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Tytuł:
Changes in selected neuroendocrine and immunological markers during exercise
Autorzy:
Grzebisz, Natalia
Powiązania:
https://bibliotekanauki.pl/articles/1192059.pdf
Data publikacji:
2016
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
cortisol
catecholamines
estradiol
exercise
Opis:
Physical exercise has multidirectional impact on the mechanisms of neuroendocrine responses. The regular and moderate stimulates the immune mechanism, whereas the interval may lead to increased susceptibility to infections. In recent years there has been increased interest in the issues of the impact of exercise on the efficiency of the immune mechanisms. In practice, such knowledge may be used to prevent infections in athletes and possible states of overtraining. Among the signaling molecules involved in the immune response of the body to exercise mentioned markers hormonal balance (testosterone, cortisol, estradiol, hormones, pituitary and hypothalamus), the metabolism of proteins and amino acids (balance nitrogen, glutamine, increase in creatine kinase). Review of the current state of knowledge about the change of levels of markers of hormonal system during exercise and suggestions direction of future research in the area of these issues have been taken in this paper. This is a translation of a part of my authorship the original source in Polish ,,Zarządzanie zmianami poziomu wybranych markerów neuroendokrynnych oraz immunologicznych podczas wysiłku fizycznego”. The text was published in an edition of the Scientific Publishing Sophia in 2015.
Źródło:
World Scientific News; 2016, 50; 239-249
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A comparative study of the effects of genistein, estradiol and raloxifene on the murine skeletal system
Autorzy:
Śliwiński, Leszek
Folwarczna, Joanna
Nowińska, Barbara
Cegieła, Urszula
Pytlik, Maria
Kaczmarczyk-Sedlak, Ilona
Trzeciak, Hanna
Trzeciak, Henryk
Powiązania:
https://bibliotekanauki.pl/articles/1040583.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
bone mechanical properties
estradiol
osteoclasts
bone mineralization
osteoblasts
genistein
raloxifene
Opis:
Genistein, a major phytoestrogen of soy, is considered a potential drug for prevention and treatment of postmenopausal osteoporosis. The aim of the present study was to compare the effects of genistein, estradiol and raloxifene on the skeletal system in vivo and in vitro. Genistein (5 mg/kg), estradiol (0.1 mg/kg) or raloxifene hydrochloride (5 mg/kg) were administered daily by a stomach tube to mature ovariectomized Wistar rats for 4 weeks. Bone mass, mineral and calcium content, macrometric parameters and mechanical properties were examined. Also the effects of genistein, estradiol and raloxifene (10-9-10-7 M) on the formation of osteoclasts from neonatal mouse bone marrow cells and the activity of osteoblasts isolated from neonatal mouse calvariae were compared. In vivo, estrogen deficiency resulted in the impairment of bone mineralization and bone mechanical properties. Raloxifene but not estradiol or genistein improved bone mineralization. Estradiol fully normalized the bone mechanical properties, whereas genistein augmented the deleterious effect of estrogen-deficiency on bone strength. In vitro, genistein, estradiol and raloxifene inhibited osteoclast formation from mouse bone marrow cells, decreasing the ratio of RANKL mRNA to osteoprotegerin mRNA expression in osteoblasts. Genistein, but not estradiol or raloxifene, decreased the ratio of alkaline phosphatase mRNA to ectonucleotide pyrophosphatase phosphodiesterase 1 mRNA expression in osteoblasts. This difference may explain the lack of genistein effect on bone mineralization observed in ovariectomized rats in the in vivo study. Concluding, our experiments demonstrated profound differences between the activities of genistein, estradiol and raloxifene towards the osseous tissue in experimental conditions.
Źródło:
Acta Biochimica Polonica; 2009, 56, 2; 261-270
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dynamics of estrogen-induced oxidative stress
Autorzy:
Kobiela, Jarek
Stefaniak, Tomasz
Krajewski, Jacek
Kalinska-Blach, Beata
Zurawa-Janicka, Dorota
Lachinski, Andrzej
Gackowski, Daniel
Olinski, Ryszard
Nowak, Jerzy
Knap, narcyz
Lipinska, Barbara
Sledzinski, Zbigniew
Wozniak, Michal
Powiązania:
https://bibliotekanauki.pl/articles/1041076.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
8-oxodGuo
estradiol
protein oxidation
carcinogenesis
DNA damage
lipid peroxidation
Opis:
The objective of this study was to assess the dynamics of oxidative damage to cellular macromolecules such as proteins, lipids and DNA under conditions of oxidative stress triggering early stages of estrogen-dependent carcinogenesis. A rodent model of carcinogenesis was used. Syrian hamsters were sacrificed after 1, 3, 5 h and one month from the initial implantation of estradiol. Matching control groups were used. Kidneys as target organs for estradiol-mediated oxidative stress were excised and homogenized for biochemical assays. Subcellular fractions were isolated. Carbonyl groups (as a marker of protein oxidation) and lipid hydroxyperoxides were assessed. DNA was isolated and 8-oxodGuo was assessed. Electron paramagnetic resonance spectroscopy was used to confirm the results for lipid peroxidation. Exposition to estradiol in the rodent model leads to damage of macromolecules of the cell, including proteins and DNA, but not lipids. Proteins appear to be the primary target of the damage but are closely followed by DNA. It has previously been speculated that protein peroxides can increase DNA modifications. This time sequence was observed in our study. Nevertheless, the direct relation between protein and DNA damage still remains unsolved.
Źródło:
Acta Biochimica Polonica; 2007, 54, 2; 289-295
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Electron beam sterilization of implantable rods with risperidone and with 17-β-estradiol: a structural, thermal and morphology study
Autorzy:
Wilińska, Justyna
Turek, Artur
Borecka, Aleksandra
Rech, Jakub
Kasperczyk, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/306226.pdf
Data publikacji:
2019
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
sterylizacja wiązką elektronów
17β-estradiol
rysperydon
electron beam sterilization
implantable rods
poly(L-lactide-co-glycolide-co-trimethylene carbonate)
risperidone
17-β-estradiol
Opis:
Poly(L-lactide-co-glycolide-co-trimethylene carbonate) rods with risperidone and 17-β-estradiol were sterilized by electron beam irradiation. The aim of the study was to assess electron beam irradiation impact on terpolymer composition, chain microstructure, glass transition temperature, molecular weight and the morphological features of rods. Methods: Hot melt extrusion in the formulation of rods was applied. Sterilization of the rods was performed by electron beam in an electron beam accelerator (10 MeV, 360 mA, 25 kGy). The following methods in the development of rods were applied: nuclear magnetic resonance, differential scanning calorimetry, gel permeation chromatography and scanning electron microscopy. Results: Sterilization influenced only glass transition temperature in blind rods and rods with risperidone. As for the other parameters, no significant changes were observed as far as a sterilization effect is concerned. However, some changes were noted after introducing drug substances and after extrusion. Conclusions: Electron beam irradiation of rods with risperidone and rods with 17-β-estradiol is an adequate method for sterilizing implantable drug delivery systems.
Źródło:
Acta of Bioengineering and Biomechanics; 2019, 21, 3; 39-47
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Specific binding sites for progesterone and 17β-estradiol in cells of Triticum aestivum L.
Autorzy:
Janeczko, Anna
Budziszewska, Bogusława
Skoczowski, Andrzej
Dybała, Małgorzata
Powiązania:
https://bibliotekanauki.pl/articles/1040676.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
vernalization
progesterone
radioligand binding assay
Triticum aestivum L.
17β-estradiol
Opis:
The presence and location of specific binding sites for progesterone and 17β-estradiol in cells of wheat were estimated using radioligand binding assay. Membrane and cytosolic fractions of non-vernalized and vernalized plants were tested using tritium-labelled ligands. Specific binding of [3H]progesterone and [3H]17β-estradiol occurs in wheat cells. The binding sites are located in membranes and in the cytosol. Specific binding of [3H]17β-estradiol is higher in the membranes than in the cytosol. Specific binding of both ligands in the cytosolic fraction is higher in vernalized plants than in non-vernalized ones. The possibility of the occurrence of steroid binding proteins specific for progesterone and 17β-estradiol, putative steroid receptors for these steroids in Triticum aestivum L., is discussed.
