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    Tytuł:
    The renaissance of vitamin D
    Autorzy:
    Wierzbicka, Justyna
    Piotrowska, Anna
    Żmijewski, Michał
    Powiązania:
    https://bibliotekanauki.pl/articles/1039195.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    vitamin D
    skin
    vitamin D deficiency
    vitamin D supplementation
    vitamin D analogs
    Opis:
    There is no doubt that vitamin D plays a crucial role in the maintenance of musculoskeletal system. But the function of this ancient molecule presumably ranges far beyond hormone-like regulation, as it could be generated by simple unicellular organisms. First, we are going to discuss the role of vitamin D as a global regulator of homeostasis from a historical perspective, but later we will focus on current views and its relevance to human physiology and pathology. Three milestones are defining the impact of vitamin D on science and humanity. Firstly, discovery that vitamin D is the cure for rickets, brought us supplementation programs and rapid irradiation of this devastating disease. Secondly, detail description of photoproduction of vitamin D, its subsequent metabolism and interaction with vitamin D receptor VDR, provided mechanistic background for future discoveries. Finally, recent large epidemiological studies provided indirect, but strong evidence that optimal level of vitamin D in serum has beneficial effects on our health and protects us from multiple diseases, including cancer. Furthermore, existence of alternative pathways of vitamin D metabolism and multiple intracellular targets broadens our understanding of its physiological activities and offers new and very promising tools for prophylactics and treatment of many diseases of civilization. Although vitamin D (and its derivatives) should not be regarded as a cure-all for every human disease, its beneficial effects on the human health have to be taken under consideration.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 4; 679-686
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Vitamin D – dietary intake, supplementation and metabolic status of Polish adults
    Autorzy:
    Kamińska, Sylwia
    Pikala, Małgorzata
    Dziankowska-Zaborszczyk, Elżbieta
    Bielecki, Wojciech
    Rębowska, Ewa
    Kozakiewicz, Krystyna
    Nadrowski, Paweł
    Drygas, Wojciech
    Kwaśniewska, Magdalena
    Powiązania:
    https://bibliotekanauki.pl/articles/2116712.pdf
    Data publikacji:
    2020-01-17
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    adults
    abdominal obesity
    metabolic disorders
    Polish
    vitamin D supplementation
    vitamin D intake
    Opis:
    ObjectivesContrary to popular opinion on the preventive properties of vitamin D, results of previous studies have been inconclusive. The aim of this research was to evaluate the associations between the intake of vitamin D and metabolic abnormalities in a representative sample of Polish adults.Material and MethodsWithin the framework of the Multi-Center National Population Health Examination Survey (referred to as WOBASZ), a random sample of 2381 adult residents of Poland (53.8% of whom were women) was examined. All the study subjects were extensively reviewed, including 24-h dietary recall. The intake of vitamin D was assessed on the basis of dietary and supplements reviews. Metabolic abnormalities were evaluated using measurements of waist circumference (WC), blood pressure (BP), serum triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and fasting glycemia. Metabolic syndrome was defined according to the International Diabetes Federation.ResultsOf all the study participants, about 4.4 % of women and 2.6% of men declared a regular supplementation of vitamin D. Among women, a significant inverse correlation between vitamin D supplementation and the mean systolic BP was found (p < 0.01). A more substantial relationship was noted after dividing the study subjects according to their body mass. Among obese men, there was a significant inverse relationship between vitamin D intake and the mean systolic BP (p < 0.01) and diastolic BP (p < 0.05), as well as a positive correlation with HDL-C (p < 0.05). Among obese women, a negative correlation was found between vitamin D supplementation and the mean systolic BP (p < 0.01) and diastolic BP (p < 0.05), and a positive correlation with TG (p < 0.05). Among non-obese male subjects, a negative correlation between vitamin D intake and WC was observed.ConclusionsThe obtained findings suggest that the correlation between vitamin D intake and metabolic abnormalities may depend on the obesity status. A higher vitamin D intake may reduce BP and increase HDL-C in obese subjects. The positive relationship between vitamin D intake and TG concentration in women needs further investigation.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2020, 33, 1; 107-118
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Vitamin D3 levels in healthy people, including a group aged over 60, in relation to BMI
    Autorzy:
    Tokarski, Sławomir
    Godala, Małgorzata
    Powiązania:
    https://bibliotekanauki.pl/articles/972728.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    healthy people
    supplementation
    vitamin D deficiency
    BMI
    Opis:
    Vitamin D plays a role not only in the remodeling of bone, but also in functions involving other organs. Its tissue availability depends on dermal synthesis and/or ingestion from diet, as well as on the amount of adipose tissue binding vitamin D into its cells. This study evaluates vitamin D concentrations in relation to body-mass index (BMI) in healthy people aged over 60 and living in the Subcarpathian Province of southeastern Poland. The study involved 246 participants – 172 women (69.9%), 74 men (31.1%), with an average age of 6.9 (±11.9). The mean concentrations of vitamin D, assessed with ECLIA method, was 18 ng/ml, which indicates a marked deficiency in vitamin D. Defined vitamin D deficiency (<20ng/ml) was noted in 62% of participants without any difference between males and females. There was no correlation between BMI and vitamin D deficiency in the studied group. The results suggest the need for vitamin supplementation in healthy people aged over 60 according to the guidelines.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2017, 11, 1; 25-29
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analysis of Vitamin D Content in Dietary Supplements Available in the EU
    Analiza zawartości witaminy D w suplementach diety dostępnych w krajach UE
    Autorzy:
    Domański, Maciej
    Domańska, Anna
    Żukiewicz-Sobczak, Wioletta
    Weiner, Marcin
    Powiązania:
    https://bibliotekanauki.pl/articles/2188115.pdf
    Data publikacji:
    2023-03-31
    Wydawca:
    Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
    Tematy:
    vitamin deficiency
    vitamin D
    dietary supplements
    supplementation
    niedobór witaminowy
    witamina D
    suplementy diety
    suplementacja
    Opis:
    Background. Vitamin D occurs in two forms: D2 (ergocalciferol) and D3 (cholecalciferol). Deficiency of vitamin D can lead to rickets in children, while in adults to osteoporosis, depression and multiple sclerosis. The aim of the pilot study was to analyze dietary supplements in terms of the actual content of vitamin D3. Material and methods. The object of the study was ten random samples of dietary supplements from different manufacturers containing in their composition different values of vitamin D3. The manufacturers included a declaration on the content of vitamin D3 on the packaging. The actual content of vitamin D3 was determined using high-performance liquid chromatography (HPLC). The content of vitamin D3 was determined based on a standard curve. Sigma Aldrich’s Cholecalciferol standard was used. Results. In all the analyzed dietary supplements, the actual content of vitamin D is much lower than declared by the manufacturer. The carried-out tests revealed that the content of vitamin D3 in the analyzed supplements varied from 1.02 to 59.56 μg. In three cases borderline low values of vitamin D3 were noted. Furthermore, supplement 6 and 9 contained too low dosage of vitamin D3 to supplement a daily demand of an organism for this vitamin. Conclusions. Controlling the shortage of vitamin D in an organism decreases the risk of occurrence of civilization diseases. The results of own pilot studies and studies of other authors prove that this type of research should be continued in a wider scope on various food categories.
