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Tytuł:
Psychological Well-Being in Women with Insulin Resistance and the Role of Sense of Self-Dignity
Autorzy:
Gabryś, Agnieszka
Gulip, Małgorzata
Powiązania:
https://bibliotekanauki.pl/articles/31341014.pdf
Data publikacji:
2023
Wydawca:
Katolicki Uniwersytet Lubelski Jana Pawła II. Towarzystwo Naukowe KUL
Tematy:
insulin resistance
psychological well-being
self-dignity
women with insulin resistance
Opis:
The aim of this study was to examine the contribution of the sense of self-dignity in accounting for the variability of psychological well-being in women with insulin resistance. The sample consisted of 109 women diagnosed with insulin resistance. The associations between the variables were examined using correlation and regression analyses. The study found significant relationships between dimensions of the sense of self-dignity and psychological well-being in the surveyed women. The loss dimension of the sense of self-dignity had the highest contribution in accounting for all the dimensions of psychological well-being. Although weaker than for the loss dimension, a statistically significant contribution was also found for the total score of the sense of self-dignity in the surveyed women with insulin resistance.
Źródło:
Roczniki Psychologiczne; 2023, 26, 1; 83-93
1507-7888
Pojawia się w:
Roczniki Psychologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Relationship between obesity, insulin resistance and cell membrane properties
Autorzy:
Ahyayauch, Hasna
Powiązania:
https://bibliotekanauki.pl/articles/25106323.pdf
Data publikacji:
2023-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
insulin resistance
membrane properties
obesity
Opis:
Introduction and aim. The obesity is one of the greatest public health problems in developing countries and it is a triggering factor for diabetes associated with insulin resistance. The importance of cell membrane lipids as essential regulators of insulin resistance, since changes in the dynamic properties of the cell membrane (e.g., membrane fluidity), could be one of the events by which obesity affects insulin sensitivity. Thus, the insulin resistance may not only be a cause but also a consequence of lipid disorders such as dyslipidemia and/or cell membrane phospholipid composition change. The modification of plasma membrane lipid composition can change membrane biophysical properties and thus influencing protein-lipid interactions, enzymatic activity and regulation of surface receptors. Alterations in the lipid composition modify the fluidity of plasma membranes and the expression of membrane functions, such as receptor binding and enzyme activities. This review summarizes the current knowledge on the effects of the modulation of plasma membrane lipid composition and membrane fluidity in the functionality of membrane proteins involved in insulin activity, including the insulin receptor, glucose transport and Na+/K+ ATPase and, in turn, the key features of the metabolic syndrome. Material and methods. References for that article were found through PubMed and Google Scholar, using terms: “obesity”, “insulin resistance” and “membrane properties”. The research was limited to abstracts and available full-text articles. Analysis of the literature. There is a strong relationship between dietary lipids, membrane lipid profiles and insulin resistance. The changes in the dynamic properties of the cell membrane (e.g., membrane fluidity), could be one of the events by which obesity affects insulin sensitivity. The modification of plasma membrane lipid composition can change membrane biophysical properties and thus influencing protein–lipid interactions, enzymatic activity, and regulation of surface receptors. Modifications of membrane phospholipid composition could have a role in the insulin action by altering membrane fluidity and, as a consequence, the insulin signaling pathway. Conclusion. As conclusion the membrane-lipid therapy approach can be used to treat important pathologies such as obesity and many others diseases such as : cancer, cardiovascular pathologies, neurodegenerative processes, obesity, metabolic disorders, inflammation, and infectious and autoimmune diseases. This pharmacological strategy aims to regulate cell functions by influencing lipid organization and membrane fluidity, inducing a concomitant modulation of membrane protein localization and activity which might serve to reverse the pathological state. Through this review we suggest an in-depth analysis of the membrane lipid therapy field, especially its molecular bases and its relevance to the development of innovative therapeutic approaches.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 2; 357-364
