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Wyszukujesz frazę "gene fusion" wg kryterium: Temat

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    Wyświetlanie 1-5 z 5
    Tytuł:
    In vitro co-stimulation of anti-tumor activity by soluble B7 molecules
    Autorzy:
    He, Wei
    Hu, Zhong-Bo
    Liu, Fang
    Feng, Xian-Qi
    Zou, Ping
    Powiązania:
    https://bibliotekanauki.pl/articles/1041178.pdf
    Data publikacji:
    2006
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    immunotherapy
    tumor escape
    gene fusion
    recombinant fusion proteins
    Opis:
    In order to investigate the anti-tumor activity of a soluble B7-1/immunoglobulin G fusion protein and explore an effective method to eliminate immune escape of tumor cells, a recombinant vector encoding this fusion protein was constructed and constitutively expressed in Chinese hamster ovary cells. After purification with protein G affinity chromatography, the soluble fusion protein was tested for bioactivity. Results showed that the fusion protein could significantly increase the density of B7-1 molecules on WEHI-3 cells, a mouse leukemia cell line. Through allogeneic mixed lymphocyte tumor cultures, it was demonstrated that, with the presence of the first signal, it could also significantly enhance T cell activation and killing activity against WEHI-3 cells and interleukin-2 secretion by activated mouse T lymphocytes. The conclusion can be drawn that the soluble B7-IgG fusion protein has a potent capacity to generate or enhance anti-tumor immune response in vitro, and its clinical value deserves further investigation.
    Źródło:
    Acta Biochimica Polonica; 2006, 53, 4; 807-813
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Data mining methods for gene selection on the basis of gene expression arrays
    Autorzy:
    Muszyński, M.
    Osowski, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/329803.pdf
    Data publikacji:
    2014
    Wydawca:
    Uniwersytet Zielonogórski. Oficyna Wydawnicza
    Tematy:
    gene expression array
    gene ranking
    feature selection
    clusterization measures
    fusion
    SVM classification
    ekspresja genów
    selekcja cech
    klasyfikacja SVM
    Opis:
    The paper presents data mining methods applied to gene selection for recognition of a particular type of prostate cancer on the basis of gene expression arrays. Several chosen methods of gene selection, including the Fisher method, correlation of gene with a class, application of the support vector machine and statistical hypotheses, are compared on the basis of clustering measures. The results of applying these individual selection methods are combined together to identify the most often selected genes forming the required pattern, best associated with the cancerous cases. This resulting pattern of selected gene lists is treated as the input data to the classifier, performing the task of the final recognition of the patterns. The numerical results of the recognition of prostate cancer from normal (reference) cases using the selected genes and the support vector machine confirm the good performance of the proposed gene selection approach.
    Źródło:
    International Journal of Applied Mathematics and Computer Science; 2014, 24, 3; 657-668
    1641-876X
    2083-8492
    Pojawia się w:
    International Journal of Applied Mathematics and Computer Science
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Expression of bovine leukemia virus protein p24 in Escherichia coli and its use in the immunoblotting assay.
    Autorzy:
    Bicka, Leokadia
    Kuźmak, Jacek
    Kozaczyńska, Bożena
    Płucienniczak, Andrzej
    Skorupska, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1044191.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    bovine leukemia virus
    fusion protein p24
    immunoblotting assay
    gag gene cloning
    Opis:
    The gag gene encoded protein, p24 of bovine leukemia virus (BLV), was cloned and expressed as thioredoxin-6xHis-p24 protein in Escherichia coli. The bacterial cells carrying plasmid pT7THis-p24 expressed the protein of 38 kDa that was detected by immunoblotting analysis using anti-p24 monoclonal antibodies and sera from BLV infected cattle and sheep. The purified p24 fusion protein was shown to be sensitive and specific for detection of BLV antibodies in the infected cattle.
    Źródło:
    Acta Biochimica Polonica; 2001, 48, 1; 227-232
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cloning of a Rift Valley Fever fusion gene in a plant virus derived replicon vector
    Autorzy:
    Omosimua, Rebecca Oziohu
    Iyappan, Gowtham
    Obembe, Olawole
    Ogunkanmi, Adebayo
    Sathishkumar, Ramalingam
    Powiązania:
    https://bibliotekanauki.pl/articles/1193478.pdf
    Data publikacji:
    2021
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    DNA Cloning
    Escherichia coli DH5α cells
    PBYR2e3K2Mc-GFP
    PBYR2e3K2Mc-RVFV
    RVF disease
    RVFV fusion gene
    bean yellow dwarf derived vector
    emerging disease
    geminivirus vector
    zoonotic disease
    Opis:
    Rift Valley fever (RVF) disease is an emerging viral zoonotic disease caused by Rift Valley fever virus (RVFV). RVF disease is seemingly becoming more severe in endemic populations and in areas of new outbreak. RVF disease is listed by WHO as requiring urgent research and development attention. There is no therapeutics or licensed vaccine for human use in the case of an eventual outbreak. There is a need to clone RVFV genes in cloning vectors which may be useful to produce antigens in plant cells or may be tested directly as DNA vaccines. A synthesized Rift Valley fever virus fusion gene was cloned in a bean yellow dwarf virus derived replicon vector; PBYR2e3K2Mc-GFP by removing and replacing the GFP gene. The cloned PBYR2e3K2Mc-RVFV fusion gene was confirmed by PCR, restriction digestion and DNA sequencing. This cloned RVFV fusion gene in plant virus vector can be used for subsequent protein expression in plants cells or used directly tested as DNA vaccines in future studies.
    Źródło:
    World Scientific News; 2021, 158; 159-172
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Immunogenicity of recombinant bacterial antigens expressed as fusion proteins in transgenic rice seeds
    Autorzy:
    Zaman, S.
    Islam, S.M.T.
    Khan, M.K.
    Alam, M.M.
    Uddin, M.I.
    Baby, N.I.
    Islam, S.
    Bhuiyan, T.R.
    Qadri, F.
    Seraj, Z.I.
    Powiązania:
    https://bibliotekanauki.pl/articles/80383.pdf
    Data publikacji:
    2017
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    rice seed
    transgenic rice plant
    gene sequence
    fusion protein
    tuberculosis
    vaccine
    oral vaccine
    Ag85B antigen
    cholera
    bacterial antigen
    immunogenicity
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2017, 98, 4
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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