Temat: estrogen receptor - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Breast cancer and factors affecting survival rate. Narrative review article
Autorzy:: Elzohry, Alaa Ali M.
Fikry, Engy Mohamed
Elhamed, Mohammed Farghaly Abd
Powiązania:: https://bibliotekanauki.pl/articles/1065175.pdf
Data publikacji:: 2019
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:: Breast cancer
Estrogen receptor ER
Progesterone receptor (PR)
Opis:: Breast cancer is the most common malignancy in women and it was estimated as the fifth cause of death from malignancy in the world. The objective of this review is to illustrate the incidence of cancer breast and demonstrate different factors affecting survival rate.
Źródło:: World Scientific News; 2019, 120, 2; 275-281
2392-2192
Pojawia się w:: World Scientific News
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Pathophysiological roles of ERα in the ER signaling mediated oncogenesis of breast cancer
Autorzy:: Abda Neja, Sultan
Powiązania:: https://bibliotekanauki.pl/articles/2040136.pdf
Data publikacji:: 2020-12-30
Wydawca:: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:: breast, cancer
estrogen receptor alpha
oncogenesis
Opis:: Introduction. Estrogen receptors (ER) are members of nuclear receptors that act in the ER signaling pathway regulating the pathophysiology of hormone-responsive target cells including breast tissue. Aim. This detailled review literature was written on the pathophysiology of ER signaling as well as the effect altered ERα and associated pathway derangement in the oncogenesis of breast cancer. Material and methods. This review was performed according to systematic literature search of three major bibliographic databases (Scopus, PubMed, and Cochran). Analysis of the literature. In this pathway, estrogen receptor alpha (ERα) is a key estradiol-17β (E2) induced transcription factor that has been implicated in the initiation and development of the major fraction of breast cancers. Hence understanding the ERα-mediated ER signaling that results in alterations from normal phenotypic features of breast tissue to the oncogenic features of breast cancer is important. The oncogenic effect of ERα in ER signaling is driven by combinations of molecular assets within the cancer cells. Normally, the transcriptional activity of ERα is controlled by tight regulation of its protein level inside the cells. Altered stability and activity of ERα due to its phosphorylation, ubiquitination, glycosylation, sumoylation, and acetylation events can trigger oncogenic ER signaling. Conclusion. The function and activity of ERα is also modulated by its interaction with coregulators as well as crosstalk with oncogenic factors from other oncogenic pathways. These all events increase the complexity of the progression of ER+ breast cancer and its response to endocrine therapy
Źródło:: European Journal of Clinical and Experimental Medicine; 2020, 4; 289-302
2544-2406
2544-1361
Pojawia się w:: European Journal of Clinical and Experimental Medicine
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: The ESR1 and GPX1 gene expression level in human malignant and non-malignant breast tissues
Autorzy:: Król, Magdalena
Galicki, Michał
Grešner, Peter
Wieczorek, Edyta
Jabłońska, Ewa
Reszka, Edyta
Morawiec, Zbigniew
Wąsowicz, Wojciech
Gromadzińska, Jolanta
Powiązania:: https://bibliotekanauki.pl/articles/1038523.pdf
Data publikacji:: 2018
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: estrogen receptor
antioxidant enzymes
gene expression
breast cancer tissue
Opis:: Background: The aim of this study was to establish whether the gene expression of estrogen receptor alpha (encoded by ESR1) correlates with the expression of glutathione peroxidase 1 (encoded by GPX1) in the tumor and adjacent tumor-free breast tissue, and whether this correlation is affected by breast cancer. Such relationships may give further insights into breast cancer pathology with respect to the status of estrogen receptor. Methods: We used the quantitative real-time PCR technique to analyze differences in the expression levels of the ESR1 and GPX1 genes in paired malignant and non-malignant tissues from breast cancer patients. Results: ESR1 and GPX1 expression levels were found to be significantly down-regulated by 14.7% and 7.4% (respectively) in the tumorous breast tissue when compared to the non-malignant one. Down-regulation of these genes was independent of the tumor histopathology classification and clinicopathological factors, while the ESR1 mRNA level was reduced with increasing tumor grade (G1: 103% vs. G2: 85.8% vs. G3: 84.5%; p<0.05). In the non-malignant and malignant breast tissues, the expression levels of ESR1 and GPX1 were significantly correlated with each other (Rs=0.450 and Rs=0.360; respectively). Conclusion: Our data suggest that down-regulation of ESR1 and GPX1 was independent of clinicopathological factors. Down-regulation of ESR1 gene expression was enhanced by the development of the disease. Moreover, GPX1 and ESR1 gene expression was interdependent in the malignant breast tissue and further work is needed to determine the mechanism underlying this relationship.
