefficient of progesterone was evaluated by standard procedures. The statistically significant reduction of log P values for progesterone was determined in the presence of catnip dry extract.
    W pracy oceniono wpływ wyciągu suchego z Nepeta cataria var. citriodora (kocimiętki cytrynowej) oraz kwasu oleanolowego i ursolowego (promotory wchłaniania) na penetrację substancji czynnej. W badaniach wykorzystano hydrożele wykonane z hydroksypropylmetylcelulozy, progesteronu (substancja modelowa), promotorów wchłaniania i etanolu. Badania in vitro penetracji progesteronu były oparte o metodę zaproponowaną przez Fürsta, wykorzystującą sztuczne lipofilowe błony wykonane z koloksyliny i dodekanolu. Analiza statystyczna wykazała zwiększoną penetrację progesteronu spowodowaną obecnością wyciągu suchego w porównaniu z kwasem ursolowym i próbą odniesienia. Metodę HPLC wykorzystano do zbadania wpływu promotorów na właściwości fizyko-chemiczne progesteronu. Rozpuszczalność progesteronu była badana w układzie rozpuszczalników odpowiadającej fazie płynnej żeli. Statystycznie istotny wzrost rozpuszczalności progesteronu zaobserwowano w obecności wyciągu suchego w porównaniu z próbą zawierającą kwas ursolowy. Współczynnik podziału określono za pomocą standartowych procedur. Statystycznie istotny spadek wartości log P progesteronu zaobserwowano w obecności wyciągu suchego z kocimiętki.
    Źródło:
    Herba Polonica; 2013, 59, 3
    0018-0599
    Pojawia się w:
    Herba Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pentacyclic triterpenoids and polyphenols accumulation in cell suspension culture of Chaenomeles japonica (Thunb.) Lindl. ex Spach
    Autorzy:
    Kikowska, M.
    Wlodarczyk, A.
    Stochmal, A.
    Zuchowski, J.
    Thiem, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/71498.pdf
    Data publikacji:
    2019
    Wydawca:
    Instytut Włókien Naturalnych i Roślin Zielarskich
    Tematy:
    pentacyclic triterpenoid
    triterpenoid
    polyphenol
    accumulation
    cell suspension
    callus
    Chaenomeles japonica
    Japanese quince
    chlorogenic acid
    ursolic acid
    oleanolic acid
    Opis:
    Introduction: Callus and cell suspension cultures are widely applied in investigation of production of highvalue secondary metabolites, which may be used as cosmeceuticals, nutraceuticals and pharmaceuticals. Plant cell cultures are promising alternative to intact plant sources for the production of plant-derived drugs of industrial importance. Objective: The aim of the study was to (i) initiate the cell suspension culture of Chaenomeles japonica from homogenous and uniform callus, (ii) stabilize the selected line and (iii) verify its ability to produce the desired groups of secondary metabolites – pentacyclic triterpenoids and polyphenols. Methods: To establish a cell suspension culture, stabilized and homogeneous callus was selected. Cell cultures were systematically passaged every 2 weeks to fresh liquid medium with the same composition. Biomass from cultures at the growth phase and stationary phase was designated for phytochemical research. UHPLC-DAD-MS analyzes were performed. At the same time, their macroscopic and microscopic observations were carried out. Results: Cells of suspension culture line A2 were characterized by the intense divisions. Cell culture extracts (both from the growth phase and stationary phase) contained pentacyclic triterpenoids. In addition, phenolic compounds (chlorogenic acid and proanthocyanidins type B) and in a small amount also epicatechin are present in the extract of the cells harvested from the growth phase. In the present studies, three pentacyclic triterpenoids were detected and quantified in the extracts of cell suspensions and callus line A2. Ursolic and oleanolic acids were the main triterpenoids in the studied extracts. The cell suspension culture from the growth phase exhibited the highest content of ursolic, oleanolic, and betulinic acid (separately and together). Conclusion: The cell suspension culture of Chaenomeles japonica is a promising source of pentacyclic triterpenoids.
    Źródło:
    Herba Polonica; 2019, 65, 1
    0018-0599
    Pojawia się w:
    Herba Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Chemical constituents of ethanol extract of leaves and molluscicidal activity of crude extracts from Vitex trifolia Linn.
    Składniki chemiczne etanolowego wyciągu z liści i działanie przeciwślimakowe nieoczyszczonego wyciągu z Vitex trifolia Linn.
    Autorzy:
    Jangwan, J.S.
    Aquino, R.P.
    Mencherini, T.
    Picerno, P.
    Singh, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/71567.pdf
    Data publikacji:
    2013
    Wydawca:
    Instytut Włókien Naturalnych i Roślin Zielarskich
    Tematy:
    chemical constituent
    ethanol extract
    leaf
    molluscicidal activity
    crude extract
    Vitex trifolia
    Verbenaceae
    beta-sitosterol
    ursolic acid acetate
    Opis:
    β-sitosterol and two triterpenoids: ursolic acid acetate and platanic acid have been isolated from ethanolic extract of Vitex trifola leaves. β-sitosterol was previously isolated from the leaves, stem and seeds of Vitex trifolia. Ursolic acid acetate has been isolated for the first time in this plant species. Platanic acid has been reported for the first time in Vitex trifolia and even in the family of this plant: Verbenaceae. These compounds were characterized using spectroscopic methods including 1D-1HNMR, 13CNMR, ESIMS and 2D-NMR (HSQC, HMBC, COSY) experiments and confirmed by comparison of their NMR data with those from the literature. A preliminary molluscicidal test for ethanol, chloroform and n-hexane extracts of leaves of Vitex trifolia against Biomphalaria alexandrina adult snails showed that ethanol extract of leaves with LC50 value 26.42 mg/l (27.92 mg/l – 24.99 mg/l) was more effective than n-hexane extract with LC50 value 35.48 mg/l (43.81 mg/l – 28.72mg/l) and chloroform extract with LC50 value 46.77 mg/l (53.59 mg/l – 43.81 mg/l) after 24 h exposure.
    Z etanolowego wyciągu z liści Vitex trifola wyizolowano β-sitosterol i dwa triterpenoidy: octan kwasu ursolowego i kwas platanowy. Poprzednio z liści, łodyg i nasion Vitex trifola był wyizolowant β-sitosterol. Octan kwasu ursolowego został wyizolowany po raz pierwszy z rośliny tego gatunku. Występowanie kwasu platanowego w Vitex trifolia oraz w rodzinie Verbenaceae zostało opisane po raz pierwszy. Składniki te scharakteryzowano, używając metod spektroskopowych, stosując badania 1D-1HNMR, 13CNMR, ESIMS and 2D-NMR (HSQC, HMBC, COSY) oraz potwierdzono porównaniem ich danych NMR z danymi literaturowymi. Wstępny test działania przeciwślimakowego wyciągów etanolowego, chloroformowego i n-heksanowego z liści Vitex trifolia przeciw dorosłym ślimakom Biomphalaria
    Źródło:
    Herba Polonica; 2013, 59, 4
    0018-0599
    Pojawia się w:
    Herba Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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