- Tytuł:
- Application of genetic semihomology algorithm to theoretical studies on various protein families.
- Autorzy:
-
Leluk, Jacek
Hanus-Lorenz, Beata
Sikorski, Aleksander - Powiązania:
- https://bibliotekanauki.pl/articles/1044159.pdf
- Data publikacji:
- 2001
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
multiple alignment
cryptic mutations
genetic semihomology
sequence consensus - Opis:
- Several protein families of different nature were studied for genetic relationship, correct alignment at non-homologous fragments, optimal sequence consensus construction, and confirmation of their actual relevance. A comparison of the genetic semihomology approach with statistical approaches indicates a high accuracy and cognition significance of the former. This is particularly pronounced in the study of related proteins that show a low degree of homology. The sequence multiple alignments were verified and corrected with respect to the questionable, non-homologous fragments. The verified alignments were the basis for consensus sequence formation. The frequency of six-codon amino acids occurrence versus position variability was studied and their possible role in amino acid mutational exchange at variable positions is discussed.
- Źródło:
-
Acta Biochimica Polonica; 2001, 48, 1; 21-33
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł