Temat: epigenetic - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Environmental risk factors and epigenetic alternations in psoriasis
Autorzy:: Roszkiewicz, M.
Dopytalska, K.
Szymańska, E.
Jakimiuk, A.
Walecka, I.
Powiązania:: https://bibliotekanauki.pl/articles/2085926.pdf
Data publikacji:: 2020
Wydawca:: Instytut Medycyny Wsi
Tematy:: psoriasis
habits
environmental factors
epigenetic alternations
Opis:: Introduction and objective. Psoriasis isa quite common, chronic and immune-mediated skin disorder. The prevalence of psoriasis differs in various countries, but it is said to affect 2% of the world’s population in general. Psoriasis has many different clinical features but all lesions have the same characteristic: erythema, thickening and scale, although other clinical features are also connected, such as psoriatic arthritis, obesity and metabolic syndrome. All of these may lead to conditions impairing the quality of life. This review is an attempt to summarize recent data regarding environmental factors, together with epigenetic markers and processes playing an important role in psoriasis. State of knowledge. Many different environmental factors play a role in genetically predisposed patients. This is causes epigenetic alternations which may be a linking part in the whole process. Many studies have indicated a connection between psoriasis and various genes and antigens. The presence of HLA-Cw6 is common as well a strong link between its presence and the onset of psoriasis being observed. The main alternations are DNA methylation, histone’s modifications and the role of microRNA. Excessive reaction is usually not present without a triggering factor. Environmental factors are mostly rated, such as drugs, life style and habits (smoking, alcohol), diet, physical trauma (skin injury provoking Koebner phenomenon), stress, microorganism and infections. Conclusions. The correlation between pathogenesis of psoriasis and environmental risk factors, together with epigenetic alternations still require more investigation. Education about diet habits, nutrition, weight loss and healthy lifestyle seems to be important during the treatment of psoriasis.
Źródło:: Annals of Agricultural and Environmental Medicine; 2020, 27, 3; 335-342
1232-1966
Pojawia się w:: Annals of Agricultural and Environmental Medicine
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 2.

Tytuł:: Androgen receptor modulation and bladder cancer prevention – a short review
Autorzy:: Wieczorek, Edyta
Farooqi, Ammad A.
Reszka, Edyta
Powiązania:: https://bibliotekanauki.pl/articles/2081138.pdf
Data publikacji:: 2022-04-22
Wydawca:: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:: AR
detoxification
DIM
epigenetic regulation
occupational exposure
UGT
Opis:: The prevalence of bladder cancer (BCa) is 4 times higher in men as compared to women, and gender differences have been the focus of attention for few years. Androgen receptor (AR) may be a putative explanation for gender differences. It may also be related to unfavourable BCa progression and development because of the increased androgen sensitivity of urothelium to carcinogens. Moreover, cigarette smoking and occupational exposure to carcinogens have been reported to play contributory roles with the highest attributable risk of BCa. In this review, the authors attempt to summarize the seminal research works that synthesized current understanding of the central role of AR in the negative regulation of carcinogen detoxification activity in BCa. In particular, the authors discuss the regulatory effects of 3,3’-diindolylmethane on AR gene transcription through microRNA as its suggested effect on the prevention of BCa. Moreover, to show the still existing problem of occupational exposure and BCa incidence, the authors review recent studies in this area. Based on the rapidly accumulating scientific evidence, it seems pragmatic that androgen/AR-mediated interference in the detoxification mechanism may be inhibited by phytochemicals. Therefore, collectively, nutrition has a key role as gene–nutrient interactions are important contributors to BCa prevention, also through epigenetic modifications. Here, the authors have derived suggestions for future research. Med Pr. 2022;73(2):151–62
Źródło:: Medycyna Pracy; 2022, 73, 2; 151-162
0465-5893
2353-1339
Pojawia się w:: Medycyna Pracy
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 3.

