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Tytuł:
Cytotoxicity and inhibitory properties against topoisomerase II of doxorubicin and its formamidine derivatives
Autorzy:
Kik, Krzysztof
Studzian, Kazimierz
Wąsowska-Łukawska, Małgorzata
Oszczapowicz, Irena
Szmigiero, Leszek
Powiązania:
https://bibliotekanauki.pl/articles/1040646.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
formamidinodoxorubicins
doxorubicin
topoisomerase II
Opis:
This work was undertaken to compare cytotoxicity, DNA damaging properties and effect on DNA cleavage by topoisomerase II of the anthracycline drug doxorubicin (DOX) and its two derivatives with a formamidino group containing a cyclic amine moiety such as morpholine (DOXM) or hexamethyleneimine (DOXH). The tetrazolium dye colorimetric assay was used to determine the cytotoxic activity of anthracyclines toward L1210 leukemia cells. DNA damage was measured by alkaline elution technique. The effect of anthracyclines on DNA cleavage was studied in a cell-free system containing supercoiled pBR322 DNA and purified human topoisomerase II. The cytotoxicity data and the results of studies on the mechanism of DNA break formation by anthracyclines at the cellular level and in the cell-free system showed that the presence of the formamidino group in the doxorubicin molecule reduced its ability to stimulate DNA cleavage by DNA topoisomerase II. Conclusion: DNA topoisomerase II is not a primary cellular target for DOXM or DOXH. An advantageous feature of formamidinoanthracyclines is their mechanism of cytotoxic action which is not related to the inhibition of DNA topoisomerase II. Therefore this class of anthracyclines seems to be a good source for selection of an anticancer drug directed toward cancer cells with the developed multidrug resistance attributed to the presence of altered DNA topoisomerase II.
Źródło:
Acta Biochimica Polonica; 2009, 56, 1; 135-142
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Efficacy and safety of liposomal doxorubicin in a patient treated for metastatic breast cancer
Autorzy:
Streb, Joanna
Słowik, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1065206.pdf
Data publikacji:
2015
Wydawca:
Medical Education
Tematy:
breast cancer
cardiotoxicity
liposomal doxorubicin
Opis:
Liposomal doxorubicin is a newer form of chemotherapeutic agents that, due to its own special properties, preferably accumulates in cancer tissue. On the other hand, it shows lower affinity to cardiomyocytes and in this way is less cardiotoxic. As a result of that, there is the possibility to use liposomal form of doxorubicin until disease progression or chemotherapy intolerance in palliative setting, without treatment cessation after reaching the maximum cumulative dose of conventional doxorubicin. In this article we describe the case of a female patient diagnosed with breast cancer who was primary treated with adjuvant treatment, including chemotherapy and in whom a disease recurrence occurred after seven years of observation. As a primary palliative treatment the patient received chemotherapy based on liposomal doxorubicin and cyclofosphamide with a very good tolerance. The initial response was partial remission in lungs and in mediastinal lymph nodes. During the whole course of therapy there were no pathological changes in electrocardiogram, no signs and no symptoms of congestive heart failure, and the left ventricular ejection fraction was within normal limits.
Źródło:
OncoReview; 2015, 5, 2; A67-70
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biodistribution of doxorubicin-loaded succinoyl chitosan nanoparticles in mice injected via intravenous or intranasal routes
Autorzy:
Zubareva, Anastasia
Shcherbinina, Tatyana
Varlamov, Valery P.