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Myocardial remodeling in rats with metabolic syndrome: role of Rho-kinase mediated insulin resistance
Autorzy:
Li, Chuan-Bao
Li, Xiao-Xing
Chen, Yu-Guo
Gao, Hai-Qing
Bao, Cheng-Mei
Liu, Xiang-Qun
Bu, Pei-Li
Zhang, Juan
Zhang, Yun
Ji, Xiao-Ping
Powiązania:
https://bibliotekanauki.pl/articles/1039743.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Rat
Metabolism
Myocardium
Phosphorylation
Insulin resistance
Opis:
Insulin resistance (IR) plays a critical role in metabolic syndrome (MS). Previous studies have demonstrated that activated ROCK is increased in MS patients. However, the effect of Rho-kinase (ROCK) on IR has not been definitely determined. Thus, the aims of the present study were to determine whether ROCK activation induces IR or affects myocardial structure and function, as well as the possible mechanisms underlying this process. Wistar rats fed high fat, high glucose and high salt diet sewed as model of MS and we used transmission electron microscopy, echocardiogram technology, and terminal deoxynucleotidyl transferase-mediated DNA nick-end labeling staining to identify any myocardial damage. The protein levels of MYPT-1 (characteristic of ROCK activation), IRS-1 and AKT were analyzed by immunohistochemistry and Western blotting. In hearts from MS rats, we found increased protein levels of phospho-MYPT-1 and phospho-IRS-1 (Ser307) and decreased phospho-AKT compared to levels in normal rats. In conclusion, the results suggest that ROCK-mediated IR is involved in the development of myocardial impairments in MS rats and that this effect is mediated probably via the IRS-1/PI3-kinase/AKT pathway.
Źródło:
Acta Biochimica Polonica; 2012, 59, 2; 249-254
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cardiovascular system diseases in patients with polycystic ovary syndrome - the role of inflammation process in this pathology and possibility of early diagnosis and prevention
Autorzy:
Marciniak, Aleksandra
Nawrocka-Rutkowska, Jolanta
Brodowska, Agnieszka
Wiśniewska, Berenika
Starczewski, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/989746.pdf
Data publikacji:
2016
Wydawca:
Instytut Medycyny Wsi
Tematy:
pcos
cvd
insulin resistance
obesity
inflammation
Opis:
Polycystic ovary syndrome is a disorder which affects 5–10% of women in reproductive age. PCOS is a cause of hyperandrogenism, menstrual disorders and infertility. The most common clinical symptoms are hirsutism, acne and obesity. Patients often suffer from metabolic disorders: insulin resistance, hyperinsulinemia, dislipidemia, leading to atherosclerosis and others irregularities of the metabolic syndrome. Patients are in the high risk group for cardiovascular diseases (CVD) development because of the metabolic abnormalities. Obesity is observed in 35–60% of women with PCOS. Lean women with PCOS are also exposed to a greater risk of glucose intolerance development and abnormalities in lipid profile than women without PCOS with comparable BMI. Adipocytes are the source of many compounds of the paracrine and endocrine activity. Some of them are also markers and mediators of inflammation. Increased levels of proinflammatory cytokines in blood can promote atherosclerosis and cardiovascular disease. Markers: IL-18, TNF, IL-6 and hs-CRP are often elevated in patients with polycystic ovary syndrome. An increase in inflammatory markers may be an early indicator of the risk of developing insulin resistance and atherosclerosis, and may become a useful prognostic and therapeutic tool for monitoring patients with PCOS: lean and those with overweight and obesity. Assessment of the concentrations of inflammatory markers may become a very useful test in evaluating the risk of developing atherosclerosis and cardiovascular disease, long before their clinical manifestation. It will also allow for the appropriate prophylaxis.
