- Tytuł:
- Self-assembling micelles obtained from PLLA/PEG and PDLA/PEG block copolymers in aqueous solutions
- Autorzy:
-
Wu, X
Li, S. - Powiązania:
- https://bibliotekanauki.pl/articles/285984.pdf
- Data publikacji:
- 2012
- Wydawca:
- Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
- Tematy:
-
polylactide
polyethylene glycol
stereocomplexation
self-assembly
anisotropy - Opis:
- A series ofpolylactide-poly(ethylene glycol) (PLA- PEG) block copolymers were synthesized by ring-opening polymerization of L- or D-lactide in the presence of mono- or dihydroxyl PEG, using nontoxic zinc lactate as catalyst. Micelles were then prepared by direct dissolution of the obtained copolymers in aqueous medium without heating or using any organic solvents. Aqueous gel permeation chromatography and dynamic light scattering measurements were carried out to characterize the resulting micelles. Generally, mixed micelles containing both PLLA/PEG and PDLA/PEG copolymers appear lager and more compact compared to single ones. However, the size of mixed micelles is smaller than that of single ones which exhibit an anisotropic structure since stereocomplexation disfavors the formation of anisotropic micelles. The copolymer parameters such as structures, molar mass and PEG fraction strongly influence the formation of anisotropic micelles, and thus lead to various micellar sizes.
- Źródło:
-
Engineering of Biomaterials; 2012, 15, 113; 6-8
1429-7248 - Pojawia się w:
- Engineering of Biomaterials
- Dostawca treści:
- Biblioteka Nauki
Artykuł