Tytuł:: Inclusions in anhydrite crystals from blue halite veins in the Kłodawa Salt Dome (Zechstein, Poland)
Autorzy:: Toboła, T. T.
Powiązania:: https://bibliotekanauki.pl/articles/2059913.pdf
Data publikacji:: 2016
Wydawca:: Państwowy Instytut Geologiczny – Państwowy Instytut Badawczy
Tematy:: blue halite
hydrothermal environment
salt domes
anhydrite
epigenetic salt
Opis:: The occurrence of both the blue and violet halites is one of the most interesting phenomena in nature. Despite numerous laboratory and field works, their origin in natural evaporitic environments has not been satisfactorily explained. In the Kłodawa Salt Dome (Zechstein, Central Po land), blue or vio let halites occur relatively frequently. Their accumulations differ in size and intensity of colours. In this paper, petrological features of anhydrite crystals derived from one of the largest outcrops of the blue halite at the Kłodawa Salt Mine are presented. Anhydrite is one of solid inclusions encountered in blue-coloured halite crystals. Special attention was paid to fluid inclusions present in this anhydrite. The microthermometric measurements showed two directions of homogenisation, i.e., towards the liquid phase (LG→L, LL→L) ortowards the gas phase (LG→G). In the former case, the temperatures ranged from 174 to 513°C, whereas in the latter one, the values from 224 to 385°C were measured. The composition of inclusions is relatively variable. We can observe transparent and opaque daughter minerals as well as CO2 in the liquid phase accompanied by a variable amount of methane or hydrogen sulphide. These features of inclusions indicate that anhydrite crystals and, thus, blue halite were formed under the influence of hydrothermal conditions. Observations in the mine workings combined with petrological studies enable to conclude that blue colouration of halite crystals is controlled by three factors: a high temperature, reducing conditions and defects in halite lattice related to tectonic stress.
Źródło:: Geological Quarterly; 2016, 60, 3; 572--585
1641-7291
Pojawia się w:: Geological Quarterly
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 4.

Tytuł:: Chromatin immunoprecipitation — new approach for revealing histone modifications in plants under heavy metal stress — theoretical review on advantages, drawbacks and questions
Autorzy:: Kwaśniewski, P.
Powiązania:: https://bibliotekanauki.pl/articles/115479.pdf
Data publikacji:: 2010
Wydawca:: Fundacja na Rzecz Młodych Naukowców
Tematy:: chromatin dynamics
heavy metal stress
ecophysiology
ChIP
immunoprecipitation
histone modifications
epigenetic
Opis:: Heavy metal contamination is a major environmental problem. A coordinated network of molecular processes participates in plant response to heavy metals. The metal-dependent gene expression is regulated on multiple levels and may include chromatin modifi cations. One of the methods which allows to understand the role of histone post-translational modifi cations in plant cell response to heavy metals may be chromatin immunoprecipitation.
Źródło:: Challenges of Modern Technology; 2010, 1, 1; 7-10
2082-2863
2353-4419
Pojawia się w:: Challenges of Modern Technology
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 5.

Tytuł:: Epigenetic modulation of the activity of transgen and endogenous gene based on the example of chalcone synthase in flax
Autorzy:: Zuk, M.
Dzialo, M.
Szopa, J.
Powiązania:: https://bibliotekanauki.pl/articles/951257.pdf
Data publikacji:: 2015
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: epigenetic modulation
mutagenesis
genetic modification
chalcone synthase
flax
transgenic plant
phenylpropanoid
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2015, 96, 1
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 6.

Tytuł:: Actinomycin D as an Epimutagen in Protists
Autorzy:: Uspenskaya, Zoya I.
Yudin, Alexander L.
Powiązania:: https://bibliotekanauki.pl/articles/52376322.pdf
Data publikacji:: 2017
Wydawca:: Uniwersytet Jagielloński. Wydawnictwo Uniwersytetu Jagiellońskiego
Tematy:: actinomycin D
Amoeba proteus
Dileptus anser
epigenetic variation
epimutagen
inheritable destabilization of characters
Opis:: A previously unrecorded property of actinomycin D, a well-known antibiotic, was discovered in the course of long-term genetic research on the amoeba Amoeba proteus and the ciliate Dileptus anser. In these protists actinomycin D can induce an unusual type of hereditary variation, which we refer to as the inheritable destabilization of characters. A number of features indicate that this variation is epigenetic, that is, not caused by mutations in the DNA. Therefore, actinomycin D may be considered as an inducer of epigenetic inheritable changes, in other words, as an epimutagen.
Źródło:: Acta Protozoologica; 2017, 56, 3; 139-147
0065-1583
1689-0027
Pojawia się w:: Acta Protozoologica
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 7.

Tytuł:: Comparison of epigenetic changes induced by particular phytohormones and oligonucleotide sequences in flax
Autorzy:: Dzialo, M.
Zuk, M.
Szopa-Skorkowski, J.
Powiązania:: https://bibliotekanauki.pl/articles/951289.pdf
Data publikacji:: 2015
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: conference
epigenetic change
phytohormone
oligonucleotide
flax
Linum usitatissimum
DNA sequence
methylation
flavonoids
chalcone synthase
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2015, 96, 1
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 8.

Tytuł:: Stress and cancer
Stres i nowotwór
Autorzy:: Jośko-Ochojska, Jadwiga
Brus, Ryszard
Powiązania:: https://bibliotekanauki.pl/articles/1035520.pdf
Data publikacji:: 2020
Wydawca:: Śląski Uniwersytet Medyczny w Katowicach
Tematy:: stress
cancer
catecholamines
glucocorticosteroids
vegf
angiogenesis
telomeres
epigenetic inheritance
stres
nowotwór
katecholaminy
glikokortykosteroidy
angiogeneza
telomery
dziedziczenie epigenetyczne
Opis:: Scientific research has shown that during stress, the secretion of hormones and neurotransmitters in the brain, etc. is definitely stronger and longer lasting when persons are convinced that they cannot cope with the requirements of a stressful situation, i.e. they are in a state of uncontrolled stress. The main indicator of this condition is a long-term increase in the concentration of stress hormones in the blood. The higher the catecholamine concentration, the more DNA damage, the more cells undergoing tumour transformation, the larger the tumour and the more advanced the disease. Catecholamines also narrow blood vessels, which leads to an increase in VEGF expression, responsible for an increase in angiogenesis, and hence tumour growth and tumour metastasis. Cortisol contributes to inhibition of the immune system and changes in the central nervous system. Under uncontrolled stress, telomeres are shortened, which is another reason for shortening life expectancy. It has also been proven that stress and trauma are inherited in subsequent generations in the mechanism of epigenetic inheritance. Despite epigenetic predispositions to develop various malignancies, including ovarian, stomach and colorectal cancer, people can move from uncontrolled to controlled stress in a particular situation, even though the situation itself does not change. This is a breakthrough message. During cancer, the transition to controlled stress definitely supports therapy, increasing your chances of survival or even recovery. The most common condition for taking control of stress is to change your current lifestyle.
Badania naukowe dowiodły, że w czasie stresu wydzielanie hormonów, neuroprzekaźników w mózgu itp. jest zdecydowanie silniejsze i trwa dłużej, zwłaszcza jeśli człowiek jest przekonany, że nie będzie w stanie sprostać wymaganiom sytuacji stresowej, czyli pozostaje w stanie stresu niekontrolowanego. Głównym wskaźnikiem tego stanu jest długo trwający przyrost stężenia hormonów stresu we krwi. Im większe stężenie katecholamin, tym więcej uszkodzeń DNA, więcej komórek ulegających transformacji nowotworowej, większy guz i bardziej zaawansowana choroba. Katecholaminy ponadto zwężają naczynia krwionośne, co przyczynia się do wzrostu ekspresji czynnika VEGF, który zwiększa angiogenezę, wzrost guza i przerzuty nowotworowe. Kortyzol przyczynia się do hamowania układu immunologicznego i zmian w ośrodkowym układzie nerwowym. W stresie niekontrolowanym skróceniu ulegają telomery, które są kolejną przyczyną skrócenia długości życia. Dowiedziono także, że stres i trauma są dziedziczone w kolejnych pokoleniach w mechanizmie dziedziczenia epigenetycznego. Pojawiają się wtedy predyspozycje epigenetyczne do zachorowania na różne nowotwory złośliwe, w tym raka jajnika, żołądka, jelita grubego. W konkretnej sytuacji można jednak przejść ze stresu niekontrolowanego do kontrolowanego, mimo że sama sytuacja się nie zmienia, i to jest wiadomość przełomowa. W trakcie choroby nowotworowej wejście w stan stresu kontrolowanego zdecydowanie wspomaga terapię, zwiększając szansę na przeżycie lub nawet wyzdrowienie. Najczęściej warunkiem przejęcia kontroli nad stresem jest zmiana dotychczasowego stylu życia. Radzenie sobie ze stresem, aktywność ruchowa i zdrowe odżywianie się są w stanie nawet doprowadzić do zmian na poziomie epigenomu, a badania naukowe dowodzą, że możemy wtedy uporać się z licznymi odziedziczonymi predyspozycjami, zmniejszając prawdopodobieństwo zachorowania na nowotwory złośliwe.
Źródło:: Annales Academiae Medicae Silesiensis; 2020, 74; 166-180
1734-025X
Pojawia się w:: Annales Academiae Medicae Silesiensis
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 9.