Źródło:: Acta Biochimica Polonica; 2018, 65, 1; 51-57
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Effects of 17-beta estradiol and estriol on NMDA-induced toxicity and apoptosis in primary cultures of rat cortical neurons
Autorzy:: Kajta, M.
Budziszewska, B.
Marszal, M.
Lason, W.
Powiązania:: https://bibliotekanauki.pl/articles/70785.pdf
Data publikacji:: 2001
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: cortical neuron
oestriol
oestriadol-17beta
estrogen
toxicity
estrogen receptor
neurotoxicity
apoptosis
hypoglycemia
rat
Źródło:: Journal of Physiology and Pharmacology; 2001, 52, 3
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Regulation of steroidogenic function of mouse Leydig cells: G-coupled membrane estrogen receptor and peroxisome proliferator-activated receptor partnership
Autorzy:: Gorowska-Wojtowicz, E.
Dutka, P.
Kudrycka, M.
Pawlicki, P.
Milon, A.
Plachno, B.J.
Tworzydlo, W.
Pardyak, L.
Kaminska, A.
Hejmej, A.
Bilinska, B.
Kotula-Balak, M.
Powiązania:: https://bibliotekanauki.pl/articles/70604.pdf
Data publikacji:: 2018
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: Leydig cell
steroidogenic function
mice
mouse
G-coupled membrane estrogen receptor
peroxisome proliferator-activated receptor
lutropin
cholesterol level
steroidogenesis
Źródło:: Journal of Physiology and Pharmacology; 2018, 69, 3
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Preliminary evaluation of ER- and AhR-mediated gene expression patterns in rainbow trout (Oncorhynchus mykiss) liver after short-term exposure to zearalenone in binary mixtures
Autorzy:: Woźny, M.
Brzuzan, P.
Wolińska, L.
Góra, M.
Łuczyński, M. K.
Powiązania:: https://bibliotekanauki.pl/articles/363144.pdf
Data publikacji:: 2010
Wydawca:: Uniwersytet Warmińsko-Mazurski w Olsztynie
Tematy:: receptor AhR
benzo(a)piren
ścieżka sygnałowa
17beta-estradiol
receptor estrogenowy
zearalenone
aryl hydrocarbon receptor
benzo(a)pyrene
crosstalk
estrogen receptor
Opis:: While estrogenic properties of mycotoxin zearalenone (ZEA) has been an extensively studied issue, little is known about molecular background of its biological responses that cannot be simply explained by the estrogenic potential. The present study describes effects of ZEA (10mg*kg-1 body weight) in binary mixtures either with benzo[a]pyrene (B[a]P), or with 17β-estradiol (E2) on ER- and AhR-dependent gene expression in juvenile rainbow trout liver, evaluated using Real-Time qPCR. The study revealed dual nature of ZEA, as the treatment with this compound alone increased mRNA levels of both ER- and AhR-mediated gene expression. However, our results did not show any synergistic or additive effect of ZEA in binary mixures with E2 or B[a]P on studied gene expression levels. Whether the intriguing potential of ZEA to elicit distinct signals was a result of binding affinity to AhR or/and ER and AhR mutual receptor interactions, should be investigated in further experiments.
Źródło:: Environmental Biotechnology; 2010, 6, 1; 16-23
1734-4964
Pojawia się w:: Environmental Biotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Synthetic derivatives of genistein, their properties and possible applications
Autorzy:: Rusin, Aleksandra
Krawczyk, Zdzisław
Grynkiewicz, Grzegorz
Gogler, Agnieszka
Zawisza-Puchałka, Jadwiga
Szeja, Wiesław
Powiązania:: https://bibliotekanauki.pl/articles/1040415.pdf
Data publikacji:: 2010
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: synthetic genistein derivatives
inhibition of cell proliferation
tyrosine kinases
selective estrogen receptor modulators
anticancer activity
antimicrobial activity
Opis:: Genistein, the principal isoflavone constituent of soybean, attracts much attention as a natural molecule with significant affinity towards targets of potential medicinal interest, but also as a food supplement or prospective chemopreventive agent. Since its physicochemical properties are considered suboptimal for drug development, much effort has been invested in designing its analogs and conjugates in hope to obtain compounds with improved efficacy and selectivity. The aim of this article is to summarize current knowledge about the properties of synthetic genistein derivatives and to discuss possible clinical application of selected novel compounds. Some basic information concerning chemical reactivity of genistein, relevant to the synthesis of its derivatives, is also presented.
Źródło:: Acta Biochimica Polonica; 2010, 57, 1; 23-34
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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