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Wyszukujesz frazę "Lasota, Joanna." wg kryterium: Wszystkie pola


Wyświetlanie 1-3 z 3
Tytuł:
Influence of tire pressure on fuel consumption in trucks with installed tire pressure monitoring system (TPMS)
Autorzy:
Szczucka-Lasota, Bożena
Kamińska, Joanna
Krzyżewska, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/198221.pdf
Data publikacji:
2019
Wydawca:
Politechnika Śląska. Wydawnictwo Politechniki Śląskiej
Tematy:
tire
pressure
monitoring
TPMS
fuel consumption
opona
ciśnienie
zużycie paliwa
Opis:
In recent years, the development of IT systems for fleet monitoring was observed. Tire pressure monitoring systems are constantly improved. Decreased values in tire pressure can cause deformation of tires. Monitoring of tire pressure is an important function in oversized transport trucks. Tire pressure and rolling resistant influence fuel consumption. The purpose of this paper was to determine the impact of tire pressure on fuel consumption in a fleet of trucks with tire pressure monitoring system installed and to determine the impact of other factors that may affect fuel consumption, such as the vehicle weight, brake usage and cruise control usage. The results of the research were developed using a multiple regression model describing the above dependence.
Źródło:
Zeszyty Naukowe. Transport / Politechnika Śląska; 2019, 103; 167-181
0209-3324
2450-1549
Pojawia się w:
Zeszyty Naukowe. Transport / Politechnika Śląska
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Targeting the hypoxia pathway in malignant plasma cells by using 17-allylamino-17-demethoxygeldanamycin
Autorzy:
Kocemba-Pilarczyk, Kinga
Ostrowska, Barbara
Trojan, Sonia
Aslan, Ecce
Kusior, Dorota
Lasota, Małgorzata
Lenouvel, Claire
Dulińska-Litewka, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1038530.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Multiple myeloma
HIF-1
hypoxia
17-AAG
Opis:
Multiple myeloma (MM) is characterized as a clonal expansion of malignant plasma cells in the bone marrow, which is often associated with pancytopenia and osteolytic bone disease. Interestingly, myeloma-infiltrated bone marrow is considered to be hypoxic, providing selection pressure for a developing tumour. Since HSP90 was shown to participate in stabilization of the subunit of the key transcription factor HIF-1, which controls the hypoxic response, the aim of this study was to investigate the influence of a HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG), on MM cells cultured under low oxygenation conditions. We confirmed that 17-AAG inhibits hypoxic induction of the HIF-1 target genes in malignant plasma cells and demonstrate the concentration range of severe hypoxia-specific cytotoxicity. Next, we selected the malignant plasma cells under severe hypoxia/re-oxygenation culture conditions in the presence or absence of 17-AAG and subsequently, the cells which survived were further expanded and analyzed. Interestingly, we have noticed significant changes in the survival and the response to anti-MM drugs between the parental cell lines and those selected in cyclic severe hypoxia in the presence and absence of 17-AAG. Importantly, we also observed that the lack of oxygen itself, irrespectively of HIF-1 inhibition, is the main/pivotal factor driving the selection process in the experiments presented here.
Źródło:
Acta Biochimica Polonica; 2018, 65, 1; 101-109
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-3 z 3

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