Tytuł:: Epigenetic silicification of the Upper Oxfordian limestones in the Sokole Hills (Kraków-Częstochowa Upland): relationship to facies development and tectonics
Autorzy:: Matyszkiewicz, J.
Kochman, A.
Rzepa, G.
Gołębiowska, B.
Krajewski, M.
Gaidzik, K.
Żaba, J.
Powiązania:: https://bibliotekanauki.pl/articles/138902.pdf
Data publikacji:: 2015
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: Upper Jurassic limestones
epigenetic silicification
tectonic deformations
Kraków-Częstochowa Upland
wapienie górnej jury
deformacje tektoniczne
Wyżyna Krakowsko-Częstochowska
Opis:: A spectacular epigenetic silicification was encountered in the Oxfordian bedded limestones exposed in the Sokole Hills situated in the Kraków-Częstochowa Upland. The main epigenetic mineral is microcrystalline quartz accompanied by minor goethite, hematite, barite, galena and sphalerite. Locally, the mineralized limestones reveal Pb and Cu contents exceeding over 150 times the background values of these metals in unmineralized limestones. The epigenetic mineralization of the bedded limestones was probably a two-stage process. During the first, Early Cretaceous stage, silicified limestones formed at the erosional surface of a denuded carbonate complex. Such silicification greatly limited the progress of the first karstification phase of the Upper Jurassic carbonates initiated in the Hauterivian. The sources of silica accumulated in the limestones were descending solutions enriched in silica derived from the weathering zone. This silicification affected the topmost part of the Upper Jurassic massive limestones and the deeper portions of the bedded limestones along the fracture systems and stylolites. Early Cretaceous tectonic activity generated new dislocations and re-opened the existing faults, which were subsequently filled with permeable Albian quartz sands. These openings became the migration pathways for ascending, warm, relict, sulphide-carrying hydrothermal solutions at the second formation stage of the epigenetic mineralization. The newly supplied silica from the Albian sands precipitated on the silicified limestones and, as concentric rims, on brecciated, early diagenetic cherts. The second-stage mineralization proceeded under phreatic conditions, presumably close to a fluctuating mixing zone of ascending, warm hydrothermal solutions and descending cold groundwaters. The brecciated cherts acting as silica crystallization nuclei indicate that the last mineralization stage probably followed the final phase of Cenozoic faulting.
Źródło:: Acta Geologica Polonica; 2015, 65, 2; 181-203
0001-5709
Pojawia się w:: Acta Geologica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 10.

