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Tytuł:
Tandemly repeated trinucleotides - comparative analysis
Autorzy:
Piwowar, Monika
Meus, Jan
Piwowar, Piotr
Wiśniowski, Zdzisław
Stefaniak, Justyna
Roterman, Irena
Powiązania:
https://bibliotekanauki.pl/articles/1041237.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
trinucleotide tandem repeats
microsatellites
neurodegenerative disease
Opis:
Characteristics of 64 possible tandem trinucleotide repeats (TSSR) from Homo sapiens (hs), Mus musculus (mm) and Rattus norvegicus (rn) genomes are presented. Comparative analysis of TSSR frequency depending on their repetitiveness and similarity of the TSSR length distributions is shown. Comparative analysis of TSSR sequence motifs and association between type of motif and its length (n) using ρ-coefficient method (quantitatively measuring the association between variables in contingency tables) is presented. These analyses were carried out in the context of neurodegenerative diseases based on trinucleotide tandems. The length of these tandems and their relation to other TSSR is estimated. It was found that the higher repetitiveness (n) the lower frequency of trinucleotides tandems. Differences between genomes under consideration, especially in longer than n=9 TSSR were discussed. A significantly higher frequency off A- and T-rich tandems is observed in the human genome (as well as in human mRNA). This observation also applies to mm and rn, although lower abundant in proportion to human genomes was found. The origin of elongation (or shortening) of TSSR seems to be neither frequency nor length dependent. The results of TSSR analysis presented in this work suggest that neurodegenerative disease-related microsatellites do not differ versus the other except the lower frequency versus the other TSSR. CAG occurs with relatively high frequency in human mRNA, although there are other TSSR with higher frequency that do not cause comparable disease disorders. It suggests that the mechanism of TSSR instability is not the only origin of neurodegenerative diseases.
Źródło:
Acta Biochimica Polonica; 2006, 53, 2; 279-287
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Newest therapeutic options for adrenoleukodystrophy
Autorzy:
Gołębiowska, Maria
Gołębiowska, Beata
Beń-Skowronek, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/1163988.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
X-ALD
adrenoleukodystrophy
gene therapy
neurodegenerative disorders
Opis:
X-linked adrenoleukodystrophy is a genetic disease correlated with mutation of ATP-binding cassette, which results in errors of peroxisomal beta oxidation and accumulation of impaired very long chain fatty acids. This leads to degeneration of adrenal glands, spinal cord and myelin sheaths. Despite nearly 100 years of ALD history, the treatment is limited to few therapeutic options, mainly Lorenzo’s Oil and Hematopoetic stem cell transplant. Available therapy can only slow the progression of the disease in early stages. The aim of our study was to present the newest therapeutic options in X-ALD. Substantial articles on new treatment of X-ALD from period 2007-2018 in the Asian, European and American regions have been analyzed. Among 219 articles in PubMed Medline database related to therapy and treatment of X-ALD, 13 articles were selected for analysis, reviewed and divided into two main groups: cause-related treatment (11 articles) and symptoms-related treatment (2 articles). Within cause-related treatment, the usage of known medications such as eg. pioglitazone, natural phenols - resveratrol, gene therapy with adenoassociated virus serotype 9 or combined therapies (Hematopoetic Stem Cell Gene Therapy) have been reviewed. Symptoms related treatment attempted to reduce spasticity and secondary dystonia in X-ALD patients. Reviewed research presents progress in development of treatment options for X-ALD, however still in primary in vitro and animal tested stages. Secondary neurological symptoms medication is awaiting for better solutions for ALD patients, in order to improve their Quality of Life and allow symptomless course for a longer time.
Źródło:
World Scientific News; 2018, 108; 133-143
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sub-cellular elemental imaging of human muscle tissues affected by neuromuscular diseases
Autorzy:
Śliż-Szpytna, Patrycja
Lankosz, Marek
Dudała, Joanna
Adamek, Dariusz
Radwanska, Edyta
Kwinta, Borys
Jakšić, Milko
Božičević Mihalić, Iva
Provatas, Georgios
Powiązania:
https://bibliotekanauki.pl/articles/2055672.pdf
Data publikacji:
2021
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
dystrophy
elemental analysis
myopathy
neurodegenerative diseases
PIXE
Opis:
Various types of neuromuscular diseases differ in symptoms, pathology, and clinical picture but one of their common elements is muscle weakness, which could lead to human motor activities impairment and in many cases to shortening of life span and even death due to respiratory failure. That is why it is very important to better understand the underlying causes of these diseases to be able to implement new methods of treatment more effectively. This paper presents the results of the elemental analysis of human muscular tissues affected by dystrophy and myopathy. For this purpose, the particle-induced X-ray emission method was used, which is perfectly suited for measuring light elements. The samples were analysed for differences in the elemental composition of Na, Mg, P, S, Cl, K, Fe, Zn, and Br. The results were presented in the form of elemental concentration maps and a thorough statistical analysis of the obtained data using the advanced statistical methods.
