Autor: Okruszek, Andrzej - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Synthesis and interaction with thymidylate synthase of 5'-dithiophosphate and 5'-fluorothiophosphate of thymidine
Autorzy:: Gołos, Barbara
Misiura, Konrad
Olesiak, Magdalena
Okruszek, Andrzej
Rode, Wojciech J.
Powiązania:: https://bibliotekanauki.pl/articles/1044856.pdf
Data publikacji:: 1998
Wydawca:: Polskie Towarzystwo Biochemiczne
Źródło:: Acta Biochimica Polonica; 1998, 45, 1; 83-86
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: DNAzyme as an efficient tool to modulate invasiveness of human carcinoma cells
Autorzy:: Wiktorska, Magdalena
Papiewska-Pająk, Izabela
Okruszek, Andrzej
Sacewicz-Hofman, Izabela
Niewiarowska, Jolanta
Powiązania:: https://bibliotekanauki.pl/articles/1040367.pdf
Data publikacji:: 2010
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: cancer cells
DNAzyme
integrin
Opis:: In this study we evaluated efficiency of DNAzymes to modulate motility of cancer cells, an important factor in the progression and metastasis of cancers. For this purpose we targeted β1 integrins that are predominant adhesive receptors in various carcinoma cell lines (CX1.1, HT29, LOVO, LS180, PC-3). To evaluate invasiveness of cancer cells, we used a transwell migration assay that allowed analyzing chemotactic migration of colon carcinoma cell lines across an ECM-coated membrane. Their adhesive properties were also characterized by the analysis of adhesion to fibronectin, laminin and collagen. In addition, the expression of major integrin subunits, selected intact β1 integrins, and other adhesive receptors (ICAM, E-selectin, uPAR) was analyzed by flow cytometry. Inhibition of β1 integrin expression by DNAzyme to β1 mRNA almost abolished the invasiveness of the CX1.1, HT29, LS180, LOVO and PC-3 cells in vitro. These data show that DNAzymes to β1 integrin subunit can be used to inhibit invasiveness of carcinoma cells.
Źródło:: Acta Biochimica Polonica; 2010, 57, 3; 269-275
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki