- Tytuł:
- Formation and characterization of succinoyl chitosan particles loaded with warnerin
- Autorzy:
-
Shagdarova, Balzhima Ts
Ilyina, Alla V.
Lopatin, Sergey A.
Korobov, Vladimir P.
Lemkina, Larisa M.
Varlamov, Valery P. - Powiązania:
- https://bibliotekanauki.pl/articles/1034836.pdf
- Data publikacji:
- 2015
- Wydawca:
- Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
- Tematy:
-
chitosan nanoparticles
coacervation method
succinoyl chitosan
warnerin - Opis:
- This study aims to obtain nanoparticles based on succinoyl chitosan loaded with Warnerin (War-SCNPs), low molecular weight cationic peptide. The nanoparticles of succinoyl chitosan (SCNPs) were prepared by salt coacervation method, and Warnerin loading efficiency on SCNPs was reached 75% in the optimum conditions, particularly, ration (SCNPs : peptide) was equal to (1.75 : 1, μg / ml ). Formed War-SCNPs were stable, had a weak electric charge from (-4.4) to (-14,6) mV. Determining of SCNPs size showed that a main fraction of SCNPs had the size of 160 nm, and after the peptide sorption War-SCNPs size increased up to 330 nm. The experimental data of this study will likely impact War-SCNPs use as therapeutic delivery systems of the peptide to be administered parenteral.
- Źródło:
-
Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 246-253
1896-5644 - Pojawia się w:
- Progress on Chemistry and Application of Chitin and its Derivatives
- Dostawca treści:
- Biblioteka Nauki
Artykuł