Źródło:
Nukleonika; 2021, 66, 4; 159--164
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
CHARACTERISTICS OF ARABIC HANDWRITING ON GRAPHIC TABLET IN NEURODEGENERATIVE DISEASE: PRELIMINARY RESULTS BETWEEN PATIENTS WITH ALZHEIMER’S DISEASE AND HEALTHY CONTROLS
Autorzy:
Ghita, Aboulem
Ibtissame, Aouraghe
Alae, Ammour
Ghizlane, Khaissidi
Mostafa, Mrabti
Faouzi, Belahsen M
Powiązania:
https://bibliotekanauki.pl/articles/2138163.pdf
Data publikacji:
2022-03-21
Wydawca:
Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
Tematy:
Handwriting
neurodegenerative disease
Alzheimer's disease
graphics tablet
Opis:
Handwriting is a component of the complex language that came about late in the history of mankind and which develops late in human beings. Numerous works have raised changes in both the graphic and kinematic characteristics of writing. Although, age does not modify the lexical and syntactic parameters of language, it can however modify its spatial structure, especially pressure and speed. Many neurodegenerative pathologies, especially Alzheimer's disease, are characterized by a progressive disorganization of writing. Depending on the cognitive stage of the dementia, the graphic gesture deteriorates as does the spatial construction. Objective: Our study aims at assessing the characteristics of Arabic writing in a healthy Moroccan population and to compare it to people with mild to moderate Alzheimer's disease. Our objective is to help health professionals detect early cognitive deterioration in neurodegenerative diseases by analyzing the graphic gesture. Handwriting is captured on a graphic tablet (WACOM) and is analyzed "online" as a sequence of acquired signals (position, pressure, speed and pen inclination) in Moroccan patients with mild to moderate Alzheimer's disease and these were compared to those of normal volunteers. We performed a first analysis of the results from 18 Alzheimer's patients compared to 18 control subjects. The results reveal differences between the control and Alzheimer's groups. AD subjects had lower speeds and accelerations compared to the control subjects. The time spent on paper and in the air was significantly greater in the AD subjects. This preliminary analysis of the results allowed us to identify distinguishing characteristics through the analysis of different handwriting parameters in order to identify the two groups studied.
Źródło:
Acta Neuropsychologica; 2022, 20(1); 53-65
1730-7503
2084-4298
Pojawia się w:
Acta Neuropsychologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
PSYCHOLOGICAL RESOURCES OF CAREGIVERS OF INDIVIDUALS SUFFERING FROM PARKINSON’S DISEASE, AND THEIR DECLARED FEELING OF BURDEN
Autorzy:
Golińska, Paulina
Bidzan, Mariola
Brown, Jason W
Powiązania:
https://bibliotekanauki.pl/articles/2137783.pdf
Data publikacji:
2017-12-13
Wydawca:
Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
Tematy:
caregivers
neurodegenerative diseases
executive function
cognitive dysfunction
sense of coherence
Opis:
The subject literature identifies many predictors of a feeling of burden, yet it often ignores aspects of the psychological and social functioning of caregivers, i.e., resources for efficiently coping with a difficult situation. This study aimed to verify the predictors of a feeling of burden experienced by the caregivers of individuals suffering from Parkinson’s disease, taking into account the cognitive functioning of the patients as well as the psychological resources and social competences of the caregivers themselves. A cross-sectional study was conducted on 20 individuals suffering from Parkinson’s disease and their caregivers. It included a neuropsychiatric examination of the patients, with a special focus on executive functions, as well as an assessment of the psychological and social resources of their caregivers using standard psychometric methods. Self esteem was measured using the SES scale and sense of coherence was measured using SOC-29. The statistical analysis included correlation analysis and multiple hierarchical regression. The duration of the disease as well as cognitive impairments, especially executive dysfunction, are significant predictors of a feeling of burden. A high sense of coherence is associated with a positive assessment of one’s own resources in the context of coping with a difficult situation. The feeling of burden experienced by caregivers of individuals suffering from neurodegenerative disorders is a complex phenomenon, composed of many factors. The predictors discusse in this study point to various individual differences in the psychological resources possessed by caregivers.
