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    Wyświetlanie 1-6 z 6
    Tytuł:
    Autoimmunity markers in subjects with diabetes
    Autorzy:
    Litwińczuk-Hajduk, Joanna
    Bernat-Karpińska, Małgorzata
    Kowrach, Marek
    Cielecka-Kuszyk, Joanna
    Piątkiewicz, Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/972601.pdf
    Data publikacji:
    2016
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    diabetes
    anty-GAD
    ANA
    ASMA
    APCA
    Opis:
    Introduction. Diabetes is a growing social and epidemiological problem. Accordingly, the incidence of complications associated with diabetes can cause a persistent high percentage of diseases of the cardiovascular system, kidney and nervous systems, and impaired vision. Objective. The aim of the study was to evaluate the incidence of immunological markers in patients with type 1 diabetes and those with type 2 diabetes: the anti-GAD, ANA, AMA, ASMA, APCA and LKM, compared to healthy people. Another objective of the study was to evaluate the correlation between their presence and the degree of metabolic control in both groups. Materials and methods. The study comprised 100 subjects aged 25–75 years with a body mass index (BMI) between 20–30 kg / m2, hospitalized in the Department of Internal Diseases, Diabetology and Endocrinology, at the Medical University of Warsaw, with previously diagnosed diabetes who were assigned to one of 2 groups (50 subjects with type 1 diabetes and 50 subjects with type 2 diabetes). The control group consisted of 21 healthy individuals without the diagnosis of diabetes and a prediabetic state. All the study participants had the examined antibodies determined along with the panel of biochemical tests and neurological examination for diabetic neuropathy and fundus examination. Results. Anti-GAD antibodies were present in both groups of patients. Their presence was found in 30% of people with type 1 diabetes and in 16% of people with diabetes type 2. The presence of ANA antibodies was found in 24% of people with type 1 diabetes and 22% of people with type 2 diabetes. There was no correlation between the presence of ANA antibodies ANA and duration of diabetes. In the group of patients with type 1 diabetes, there was a correlation between the presence of ANA and the incidence of diabetic polyneuropathy. ASMA and APCA antibodies occurred with equal frequency in both studied groups (4% vs. 10%). There were no antibodies of AMA or anti-LKM in any of the patients. Conclusions. Marking of ANA antibodies in patients with type 1 diabetes may be a marker used to isolate a group of patients at risk of developing diabetic neuropathy. The presence of anti-GAD in type 2 diabetes may be a LADA marker which specifically marks the group of patients with type 2 diabetes, in whom there is a faster metabolic death of beta cells. The current classification of diabetes is vague, and in the near future it should be modified based on specific patient characteristics, phenotypic appearance, as well as the results of additional tests. Determination of antibodies AMA, ASMA, APCA and anti-LKM does not seem to be significant in the diagnosis of diabetes and its chronic complications.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2016, 10, 1; 28-33
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Antyscam : Practical Web Spam Classifier
    Autorzy:
    Luckner, Marcin
    Gad, Michał
    Sobkowiak, Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/226008.pdf
    Data publikacji:
    2019
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    web spam detection
    spam detection
    imbalanced sets classification
    automatic classification
    machine learning
    Opis:
    To avoid of manipulating search engines results by web spam, anti spam system use machine learning techniques to detect spam. However, if the learning set for the system is out of date the quality of classification falls rapidly. We present the web spam recognition system that periodically refreshes the learning set to create an adequate classifier. A new classifier is trained exclusively on data collected during the last period. We have proved that such strategy is better than an incrementation of the learning set. The system solves the starting–up issues of lacks in learning set by minimisation of learning examples and utilization of external data sets. The system was tested on real data from the spam traps and common known web services: Quora, Reddit, and Stack Overflow. The test performed among ten months shows stability of the system and improvement of the results up to 60 percent at the end of the examined period.
    Źródło:
    International Journal of Electronics and Telecommunications; 2019, 65, 4; 713-722
    2300-1933
    Pojawia się w:
    International Journal of Electronics and Telecommunications
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    „Ojcowskim sercem i słowem” - instrukcja wychowawcza autorstwa Hieronima Floriana Radziwiłła
    „Fatherly heart and word” - educational instruction by Hieronim Florian Radziwill
    Autorzy:
    Gad, Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/459614.pdf
    Data publikacji:
    2016
    Wydawca:
    Fundacja Pro Scientia Publica
    Tematy:
    Hieronim Florian Radziwiłł, wychowanie, magnat, szlachta, instrukcja, dziedzic, dzieci
    Hieronim Florian Radziwill, education, lord, nobility, instruction, heir, children
    Opis:
    Hieronim Florian Radziwill was the eighteenth-century magnate, who was married three times. In anticipation of the desired heir he wrote the instruction of education called "Education, which, when the God Almighty allow us to have children, I will give". The instruction consisted of 67 points, in which prince described and explained his educational methods. Although, it might seem to be too strict, at each point was stated a rational substantiation, that explains the points of the magnate’sviews to the reader. There is no possibility to deny the rationale of explanations and arguments with which individual points of the instruction were referenced.
    Hieronim Florian Radziwiłł był XVIII-wiecznym magnatem, który żenił się trzykrotnie. W oczekiwaniu na upragnionego dziedzica napisał instrukcję wychowawczą pt.: „Edukacja, którą, gdy mi Bóg wszechmogący pozwoli mieć dziadki, dać myślę”. Instrukcja liczyła 67 punktów w których książę opisał i wyłożył swoje metody wychowawcze. Pomimo, że miejscami może wydawać się ona nadto surowa, przy każdym punkcie zostało zamieszczone uzasadnienie, które wyjaśnia czytelnikowi poglądy magnata. Nie sposób odrzucić racjonalności wyjaśnień i argumentów, którymi poszczególne punkty pisma zostały opatrzone.
    Źródło:
    Ogrody Nauk i Sztuk; 2016, 6; 215-226
    2084-1426
    Pojawia się w:
    Ogrody Nauk i Sztuk
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    „Najukochańszy tyran” — Hieronim Florian Radziwiłł w listach drugiej żony Magdaleny z Czapskich
    “The dearest tyrant” — Hieronim Florian Radziwiłł in the letters of his second wife, Magdalena z Czapskich
    Autorzy:
    Gad, Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/1901478.pdf
    Data publikacji:
    2019-12-29
    Wydawca:
    Wydawnictwo Uniwersytetu Śląskiego
    Tematy:
    Hieronim Florian Radziwiłł
    Magdalena z Czapskich
    Opis:
    The article is devoted to the relationship of Hieronim Florian Radziwiłł and his second wife, Magdalena z Czapskich. The marriage which was contracted in 1745 lasted for only a few years after which the duchess shared the fate of the magnate’s first wife and in 1750 she fled her husband. On the basis of the extant correspondence the complex relations of the married couple were presented, beginning from the secret wedding that was planned, in a time when Radziwiłł was in the state of separation from his first wife, until the letters which bear the post -1750 date, when the requests of the great lady to her husband that he sent her her things were left unanswered. In the article special emphasis is placed on Radziwiłłowa’s letters which are full of complaints and regret, sent to her husband during his absence from home when the magnate left Biała to engage in business or entertain- ment
    Źródło:
    Wieki Stare i Nowe; 2015, 8, 13; 69-87
    1899-1556
    2353-9739
    Pojawia się w:
    Wieki Stare i Nowe
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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