Svirshchevskaya, Elena
Powiązania:
https://bibliotekanauki.pl/articles/1035197.pdf
Data publikacji:
2014
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
biodistribution
doxorubicin
succinoyl chitosan nanoparticles
Opis:
Chitosan (Chi) is an extremely promising natural biopolymer with remarkable potency for the development of drug and vaccine delivery nanosystems. Various Chi derivatives are used to form nanoparticles (NPs) with unique properties. However, the efficacy of the therapy delivered by Chi NPs depends significantly on NP biodistribution in the body. The aim of this study was the analysis of biodistribution of NPs formed by succinoyl Chi and loaded with doxorubicin (SCNPDOX). We compared the distribution of free DOX and SCNP-DOX after intravenous (i.v.) and intranasal (i.n.) delivery into tumour-bearing mice. Distribution of DOX and SCNP-DOX was comparable after i.v. injection while they differed significantly after i.n. instillation.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 145-154
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Liposomal doxorubicin in first line metastatic HER-2-positive breast cancer for prevention the cardiotoxicity
Autorzy:
Chmielowska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1065040.pdf
Data publikacji:
2015
Wydawca:
Medical Education
Tematy:
HER-2 overexpression
cardiotoxicity
liposomal doxorubicin
Opis:
We describe a 62 year old female with metastatic HER-2-positive breast cancer, and with independent cardiovascular comorbidities. She was earlier treated with J131 therapy due to thyroid toxicity. She developed grade 2 mitral and tricuspid valvular insufficiency as a result of uncontrolled hypertension. In 2013, the patient was diagnosed with luminal B2 breast cancer with liver and bone metastases, and a large infiltration of the left breast together with the surrounding soft tissue. She was treated with liposomal doxorubicin and cyclophosphamide, with the dose of anthracycline slightly reduced to 50 mg/m2 because of the elevated liver enzymes. She was in complete remission during treatment, without any cardiac or hematologic toxicity. The treatment was prolonged to eight cycles until the liver tests returned to normal. The cumulative dose of liposomal doxorubicin amounted to 400 mg/m2 (with the maximum recommended dose of 600 mg/m2). We decided to administer the liposomal form of doxorubicin, which is less cardiotoxic than conventional doxorubicin, as first-line treatment in order to prevent cardiotoxicity in a patient who is a candidate for another cardiotoxic therapy involving trastuzumab in the future. The patient’s disease progressed 10 months following the completion of first-line therapy. There are no cardiologic contraindications to trastuzumab and there are no signs of liposomal doxorubicin-related cardiotoxicity or deterioration of the valvular insufficiency.
Źródło:
OncoReview; 2015, 5, 1; A11-A15
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Aromatic indolinic aminoxyls as antioxidants in cardiac sarcoplasmic reticulum lipid and protein oxidation.
Autorzy:
Kulawiak-Gałąska, Dorota
Woźniak, Michał
Greci, Lucedio
Powiązania:
https://bibliotekanauki.pl/articles/1043805.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
doxorubicin
protein and lipid oxidation
indolinic aminoxyl
Opis:
The results presented demonstrate the influence of aromatic indolinic aminoxyls: 1,2-dihydro-2-ethyl-2-phenyl-3H-indole-3-phenylimino-1-oxyl (IA-C2) and 1,2-dihydro-2-octadecyl-2-phenyl-3H-indole-3-phenylimino-1-oxyl (IA-C18) on oxidation of lipids and proteins of cardiac sarcoplasmic reticulum membranes. We have used doxorubicin and t-butyl hydroperoxide as agents inducing oxidative stress in isolated rat cardiac sarcoplasmic reticulum membrane system. Carbonyl groups were measured as the end product of membrane protein oxidation, and thiobarbituric acid reactive substances were assessed as a marker of lipid peroxidation. Inhibition of peroxidation of certain membrane components depends on the length of acyl chain. Aminoxyl IA-C2 inhibits the lipid peroxidation process while IA-C18 is an efficient protector against protein oxidation.
