- Tytuł:
- Synthesis of 11C-methionine through gas phase iodination using Synthra MeIPlus synthesis module
- Autorzy:
-
Kilian, K.
Pękal, A.
Juszczyk, J. - Powiązania:
- https://bibliotekanauki.pl/articles/148779.pdf
- Data publikacji:
- 2016
- Wydawca:
- Instytut Chemii i Techniki Jądrowej
- Tematy:
-
11C-methionine
11C-radiopharmaceuticals
gas phase iodination - Opis:
- A method of 11C-methionine synthesis using ‘bubbling’ method is presented. 11C-methionine was synthesized via 11C methylation from L-cysteine thiolactone (2 mg) in a 300 L solution of 2:1:1 (v/v) 1 M NaOH, ethanol, and water at ambient temperature (85°C, 5 min). The radiochemical purity of radiotracer was higher than 99% and enantiomeric purity (L-11C-methionine) was 91.6 ± 0.4%. The fi nal product met the requirements of European Pharmacopoeia monograph. The proposed 11C-methionine synthesis is a reliable tool for routine manufacturing in clinical applications and animal studies.
- Źródło:
-
Nukleonika; 2016, 61, 1; 29-33
0029-5922
1508-5791 - Pojawia się w:
- Nukleonika
- Dostawca treści:
- Biblioteka Nauki
Artykuł