Temat: enkephalin - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Fluorescence decay time distribution analysis of cyclic enkephalin analogues; Influence of solvent and Leu configuration in position 5 on conformation
Autorzy:: Malicka, Joanna
Ganzynkowicz, Robert
Groth, Małgorzata
Czaplewski, Cezary
Karolczak, Jerzy
Liwo, Adam
Wiczk, Wiesław
Powiązania:: https://bibliotekanauki.pl/articles/1044169.pdf
Data publikacji:: 2001
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: lifetime distribution
fluorescence
energy transfer
conformation
enkephalin
Opis:: Lifetime distribution analysis were performed to study the influence of Leu configuration in position 5 on changes of the peptide chain of cyclic analogues of enkephalins containing a fluorescence donor and acceptor in different solvents. The configuration change of Leu5 in all the analogues of enkephalins studied which contain donor-acceptor pairs has no apparent influence on Trp lifetime distributions. In contrast, there is a significant solvent effect on the shape of lifetime distribution.
Źródło:: Acta Biochimica Polonica; 2001, 48, 1; 95-102
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Skocz do pozycji: 2.

Tytuł:: A novel cis-peptide bond motif inducing β-turn type VI. The synthesis of enkephalin analogues modified with 4-aminopyroglutamic acid.
Autorzy:: Kaczmarek, Krzysztof
Kaleta, Maciej
Chung, Nga
Schiller, Peter
Zabrocki, Janusz
Powiązania:: https://bibliotekanauki.pl/articles/1044069.pdf
Data publikacji:: 2001
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: constrained enkephalin analogues
4-aminopyroglutamic acid
cis-peptide bond
β-turn mimetic
Opis:: A new pathway leading to a mixture of four isomers of 4-aminopyroglutamic acid is described. Michael type addition of Z-ΔAla-OMe to enolates prepared from acylaminomalonates, followed by hydrolysis and decarboxylation give protected 4-aminopyroglutamic acid with the 4-aminopyroglutamic acid with the cis:trans ratio approximately 3:2. This mixture was incorporated into Leu-enkephalin (position 2-3). After separation of peptides it appeared that all analogues were essentially inactive in guinea pig ileum and mouse vas deferens bioassays.
Źródło:: Acta Biochimica Polonica; 2001, 48, 4; 1159-1163
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki