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Tytuł:
Are Tandem Classrooms Effective in Developing Intercultural Communicative Competence?
Autorzy:
Koh, Taejin
Choi, Sungeun
Park, Jeong Kyung
Park, Kyungeun
Powiązania:
https://bibliotekanauki.pl/articles/1963619.pdf
Data publikacji:
2020-09-30
Wydawca:
Wydawnictwo Adam Marszałek
Tematy:
Tandem
Intercultural Communicative Competence
International Students
Tandem Classroom
Curriculum
Opis:
The aim of this paper is to explore the effectiveness of tandem classrooms in promoting intercultural communicative competence by comparing the competence of students before and after participation in tandem classes. This research is based on the descriptive statistics from a survey administered at a university in South Korea. The survey was conducted in 2016 during the second semester, and it used students who participated in tandem classrooms by employing a questionnaire to measure the effectiveness of the tandem classrooms in relation to intercultural communicative competence and the students’ perception of their own competence after completing the tandem classes. The result of the research shows that unlike the initial expectations, there is no meaningful sign that the surveyed students have developed intercultural communicative competence, which means that tandem classrooms did not actively help students improve this competence. In this study, an in-depth interview with students was also conducted in 2019 to find out why such a result occurred. Although tandem classrooms would be highly valuable as a language learning method, the approach may require redesigning and reimplementation in great detail to become a method for developing intercultural communicative competence. Therefore, this study highlights the underlying need for a revised curriculum for students attending tandem classrooms.
Źródło:
The New Educational Review; 2020, 61; 87-96
1732-6729
Pojawia się w:
The New Educational Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of technological usefulness of panel production line in shipbuilding process
Autorzy:
Urbański, T.
Graczyk, T.
Taraska, M.
Iwańkowicz, R.
Powiązania:
https://bibliotekanauki.pl/articles/259325.pdf
Data publikacji:
2018
Wydawca:
Politechnika Gdańska. Wydział Inżynierii Mechanicznej i Okrętownictwa
Tematy:
panel production line
welding technology
SAW
SAW-tandem
GMAW-tandem
FCAW
ship hull
Opis:
This paper presents assessment of technological usefulness of panel production line in prefabrication process of large ship hull sections, in which special attention is paid to producibility of welding operations. Basing on the assessment these authors worked out hierarchy of analyzed sequences of welding technological processes as well as production line stands used for the processes. The assessment was performed on the basis of analysis of a concept of panel production line based on real production lines functioning in shipbuilding industry, as well as technical documentation of typical hull sections of a multi-purpose ferry. The presented analysis took into account impact of technological - constructional parameters onto producibility of welding process of prefabricated sections. Among these parameters the following were numbered: mass of the sections and number of their elements, total length of welds, labour consumption, material consumption as well as linear heat input in welding operations. On the basis of the achieved results, places which worsen effectiveness of production line operation were identified, as a result it was possible to formulate proposals for modernization of flow prefabrication line for hull sections.
Źródło:
Polish Maritime Research; 2018, S 1; 134-144
1233-2585
Pojawia się w:
Polish Maritime Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
LEARNER AUTONOMY AS A SOCIAL CONSTRUCT IN THE CONTEXT OF ITALKI
Autorzy:
Anna, Turula
Powiązania:
https://bibliotekanauki.pl/articles/955867.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Marii Curie-Skłodowskiej w Lublinie. IATEFL Poland Computer Special Interest Group
Tematy:
learner autonomy
tandem learning
online ethnography
Opis:
The article looks at language learner autonomy as a social construct in relation to the context and its user based on the example of Italki, a social networking site for tandem language learning. Considering the two foci – the context and the learner – the study is divided into two parts, both carried out from the perspective of online ethnography, each utilising different techniques and tools. Part 1, based on participatory observation and user experience of the author, was aimed at investigating the context of Italki as a language learning environment. Its affordances, noted in the course of the study, are analysed against the three aspects of social learner autonomy (Murray 2014): emotional, political, and spatial, in order to investigate the potential of Italki for interdependent learning. In Part 2 of the study, with its focus on the learner, the data were gathered by means of semi-structured open-ended interviews with Italki users (N=10). One of these interviews evolved into a case study, in which elements of social network analysis (SNA) were utilized to look at learner autonomy of an individual user. The results of the study indicate that learner autonomy in the digital age can be both self- and other-regulated; characterized by learner independence as well as interdependence. All this is very much promoted by new tendencies in language learning and affordances offered by the new media. At the same time, though, the nature of the autonomy exercised will, to a large extent, be determined by individual learner agendas, motives and attitudes.
Źródło:
Teaching English with Technology; 2017, 17, 2; 3-28
1642-1027
Pojawia się w:
Teaching English with Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Tandemly repeated trinucleotides - comparative analysis
Autorzy:
Piwowar, Monika
Meus, Jan
Piwowar, Piotr
Wiśniowski, Zdzisław
Stefaniak, Justyna
Roterman, Irena
Powiązania:
https://bibliotekanauki.pl/articles/1041237.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
trinucleotide tandem repeats
microsatellites
neurodegenerative disease
Opis:
Characteristics of 64 possible tandem trinucleotide repeats (TSSR) from Homo sapiens (hs), Mus musculus (mm) and Rattus norvegicus (rn) genomes are presented. Comparative analysis of TSSR frequency depending on their repetitiveness and similarity of the TSSR length distributions is shown. Comparative analysis of TSSR sequence motifs and association between type of motif and its length (n) using ρ-coefficient method (quantitatively measuring the association between variables in contingency tables) is presented. These analyses were carried out in the context of neurodegenerative diseases based on trinucleotide tandems. The length of these tandems and their relation to other TSSR is estimated. It was found that the higher repetitiveness (n) the lower frequency of trinucleotides tandems. Differences between genomes under consideration, especially in longer than n=9 TSSR were discussed. A significantly higher frequency off A- and T-rich tandems is observed in the human genome (as well as in human mRNA). This observation also applies to mm and rn, although lower abundant in proportion to human genomes was found. The origin of elongation (or shortening) of TSSR seems to be neither frequency nor length dependent. The results of TSSR analysis presented in this work suggest that neurodegenerative disease-related microsatellites do not differ versus the other except the lower frequency versus the other TSSR. CAG occurs with relatively high frequency in human mRNA, although there are other TSSR with higher frequency that do not cause comparable disease disorders. It suggests that the mechanism of TSSR instability is not the only origin of neurodegenerative diseases.
Źródło:
Acta Biochimica Polonica; 2006, 53, 2; 279-287
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
“Three months on, I still sound like an Anglophone”: Tales of Success and Failure told by English and French Tandem Partners
Autorzy:
Scheuer, Sylwia
Horgues, Céline
Powiązania:
https://bibliotekanauki.pl/articles/22446730.pdf
Data publikacji:
2023
Wydawca:
Wydawnictwo Uniwersytetu Śląskiego
Tematy:
corrective feedback
tandem learning
uptake
phonetic developmen
Opis:
This paper reports on two ways in which success and failure can be operationalized and quantified in a non-institutional L2 learning context such as language tandem setting. We draw on the SITAF database, where we gathered 25 hours of video-recorded conversations held by 21 pairs, each consisting of a native speaker of English and a native speaker of French. The tandems performed collaborative tasks in both languages, thus giving each participant ample opportunity to be both the ‘expert’ and the ‘novice’ (learner) part of the dialogue. The tandem partners met regularly and autonomously outside of the recording sessions, and making progress in their L2 was one of their declared goals. Two possible measures of success in achieving this goal are: (1) the quality and quantity of learner uptake which followed the expert’s corrective feedback (CF) during the recorded conversations. Significant differences between the two L1 groups were observed: while 52% of the CF given by the native French speakers met with total uptake, over 52% of the English CF generated no uptake at all; (2) the participants’ own narratives of progress, as both the experts and the learners, obtained through questionnaires they filled out at the end of the program. Our study aims to contribute to the discussion on the stakes of successful L2 informal learning (with a focus on the acquisition of L2 pronunciation) by adopting a perspective which combines learners’ spoken output data and learners’ perceptions of their own language learning activity.
Źródło:
Theory and Practice of Second Language Acquisition; 2023, 9, 2; 1-28
2450-5455
2451-2125
Pojawia się w:
Theory and Practice of Second Language Acquisition
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A tandem version of the cops and robber game played on products of graphs
Autorzy:
Clarke, Nancy
Nowakowski, Richard
Powiązania:
https://bibliotekanauki.pl/articles/744348.pdf
Data publikacji:
2005
Wydawca:
Uniwersytet Zielonogórski. Wydział Matematyki, Informatyki i Ekonometrii
Tematy:
game
cop
tandem-win
pursuit
graph
product
Opis:
In this version of the Cops and Robber game, the cops move in tandems, or pairs, such that they are at distance at most one from each other after every move. The problem is to determine, for a given graph G, the minimum number of tandems sufficient to guarantee a win for the cops. We investigate this game on three graph products, the Cartesian, categorical and strong products.
Źródło:
Discussiones Mathematicae Graph Theory; 2005, 25, 3; 241-249
2083-5892
Pojawia się w:
Discussiones Mathematicae Graph Theory
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Experimental Research of Tandem-Scheme UAV Model Aerodynamic Characteristics
Autorzy:
Masko, O. M.
Kryvokhatko, I. S.
Sukhov, V. V.
Powiązania:
https://bibliotekanauki.pl/articles/213671.pdf
Data publikacji:
2014
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Lotnictwa
Tematy:
UAV
tandem-scheme
aerodynamic characteristics
wingspan
stagger
dihedral angles
Opis:
Tandem-wing aerodynamic scheme became widespread for tube launch UAV due to possibility of required flight performance realization under tight dimension constraints. In this work results of wind tunnel weight and visual tests of UAV model with wingspans about 1 m are presented. Model aerodynamic characteristics were defined by six-component wind tunnel balance at Mach number 0.075 and Reynolds number 187 000 calculated for one wing chord of 0.11 m. Model stagger (390, 490, 590 mm), rear wing dihedral angle (0°, -5°, -9°), forward-to-rear wingspan ratio (0.67; 0.9; 0.92; 1.24) were variable. It was determined that model is longitudinal and directional static stable, has high maximal lift-drag ratio (in range from 10.6 to 13.7) and acceptable maximal lift coefficient without flaps (from 1.05 to 1.09) and critical angle of attack (from 15.1 to 16.4°). Stagger increasing leads to zero or positive maximal lift-drag ratio increasing. If forward wing span is larger than rear wing span than stagger increasing is more effective with zero dihedral angle. If rear wing span is larger than forward wing span than stagger increasing is more effective with negative dihedral angle.
Źródło:
Prace Instytutu Lotnictwa; 2014, 4 (237) December 2014; 63-75
0509-6669
2300-5408
Pojawia się w:
Prace Instytutu Lotnictwa
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of microsatellite instability and loss of heterozygosity in breast cancer with the use of a well characterized multiplex system.
Autorzy:
Powierska-Czarny, Jolanta
Miścicka-Śliwka, Danuta
Czarny, Jakub
Grzybowski, Tomasz
Woźniak, Marcin
Drewa, Gerard
Czechowicz, Włodzimierz
Sir, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1043412.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
microsatellite instability
short tandem repeats
multiplex DNA typing
breast cancer
Opis:
Analysis of microsatellite instability (MI) and loss of heterozygosity (LOH) is recommended for screening patients with sporadic and hereditary malignancies. This study shows an application of a fluorescent hexaplex PCR system for microsatellite typing on A.L.F. DNA Sequencer (Pharmacia Biotech). This technique detects changes in microsatellites providing a time-efficient, reliable and accurate method for MI and LOH analyses. The Fragment Manager software was used for automated size calculation and quantitation of DNA fragments, enabling rapid and precise measurement of allelic ratios. We examined 70 breast cancer and 70 control DNA specimens, classified all the patterns of microsatellite alterations, and set up MI and LOH assessment criteria for the automated multiplex fluorescent method.
