- Tytuł:
-
Białka błony zewnętrznej fusobacterium nucleatum jako potencjalny czynnik promocji nowotworu jelita grubego
Outer membrane proteins of fusobacterium nucleatum as a potential factor of colorectal cancer promotion - Autorzy:
-
Lesiów, M. K.
Krupa, K.
Komarnicka, U. K.
Walencik, P. K. - Powiązania:
- https://bibliotekanauki.pl/articles/171956.pdf
- Data publikacji:
- 2018
- Wydawca:
- Polskie Towarzystwo Chemiczne
- Tematy:
-
Fusobacterium nucleatum
białka błony zewnętrznej
kompleksy miedzi(II)
reaktywne formy tlenu
Fusobacteriumnucleatum
outer membrane proteins
copper(II) complexes
reactive oxygen species - Opis:
- Fusobacterium nucleatum is a Gram-negative, anaerobic bacterium located in an oral cavity. This bacterium can migrate with blood to the different part of the human body e.g colon. The studies suggest participation of Fn in a colorectal cancer promotion, but a particular mechanism of this disease is still unclear. Colorectal cancer leads to million of new death cases each year. It is third in the worldwide in terms of mortality. The predictions for the coming years are not optimistic. The statistics encourage researchers to know the details of the mechanism of colorectal cancer. It is suggest, that outer membrane proteins of Fn are responsible for development of this disease. Transition metal ions such as Cu(I), Cu(II), Fe(II) can coordinate to proteins and generate free radicals by Fenton reaction. Reactive oxygen species (ROS) destroy important biological macromolecules such as DNA, proteins or lipids and cause different diseases. The paper presents characteristics of Fn and its outer membrane proteins, description of copper(II) complexes and their ability to ROS generation.
- Źródło:
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Wiadomości Chemiczne; 2018, 72, 7-8; 585-596
0043-5104
2300-0295 - Pojawia się w:
- Wiadomości Chemiczne
- Dostawca treści:
- Biblioteka Nauki
Artykuł