- Tytuł:
- Interactions of Some Organic Solvents: Hydrocarbons and Chloroalkene
- Autorzy:
-
Skowroń, J.
Miranowicz-Dzierżawska, K.
Zapór, L.
Gołofit-Szymczak, M.
Starek, A. - Powiązania:
- https://bibliotekanauki.pl/articles/90439.pdf
- Data publikacji:
- 2001
- Wydawca:
- Centralny Instytut Ochrony Pracy
- Tematy:
-
n-hexane
ethylbenzene
tetrachloroethylene
metabolic interactions
toxicodynamic interactions
interakcje metaboliczne
tetrachloroetylen
etylobenzen - Opis:
- Metabolic and toxicodynamic interactions of some organic solvents in rats repeatedly treated with medium dose levels were examined. It was shown that both n-hexane and ethylbenzene significantly inhibited tetrachloroethylene metabolism during a 2-week period. n-Hexane and tetrachloroethylene enhanced metabolism of ethylbenzene whereas ethylbenzene suppressed n-hexane metabolism only at the end of the experiment. Biochemical changes, especially the drop in the level of non-protein sulfhydryl groups in tissues of rats treated with organic solvent mixtures, were significantly less pronounced than those observed after these chemicals were administered separately. These results demonstrate that metabolic interactions between hydrocarbons and chloroalkene may lead to a modification of the biological response to these compounds.
- Źródło:
-
International Journal of Occupational Safety and Ergonomics; 2001, 7, 1; 35-47
1080-3548 - Pojawia się w:
- International Journal of Occupational Safety and Ergonomics
- Dostawca treści:
- Biblioteka Nauki
Artykuł