Źródło:
Acta Biochimica Polonica; 2003, 50, 4; 1195-1203
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A Comparative Numerical and Experimental Study of Light Weight Materials for Neutralizing Explosive Reactive Armour
Autorzy:
Naeem, Khalid
Hussain, Arshad
Malik, Abdul Qadeer
Abbas, Shakeel
Ahmad, Iftikhar
Farrukh, Sarah
Powiązania:
https://bibliotekanauki.pl/articles/27788026.pdf
Data publikacji:
2021
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
simulation
explosive reactive armour
Kontakt-5
non-initiating precursor
tandem
Opis:
Explosive reactive armour (ERA) consists of an explosive sandwiched between two metal plates fitted on armoured vehicles to enhance their protection. To defeat an ERA mounted vehicle, its ERA must be neutralized first. A precursor fitted in a TANDEM warhead is used for this purpose in two modes. One is to detonate the ERA and the other is without detonation. This paper presents work performed on the ability of light-weight materials to neutralize the Kontakt-5 ERA without detonation. The precursor performing in this manner is known as a non-initiating precursor (NIP). Eight experiments were performed with aluminium, Teflon® and perspex as liners, against Kontakt-5 ERAs at about 90º and 30º inclination. In five of these experiments, the ERA did not detonate, however in three experiments it did detonated. In all of the experiments the precursor over-performed, producing a prominent hole in the target larger than that predicted by simulation. The over-performance was balanced by decreasing the angle of attack. These experiments demonstrated that an NIP depends strongly upon the ERA as well as on the angle of attack. The overall conclusion from this work is that an NIP is a promising technique to defeat a specific ERA without detonation.
Źródło:
Central European Journal of Energetic Materials; 2021, 18, 2; 271--286
1733-7178
Pojawia się w:
Central European Journal of Energetic Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Morphology of an ITO recombination layer deposited on a silicon wire texture for potential silicon/perovskite tandem solar cell applications
Autorzy:
Kulesza-Matlak, Grazyna
Szindler, Marek
Szindler, Magdalena M.
Sypien, Anna
Major, Lukasz
Drabczyk, Kazimierz
Powiązania:
https://bibliotekanauki.pl/articles/27315696.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Stowarzyszenie Elektryków Polskich
Tematy:
tandem solar cell
silicon nanowires
MAE etching
ITO
recombination layer
Opis:
This paper presents research on the deposition of an indium tin oxide (ITO) layer which may act as a recombination layer in a silicon/perovskite tandem solar cell. ITO was deposited by magnetron sputtering on a highly porous surface of silicon etched by the metal-assisted etching method (MAE) for texturing as nano and microwires. The homogeneity of the ITO layer and the degree of coverage of the silicon wires were assessed using electron microscopy imaging techniques. The quality of the deposited layer was specified, and problems related to both the presence of a porous substrate and the deposition method were determined. The presence of a characteristic structure of the deposited ITO layer resembling a "match" in shape was demonstrated. Due to the specificity of the porous layer of silicon wires, the ITO layer should not exceed 80 nm. Additionally, to avoid differences in ITO thickness at the top and base of the silicon wire, the layer should be no thicker than 40 nm for the given deposition parameters.
Źródło:
Opto-Electronics Review; 2023, 31, 4; art. no. e148222
1230-3402
Pojawia się w:
Opto-Electronics Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The tandem scanning reflected light microscope
Autorzy:
Petran, M.
Hadravsky, M.
Boyde, A.
Powiązania:
https://bibliotekanauki.pl/articles/25099.pdf
Data publikacji:
1995
Wydawca:
Polska Akademia Nauk. Instytut Agrofizyki PAN
Tematy:
living tissue
microscopy
tandem scanning reflected light microscope
biological material
Źródło:
International Agrophysics; 1995, 09, 4
0236-8722
Pojawia się w:
International Agrophysics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
AP-MOVPE Technology and Characterization of InGaAsN p-i-n Subcell for InGaAsN/GaAs Tandem Solar Cell
Autorzy:
Dawidowski, W.
Ściana, B.
Zborowska-Lindert, I.
Mikolásek, M.
Latkowska, M.
Radziewicz, D.
Pucicki, D.
Bielak, K.