Źródło:
Acta Biochimica Polonica; 2008, 55, 4; 707-711
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Changes in expression of serine proteases HtrA1 and HtrA2 during estrogen-induced oxidative stress and nephrocarcinogenesis in male Syrian hamster
Autorzy:
Zurawa-Janicka, Dorota
Kobiela, Jaroslaw
Stefaniak, Tomasz
Wozniak, Agnieszka
Narkiewicz, Joanna
Wozniak, Michał
Limon, Janusz
Lipinska, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/1040768.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
17-β-estradiol
HtrA proteases
estrogen-induced carcinogenesis
oxidative stress
Opis:
Serine proteases HtrA1 and HtrA2 are involved in cellular stress response and development of several diseases, including cancer. Our aim was to examine the involvement of the HtrA proteins in acute oxidative stress response induced in hamster kidney by estrogen treatment, and in nephrocarcinogenesis caused by prolonged estrogenization of male Syrian hamster. We used semi-quantitative RT-PCR to estimate the HtrA1 and HtrA2 mRNA levels in kidney tissues, and Western blotting to monitor the amount of the HtrA proteins. Within the first five hours following estrogen administration both HtrA1 mRNA and the protein levels were increased significantly. No changes in the expression of HtrA2 were observed. This indicates that HtrA1 may be involved in the response against oxidative stress induced by estrogen treatment in hamster kidney. During prolonged estrogenization, a significant reduction of the HtrA1 mRNA and protein levels was observed after 6 months of estradiol treatment, while the expression of HtrA2 was significantly elevated starting from the third month. This suggests an involvement of the HtrA proteins in estrogen-induced nephrocarcinogenesis in hamster. Using fluorescence in situ hybridization we localized the HtrA1 gene at the qb3-4 region of Syrian hamster chromosome 2, the region known to undergo a nonrandom deletion upon prolonged estrogenization. It is possible that the reduced level of HtrA1 expression is due to this chromosomal aberration. A full-length cDNA sequence of the hamster HtrA1 gene was obtained. It codes for a 50 kDa protein which has 98 and 96% identity with mouse and human counterparts, respectively.
Źródło:
Acta Biochimica Polonica; 2008, 55, 1; 9-20
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oocyte hydration in round goby Neogobius melanostomus from the Gulf of Gdańsk: another invasive strategy?
Autorzy:
Kalamarz-Kubiak, H.
Guellard, T.
Powiązania:
https://bibliotekanauki.pl/articles/47646.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Instytut Oceanologii PAN
Tematy:
oocyte
hydration
round goby
Neogobius melanostomus
non-native species
estradiol
Gdansk Gulf
Źródło:
Oceanologia; 2019, 61, 4
0078-3234
Pojawia się w:
Oceanologia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Can transforming growth factor-β1 and retinoids modify the activity of estradiol and antiestrogens in MCF-7 breast cancer cells?