Źródło:
Acta Biochimica Polonica; 2002, 49, 1; 43-49
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Resistance of gloves and protective clothing materials to permeation of cytostatic solutions
Autorzy:
Krzemińska, Sylwia
Pośniak, Małgorzata
Szewczyńska, Małgorzata
Powiązania:
https://bibliotekanauki.pl/articles/2159915.pdf
Data publikacji:
2017-12-21
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
permeation
cytostatic
protective materials
docetaxel
fluorouracil
Doxorubicin
Opis:
Objectives The objective of the work was to determine the resistance of selected protective clothing and glove materials to permeation of cytostatics such as docetaxel, fluorouracil, and doxorubicin. Material and Methods The following glove materials were used: natural rubber latex (code A), acrylonitrile-butadiene rubber (code B) and chloroprene rubber (code C). In addition, we tested a layered material composed of a non-woven polyester (PES), a polypropylene (PP) film, and a non-woven PP used for protective coats (code D). The cytostatics were analyzed by liquid chromatography with diode array detection. The tested samples were placed in a purpose-built permeation cell modified to be different from that specified in the standard EN 6529:2001. Results The tested materials were characterized by good resistance to solutions containing 2 out of the 3 selected cytostatics: doxorubicin and 5-fluorouracil, as indicated by a breakthrough time of over 480 min. Equally high resistance to permeation of the third cytostatic (docetaxel) was exhibited by natural rubber latex, acrylonitrile-butadiene rubber, and chloroprene rubber. However, docetaxel permeated much more readily through the clothing layered material, compromising its barrier properties. Conclusions It was found that the presence of additional components in cytostatic preparations accelerated permeation through material samples, thus deteriorating their barrier properties. Int J Occup Med Environ Health 2018;31(3):341–350
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2018, 31, 3; 341-350
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modulation of Doxorubicin Cytotoxicity by Isoliquiritin and Cynarin Combination on Different Cancer Cell Lines
Autorzy:
Al-AdamI, Salat G.
Al-Khateeb, EKBAL H.
NUMAN, NAWFAL A.
ABBAS, Mannal M.
Tawfiq, FATIMA A.
Shakya, Ashok K.
Powiązania:
https://bibliotekanauki.pl/articles/895633.pdf
Data publikacji:
2020-06-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
cytotoxicity
doxorubicin
cancer cells
Modulation
Cynarin
Isoliquiritin
Opis:
Natural polyphenolic compounds produced by plant exhibit many pharmacological effects including antioxidant, chemopreventive as well as anticancer properties. This study was conducted to investigate the effect of cynarin ( from Artichoke, Cynara scolymus) and isoliquiritin (from Licorice, Glycyrrhiza uralensis) on doxorubicin (positive control) cytotoxicity in different cell lines including normal (Fibroblasts MCR-5 and Myoblasts H9c2) and cancer (colorectal HCT-116 and hepatocellular HEP-G2) cell lines. The cytotoxic effect of doxorubicin, isoliquiritin and cynarin alone or in different combination was studied on cancer cell lines as well as normal cell lines. The results obtained indicated that both cynarin and isoliquiritin enhance the cytotoxicity of doxorubicin. Both cynarin and isoliquiritin also reduce the cardiotoxicity of doxorubicin on normal cardiac cell lines. The combination of the three compounds (cynarin, isoliquiritin and doxorubicin) result in decrease the cytotoxicity of doxorubicin, which may indicate the presence of interaction and/or antagonism effect between cynarin and isoliquiritin. Cynarin was found to enhance the growth of (HCT-116 and HEP-G2) this might suggest avoiding use of Artichoke in subjects’ susceptibility for these cancers. All results were evaluated using statistical path and showed significant findings. The mechanism of enhanced doxorubicin’s cytotoxicity by cynarin or isoliquiritin also require further investigation to explain the increasing and/or the decreasing effect of these polyphenolic compounds on cytotoxicity of doxorubicin. The current finding can help to start with safe minimum dose of two or three combination of compounds in the context of clinical trials and practice.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 475-484
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Combination of combretastatin A4 phosphate and doxorubicin-containing liposomes affects growth of B16-F10 tumors
Autorzy:
Mitrus, Iwona
Sochanik, Aleksander
Cichoń, Tomasz
Szala, Stanisław
Powiązania:
https://bibliotekanauki.pl/articles/1040651.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
CA4P
doxorubicin
liposomes
combined therapy
Opis:
The study aimed to check the effectiveness of anticancer therapy combining a vascular-disruptive drug (combretastatin phosphate, CA4P) and a liposomal formulation of a chemotherapeutic (doxorubicin). CA4P was synthesized in our laboratory according to a previously described procedure. The antivascular drug and long-circulating doxorubicin-loaded liposomes were used to treat B16-F10 murine melanoma experimental tumors. Seventy-four hours after drug administration, a decrease in the number of tumor blood vessels was apparent and necrotic areas within tumors were visible. Combination therapy consisting of alternate administrations of CA4P and liposomal doxorubicin yielded greater inhibition of tumor growth than monotherapies alone. The best therapeutic results were obtained with the antivascular drug administered intratumorally every second day at 50 mg/kg body mass. In the case of combined therapy, the best results were obtained when the vascular-disruptive agent (CA4P) and the antineoplastic agent (liposomal doxorubicin) were administered in alternation.
Źródło:
Acta Biochimica Polonica; 2009, 56, 1; 161-165
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Efficacy and safety of non-pegylated liposomal doxorubicin in metastatic breast cancer therapy
Autorzy:
Wójcik, Elżbieta
Kufel-Grabowska, Joanna
Gierba-Tomczyk, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1062503.pdf
Data publikacji:
2017
Wydawca:
Medical Education
Tematy:
breast cancer
non-pegylated liposomal doxorubicin
treatment
Opis:
Breast cancer is the most frequently diagnosed female cancer in Poland (over 17,500 women). Anthracyclines have become one of the most important drugs in breast cancer systemic treatment. In the treatment of metastatic disease combination chemotherapy with doxorubicin provides the objective response rate of 60–85%, and the median time of progression-free survival is about 12 months. Non-pegylated liposomal doxorubicin (NPLD) in combination with cyclophosphamide is associated with a lower risk of cardiotoxicity, higher efficacy and more favourable toxicity profile as compared with conventional anthracycline regimes. Two cases of females patients treated with NPLD described in this article demonstrate the importance of the choice of chemotherapy, professional monitoring, early detection and treatment of adverse effects. Non-pegylated liposomal doxorubicin ordained in systemic treatment of stage IV breast cancer prolongs survival and enhances the quality of life. It is a reasonable option for palliative therapy.
Źródło:
OncoReview; 2017, 7, 4; 162-167
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adriamycin cardiomyopathy with congestive heart failure, cardiogenic shock and emergency heart transplant: 30-year follow up
Autorzy:
Mursleen, Asma
Harrison, Eric E.
Powiązania:
https://bibliotekanauki.pl/articles/1065074.pdf
Data publikacji:
2015
Wydawca:
Medical Education
Tematy:
doxorubicin cardiomyopathy
heart transplant survivor
heart transplantation
Opis:
Doxorubicin chemotherapeutic agent is widely utilized for many types of cancers since the late 1960s. Cardiomyopathy is a well-known side effect of doxorubicin often limiting its use. In many cases doxorubicin cardiomyopathy can lead to end stage cardiac failure requiring heart transplantation. The quality of life of heart transplant patients is exceptional with most patients being able to continue normal activities following recovery. There has been significant advancement in cardiac transplantation since it was first attempted in 1967 in Cape Town, South Africa. Drugs such as cyclosporine played an important role in preventing graft failure and prolonging patient survival. Cardiac transplant can extend a patients’ life by over a decade. The patient in this case, Mr. Glen Frank Spurling, has survived 30 years following his cardiac transplant surgery. In this article an overview of doxorubicin cardiotoxicity, cardiac transplantation, and an interview with Mr. Glen Frank Spurling is presented.