Tytuł:: Oral squamous cell carcinoma (OSCC) - molecular, viral and bacterial concepts
Autorzy:: Polz-Gruszka, D.
Macielag, P.
Foltyn, S.
Polz-Dacewicz, M.
Powiązania:: https://bibliotekanauki.pl/articles/3323.pdf
Data publikacji:: 2014
Wydawca:: Instytut Medycyny Wsi
Tematy:: human disease
cancer
oral squamous cell carcinoma
molecular aspect
viral aspect
bacterial concept
genetic abnormality aspect
epigenetic aspect
Opis:: Head and neck cancers constitute the sixth most common malignant tumours worldwide, and are one of the majors problems of global public health. In the oral cavity there are several types of oral cancers, but around 90% are squamous cell carcinoma. Many different risk factors play a role in the etiology of head and neck cancer. The aim of this study is presentation from the aspect of molecular, viral and bacterial infection. Knowledge about all factors which influence the development of these malignances is essential for diagnostics and successful treatment.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2014, 08, 2
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 11.

Tytuł:: Sedimentology of the “ore-bearing dolomite” of the Kraków-Silesia region (Middle Triassic, southern Poland)
Autorzy:: Matysik, M.
Powiązania:: https://bibliotekanauki.pl/articles/191964.pdf
Data publikacji:: 2014
Wydawca:: Polskie Towarzystwo Geologiczne
Tematy:: ore-bearing dolomite
epigenetic dolomitization
lead-zinc mineralization
facies pattern
peritidal and subtidal facies
Middle Triassic
muschelkalk
Upper Silesia
Polska
Opis:: The depositional history and facies heterogeneity of the epigenetically dolomitized Middle Triassic carbonates of southern Poland are poorly recognized, and existing concepts of fluid circulation entirely overlook the primary lithology as a factor controlling fluid flow. This study reconstructs the consecutive phases of Kraków-Silesia Sub-basin history in the Anisian and highlights their influence on the development of the so-called “ore-bearing dolomite”. Extensive fieldwork and microfacies analyses were carried out in order to decipher the original depositional fabric of the ore-bearing dolomites. As a rule, epigenetic dolomitization affected a horizon of porous strata, 35 m thick and resting directly on impermeable, wavy-nodular clay-rich calcilutites of the Gogolin Formation, which represent the interval of deepest and fully marine (offshore) sedimentation. The sedimentary succession of the porous strata is bipartite. The lower part (Olkusz Beds) is composed of Balanoglossites and Thalassinoides micritic firmgrounds and peloidal packstones-grainstones, representing shoreface-foreshore facies assemblages, whereas the upper part (Diplopora Beds) consists of dolocretes, rhizolites, cryptalgal laminites, peloidal packstones-grainstones and bioturbated fine-grained dolostones, formed in a system of tidal flats and lagoons. These two parts are separated by a subaerial disconformity, which marks a sequence boundary. During emersion, the underlying deposits were subjected to meteoric diagenesis, which led to the development of moldic porosity. This combination of depositional history and diagenetic alteration determined the routes of initial migration of dolomitizing solutions on the one hand, and the location of cavern formation on the other. Owing to progressive dissolution, small caverns were changed into large karstic forms, in which the ore minerals precipitated ultimately. These findings emphasize the importance of sedimentological analysis to the understanding of the evolution of the Kraków-Silesia ore province.
Źródło:: Annales Societatis Geologorum Poloniae; 2014, 84, 2; 81-112
0208-9068
Pojawia się w:: Annales Societatis Geologorum Poloniae
Dostawca treści:: Biblioteka Nauki