Źródło:
Acta Neuropsychologica; 2017, 15(4); 391-405
1730-7503
2084-4298
Pojawia się w:
Acta Neuropsychologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Drosophila melanogaster (Meigen, 1830): A Potential Model for Human Diseases
Autorzy:
Adesola, Ridwan Olamilekan
Lawal, Jadalhaq Taiwo
Oladele, Oluwatobi Emmanuel
Powiązania:
https://bibliotekanauki.pl/articles/1031442.pdf
Data publikacji:
2021
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Drosophila melanogaster
Huntington’s disease
human diseases
neurodegenerative disease
spinocerebellar ataxia type 3
Opis:
Over some time, Drosophila melanogaster (Meigen, 1830), commonly called fruit fly, has been used as a model organism in both scientific and medical research. Drosophila in comparison with other mammalian species shares some basic features like physiological, biological, biochemical, and neurological resemblances which make them suitable for use for biomedical research. Fruit fly can be maintained efficiently at a reduced cost in the laboratory, and it is endorsed as an alternative model compared to other vertebrates. It is confirmed and documented that almost 75 % of human disease-causing genes have functional similarities in Drosophila. Nevertheless, the use of D. melanogaster as a model organism was not narrowed to genetic research only, but several experiments. The use of this organism as a model for human diseases has also led to findings like neurodegenerative diseases, Huntington’s disease, spinocerebellar ataxia type 3, cancer, cardiovascular, inflammation and infectious diseases, and metabolic disorders. The fly is used as an ideal model organism for neurodegenerative disease studies such as Alzheimer’s and Parkinson’s, which have become more predominant in today's aging population due to its complex nervous system which conserved neurological function, and the human disease-related loci. In this review, we presented and discussed Drosophila melanogaster as a model to study several human diseases.
Źródło:
World News of Natural Sciences; 2021, 36; 42-59
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Caring for patients with Huntington disease - a survey of caregivers’ experiences and views
Autorzy:
Domaradzki, J.
Powiązania:
https://bibliotekanauki.pl/articles/3577.pdf
Data publikacji:
2015
Wydawca:
Instytut Medycyny Wsi
Tematy:
carer
patient
human disease
neurodegenerative disease
Huntington's disease
brain disease
behavioural disturbance
experience
Opis:
Introduction. Despite the growing interest in the consequences of caring for patients with Huntington disease (pHD), little is known about the family caregivers of such patients in Poland. Identification of their needs can improve caregivers’ wellbeing, the quality of care and condition of pHD. The aim of this study was to understand the social functioning of family caregivers of pHD and their perception of the caregiving role. Materials and methods. Data was collected from 55 family caregivers of pHD. A structured questionnaire was used consisting of 86 questions subsumed into five domains: ‘Problems’ and ‘Feelings related to caregiving’, ‘Attitude toward caregiving’, ‘Satisfaction with life’ and ‘Perception of healthcare services’. Correlations between the different scales and other characteristics were measured as potential predictors of the burden. Non-parametric statistical methods were used in the analysis. Results. Most respondents experienced a high (50.9%) or moderate (30.95%) feeling of burden. Although 70.9% of caregivers perceived caregiving positively, for many it was a source of negative feelings. Only 10.9% of respondents declared that caregiving decreased their QoL. Carers’ perception of caregiving was mostly influenced by their negative experiences with the healthcare system. Respondents’ domicile, religious practices, age, income, marital status, time of diagnosis and of caregiving, patient’s age and stage of disease also influenced their experiences. Conclusions. Health professionals and policy planners should focus on monitoring caregivers’ health, identifying their needs, sources of distress, and supporting caregivers’ coping strategies. They should also be better educated about the clinical and practical aspects of HD.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2015, 09, 2
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Risk agents related to work and amyotrophic lateral sclerosis: An occupational medicine focus
Autorzy:
Garzillo, Elpidio Maria
Miraglia, Nadia
Pedata, Paola
Feola, Daniela
Lamberti, Monica
Powiązania:
https://bibliotekanauki.pl/articles/2177444.pdf
Data publikacji:
2015-12-23
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
occupational exposure
amyotrophic lateral sclerosis
occupational medicine
neurodegenerative processes
heavy metals
working adults
Opis:
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons. In recent years, in addition to several studies about genetic mechanisms leading to motor neurons damage, various epigenetic theories have been developed, involving the study of the patients’ work and lifestyle. The work aims at focusing the role of occupational exposure related to ALS by literature data analysis. Articles, selected on the basis of keywords, year of publication and topics, are related to occupational exposure, suggesting an impact on ALS onset. The literature review shows that there are still a lot of biases in the studies design, which actually do not allow to draw unequivocal conclusions.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2016, 29, 3; 355-367
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Czy schizofrenia jest chorobą neuodegeneracyjną, czy neurorozwojową?