Źródło:
Annals of Agricultural and Environmental Medicine; 2016, 23, 4
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Obesity-diabetes-endocrinopathy – the metabolic connection
Autorzy:
Kozakowski, Jarosław
Dudek, Piotr
Zgliczyński, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2216797.pdf
Data publikacji:
2022-12-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
diabetes
endocrinopathy
hypogonadism
insulin resistance
obesity
Opis:
Introduction and aim. The article outlines the mechanisms of interrelationships between obesity, type 2 diabetes, and certain disorders of the endocrine system. The paper explains how insulin resistance develops, which is a key link between obesity and several related disorders, how hypercortisolemia leads to the development of obesity and glucose intolerance, why thyroid dysfunctions are bidirectionally associated with metabolic disturbances, in what way excessive body weight leads to the hypogonadism in men, or how menopause promotes the development of abdominal obesity, carbohydrate intolerance and, in some cases type 2 diabetes. Material and methods. Scientific articles were reviewed by searching for information using the online database with scientific articles, including PubMed, Google Scholar and other available scientific databases. Analysis of the literature. The huge prevalence of obesity, diabetes, and hormonal disorders (e.g., autoimmune thyroid disease, female and male hypogonadism) over the contemporary world together with the serious health consequences of these conditions makes up a specific triangle of metabolic connections, increasingly absorbing the human, organizational and financial resources of health systems. Conclusion. Recognizing the relationship between the components of this triangle and understanding the risks arising from this phenomenon may allow to effectively reduce its impact on our health.
Źródło:
European Journal of Clinical and Experimental Medicine; 2022, 4; 459-469
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Raised plasma insulin level and homeostasis model assessment (HOMA) score in cerebral malaria: evidence for insulin resistance and marker of virulence
Autorzy:
Eltahir, Elrashid
ElGhazali, Gehad
A-Elgadir, Thoraya
A-Elbasit, Ishraga
Elbashir, Mustafa
Giha, Hayder
Powiązania:
https://bibliotekanauki.pl/articles/1040314.pdf
Data publikacji:
2010
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
insulin resistance
virulence
hyperglycaemia
HOMA
cerebral malaria
Opis:
Objective: To study the glycaemic profile of patients with severe malaria (SM). Methods: For this purpose, 110 SM patients were recruited. Pre-treatment random blood glucose and plasma insulin were measured in a subset of donors. An ex-vivo experiment was developed for estimation of glucose consumption by parasitized erythrocytes. Results: Hyperglycaemia was frequent in SM but more commonly associated with cerebral malaria (CM), while hyperinsulinaemia was recognized in severe-malarial-hypotension (median, 25 %-75 %, 188.2, 93.8-336.8 pmol/L). The plasma insulin level was positively correlated with age (CC = 0.457, p < 0.001) and negatively with parasitaemia (CC = -0.368, p = 0.045). Importantly, fatal-CM was associated with hyperglycaemia (12.22, 6.5-14.6 mmol/L), hyperinsulinaemia (141.0, 54.0-186.8 pmol/L) and elevated homeostasis model assessment (HOMA) values. However, there was a trend of higher glucose consumption by parasites in CM compared with that in uncomplicated malaria (UM). Conclusion: Hyperglycaemia, hyperinsulinaemia and elevated HOMA are evidence for insulin resistance and possibly pancreatic B-cell dysfunction in fatal-CM.
Źródło:
Acta Biochimica Polonica; 2010, 57, 4; 513-520
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preparation of patients submitted to thyroidectomy with oral glucose solutions
Autorzy:
Lubiszewski, Michał
Drozda, Rafał
Śmigielski, Janusz
Kuzdak, Krzysztof
Kołomecki, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1394599.pdf
Data publikacji:
2012
Wydawca:
Index Copernicus International
Tematy:
postoperative insulin-resistance
thyroidectomy
response to injury
Opis:
The aim of the study was to determine postoperative insulin-resistance in patients subject to total thyroidectomy, the prevalence of subjective feelings of hunger immediately before surgery, and the incidence of nausea/ vomiting after surgery in patients prepared for elective operations by means of oral glucose solutions. Material and methods. The study group comprised 115 patients, including 71 patients prepared for surgery by means of oral glucose solutions (12.5% glucose) administered 12 and 3 hours before the procedure, at a dose of 800 and 400 ml. The control group comprised 44 patients prepared for surgery by means of the traditional manner- the last meal was served before 2pm the day before the surgical procedure, while fluids before 10pm. Considering both groups, we evaluated glucose and insulin levels three times, as well as determined the insulin-resistance ratio (HOMA-IR) 24 before, and 12 hours and 7 days after surgery. The incidence of nausea and vomiting after surgery, and the subjective feeling of hunger before surgery were also evaluated. Results. Statistically significant differences considering insulin level and HOMA-IR values were observed during the II and III measurements. The glucose and insulin values, and the HOMA-IR insulinresistance ratio, showed no statistically significant differences during measurement I. No statistically significant glucose level differences were observed during measurements II and III. A significantly greater subjective feeling of hunger before surgery and nausea/vomiting afterwards were observed in the control group. Conclusions. The preparation of patients with oral glucose solutions decreases the incidence of postoperative (thyroidectomy) insulin-resistance, and occurrence of nausea/vomiting during the postoperative period.
Źródło:
Polish Journal of Surgery; 2012, 84, 5; 253-257
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Liver mitochondria and insulin resistance
Autorzy:
Vial, Guillaume
Dubouchaud, Hervé
Leverve, Xavier
Powiązania:
https://bibliotekanauki.pl/articles/1040285.pdf
Data publikacji:
2010
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
oxidative phosphorylation
insulin resistance
mitochondria
membrane potential
Opis:
With a steadily increasing prevalence, insulin resistance (IR) is a major public health issue. This syndrome is defined as a set of metabolic dysfunctions associated with, or contributing to, a range of serious health problems. These disorders include type 2 diabetes, metabolic syndrome, obesity, and non-alcoholic steatohepatitis (NASH). According to the literature in the field, several cell types like β-cell, myocyte, hepatocyte and/or adipocyte, as well as related complex signaling environment involved in peripheral insulin sensitivity are believed to be central in this pathology. Because of the central role of the liver in the whole-body energy homeostasis, liver insulin sensitivity and its potential relationship with mitochondrial oxidative phosphorylation appear to be crucial. The following short review highlights how liver mitochondria could be implicated in IR and should therefore be considered as a specific therapeutic target in the future.
Źródło:
Acta Biochimica Polonica; 2010, 57, 4; 389-392
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
AS-30D hepatoma as a model to study on insulin resistance in vitro
Autorzy:
Wierzbicka-Bregier, Katarzyna
Brutkowski, Wojciech
Borkowska, Anna
Milewski, Krzysztof
Zabłocki, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1039458.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
AS-30D hepatoma
insulin resistance
palmitate
rosiglitazone
Opis:
Studies on insulin resistance of liver cells are often performed with the use of various hepatoma cell lines. Such an approach allows investigating selected biochemical pathways at the cellular level. However, possible modifications of metabolic processes due to the neoplastic nature of such cells must be considered. Expanding the diversity of hepatoma cell lines used in metabolic studies could deliver new data for comparison with those obtained for other cell lines and should reduce the risk of misleading conclusions. In this study rat hepatoma AS-30D cells were tested as a potential model for studies on palmitate-induced insulin resistance. It was found that insulin-induced Akt kinase phosphorylation was substantially reduced in cells incubated with palmitate at a concentration as low as 75 µM. This effect was not accompanied by excessive reactive oxygen species (ROS) generation or increased Jun N-terminal kinase (JNK) phosphorylation. Moreover, preincubation of AS-30D cells with rosiglitazone, an antidiabetic agonist of peroxisome proliferator-activated receptor gamma (PPARγ), efficiently prevented the palmitate-induced insulin resistance. We conclude that AS-30D hepatoma cells may be used as a model sensitive to insulin and vulnerable to palmitate-induced insulin resistance.