Badura, M.
Kováč, J.
Tłaczała, M.
Powiązania:
https://bibliotekanauki.pl/articles/226630.pdf
Data publikacji:
2014
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
dilute nitrides
AP MOVPE
subcell
tandem solar cell
J-V characteristics
Opis:
Tandem (two p-n junctions connected by tunnel junction) and multijunction solar cells (MJSCs) based on AIIIBV semiconductor compounds and alloys are the most effective photovoltaic devices. Record efficiency of the MJSCs exceeds 44% under concentrated sunlight. Individual subcells connected in series by tunnel junctions are crucial components of these devices. In this paper we present atmospheric pressure metal organic vapour phase epitaxy (AP-MOVPE) of InGaAsN based subcell for InGaAsN/GaAs tandem solar cell. The parameters of epitaxial structure (optical and electrical), fabrication process of the test solar cell devices and current-voltage (J-V) characteristics are presented and discussed.
Źródło:
International Journal of Electronics and Telecommunications; 2014, 60, 2; 151-156
2300-1933
Pojawia się w:
International Journal of Electronics and Telecommunications
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Calculation of the optimal braking force distribution in three-axle trailers with tandem suspension
Autorzy:
Kamiński, Zbigniew
Powiązania:
https://bibliotekanauki.pl/articles/2105986.pdf
Data publikacji:
2022
Wydawca:
Politechnika Białostocka. Oficyna Wydawnicza Politechniki Białostockiej
Tematy:
agriculture trailer
tandem axles
air braking system
braking force distribution
optimization
Opis:
Heavy agricultural trailers can be equipped with a three-axle chassis with a tandem axle set at the rear and one mounted on a turntable at the front. In such trailers, selection of the distribution of braking forces that meet the requirements of the EU Directive 2015/68, with regard to braking, largely depends on the type of tandem suspension used. The requirements for brake force distribution in agricultural trailers of categories R3 and R4 are described. On this basis, a methodology for calculating the optimal linear distribution of braking forces, characteristic of agricultural trailers with air braking systems, was developed. An analysis of the forces acting on a 24-tonne three-axle trailer during braking was performed for five different suspensions of the rear tandem axle. An optimization algo-rithm using the quasi Monte Carlo method was described, on the basis of which a computer program for selection of the linear distribution of braking forces was developed. The calculations were made for an empty and loaded trailer with and without the weight of the tandem suspension. The most uniform distribution of braking forces was obtained for two leaf spring with dynamic equalization and air suspension, in which the ratio of the braking force of the tandem axle and the total braking force varied between 22.9% and 25.5% for the different calculation variants. A large variation in the braking force distribution was achieved for the two leaf spring suspension, in which the ratio of tandem axle braking force and the total braking force ranged from 2.7% to 6.4% for the leading axle and from 27.8% to 36.2% for the trailing axle. The presented calculation methodology can be used in the initial phase of the design of air braking systems for three-axle agricultural trailers.