Autorzy:
Czeczuga-Semeniuk, Ewa
Anchim, Tomasz
Dzięcioł, Janusz
Dąbrowska, Milena
Wołczyński, Sławomir
Powiązania:
https://bibliotekanauki.pl/articles/1041552.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
estradiol
apoptotic index
tamoxifen
TGF-β1
proliferation
MCF-7
retinoids
Opis:
Retinoic acid and transforming growth factor-β (TGF-β) affect differentiation, proliferation and carcinogenesis of epithelial cells. The effect of both compounds on the proliferation of cells of the hormone sensitive human breast cancer cell line (ER+) MCF-7 was assessed in the presence of estradiol and tamoxifen. The assay was based on [3H]thymidine incorporation and the proliferative activity of PCNA- and Ki 67-positive cells. The apoptotic index and expression of the Bcl-2 and p53 antigens in MCF-7 cells were also determined. Exogenous TGF-β1 added to the cell culture showed antiproliferative activity within the concentration range of 0.003-30 ng/ml. Irrespective of TGF-β1 concentrations, a marked reduction in the stimulatory action of estradiol (10-9 and 10-8 M) was observed whereas in combination with tamoxifen (10-7 and 10-6 M) only 30 ng/ml TGF-β1 caused a statistically significant reduction to aproximately 30% of the proliferative cells. In further experiments we examined the effect of exposure of breast cancer cells to retinoids in combination with TGF-β1. The incorporation of [3H]thymidine into MCF-7 cells was inhibited to 52 ± 19% (control =100%) by 3 ng/ml TGF-β1, and this dose was used throughout. It was found that addition of TGF-β1 and isotretinoin to the culture did not decrease proliferation, while TGF-β1 and tretinoin at low concentrations (3 × 10-8 and 3 × 10-7 M) reduced the percentage of proliferating cells by aproximately 30% (67±8% and 67±5%, P <0.05 compared to values in the tretinoin group). Both retinoids also led to a statistically significant decrease in the stimulatory effect of 10-9 M estradiol, attenuated by TGF-β1. In addition, the retinoids in combination with TGF-β1 and tamoxifen (10-6 M) caused a further reduction in the percentage of proliferating cells. Immunocytochemical analysis showed that all the examined compounds gave a statistically significant reduction in the percentage of cells with a positive reaction to PCNA and Ki 67 antigen. TGF-β1, isotretinoin and tretinoin added to the culture resulted in the lowest percentage of PCNA positive cells. However, the lowest fraction of Ki 67 positive cells was observed after addition of isotretinoin. The obtained results also confirm the fact that the well-known regulatory proteins Bcl-2 and p53 play an important role in the regulation of apoptosis in the MCF-7 cell line, with lowered Bcl-2 expression accompanying easier apoptotic induction. The majority of the examined compounds act via the p53 pathway although some bypass this important proapoptotic factor.
Źródło:
Acta Biochimica Polonica; 2004, 51, 3; 733-745
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The level of endogenous DNA damage in lymphocytes isolated from blood is associated with the fluctuation of 17β-estradiol concentration in the follicular phase of healthy young women.
Autorzy:
Kapiszewska, Maria
Kalemba, Malgorzata
Grzesiak, Aneta
Kocemba, Kinga
Powiązania:
https://bibliotekanauki.pl/articles/1041444.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
endogenous DNA damage
catechol-O-methyltransferase (COMT)
comet assay
17β-estradiol
Opis:
The aim of this study was to evaluate whether the differences in plasma 17β-estradiol concentration in early and late follicular phases of the menstrual cycle can affect the level of endogenous DNA damage in lymphocytes assessed by comet assay, and whether the extent of this damage in the follicular phase is associated with the genotype of catechol-O-methyltransferase (COMT). The level of DNA damage was positively correlated with 17β-estradiol concentration only in the late follicular phase. Subjects with the COMT L/L homozygous mutated variant revealed more DNA damage as compared to individuals with the COMT wild-type and heterozygous (H/L+HH) genotype.
Źródło:
Acta Biochimica Polonica; 2005, 52, 2; 535-539
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
17 beta-estradiol affects proliferation and apoptosis of canine bone marrow mesenchymal stem cells in vitro
Autorzy:
Zhou, Z.-H.
Gu, C.-W.
Li, J.
Huang, X.-Y.
Deng, J.-Q.
Shen, L.-H.
Cao, S.-Z.
Deng, J.-L.
Zuo, Z.-C.
Wang, Y.
Ma, X.-P.
Ren, Z.-H.
Yu, S.-M.