Źródło:
Acta Biochimica Polonica; 2013, 60, 4; 635-640
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Combined effects of caffeine and aerobic exercise on leptin levels and some indices of insulin resistance in diabetics
Autorzy:
Amaghani, Akram
Jamali Gharakhanlou, Bahram
Zarghami Khamneh, Ali
Radkhah, Nima
Powiązania:
https://bibliotekanauki.pl/articles/28761958.pdf
Data publikacji:
2023
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
caffeine
aerobic exercise
type 2 diabetes
leptin
insulin resistance
Opis:
The study aimed to examine the combined effects of caffeine and aerobic exercise on leptin levels and some indices of insulin resistance in diabetics Thirty-two males with type 2 diabetes participated in a quasi-experimental and double-blind design. All participants were divided into four homogeneous groups of 8 individuals, including placebo (P), caffeine supplementation (C), aerobic training (AT), and aerobic training and caffeine (AT + C). The design protocol included eight weeks of aerobic exercise and caffeine consumption. Blood samples were taken to measure serum levels of leptin, glucose, insulin, HbA1c, HOMA-IR, and insulin sensitivity (QUICKI) indices at two phases. Data were analyzed by repeated measure ANOVA, Bonferroni posthoc, and independent T-test at a significant level of a ≤ 0.05. The results showed that the levels of leptin, glucose, insulin, HbA1c, and HOMA-IR in the three intervention groups significantly decreased compared to the placebo group (P = 0.001). In addition, QUICKI was significantly increased in the three groups of caffeine (C), aerobic training (AT), and aerobic training + caffeine (AT + C) compared to the placebo group (P = 0.001). Also, the AT+C group has double effects on the investigated indices compared to the caffeine (C) group (P = 0.001). Regular aerobic exercise and caffeine supplementation may be more effective treatments for improving insulin resistance indicators associated with type 2 diabetes.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2023, 44; 15-26
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Serum concentration of visfatin is decreased in patients with chronic heart failure
Autorzy:
Straburzyńska-Migaj, Ewa
Pilaczyńska-Szcześniak, Łucja
Nowak, Alicja
Straburzyńska-Lupa, Anna
Śliwicka, Ewa
Grajek, Stefan
Powiązania:
https://bibliotekanauki.pl/articles/1039706.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
insulin resistance
C-reactive protein
heart failure
lipoproteins
visfatin
Opis:
Background. There is an increasing interest in the role of adipocytokines in cardiovascular pathophysiology. Aim. The aim of the study was to compare visfatin levels, a novel adipokine, in patients with heart failure (HF) due to the left ventricular systolic dysfunction with those in age- and body mass index (BMI) - matched healthy controls in relation to the parameters of glucose metabolism and high sensitivity C-reactive protein (hsCRP) levels. Material/Subjects and Methods. The study population consisted of 28 males with systolic HF referred for cardiopulmonary exercise testing, divided into two subgroups based on their NYHA class (HF patients NYHAI+II, n=17, and HF patients NYHAIII+IV, n=11), and 23 controls. The following indices were measured in a serum samples: visfatin, hsCRP, glucose and lipid metabolism parameters, and the insulin resistance index HOMAIR (homeostasis model assessment insulin resistance) was calculated. Results. Concentrations of visfatin and high-density lipoprotein cholesterol (HDL-cholesterol) in the HF subjects were significantly lower (p≤0.01) than in controls. The Kruskal-Wallis test showed significant differences between three groups (controls and both subgroups of heart failure patients) in mean levels of visfatin, hsCRP, glucose, HOMAIR and HDL-cholesterol. Conclusion. Serum visfatin concentrations in patients with systolic HF, particularly with more advanced NYHA classes, are significantly lower in comparison to healthy controls and are independent of age or anthropometric and metabolic parameters.