Źródło:
OncoReview; 2015, 5, 1; A5-A10
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Methylxanthines (caffeine, pentoxifylline and theophylline) decrease the mutagenic effect of daunomycin, doxorubicin and mitoxantrone
Autorzy:
Piosik, Jacek
Gwizdek-Wiśniewska, Anna
Ulanowska, Katarzyna
Ochociński, Jakub
Czyż, Agata
Węgrzyn, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1041344.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Vibrio harveyi mutagenicity assay
mitoxantrone
doxorubicin
daunomycin
xanthines
Opis:
Previously performed experiments showed that methylxanthines, especially caffeine, may protect cells against cytostatic or cytotoxic effects of several aromatic compounds. One of the proposed mechanisms of this protection is based on stacking interactions between π electron systems of polycyclic aromatic molecules. In this work, we demonstrate that caffeine and other methylxanthines - pentoxifylline and theophylline - significantly decrease mutagenicity of the anticancer aromatic drugs daunomycin, doxorubicin and mitoxantrone. The spectrophotometric titration of these aromatic compounds by methylxanthines indicated formation of mixed aggregates. The concentrations of free active forms of the drugs decreased when the concentrations of methylxanthines increased in the mixture. Therefore, likely methylxanthines may play a role of scavengers of the free active forms of daunomycin, doxorubicin and mitoxantrone.
Źródło:
Acta Biochimica Polonica; 2005, 52, 4; 923-926
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Opracowanie bioresorbowalnych wielowarstwowych nośników polimerowych do kontrolowanego uwalniania doksorubicyny
Elaboration of bioresorbable multilayered polymeric carriers for controlled doxorubicin release
Autorzy:
Stokłosa, K.
Kasperczyk, J.
Dobrzyński, P.
Smola, A.
Powiązania:
https://bibliotekanauki.pl/articles/284022.pdf
Data publikacji:
2010
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
polimery
doksorubicyna
bioresorbowalne polimery
polymers
doxorubicin
bioresorbable polymers
Opis:
W pracy przedstawiono wyniki badań uwalniania i degradacji in vitro do sztucznego płynu mózgowo- rdzeniowego (aCFS) dla wielowarstwowych matryc polimerowych zawierających doksorubicynę jako substancję leczniczą. Proponowany system terapeutyczny zbudowany jest z trzech warstw, tj. 2 zewnętrznych warstw kopolimeru glikolidu z ε-kaprolaktonem i 1 wewnętrznej warstwy kopolimeru glikolidu z D,L-laktydem z 10% zawartością cytostatyka. System wielowarstwowy utworzono przez kompresję w określonych warunkach: temperatury, nacisku i czasu. Postęp degradacji został potwierdzony przy pomocy zmian mikrostruktury łańcuchów metodą spektroskopii magnetycznego rezonansu jądrowego. Kinetykę uwalniania doksorubicyny z matryc jednowarstwowych i trójwarstwowych obserwowano przy pomocy spektroskopii UV-VIS. Zastosowanie trójwarstwowej matrycy pozwoliło na zmniejszenie początkowego wyrzutu leku z powierzchni nośnika polimerowego a tym samym zmniejszenie inhibicji uwalniania do 100 godzin eksperymentu.
In this work the results of in vitro release and degradation to artificial cerebrospinal fluid solution (aCFS) from multi-layered polymeric matrices containing cytostatic drug were performed.. The proposed therapeutic system was constructed from three layers: the glycolide/caprolactone copolymer were used in two external layers and glycolide/D,L-lactide copolymer in internal layer containing 10-weight % of cytostatic agent.. Three-layered drug release system was made by compression at suitable conditions of time, temperature and pressure. The degradation of three-layered polymeric matrices was confirmed on the basis of changes in copolymer chain microstructure using high resolution NMR spectroscopy. Kinetics of doxorubicin release from mono- and three-layered matrices was observed by UV-VIS spectroscopy. Application of three-layered matrix may be used to reduction of burst effect from polymeric carrier surface and to reduction of inhibition effect of doxorubicin release observed in first stage from mono-layered matrix.
