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    Wyświetlanie 1-4 z 4
    Tytuł:
    The human genome structure and organization.
    Autorzy:
    Makałowski, Wojciech
    Powiązania:
    https://bibliotekanauki.pl/articles/1044086.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Opis:
    Genetic information of human is encoded in two genomes: nuclear and mitochondrial. Both of them reflect molecular evolution of human starting from the beginning of life (about 4.5 billion years ago) until the origin of Homo sapiens species about 100000 years ago. From this reason human genome contains some features that are common for different groups of organisms and some features that are unique for Homo sapiens. 3.2 × 1.00e+9 base pairs of human nuclear genome are packed into 23 chromosomes of different size. The smallest chromosome - 21st contains 5 × 1.00e+7 base pairs while the biggest one -1st contains 2.63 × 1.00e+8 base pairs. Despite the fact that the nucleotide sequence of all chromosomes is established, the organisation of nuclear genome put still questions: for example: the exact number of genes encoded by the human genome is still unknown giving estimations from 30 to 150 thousand genes. Coding sequences represent a few percent of human nuclear genome. The majority of the genome is represented by repetitive sequences (about 50%) and noncoding unique sequences. This part of the genome is frequently wrongly called "junk DNA". The distribution of genes on chromosomes is irregular, DNA fragments containing low percentage of GC pairs code lower number of genes than the fragments of high percentage of GC pairs.
    Źródło:
    Acta Biochimica Polonica; 2001, 48, 3; 587-598
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Can chromatin conformation technologies bring light into human molecular pathology?
    Autorzy:
    Kubiak, Marta
    Lewandowska, Marzena
    Powiązania:
    https://bibliotekanauki.pl/articles/1038988.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    chromosome conformation capture
    human molecular pathology
    chromatin
    chromatin looping
    genome organization
    Opis:
    Regulation of gene expression in eukaryotes involves many complex processes, in which chromatin structure plays an important role. In addition to the epigenetic effects, such as DNA methylation and phosphorylation or histone modifications, gene expression is also controlled by the spatial organization of chromatin. For example, distant regulatory elements (enhancers, insulators) may come into direct physical interaction with target genes or other regulatory elements located in genomic regions of up to several hundred kilobases in size. Such long-range interactions result in the formation of chromatin loops. In the last several years, there has been a rapid increase in our knowledge of the spatial organization of chromatin in the nucleus through the chromosome conformation capture (3C) technology. Here we review and compare the original 3C and 3C-based methods including chromosome conformation capture-on-chip (4C), chromosome conformation capture carbon copy (5C), hi-resolution chromosome confomation capture (HiC). In this article, we discuss different aspects of how the nuclear organization of chromatin is associated with gene expression regulation and how this knowledge is useful in translational medicine and clinical applications. We demonstrate that the knowledge of the chromatin 3D organization may help understand the mechanisms of gene expression regulation of genes involved in the development of human diseases, such as CFTR (responsible for cystic fibrosis) or IGFBP3 (associated with breast cancer pathogenesis). Additionally, 3C-derivative methods have been also useful in the diagnosis of some leukemia subtypes.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 3; 483-489
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Application of molecular techniques to taxonomic studies
    Autorzy:
    Lesicki, A.
    Szweykowska-Kulinska, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/84088.pdf
    Data publikacji:
    1999
    Wydawca:
    Uniwersytet Mikołaja Kopernika. Wydział Biologii i Ochrony Środowiska. Stowarzyszenie Malakologów Polskich
    Tematy:
    application
    molecular technique
    taxonomy
    genome organization
    phylogenetic analysis
    rRNA gene
    animal genome
    mitochondrial genome
    nuclear genome
    DNA hybridization
    mollusc
    phylogenesis
    Źródło:
    Folia Malacologica; 1999, 07, 4
    1506-7629
    Pojawia się w:
    Folia Malacologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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