Powiązania:
https://bibliotekanauki.pl/articles/2087308.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
apoptosis
bone marrow mesenchymal stem cells (BMSCs)
canine
proliferation
17 beta-estradiol (E2)
Źródło:
Polish Journal of Veterinary Sciences; 2020, 23, 2; 235-245
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Natural phenolic acids may increase serum estradiol level in ovariectomized rats
Autorzy:
Zych, Maria
Folwarczna, Joanna
Trzeciak, Henryk
Powiązania:
https://bibliotekanauki.pl/articles/1040548.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
rat
estradiol
p-coumaric acid
chlorogenic acid
body mass
caffeic acid
ferulic acid
Opis:
Natural phenolic acids are commonly present in plants consumed in the diet. Recently we have observed that different natural phenolic acids exert differential effects on the body mass gain in ovariectomized and non-ovariectomized female rats. The aim of the present study was to investigate the effects of ferulic, caffeic, p-coumaric and chlorogenic acids on serum estradiol and total cholesterol levels in ovariectomized and non-ovariectomized rats. The experiments were carried out on 3-month old female Wistar Cmd:(WI)WU rats, divided into following groups (n=8 in each group): non-ovariectomized control rats and non-ovariectomized rats receiving ferulic, caffeic, p-coumaric or chlorogenic acids, sham-operated control rats, ovariectomized control rats and ovariectomized rats receiving the same phenolic acids. The phenolic acids were administered at a dose of 10 mg/kg p.o. daily for 4 weeks. Serum estradiol and total cholesterol levels on the next day after the last administration of the phenolic acids were examined. The phenolic acids did not affect serum estradiol or total cholesterol levels in non-ovariectomized rats. In ovariectomized rats, caffeic acid and to a lesser extent p-coumaric acid increased serum estradiol level, which effect correlated with a decreased body mass gain. All the phenolic acids decreased serum cholesterol level in ovariectomized rats. Concluding, the anti-obesity activity of some phenolic acids may be, at least partially, connected with estrogenic pathways.
Źródło:
Acta Biochimica Polonica; 2009, 56, 3; 503-507
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparative studies on decomposition of selected estrogens and xenoestrogens by photocatalysis processes
Badania porównawcze rozkładu wybranych estrogenów i ksenoestrogenów w procesie fotokatalizy
Autorzy:
Burdzik-Niemiec, E.
Dudziak, M.
Powiązania:
https://bibliotekanauki.pl/articles/388989.pdf
Data publikacji:
2015
Wydawca:
Towarzystwo Chemii i Inżynierii Ekologicznej
Tematy:
photocatalysis
micropollutants decomposition
bisphenol A
17β-estradiol
17α-ethinylestradiol
fotokataliza
rozkład mikrozanieczyszczeń
bisfenol A
17α-etynyloestradiol
Opis:
Comparative Studies on Decomposition of Selected Estrogens and Xenoestrogens by Photocatalysis ProcessesAbstract: This study addressed the degradation efficiency of three different compounds belonging to the group of endocrine disrupting compounds (EDCs), namely 17β-estradiol (E2), 17α-ethinyl estradiol (EE2), and bisphenol A (BPA) in the photocatalysis process (UV/TiO2). The subject of the study was a synthetic municipal waste water treatment plant effluent containing inorganic and optionally organic substances and to which the investigated micropollutants were added at a concentration of 500 μg/dm3. The obtained results were compared in terms of the degradation of the selected compounds in deionized water. It was found that the efficiency of the photocatalysis depends significantly both on the environmental matrix and physico-chemical properties of the compounds present in the treated waste water. The highest degradation efficiency was observed for the synthetic effluent that contained only inorganic substances. The degradation of bisphenol A and 17α-ethinyl estradiol exceeded 90 % (after 60-minute irradiation) and 17β-estradiol was decomposed completely. The observed phenomenon can be attributed to the process termed as sensitized photocatalysis, which was enabled by inorganic substances present in the synthetic waste water. This phenomenon was not observed for the synthetic effluent that contained both inorganic and organic substances, and moreover the degradation efficiency of the micropollutans was lower. These observations were also confirmed by the results regarding the decomposition of the compounds in deionized water. In order to describe the course of photocatalytic oxidation reaction rate constants were determined as well as degradation half-lives using the Langmuir-Hinshelwood kinetic model.