Źródło:
Acta Biochimica Polonica; 2012, 59, 3; 339-343
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hepatocyte nuclear factor 4 alpha P2 promoter variants associate with insulin resistance
Autorzy:
Saif-Ali, Riyadh
Harun, Roslan
Al-Jassabi, S.
Wan Ngah, Wan
Powiązania:
https://bibliotekanauki.pl/articles/1039910.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
insulin resistance
HNF4 alpha
single nucleotide polymorphisms
haplotypes
Opis:
This study aimed to investigate the associations of hepatocyte nuclear factor 4 (HNF4) alpha single nucleotide polymorphisms (SNPs) and haplotype with insulin resistance and metabolic syndrome parameters. Nine SNPs spanning the HNF4 alpha P2 promoter (rs4810424, rs1884613 and rs1884614) and coding region (rs2144908, rs6031551, rs6031552, rs1885088, rs1028583 and rs3818247) were genotyped in 160 subjects without diabetes or metabolic syndrome. The HNF4 alpha P2 promoter SNPs rs4810424, rs1884613 and rs1884614 were associated with insulin resistance (p = 0.017; 0.037; 0.024) and body mass index (BMI) (p = 0.03; 0.035; 0.039). The intron 1D SNP rs2144908 was associated with high-density lipoprotein cholesterol (HDLc) (p = 0.020) and the intron 9 SNP rs3818247 showed association with systolic (p = 0.02) and diastolic (p = 0.034) blood pressure. HNF4 alpha common haplotype CCCGTC associated with higher insulin resistance (p = 0.022), fasting blood glucose (FBG) (p = 0.035) and lower HDLc (p = 0.001). In conclusion, subjects with HNF4 alpha P2 variants and haplotypes have been shown to have a higher insulin resistance and are therefore at a higher risk for developing type 2 diabetes mellitus.
Źródło:
Acta Biochimica Polonica; 2011, 58, 2; 179-186
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Randomized Clinical Trial to Compare the Effects of Preoperative Oral Carbohydrate Loading versus Placebo on Insulin Resistance and Cortisol Level after Laparoscopic Cholecystectomy
Autorzy:
Pędziwiatr, Michał
Pisarska, Magdalena
Matłok, Maciej
Major, Piotr
Kisielewski, Michał
Wierdak, Mateusz
Natkaniec, Michał
Budzyński, Piotr
Rubinkiewicz, Mateusz
Budzyński, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1394369.pdf
Data publikacji:
2015
Wydawca:
Index Copernicus International
Tematy:
laparoscopic cholecystectomy
insulin resistance
preoperative carbohydrate loading
perioperative care
Opis:
Postoperative insulin resistance, used as a marker of stress response, is clearly an adverse event. It may induce postoperative hyperglycemia, which according to some authors can increase the risk of postoperative complications. One of the elements of modern perioperative care is preoperative administration of oral carbohydrate loading (CHO-loading), which shortens preoperative fasting and reduces insulin resistance. The aim of the study is to establish the influence of CHO-loading on the level of insulin resistance and cortisol in patients undergoing elective laparoscopic cholecystectomy. Material and methods. Patients were randomly allocated to one of 2 groups. The intervention group included 20 patients who received CHO-loading (400 ml Nutricia pre-op®) 2 hours prior surgery. The control group received a placebo (clear water). In every patient blood samples were taken 2 hours prior to surgery, immediately after surgery, and on the 1st postoperative day. Levels and changes in glucose, cortisol and insulin resistance were analyzed in both groups. Results. Although there were differences in the levels of cortisol, insulin, and insulin resistance, no statistically significant differences were observed between groups in every measurement. The length of stay and postoperative complications were comparable in both groups. Conclusions. We believe that CHO-loading is not clinically justified in case of laparoscopic cholecystectomy. No effect on the levels of glucose, insulin resistance and cortisol was observed. Even though such procedure is safe, in our opinion there is no clinical benefit from CHO-loading prior to laparoscopic cholecystectomy.