Is schizophrenia a neurodegenerative or neurodevelopmental disease?
Autorzy:
Rabe-Jabłońska, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/945685.pdf
Data publikacji:
2005
Wydawca:
Medical Communications
Tematy:
dowody
evidence
hipoteza neurodegeneracyjna
hipoteza neurorozwojowa
neurodegenerative hypothesis
neurodevelopmental hypothesis
schizofrenia
schizophrenia
Opis:
According to the neurodevelopmental theory, etiological and pathological factors of a disease occur long before its symptoms. Cessation of the normal course of neuronal development causes disorders in their function and neuronal network, whereas after latency it leads to clinical manifestation of symptoms. In neurodegenerative diseases the specifically pathophysiological process, usually conditioned genetically, impairs selectively the ”sensitive” population of neurons and causes neuropathological symptoms and changes. The course and nature of these dysfunctions depend on superimposing of the pathological process on the normal process of development and puberty, and on individual plasticity and compensatory processes in the central nervous system. Schizophrenia meets some of these criteria, but it does not fit into the narrow definition of neurodegenerative diseases. So far no histopathological, immunocytochemical changes have been found, which would allow to identify the disease. However as early as during the first episode, most patients exhibit some characteristics of clinical deterioration, afterwads the status of most of them gets stabilized at a certain level of cognitive and social functioning, whereas in some patients the severity of the disease and cognitive dysfunctions gradually progress. The progression of schizophrenic process is also reflected in evolution of symptoms in the course of the disease, in biochemical and anatomical changes of the central nervous system. Presently, the neurodegenerative hypothesis of schizophrenia cannot be rejected. It may appear true only in a part of the patients with specific course of the disease, and in some cases neurodegeneration may be superimposed on neurodevelopmental disorders.
Zgodnie z teorią neurorozwojową etiologiczne i patologiczne czynniki choroby występują na długo przed jej objawami. Przerwanie prawidłowego przebiegu rozwoju neuronalnego powoduje zaburzenia ich funkcji oraz sieci neuronalnej, a po okresie latencji doprowadza do klinicznej manifestacji objawów. W chorobach neurodegeneracyjnych specyficzny patofizjologiczny proces, najczęściej uwarunkowany genetycznie, uszkadza selektywnie „wrażliwą” populację neuronów i wywołuje symptomy i zmiany neuropatologiczne. Przebieg w czasie i natura tych dysfunkcji zależy od nałożenia się procesu chorobowego na normalny proces rozwojowy i dojrzewania, a także od indywidualnej plastyczności i procesów kompensacyjnych w OUN. Schizofrenia spełnia niektóre z tych kryteriów, lecz nie mieści się w wąskiej definicji chorób neurodegeneracyjnych. Nie stwierdzono do tej pory zmian histopatologicznych, immunocytochemicznych pozwalających identyfikować schorzenie. Jednak już w okresie I epizodu większość chorych ma cechy klinicznej deterioracji, po czym u wielu z nich stan stabilizuje się na pewnym poziomie funkcjonowania poznawczego i społecznego, natomiast u części pacjentów nasilenie choroby i dysfunkcje poznawcze stopniowo postępują. Progresja procesu schizofrenicznego znajduje także odbicie w ewolucji objawów w miarę przebiegu choroby, zmianach biochemicznych, anatomicznych w OUN. Obecnie nie można odrzucić hipotezy neurodegeneracyjnej schizofrenii. Może się okazać prawdziwa tylko u części chorych ze specyficznym przebiegiem choroby, a w niektórych przypadkach neurodegeneracja może nakładać się na zaburzenia neurorozwojowe.
Źródło:
Psychiatria i Psychologia Kliniczna; 2005, 5, 3; 117-125
1644-6313
2451-0645
Pojawia się w:
Psychiatria i Psychologia Kliniczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
PET and SPECT imaging as a solid guide to detect and discriminate atypical phenotypes of neurodegenerative disorders
Autorzy:
Ruffini, Livia
Zilioli, Alessandro
Cervati, Veronica
Lauretani, Fulvio
Misirocchi, Francesco
Maggio, Marcello
Migliari, Silvia
Graziani, Tiziano
Cidda, Carla
Baldari, Giorgio
Spallazzi, Marco
Scarlattei, Maura
Powiązania:
https://bibliotekanauki.pl/articles/40521373.pdf
Data publikacji:
2024-03-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
atypical phenotypes
neurodegenerative diseases
positron emission tomography
single photon emission computed tomography
Opis:
Introduction and aim. Atypical or mixed presentations of neurodegenerative disorders may postpone or confound the final diagnosis. Molecular imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT) radioligands provide target-specific information and may anticipate the diagnosis by “in vivo” detection of the neuropathological substrate, as Aβ deposition, nigrostriatal dopaminergic depletion or tau inclusions. This concise review will discuss the potential of PET and SPECT imaging as a solid guide to better characterize atypical phenotypes of neurodegeneration in the clinical routine, with the potential to drive personalized interventions, improve cohort uniformity for clinical trials, and serve as biomarkers for targeted molecular therapies. Material and methods. Literature search was performed focusing on the role of PET and SPECT imaging in assessing atypical phenotypes of neurodegeneration, using the electronic source of database PubMed/MEDLINE and the web-based search engines Google, Google Scholar. Analysis of the literature. New disease-modifying drugs may increase their effect with early initiation, which is especially important in working persons and younger subjects presenting atypical symptoms. In older individuals, the coexistence of neurodegeneration, age-related changes, cerebrovascular lesions, or depression makes challenging a definitive diagnosis. Quantitative tools able to measure tracer distribution increase the accuracy of molecular neuroimaging creating topographic maps that compare subject’s data with healthy controls databases. Conclusion. Atypical phenotypes may be associated with quantitative key-pattern allowing a more precise and early diagnosis of the neurodegenerative disorder. Finally, quantitative assessment of the pathological substrates allows us to track the disease process and measure treatment response.
Źródło:
European Journal of Clinical and Experimental Medicine; 2024, 22, 1; 201-221
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characteristics of ketogenic diet and its therapeutic properties in central nervous system disorders
Charakterystyka diety ketogennej i jej właściwości terapeutycznych w chorobach centralnego układu nerwowego
Autorzy:
Liśkiewicz, Arkadiusz
Jędrzejowska-Szypułka, Halina
Lewin-Kowalik, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1039102.pdf
Data publikacji:
2012
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
ketogenic diet
ketone bodies
neurodegenerative disorders
neuroprotection
dieta ketogenna
ciała ketonowe
choroby neurodegeneracyjne
neuroprotekcja
Opis:
A fat-rich and low-carbohydrate ketogenic diet has been successfully used in epilepsy treatment in children and adults for many years. Lately, advances have been made in the use of ketogenics as therapy for other disorders such the tuberous sclerosis complex, brain tumors and neurodegenerative diseases: Alzheimer’s disease and Parkinson’s disease. Many studies have also shown its neuroprotective abilities. This neuroprotection is connected with the molecular mechanisms of a ketogenic diet and ketone metabolism. This review shows how a ketogenic diet induces ketosis, how it works and how the molecular mechanisms of a ketogenic diet may be used in the therapy of central nervous system disorders.
Wysokotłuszczowa, niskowęglowodanowa dieta ketogenna jest terapią, która od wielu lat z sukcesem jest stosowana u dzieci i dorosłych w leczeniu epilepsji. Późniejsze badania pozwoliły na rozszerzenie poszukiwań jej terapeutycznego zastosowania o stwardnienie guzowate, guzy mózgu i schorzenia neurodegeneracyjne, jak choroba Alzheimera i choroba Parkinsona. Wiele badań wykazało również neuroprotekcyjne właściwości tej terapii. Indukowanie neuroprotekcji jest związane z molekularnymi mechanizmami działania diety ketogennej i metabolizmem ciał ketonowych. Niniejsza praca opisuje działanie diety ketogennej oraz jej mechanizmy molekularne, które mogą być wykorzystywane w terapii chorób centralnego układu nerwowego.
Źródło:
Annales Academiae Medicae Silesiensis; 2012, 66, 6; 66-76
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Therapeutic garden design for patients with neurodegenerative diseases
Ogrody terapeutyczne dla pacjentow z chorobami neurodegradacyjnymi
Autorzy:
Olszewska, A. A.
Bil, J. S.
Powiązania:
https://bibliotekanauki.pl/articles/369363.pdf
Data publikacji:
2016
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
Alzheimer's
architecture
dementia
design
garden
landscape
neurodegenerative
therapeutic
Alzheimer
architektura
demencja
krajobraz
neurodegeneracyjne
ogrody
projektowanie
terapeutyczne
Opis:
This paper explores the concept of therapeutic gardens surrounding healthcare institutions treating neurodegenerative diseases, such as Alzheimer’s and Dementias. It focuses on how the design of such spaces can address the specific needs of residents, and describes the recent studies concerning the most relevant guidelines for therapeutic garden design near hospitals, medical centers, and retirement homes. The literature study is compared with results of our recent study on the brain response to different landscapedesign features. According to which an outdoor space with a high level of design compatibility, inward space composition, a clear communication and signage system, while introducing archetypal elements and factoring several visual nuances, can be especially beneficial for patients with neurodegenerative diseases.
Niniejszy artykuł omawia koncepcję ogrodów terapeutycznych przy ośrodkach opieki dla pacjentów z chorobami neurodegeneracyjnymi, takimi jak choroba Alzheimera i demencje. Opisano sposób, w jaki projektowanie takich przestrzeni może wyjść na przeciw specyficznym potrzebom mieszkańców i opisuje najnowsze badania dotyczące wytycznych dla projektowania ogrodów w pobliżu szpitali, ośrodków medycznych i domów spokojnej starości. Przegląd literatury zestawiono z wynikami najnowszych badań na temat wpływu różnych rozwiązań zaprojektowanych w krajobrazie na aktywność mózgu. Zgodnie z tymi badaniami, przestrzenie charakteryzujące się zgodnością projektu, przejrzystym systemem komunikacji i sygnalizacji, wprowadzeniem elementów archetypowych oraz nacisk na szereg wizualnych niuansów, mogą być szczególnie korzystne dla pacjentów z chorobami neurodegeneracyjnymi.
Źródło:
Przestrzeń i Forma; 2016, 25; 259-270
1895-3247
2391-7725
Pojawia się w:
Przestrzeń i Forma
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Flavonoids - food sources and health benefits
Autorzy:
Kozlowska, A.
Szostak-Wegierek, D.
Powiązania:
https://bibliotekanauki.pl/articles/872802.pdf
Data publikacji:
2014
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
flavonoids
plant metabolite
antioxidant effect
human disease
cancer
cardiovascular disease
neurodegenerative disease
nervous system
human nutrition
diet
anticancer effect
Opis:
Flavonoids are a group of bioactive compounds that are extensively found in foodstuffs of plant origin. Their regular consumption is associated with reduced risk of a number of chronic diseases, including cancer, cardiovascular disease (CVD) and neurodegenerative disorders. Flavonoids are classified into subgroups based on their chemical structure: flavanones, flavones, flavonols, flavan-3-ols, anthocyanins and isoflavones. Their actions at the molecular level include antioxidant effects, as well the ability to modulate several key enzymatic pathways. The growing body of scientific evidence indicates that flavonoids play a beneficial role in disease prevention, however further clinical and epidemiological trials are greatly needed. Among dietary sources of flavonoids there are fruits, vegetables, nuts, seeds and spices. Consumption of these substances with diet appears to be safe. It seems that a diet rich in flavonoids is beneficial and its promotion is thus justifiable.