W ramach pracy podjęto badania nad oceną efektywności rozkładu trzech różnych związków należących do grupy substancji zakłócających procesy hormonalne (z ang. Endocrine Disrupters Compounds EDCs), tj. 17β-estradiol (E2), 17α-etynyloestradiol (EE2) oraz bisfenol A (BPA) w procesie fotokatalizy (UV/TiO2). Przedmiotem badań były modelowe odpływy z oczyszczalni ścieków bytowych zawierające substancje nieorganiczne i opcjonalnie organiczne, do których dodawano badane mikrozanieczyszczenia w stężeniu 500 μg/dm3. Uzyskane wyniki badań porównano pod katem skuteczności rozkładu wybranych związków dla wody zdejonizowanej. Wykazano, że na skuteczność procesu fotokatalizy istotny wpływ ma zarówno rodzaj matrycy środowiskowej, jak i właściwości fizykochemicznych usuwanych związków. Najwyższe stopnie rozkładu uzyskano podczas oczyszczania odpływu modelowego zawierającego wyłącznie substancje nieorganiczne. Rozkład bisfenolu A oraz 17α-etynyloestradiolu przekraczał wówczas 90 % (po 60-minutowym czasie naświetlania), a 17β-estradiol został rozłożony całkowicie. Zaobserwowane zjawisko można wytłumaczyć obecnością w ściekach modelowych chemicznych substancji nieorganicznych umożliwiających przebieg tzw. fotokatalizy sensybilizowanej. W przypadku odpływu modelowego zawierającego zarówno substancje organiczne, jak i nieorganiczne tego zjawiska nie obserwowano, a efektywność rozkładu mikrozanieczyszczeń była mniejsza. Powyższe obserwacje potwierdzają również uzyskane wyniki rozkładu związków dla wody zdejonizowanej. W celu opisu przebiegu fotokatalitycznego utleniania wyznaczono stałe szybkości reakcji oraz czasy połowicznego rozkładu posługując się kinetyką modelu Langmuira-Hinshelwooda.
Źródło:
Ecological Chemistry and Engineering. A; 2015, 22, 4; 457-467
1898-6188
2084-4530
Pojawia się w:
Ecological Chemistry and Engineering. A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The pattern of steroid secretion by perifused preovulatory rat follicles
Autorzy:
Szoltys, M
Powiązania:
https://bibliotekanauki.pl/articles/70002.pdf
Data publikacji:
1995
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
radioimmunoassay
steroid production
progesterone
rat follicle
steroid
endocrinology
steroid analysis
ovulation
androgen
animal physiology
gonadotrophin
hormone free
secretion
estradiol
Źródło:
Journal of Physiology and Pharmacology; 1995, 46, 1
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preliminary evaluation of ER- and AhR-mediated gene expression patterns in rainbow trout (Oncorhynchus mykiss) liver after short-term exposure to zearalenone in binary mixtures
Autorzy:
Woźny, M.
Brzuzan, P.
Wolińska, L.
Góra, M.
Łuczyński, M. K.
Powiązania:
https://bibliotekanauki.pl/articles/363144.pdf
Data publikacji:
2010
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie
Tematy:
receptor AhR
benzo(a)piren
ścieżka sygnałowa
17beta-estradiol
receptor estrogenowy
zearalenone
aryl hydrocarbon receptor
benzo(a)pyrene
crosstalk
estrogen receptor
Opis:
While estrogenic properties of mycotoxin zearalenone (ZEA) has been an extensively studied issue, little is known about molecular background of its biological responses that cannot be simply explained by the estrogenic potential. The present study describes effects of ZEA (10mg*kg-1 body weight) in binary mixtures either with benzo[a]pyrene (B[a]P), or with 17β-estradiol (E2) on ER- and AhR-dependent gene expression in juvenile rainbow trout liver, evaluated using Real-Time qPCR. The study revealed dual nature of ZEA, as the treatment with this compound alone increased mRNA levels of both ER- and AhR-mediated gene expression. However, our results did not show any synergistic or additive effect of ZEA in binary mixures with E2 or B[a]P on studied gene expression levels. Whether the intriguing potential of ZEA to elicit distinct signals was a result of binding affinity to AhR or/and ER and AhR mutual receptor interactions, should be investigated in further experiments.
Źródło:
Environmental Biotechnology; 2010, 6, 1; 16-23
1734-4964
Pojawia się w:
Environmental Biotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prevention of cardiovascular risk factors in postmenopausal women receiving transdermal hormonal replacement therapy
Zapobieganie sercowo-naczyniowym czynnikom ryzyka u kobiet pomenopauzalnych otrzymujących przezskórną hormonalną terapię zastępczą
Autorzy:
Sieja, K.