Źródło:
Engineering of Biomaterials; 2010, 13, no. 99-101; 64-67
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anticancer activity of some new series of 2-(substituted)amino-1,3-thiazole derivatives
Autorzy:
Bakare, Safyah B.
Powiązania:
https://bibliotekanauki.pl/articles/780055.pdf
Data publikacji:
2019
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
Thiazole
Anticancer
Cell Cycle Analysis
Annexin V
FITC
Doxorubicin
Opis:
A series of thiazole derivatives were synthesized and structurally elucidated by IR, 1H NMR, 13C NMR, mass and elemental analyses. The prepared compounds were screened for their cytotoxic activity against Leukemia HL-60 cell line. Compound 4b was considered as the most promising antitumor candidate among the tested compounds. Mechanism of action of compound 4b evaluated by flow cytometric assay revealed cell cycle arrest at G2/M phase and pre-G1 apoptosis. The ratio of apoptosis was also determined. Moreover, compound 4b increased the concentration of caspase 3 by 4 fold more than untreated control.
Źródło:
Polish Journal of Chemical Technology; 2019, 21, 3; 19-25
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sarcomatoid renal-cell carcinoma: treatment strategy, review of the literature and a case report
Autorzy:
Gębara-Puchniarz, Agnieszka
Hryciuk, Beata
Stec, Rafał
Szczylik, Cezary
Grala, Bartłomiej
Kozłowski, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/1064804.pdf
Data publikacji:
2016
Wydawca:
Medical Education
Tematy:
chemotherapy
doxorubicin
gemcitabine
sarcomatoid renal-cell carcinoma
surgical treatment
Opis:
Introduction: Sarcomatoid renal-cell carcinoma is a very rare cancer characterised with aggressive course of disease and poor prognosis. At present there are no standards of care for this histologic subtype of renal cell carcinoma resistant to various forms of systemic treatment. Methods: The study describes a case of 58 year old woman after left nephrectomy for clear cell carcinoma with sarcomatoid component and after resection of right-kidney tumour for synchronous clear cell carcinoma who received first-line bevacizumab and temsirolimus under the clinical trial, and then second-line chemotherapy based on gemcitabine and doxorubicin and ifosfamide-based third-line chemotherapy. The patient underwent pulmonary metastasectomy twice, and once a metastasectomy for liver metastases. Conclusions: Surgery (including metastases treatment) followed by the systemic chemotherapy seems to be correct option of treatment in patients with renal cell carcinoma with sarcomatoid features. The development of optimum method of systemic treatment requires further prospective randomised trials.
Źródło:
OncoReview; 2016, 6, 4; A184-187
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Administration of liposomal doxorubicin in patients with metastatic breast cancer and significant concomitant cardiovascular conditions
Autorzy:
Bryjak, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/773565.pdf
Data publikacji:
2014
Wydawca:
Medical Education
Tematy:
NLPD
cardiotoxicity
conventional anthracyclines
liposomal doxorubicin
metastatic breast cancer
Opis:
A frequent dilemma faced by an oncologist about to take decision on a chemotherapeutic regime for patients with metastatic breast cancer is how to maintain balance between the expected treatment efficacy and predictable adverse events. In the case of anthracyclines what is problematic is their significant cardiotoxicity, in particular with reference to patients previously treated with them as part of adjuvant therapy. A relatively new method is replacement of conventional doxorubicin with its non-pegylated form, encapsulated in liposomes, which is capable of minimizing the side effects without compromising its therapeutic index. The present article discusses three cases of patients treated with non-pegylated liposomal doxorubicin (NPLD) as first-line chemotherapy administered for metastatic breast cancer. In all three cases considerable clinical improvement was observed, involving remission of pathological lesions and good quality of life.
Źródło:
OncoReview; 2014, 4, 4; A148-A154
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
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