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Wyświetlanie 1-15 z 20
Tytuł:
Functions of tourist maps of towns as a basis for designing their content: an example of pragmatic approach to the map language
Autorzy:
Ostrowski, Jerzy
Ostrowski, Wiesław
Powiązania:
https://bibliotekanauki.pl/articles/1968258.pdf
Data publikacji:
1988-06-01
Wydawca:
Uniwersytet Warszawski. Wydział Geografii i Studiów Regionalnych
Źródło:
Miscellanea Geographica. Regional Studies on Development; 1988, 3; 397-402
0867-6046
2084-6118
Pojawia się w:
Miscellanea Geographica. Regional Studies on Development
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Increased expression of ribosomal protein S2 in liver tumors, posthepactomized livers, and proliferating hepatocytes in vitro.
Autorzy:
Kowalczyk, Piotr
Woszczyński, Marek
Ostrowski, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1043722.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
ribosomal protein S2
partial hepatectomy
hepatocytes
hepatocellular carcinoma
Opis:
The ribosomal protein S2 (RPS2) is encoded by a gene from the highly conserved mammalian repetitive gene family LLRep3. It participates in aminoacyl-transfer RNA binding to ribosome, potentially affecting the fidelity of mRNA translation. These studies were designed to measure the expression of RPS2 during increased cell proliferation. Using Western and Northern blot analyses, we found that the levels of RPS2 protein and its corresponding mRNA were higher in mouse hepatocellular carcinoma, in mouse livers after one-third partial hepatectomy, and in serum-starved cultured hepatocytes following serum treatment. Our study shows that the increased expression of RPS2 correlates with increased cell proliferation. However, whether the altered expression of this protein reflects its involvement in cellular proliferation or represents an associated phenomena is still a key question that needs to be explored.
Źródło:
Acta Biochimica Polonica; 2002, 49, 3; 615-624
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Expression of genes encoding mitochondrial proteins can distinguish nonalcoholic steatosis from steatohepatitis
Autorzy:
Bragoszewski, Piotr
Habior, Andrzej
Walewska-Zielecka, Bozena
Ostrowski, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1041083.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
NAFLD
gene expression
NASH
mitochondria
Opis:
In patients without substantial alcohol use, triglyceride accumulation in the liver can lead to nonalcoholic fatty liver disease (NAFLD) that may progress to nonalcoholic steatohepatitis (NASH). The differential diagnosis between NAFLD and NASH can be accomplished only by morphological examination. Although the relationship between mitochondrial dysfunction and the progression of liver pathologic changes has been described, the exact mechanisms initiating primary liver steatosis and its progression to NASH are unknown. We selected 16 genes encoding mitochondrial proteins which expression was compared by quantitative RT-PCR in liver tissue samples taken from patients with NAFLD and NASH. We found that 6 of the 16 examined genes were differentially expressed in NAFLD versus NASH patients. The expression of hepatic HK1, UCP2, ME2, and ME3 appeared to be higher in NASH than in NAFLD patients, whereas HMGCS2 and hnRNPK expression was lower in NASH patients. Although the severity of liver morphological injury in the spectrum of NAFLD-NASH may be defined at the molecular level, expression of these selected 6 genes cannot be used as a molecular marker aiding histological examination. Moreover, it is still unclear whether these differences in hepatic gene expression profiles truly reflect the progression of morphological abnormalities or rather indicate various metabolic and hormonal states in patients with different degrees of fatty liver disease.
Źródło:
Acta Biochimica Polonica; 2007, 54, 2; 341-348
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Barretts esophagus associates with a variant of IL23R gene
Autorzy:
Gaj, Pawel
Mikula, Michal
Wyrwicz, Lucjan
Regula, Jaroslaw
Ostrowski, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1040756.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Barrett's esophagus
risk
SNP
IL23R
association study
Opis:
Gastroesophageal reflux disease is regarded as a spectrum of diseases: non-erosive reflux disease (NERD), erosive reflux disease (ERD), and the far end of the spectrum represented by patients with Barrett's esophagus. Among predisposing factors, both risk and protective polymorphic variants of several genes may influence the clinical outcomes of reflux disease. Consequently, different molecular mechanisms are likely to underlie the development of clinical variants of reflux disease. Ninety six patients with reflux disease were screened for polymorphisms of CARD15, SLC22A4 (OCTN1), SLC22A5 (OCTN2), DLG5, ATG16L1 and IL23R genes which had previously been found to associate with immune-mediated chronic inflammatory disorders. While none of the polymorphisms were associated with NERD or ERD, the 1142G/A variant of the IL23R gene was found to be a risk variant in Barrett's esophagus patients. The IL23/IL23R pathway may modulate STAT3 transcriptional activity which is an essential regulator not only of immune-mediated inflammation, but also of inflammatory-associated apoptosis resistance. Although the mechanisms of metaplastic transition of inflamed squamous epithelium are undetermined as yet, our findings suggest potential involvement of alternations in the IL23/IL23R pathway as a molecular background of Barrett's esophagus development.