Powiązania:
https://bibliotekanauki.pl/articles/2052604.pdf
Data publikacji:
2016
Wydawca:
Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:
postmenopause
transdermal hormone replacement therapy
estradiol
lipids
risk factors
cardiovascular diseases
okres pomenopauzalny
przezskórna hormonalna terapia zastępcza
lipidy
czynniki ryzyka
schorzenia sercowo-naczyniowe
Opis:
Postmenopausal women have higher risks and incidence of hypertension and cardiovascular disease (CVD) compared to premenopausal. In Women’s Health Initiative (WHI) studies restricted to younger postmenopausal women show that initiation of hormonal replacement therapy (HRT) closer to menopause reduced the risk of CVD. The aim of the study was the evaluation of the actual state of knowledge connected with the influence on transdermal hormonal replacement therapy (HRT), in early postmenopausal women, on the concentrations of sex hormones, lipids, coagulation markers and other parameters associated with cardiovascular risk. In women receiving transdermal hormonal replacement therapy, the significant decrease of concentrations of TC, LDL-C, lipoprotein (a), homocysteine, fibrinogen, C-reactive protein, and the increase of concentrations of HDL-C, PC-protein, PS-protein and antithrombin III in blood serum were found. This regimen did not increase arterial blood pressure. Conclusions: 1. In early postmenopausal women receiving transdermal hormonal replacement therapy the levels of estradiol, estrone and progesterone in blood serum assured the optimal concentration of these hormones. − 2. Long-term transdermal hormonal replacement therapy in early postmenopausal women resulted in beneficial effects on the concentration of sex hormones, lipids, coagulation markers and other parameters associated with cardiovascular risk. − 3. Favourable biophysical and biochemical results of the long – term transdermal hormonal replacement therapy, indicate that the presented mode of hormonal treatment is the procedure of choice in the prophylaxis and treatment of early postmenopausal women with the biochemical risk factors of arteriosclerotic vascular diseases.
Okres pomenopauzalny u kobiet cechuje się większym ryzykiem i częstością nadciśnienia tętniczego i schorzeń sercowo-naczyniowych w porównaniu z okresem premenopauzalnym. W badaniu pod nazwą Women’s Health Initiative (WHI) wykazano, że rozpoczęcie hormonalnej terapii zastępczej we wczesnym okresie pomenopauzalnym redukuje ryzyko schorzeń sercowonaczyniowych u kobiet. Celem pracy była ocena aktualnego stanu wiedzy związanego z wpływem przezskórnej hormonalnej terapii zastępczej (HTZ) we wczesnym okresie pomenopauzalnym na stężenia hormonów płciowych, lipidów, czynniki krzepnięcia krwi i inne parametry związane z ryzykiem sercowo-naczyniowym. U kobiet otrzymujących przezskórną hormonalną terapię zastępczą stwierdzono istotne obniżenie stężeń TC, LDL-C, lipoproteidy (a), białka C-reaktywnego oraz wzrost stężeń HDL-C, białek PC i PS i antytrombiny III w surowicy krwi. Przezskórny sposób podawania hormonalnej terapii zastępczej nie powoduje wzrostu ciśnienia tętniczego krwi. Wnioski: 1. Przezskórna hormonalna terapia zastępczą zastosowana we wczesnym okresie pomenopauzalnym zapewnia optymalne stężenia estradiolu, estronu i progesteronu w surowicy krwi. – 2. Długotrwale stosowana we wczesnym okresie pomenopauzalnym, przezskórna hormonalna terapia zastępcza wpływa korzystnie na stężenia hormonów płciowych, lipidów, czynniki krzepnięcia krwi i inne parametry związane z ryzykiem sercowo-naczyniowym. – 3. Korzystne biofizyczne i biochemiczne wyniki stosowania długotrwałej przezskórnej hormonalnej terapii zastępczej wskazują, że przedstawiony sposób leczenia hormonalnego jest procedurą z wyboru w profilaktyce i leczeniu kobiet we wczesnym okresie pomenopauzalnym z biochemicznymi czynnikami ryzyka miażdżycowych chorób naczyniowych.
Źródło:
Health Problems of Civilization; 2016, 10, 2; 20-24
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 16

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