Flawonoidy to grupa związków bioaktywnych występujących powszechnie w żywności pochodzenia roślinnego. Aktualne dane literaturowe wskazują, że substancje te, spożywane wraz z dietą człowieka, wykazują działanie ochronne przed wieloma chorobami przewlekłymi, w tym przed niektórymi nowotworami oraz schorzeniami układu sercowo-naczyniowego, a ponadto pozytywnie wpływają na układ nerwowy. W zależności od struktury chemicznej wyróżnia się takie podklasy flawonoidów jak: flawony, flawanony, flawonole, flawanole, antocyjany i izoflawony. Przypuszcza się, że mechanizm działania tych substancji opiera się na ich silnych właściwościach antyoksydacyjnych oraz innych mechanizmach, takich jak zdolność do modulowania licznych szlaków enzymatycznych. W wielu badaniach wykazano ich korzystne działanie w prewencji chorób przewlekłych. Jednakże poznanie dokładnego metabolizmu tych substancji wymaga prowadzenia dalszych badań. Źródłami flawonoidów w diecie człowieka są warzywa, owoce, orzechy i nasiona, a także niektóre przyprawy. Spożywanie tych substancji wraz z dietą człowieka wydaje się być bezpieczne. Uzasadnionym zatem wydaje się promowanie diety bogatej we flawonoidy.
Źródło:
Roczniki Państwowego Zakładu Higieny; 2014, 65, 2
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chromosomal localization of genes encoding small heat shock proteins (HSPB) in cattle and sheep
Chromosomowa lokalizacja genów kodujących małe białka szoku cieplnego (HSPB) u bydła i owiec
Autorzy:
Danielak-Czech, B.
Kozubska-Sobocińska, A.
Babicz, M.
Powiązania:
https://bibliotekanauki.pl/articles/2196845.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Przyrodniczy w Lublinie. Wydawnictwo Uniwersytetu Przyrodniczego w Lublinie
Tematy:
chromosomal localization
gene encoding
small heat shock protein
cattle
sheep
chromosome
fluorescent in situ hybridization
cytogenetic mapping
neurodegenerative disorder
Źródło:
Annales Universitatis Mariae Curie-Skłodowska. Sectio EE: Zootechnica; 2015, 33, 4; 21-29
0239-4243
2083-7399
Pojawia się w:
Annales Universitatis Mariae Curie-Skłodowska. Sectio EE: Zootechnica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Functioning of Lexical Connections in Patients with Neurodegenerative Diseases. Case Study of a Patient with Spinocerebellar Ataxia (SCA)
Autorzy:
Gatkowska, Izabela
Jauer-Niworowska, Olga
Powiązania:
https://bibliotekanauki.pl/articles/27311267.pdf
Data publikacji:
2023-12-15
Wydawca:
Komisja Nauk Filologicznych Oddziału Polskiej Akademii Nauk we Wrocławiu
Tematy:
linguistics
psychology
experimental lexical network
speech-language disorders
rare neurodegenerative diseases
diagnosis
tools
methods
semantic disorders
cognitive disorders
Opis:
Aim of the research: interdisciplinary description of functioning of lexical connections in a patient with spinocerebellar ataxia (SCA-type1). There is little research on lexical networks in patients with neurodegenerative diseases. Procedure: the subject was asked to give associations to 63 stimuli-lexemes. Tools used in the study: the Experimental lexical network of the Polish language, a digital recorder, an Olympus 650 DM. The Experimental lexical network was developed by Izabela Gatkowska (2017). It was created as a result of the study concerning the associations of 900 healthy Polish-speaking adults. Utterances of the subject were recorded, transcribed and compared with standard data. Results: the reactions of the subject were different from the associations presented in the Experimental lexical network. The most common verbal reactions were: creating definitions of stimuli-word meanings or making comment on them. Associations created by the subject were based on paradigmatic or syntagmatic relations. The authors explain how the specific verbal behaviour of the subject is related to the cognitive and language dysfunctions caused by the cerebellar damages. The results showed that language processing should not be regarded as separate from other cognitive functions. Verbal reactions of the subject are slightly similar to aphasic symptoms, but mostly they are related to cerebellar damage and executive disorders. The results obtained proved the validity of the connection between linguistic and psychological methods and tools in studies which concern the language behaviour of patients with neurodegenerative diseases.
Źródło:
Academic Journal of Modern Philology; 2023, 19; 65-84
2299-7164
2353-3218
Pojawia się w:
Academic Journal of Modern Philology
Dostawca treści:
Biblioteka Nauki
Artykuł
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