Źródło:
Acta Biochimica Polonica; 2008, 55, 2; 365-369
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A common cis-element in promoters of protein synthesis and cell cycle genes
Autorzy:
Wyrwicz, Lucjan
Gaj, Paweł
Hoffmann, Marcin
Rychlewski, Leszek
Ostrowski, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1041116.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
gel shift assay
regulation of transcription
comparative genomics
gene expression
promoter
bioinformatics
Opis:
Gene promoters contain several classes of functional sequence elements (cis elements) recognized by protein agents, e.g. transcription factors and essential components of the transcription machinery. Here we describe a common DNA regulatory element (tandem TCTCGCGAGA motif) of human TATA-less promoters. A combination of bioinformatic and experimental methodology suggests that the element can be critical for expression of genes involved in enhanced protein synthesis and the G1/S transition in the cell cycle. The motif was identified in a substantial fraction of promoters of cell cycle genes, like cyclins (CCNC, CCNG1), as well as transcription regulators (TAF7, TAF13, KLF7, NCOA2), chromatin structure modulators (HDAC2, TAF6L), translation initiation factors (EIF5, EIF2S1, EIF4G2, EIF3S8, EIF4) and previously reported 18 ribosomal protein genes. Since the motif can define a subset of promoters with a distinct mechanism of activation involved in regulation of expression of about 5% of human genes, further investigation of this regulatory element is an emerging task.
Źródło:
Acta Biochimica Polonica; 2007, 54, 1; 89-98
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of rainfall-runoff models performance for flood computation in mountainous basins
Autorzy:
Soczyńska, Urszula
Nowicka, Barbara
Somorowska, Urszula
Ignar, Stefan
Górski, Dariusz
Ostrowski, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/2013993.pdf
Data publikacji:
1996-06-01
Wydawca:
Uniwersytet Warszawski. Wydział Geografii i Studiów Regionalnych
Źródło:
Miscellanea Geographica. Regional Studies on Development; 1996, 7; 97-106
0867-6046
2084-6118
Pojawia się w:
Miscellanea Geographica. Regional Studies on Development
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mitochondria-associated satellite I RNA binds to hnRNP K protein
Autorzy:
Klimek-Tomczak, Karolina
Mikula, Michał
Dzwonek, Artur
Paziewska, Agnieszka
Wyrwicz, Lucjan
Hennig, Ewa
Ostrowski, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1041284.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
hnRNP K protein
SAGE
mitochondria
satellite I RNA
Opis:
hnRNP K protein, which localizes to the nucleus, cytoplasm and mitochondria, is involved in the various cellular processes that compose gene expression. We used a SAGE-based assay to profile RNAs associated with hnRNP K protein in rat mitochondria. RNA was isolated from mitoplasts obtained from highly purified and RNase-treated mitochondria. Total RNA and RNA associated with hnRNP K protein were then used as input material for generating two SAGE libraries. Mitochondrion-derived tags isolated from the total mitoplast RNA library represented 86.3%, while those isolated from the library constructed from RNA associated with hnRNP K protein represented only 28.2% of selected tags. Thus, an unexpected number of nuclear-encoded RNAs were purified from mitochondria. Many of these transcripts were co-purified with hnRNP K protein, and high levels of nuclear-encoded RNAs co-immunoprecipitating with K protein corresponded to elevated hnRNP K protein levels of the organelle. The most abundant RNAs that were co-purified with hnRNP K protein represented transcripts originating from satellite I DNA. While satellite I RNA levels were higher in the nucleus and cytoplasm than in mitochondria, the most abundant binding of satellite I transcripts to hnRNP K protein was found in mitochondria. The role of satellite I RNA in mitochondria remains to be elucidated.
Źródło:
Acta Biochimica Polonica; 2006, 53, 1; 169-178
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pre-analytical-related variability influencing serum peptide profiles demonstrated in a mass spectrometry-based search for colorectal and prostate cancer biomarkers
Autorzy:
Karczmarski, Jakub
Rubel, Tymon
Mikula, Michal
Wolski, Jan
Rutkowski, Andrzej
Zagorowicz, Edyta
Dadlez, Michal
Ostrowski, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1039544.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
mass spectrometry; peptidome; serum; cancer; fibrinopeptide A
apolipoprotein A-IV
Opis:
Although the degradome, which comprises proteolytic fragments of blood proteins, presents a potential source of diagnostic biomarkers, studies on cancer peptide biomarkers have provided inconsistent conclusions. In the present study, we reevaluated the usefulness of serum degradome analyses for searching peptide cancer biomarker candidates. Particular attention was paid to pre-analytical factors influencing the variability of determined peptide levels, including clotting time and control group selection. Studies were conducted on 44 and 86 serum samples collected from cancer patients and healthy individuals, respectively, using liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS)-based analyses. We identified 1373 unique peptides, nearly 40% of which originated from five blood proteins: fibrinogen alpha chain, apolipoprotein A-IV (APOA4), complement C3, apolipoprotein A-I, and alpha-1-antitrypsin. A set of 118 and 88 peptides exhibited highly significant differences (adjusted p-value ≤ 0.01 and fold change ≥ 2) in pair-wise comparisons of control vs. prostate cancer and control vs. colorectal cancer, respectively, with 37 peptides displaying a consistent direction of change for these pair-wise comparisons. The levels of 67 peptides differed significantly in serum samples collected from healthy individuals immediately prior to colonoscopy and those who underwent colonoscopic examination at least four weeks earlier. Of them, 49 peptides originated from APOA4. Whereas earlier studies, including ours, have utilized fragments of fibrinopeptide A (FPA) to distinguish cancer from healthy cases, here we show that their absolute abundance is a sensitive indicator of clotting time. These observations may have implications for future serum peptidome studies since these issues have not previously been recognized.
Źródło:
Acta Biochimica Polonica; 2013, 60, 3; 417-425
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Up-regulation of human PNPase mRNA by β-interferon has no effect on protein level in melanoma cell lines
Autorzy:
Gewartowski, Kamil
Tomecki, Rafal
Muchowski, Lukasz
Dmochowska, Aleksandra
Dzwonek, Artur
Malecki, Michal
Skurzak, Henryk
Ostrowski, Jerzy
Stepien, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1041287.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
polynucleotide phosphorylase
melanoma
human mitochondria
beta interferon
poly(A) tails
PNPase
Opis:
Human mitochondrial polynucleotide phosphorylase (hPNPase) is an exoribonuclease localized in mitochondria. The exact physiological function of this enzyme is unknown. Recent studies have revealed the existence of a relationship between induction of hPNPase mRNA and both cellular senescence and growth arrest of melanoma cells following β-interferon treatment. The aim of this study was to verify whether the augmented hPNPase mRNA level results in increase of the protein level. In several cell lines established from five metastatic melanoma patients we did not find any such correlation. However, an elevated level of hPNPase protein was observed in interferon-induced HeLa and Jurkat cells. This increase was correlated with a slight shortening of poly(A) tails of mitochondrial ND3 transcript.
Źródło:
Acta Biochimica Polonica; 2006, 53, 1; 179-188
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Transcriptional changes between uninflamed ulcerative colitis and familial adenomatous polyposis pouch mucosa can be attributed to an altered immune response
Autorzy:
Paziewska, Agnieszka
Horbacka, Karolina
Goryca, Krzysztof
Mikula, Michal
Jarosz, Dorota
Dabrowska, Michalina
Krokowicz, Piotr
Karon, Jacek
Ostrowski, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1039136.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
ulcerative colitis
familial adenomatous polyposis
pouch
gene expression
immune response
Opis:
A total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is considered the surgery of choice for definitive management of familial adenomatous polyposis (FAP) and some patients with ulcerative colitis (UC). However, this surgical treatment is often associated with pouchitis, a long-term complication that occurs mostly in UC patients. The purpose of this study was to better define the molecular background of pouchitis. A microarray-based survey was performed using pouch mucosal samples collected from 28 and 8 patients undergoing surgery for UC and FAP, respectively. There were 4,770 genes that significantly differentiated uninflamed from inflamed mucosal samples, and their functional features were represented mostly by metabolic and cell proliferation pathways. In contrast, functional analyses of aberrantly expressed genes between UC and FAP samples, irrespective of mucosal inflammation status, revealed multiple pathways and terms that were linked to changes in immune response. Interestingly, the comparison of uninflamed UC and FAP samples identified a set of 29 altered probe sets, including an inflammation-related transcript encoding a Charcot-Leyden crystal (CLC) protein. The most distinct changes in gene expression profiles differentiating uninflamed UC and FAP pouch mucosal samples were attributed to the Gene Ontology category innate immune response. Our study confirmed that alterations in immune responses can be found between patients who underwent surgery for UC and FAP, independent of the pouch inflammation status. This observation may be important when managing IPAA patients.