Źródło:
Polish Journal of Surgery; 2015, 87, 8; 402-408
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparison of triglyceride-glucose index and HOMA-IR as indicators of insulin resistance in obese women with subclinical hypothyroidism
Autorzy:
Onur Kirac, Cem
Sirikci, Vehbi
Avni Findikli, Huseyin
Powiązania:
https://bibliotekanauki.pl/articles/2216805.pdf
Data publikacji:
2022-12-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
HOMA-IR
insulin resistance
subclinical hypothyroidism
triglyceride-glucose index
Opis:
Introduction and aim. Thyroid hormones play an important role in glucose metabolism as in many metabolic events. The aim of our study is to evaluate the relationship between subclinical hypothyroidism (SCH) and insulin resistance, especially in obese women. Material and methods. Newly diagnosed SCH patients with body mass index (BMI) ≥30 who applied to our outpatient clinic between March 2021 and October 2021, and euthyroid obese women who applied for routine control were included in the study. In this study, we used homeostasis model assessment of insulin resistance (HOMA-IR) and triglyceride glucose (TyG) indexes, which are noninvasive, simple and useful methods for evaluating insulin sensitivity. Results. The study included 78 female patients between the ages of 19 and 64. A correlational analysis was performed between thyroid stimulating hormone (TSH) and HOMA-IR, TyG, and BMI. The results showed that TSH levels were positively correlated with HOMA-IR (R=0.297, p=0.008), TyG (R=0.316, p=0.005) and BMI (R=0.307, p=0.006). This relationship was stronger for TyG compared to the other variables. As another finding, BMI was positively correlated with HOMA-IR (R=0.359, p=0.001) and TyG (R=0.404, p<0.001). This relationship was stronger for TyG than HOMA-IR. Conclusion. These results show that patients with SCH are at risk of developing diseases that accompany insulin resistance, such as metabolic syndrome and cardiovascular disorders. The most important finding of our study is that the TyG index gives more significant results than HOMA-IR, especially in obese women.
Źródło:
European Journal of Clinical and Experimental Medicine; 2022, 4; 412-416
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of exposure to electromagnetic field radiation (EMFR) generated by activated mobile phones on fasting blood glucose
Autorzy:
Meo, Sultan A.
Al Rubeaan, Khalid
Powiązania:
https://bibliotekanauki.pl/articles/2179776.pdf
Data publikacji:
2013-04-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
mobile phone radiation
hyperglycemia
insulin resistance
β-cell function
Opis:
Objective: Extensive use of mobile phones has been accompanied by a common public debate about possible adverse effects on human health. No study has been published so far to establish any association between the fastest growing innovation of mobile phone and fasting blood glucose. The aim was to determine the effects of exposure to electromagnetic field radiation generated by mobile phones on fasting blood glucose in Wistar Albino rats. Materials and Methods: 40 Male Albino rats (Wistar Strain) were divided into 5 equally numerous groups. Group A served as the control one, group B received mobile phone radiation for less than 15 min/day, group C: 15-30 min/day, group D: 31-45 min/day, and group E: 46-60 min/day for a total period of 3 months. Fasting blood glucose was determined by using Spectrophotometer and serum insulin by Enzyme-linked Immunosorbent Assay (ELISA). The Homeostatic Model (HOMA-B) was applied for the assessment of β-cell function and (HOMA-IR) for resistance to insulin. Results: Wister Albino rats exposed to mobile phone radiation for longer than 15 min a day for a total period of 3 months had significantly higher fasting blood glucose (p < 0.015) and serum insulin (p < 0.01) compared to the control group. HOMA-IR for insulin resistance was significantly increased (p < 0.003) in the groups that were exposed for 15-30 and 46-60 min/day compared to the control rats. Conclusion: The results of the present study show an association between long-term exposure to activated mobile phones and increase in fasting blood glucose and serum insulin in Albino rats.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2013, 26, 2; 235-241
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 20

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