    Wprowadzenie. Witamina D występuje w dwóch postaciach: D2 (ergokalcyferol) i D3 (cholekalcyferol). Niedobór witaminy D może prowadzić do krzywicy u dzieci, natomiast u dorosłych do osteoporozy, depresji oraz stwardnienia rozsianego. Celem badania pilotażowego była analiza suplementów diety pod kątem rzeczywistej zawartości witaminy D3. Materiał i metody. Obiektem badań było dziesięć losowo wybranych próbek suplementów diety pochodzących od różnych producentów, zawierających w swoim składzie różne wartości witaminy D3. Producenci umieścili na opakowaniu deklarację o zawartości witaminy D3. Rzeczywistą zawartość witaminy D3 określono metodą wysokosprawnej chromatografii cieczowej (HPLC). Zawartość witaminy D3 oznaczono na podstawie krzywej wzorcowej. Zastosowano standard cholekalcyferolu firmy Sigma Aldrich. Wyniki. We wszystkich analizowanych suplementach diety rzeczywista zawartość witaminy D jest znacznie niższa niż deklarowana przez producenta. Przeprowadzone badania wykazały, że zawartość witaminy D3 w analizowanych suplementach wahała się od 1,02 do 59,56 μg. W trzech przypadkach stwierdzono granicznie niskie wartości witaminy D3. Ponadto suplementy 6 i 9 zawierały zbyt małą dawkę witaminy D3, aby uzupełnić dzienne zapotrzebowanie organizmu na tę witaminę. Wnioski. Kontrolowanie niedoboru witaminy D w organizmie zmniejsza ryzyko wystąpienia chorób cywilizacyjnych. Wyniki własnych badań pilotażowych i innych autorów dowodzą, że tego typu badania powinny być kontynuowane w szerszym zakresie w różnych kategoriach żywności.
    Źródło:
    Health Problems of Civilization; 2023, 17, 1; 97-102
    2353-6942
    2354-0265
    Pojawia się w:
    Health Problems of Civilization
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Vitamin D in SARS-CoV-2 infection
    Autorzy:
    Decyk, A.
    Kobylinska, M.
    Antosik, K.
    Kurowska, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/2083105.pdf
    Data publikacji:
    2022
    Wydawca:
    Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
    Tematy:
    COVID-19
    SARS-CoV-2 pandemic
    vitamin D3
    supplementation
    koronawirus SARS-CoV-2
    witamina D3
    suplementacja
    Opis:
    Background. SARS-CoV-2 virus is one of the largest RNA viruses, included in the coronavirus group, showing tropism to airway epithelial cells. SARS-CoV-2 causes an acute respiratory infectious disease, Covid-19. According to WHO reports, mortality due to Covid-19 is higher in the elderly and in those burdened with comorbidities such as diabetes, obstructive pulmonary disease, coronary artery disease, cancer, hypertension, hepatitis B, obesity or chronic kidney disease. Objective. The aim of the study was to review the current literature on the influence and importance of vitamin D levels on the course of SARS-CoV-2 infection. Material and method. A systematic review of studies published from January 1, 2009 to June 31, 2021 has been performed. For this purpose, bibliographic databases such as PubMed and Scopus were searched. The following keywords and combinations were used: Covid-19, vitamin D, 25-hydroxy-vitamin D, vitamin D supplementation, SARS-CoV-2. Results. It has been shown that vitamin D plays an important role in the mechanisms of the innate immunity in the course of the acute respiratory infections. The overlapping factors of the severity of COVID-19 disease, vitamin D deficiency, and the prevalence of obesity, age scare, ethnicity, has led some researchers to hypothesize that vitamin D supplementation may be promising as a preventive or therapeutic measure for COVID-19. Conclusions. A very important factor that has an immunomodulatory character is vitamin D, the adequate supplementation of which can be a preventive or therapeutic measure in case of SARS-CoV-2 infection, especially in elderly people, with obesity and other chronic diseases.
    Źródło:
    Roczniki Państwowego Zakładu Higieny; 2022, 73, 1; 5-12
    0035-7715
    Pojawia się w:
    Roczniki Państwowego Zakładu Higieny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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