Źródło:
Acta Biochimica Polonica; 2015, 62, 1; 69-75
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Gene expression alterations induced by low molecular weight heparin during bowel anastomosis healing in rats
Autorzy:
Krześniak, Natalia
Paziewska, Agnieszka
Rubel, Tymon
Skrzypczak, Magdalena
Mikula, Michał
Dzwonek, Artur
Goryca, Krzysztof
Wyrwicz, Lucjan
Jarosz, Dorota
Laubitz, Daniel
Woszczyński, Marek
Bielecki, Krzysztof
Ostrowski, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1039955.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
heparins
gene expression
wound healing
microarrays
Opis:
Colon anastomosis is therapeutically challenging because multiple, usually undetectable factors influence a spectrum of repair mechanisms. We hypothesized that low molecular weight heparins, routinely administered perioperatively, may differentially affect gene expression related to colon healing. Twenty pairs of untreated and enoxaparin-treated rats underwent left-side hemicolectomy with a primary end-to-end anastomosis. Normal colon and anastomotic bowel segments were resected on day 0 and on days 1, 3, 5, and 7 after surgery, respectively. Serial anastomosis transverse cross-sections were evaluated microscopically and by microarray (Rat Genome 230 2.0, Affymetrix). Differentially expressed probe sets were annotated with Gene Ontology. We also examined the influence of enoxaparin on fibroblast proliferation and viability in vitro. Among the 5476 probe sets, we identified differential expression at each healing time point, yielding 79 subcategories. Most indicated genes were involved in wound healing, including multicellular organismal development, locomotory behavior, immune response, cell adhesion, inflammatory response, cell-cell signaling, blood vessel development, and tissue remodeling. Although we found no intensity differences in histological features of healing between enoxaparin-treated and control rats, treatment did induce significant expression changes during early healing. Of these changes, 83 probe sets exhibited at least twofold changes and represented different functional annotations, including inflammatory response, regulation of transcription, regulation of apoptosis, and angiogenesis. Fibroblast culture confirmed an anti-viability effect of enoxaparin. Enoxaparin affects colon wound-related gene expression profiles, but further studies will resolve whether heparin treatment is a risk factor after intestinal surgery, at least in some patients.
Źródło:
Acta Biochimica Polonica; 2011, 58, 1; 79-87
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Powikłania krwotoczne z przewodu pokarmowego w przebiegu przewlekłej profilaktyki przeciwzakrzepowej antagonistami witaminy K
Autorzy:
Ostrowski, Stanisław
Sawa, Małgorzata
Zagroda, Małgorzata
Prystupa, Andrzej
Mosiewicz, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/553103.pdf
Data publikacji:
2013
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
antagoniści witaminy K
krwawienia
powikłania
Źródło:
Family Medicine & Primary Care Review; 2013, 3; 365-367
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The oxidation of WC-Co knives in wood extract
Autorzy:
Barlak, Marek
Wilkowski, Jacek
Ostrowski, Krzysztof
Werner, Zbigniew
Zagórski, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/2146692.pdf
Data publikacji:
2021
Wydawca:
Szkoła Główna Gospodarstwa Wiejskiego w Warszawie. Wydawnictwo Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie
Tematy:
WC-Co indexable knives
ion implantation
wood extract
oxidation
EDS method
Opis:
The oxidation of WC-Co knives in wood extract. The virgin WC-Co knives for wood machining and those implanted with Mg, Cr, Zn and Ni were corroded in pH 4 wood extract. A change of oxygen content throughout the experiment was determined using EDS method. The obtained results suggest a passivation of the corroded WC-Co material implanted with selected elements.
Utlenianie noży WC-Co w ekstrakcie drzewnym. Wyjściowe noże WC-Co do obróbki drewna oraz noże implantowane jonami Mg, Cr, Zn i Ni zostały poddane korozji w ekstrakcie drzewnym o wartości pH 4. Zmianę zawartości tlenu w trakcie eksperymentu oznaczono metodą EDS. Uzyskane wyniki sugerują wystąpienie zjawiska pasywacji utlenianego materiału WC-Co implantowanego wybranymi pierwiastkami.
Źródło:
Annals of Warsaw University of Life Sciences - SGGW. Forestry and Wood Technology; 2021, 114; 15--25
1898-5912
Pojawia się w:
Annals of Warsaw University of Life Sciences - SGGW. Forestry and Wood Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunoreactivity of proteolytic degradation products of human prostatic acid phosphatase
Autorzy:
Kuciel, Radosława
Mazurkiewicz, Aleksandra
Steuden, Iga
Wasylewska, Ewa
Szkudlarek, Jerzy
Dulińska, Joanna
Ostrowski, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/1045865.pdf
Data publikacji:
1988
Wydawca:
Polskie Towarzystwo Biochemiczne
Źródło:
Acta Biochimica Polonica; 1988, 35, 4; 319-330
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 20

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