Źródło:
Acta Mechanica et Automatica; 2022, 16, 3; 189--199
1898-4088
2300-5319
Pojawia się w:
Acta Mechanica et Automatica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
“I Understood You, But There was This Pronunciation Thing…”: L2 Pronunciation Feedback in English/French Tandem Interactions
Autorzy:
Horgues, Céline
Scheuer, Sylwia
Powiązania:
https://bibliotekanauki.pl/articles/620808.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
Tandem learning
L2 pronunciation
Corrective Feedback (CF)
French learners of English
Opis:
The role of corrective feedback (CF) in L2 development has been the topic of much discussion in SLA literature (see for example Sheen and Ellis 2011 for a recent overview). Researchers have focused their attention on CF provided either by language teachers or by fellow L2 learners, whereas relatively little is known about phonetic feedback offered in a non-institutional setting during peer-to-peer native/non-native interactions as is the case with tandem language learning. Tandem language exchanges represent a special learning environment, as each participant takes turns being the native and the non-native side of the dialogue. Thus, in contrast to the typical L2 learning setting, the hierarchical structure between the participants is fluid: the expert-novice power relationship evolves as the meeting progresses and the conversation switches from one language to the other. In order to see how the distinguishing characteristics of tandem learning (such as solidarity and reciprocity) shape the process of L2 phonetic development in their own specific ways, we collected an English-French Tandem Corpus as part of the SITAF project (Spécificités des Interactions verbales dans le cadre de Tandems linguistiques Anglais-Français), launched at the University of Sorbonne Nouvelle-Paris 3 in October 2012. We gathered linguistic data – both video and audio recorded – from face-to-face conversational exchanges held by 21 pairs of undergraduate students, with each ‘tandem’ consisting of a native speaker of English and a native speaker of French. The dialogues and reading passages were recorded on two occasions separated by a 3-month interval. The present paper offers a preliminary analysis of L2 pronunciation feedback on several renditions of the same text (The North Wind and the Sun), given to the French speakers by their English tandem partners. The passage was produced by each French participant three times: (1) during the ‘monitored’ reading, which was supervised by the English-speaking partner and which led to (2) the ‘second reading’ in the course of the first recording session, and then (3) the ‘final reading’ performed during the second recording session 3 months later. Data analysis will allow us to address the following questions relating to the study of phonetic corrective feedback: What is corrected by the native-speaking partner (henceforth NS)? Segmental or prosodic errors? Phonemic or allophonic deviations? What is the corrective strategy adopted by the NS? Is it explicit correction, recast, or elicitation? What is the learner’s uptake after receiving feedback? We hope that our data brings a valuable and fairly unique contribution to SLA research, helping to establish which errors get corrected and how it may have implications for setting priorities in L2 pronunciation teaching.
Źródło:
Research in Language; 2014, 12, 2; 145-161
1731-7533
Pojawia się w:
Research in Language
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polymorphic variants of MIF gene and prognosis in steroid therapy in children with idiopathic nephrotic syndrome
Autorzy:
Świerczewska, Monika
Ostalska-Nowicka, Danuta
Kempisty, Bartosz
Szczepankiewicz, Aleksandra
Nowicki, Michał
Powiązania:
https://bibliotekanauki.pl/articles/1039333.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
nephrotic syndrome
steroid resistance
MIF gene
single nucleotide polymorphism
short tandem repeat
Opis:
Nephrotic syndrome (NS) is the most common reason of proteinuria in children and can be caused by the pathology of renal glomeruli. Steroid therapy is typically used in this disorder. It has been shown that MIF is a cytokine which counteracts the immunosuppressive properties of glucocorticoids. The aim of this study was looking for a correlation between MIF polymorphisms and genetic susceptibility to steroid resistance in children with INS (Idiopathic NS). Methods: The study was performed in 71 patients with INS including SRNS (steroid resistance nephrotic syndrome) (41) and SSNS (steroid sensitive nephrotic syndrome) (30) and in 30 control subjects. We employed Sanger sequencing and capillary electrophoresis. Linkage disequilibrium was made using Haploview and PHASE. Results: We didn't observe a statistical significance between SNPs detected in patients with INS and controls. Our studies revealed statistical significance for two polymorphisms: rs2070767C > T and rs2000466T > G between patients with SRNS and SSNS. The results for rs34383331T > A are close to being statistically significant. Statistical significance was revealed for CATT5/CATT6 genotype in SRNS group vs SSNS group (OR=4.604, 95%CI=1.356-15.632, p=0.0168). We found that the frequency of 5/X-CATT genotype compared with X/X-CATT genotype was significantly higher in SRNS patients vs SSNS (OR=3.167, 95%CI=1.046-9.585, p=0.0426). In linkage disequilibrium analysis we didn't show involvement in susceptibility to INS and steroid sensitive phenotype. Conclusions: Our results suggest that the role of MIF polymorphisms in the susceptibility to positive response to steroid therapy is still unresolved. It indicates that MIF may be involved in indirect and complex molecular mechanisms of steroid activity in hormone-dependent metabolic pathways in children with INS. Because of ambiguous findings, pleiotropic features of this cytokine require that more research should be undertaken.
Źródło:
Acta Biochimica Polonica; 2014, 61, 1; 67-75
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
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