Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "dysfunction," wg kryterium: Temat

  Lista filtrów
Wyrównaj
Wyświetlanie 1-15 z 58
Tytuł:
Complex approach for diagnostics and treatment of mandibular joint disfunction accompanied with face pain
Autorzy:
Pohodenko-Chudakova, I. O.
Barmutzkaya, A. Z.
Shott, I. E.
Powiązania:
https://bibliotekanauki.pl/articles/285542.pdf
Data publikacji:
2008
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
mandibular joint
dysfunction
diagnostics
Źródło:
Engineering of Biomaterials; 2008, 11, no. 77-80; 2-3
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dysfunction and pain temporomandibular disorder caused by impeded eruption of third mandibular molars
Autorzy:
Bakalczuk, M.
Bozyk, A.
Rozylo-Kalinowska, I.
Kobylecka, E.
Szkutnik, J.
Powiązania:
https://bibliotekanauki.pl/articles/3733.pdf
Data publikacji:
2014
Wydawca:
Instytut Medycyny Wsi
Tematy:
craniomandibular dysfunction
dysfunction
temporomandibular disorder
temporomandibular region
mandibular molar
third molar extraction
symptom
Opis:
Introduction. There are reports in literature which indicate the connection between impacted third molars and occurrence of symptoms of craniomandibular dysfunctions and headaches. Objectives. The aim of this study was evaluation of the outcome of patients who reported specific symptoms of craniomandibular dysfunction and had impacted mandibular third molars. Materials and method. The research material consisted of 10 women who reported to the Department of Craniomandibular Disfunctions of the Medical University in Lublin, Poland, with pain and acoustic symptoms in the Temporomandibular joint (TMJ) area. During preliminary therapy, the patients used a silicone occlusal device; ionotherapy was ordered and the patients were recommended to eliminate parafunctions. Results. Clicks before treatments were present in 6 patients, after treatment with silicone occlusal device and ionotherapy with Profenid gel in 5 patients, while two years after extraction of the impacted teeth the clicks were no longer present, and differences in the presence of clicks analyses by means of the Q-Cochran test were statistically significant between examinations 1m vs.3 (Q=10.33; p<0.01) and examinations 2 vs.3 (Q=8.40; p<0.05). Conclusions. The study showed that extraction of the mandibular third molars can cause regression of some symptoms of craniomandibular disorders.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2014, 08, 2
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of sildenafil citrate on women affected by sexual dysfunction referred to health clinics
Autorzy:
Zeinalzadeh, Sanaz
Akbarzadeh, Marzieh
Faridi, Pouya
Mohagheghzadeh, Abdol Ali
Sayadi, Mehrab
Powiązania:
https://bibliotekanauki.pl/articles/552164.pdf
Data publikacji:
2017
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
female
sexual
dysfunction
sildenafil citrate.
Źródło:
Family Medicine & Primary Care Review; 2017, 2; 167-172
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Outcome of anthracycline-related cardiomyopathy – experience of a cardiooncology clinic at a tertiary referral cancer centre
Autorzy:
Alahari Dhir, Aruna
Daddi, Anuprita
Sawant, Sheela Prashant
Powiązania:
https://bibliotekanauki.pl/articles/1061992.pdf
Data publikacji:
2017
Wydawca:
Medical Education
Tematy:
anthracyclines
chemotherapy
left ventricular dysfunction
Opis:
Introduction: The most common form of cardiotoxicity in cancer treatment is anthracycline-related cardiomyopathy. Objective: To study the factors affecting response to heart failure (HF) therapy in patients with anthracycline- related cardiomyopathy (ARC). Methods: Patients with ARC were included in the study. ARC was defined as left ventricular ejection fraction (LVEF) < 50% in patients who had received anthracycline based chemotherapy. 2Decho was done at baseline and every 3 months after starting anti-heart failure treatment. The primary endpoint of the study was response to anti-heart failure treatment. The patients were considered as responders when LVEF increased at least 10 absolute points. The secondary endpoint was overall survival. Results: 177 patients with ARC were included in the study. The median cumulative dose of doxorubicin was 275 mg/m2. Median clinical follow up duration was 19 months (range 3–73 months). 55% were responders. 25 cumulative doxorubicin dose of more than 200 mg/m2 increased the likelihood of non-response (p = 0.008), by a factor of 3.07 (95% CI: 1.34–7.05). 25 patients expired. There was a significant difference in overall survival among responders as compared to non-responders (p value: 0.002, log rank test). Conclusions: In patients with ARC cumulative doxorubicin dose of more than 200 mg/m2 increased the likelihood of non-response to anti-heart failure treatment. Responders have a better overall survival compared to non-responders in patients with ARC.
Źródło:
OncoReview; 2017, 7, 4; 155-161
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Heart rate variability – clinical significance87
Autorzy:
Urbanik, Dominika
Podgórski, Maciej
Mazur, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/551741.pdf
Data publikacji:
2018
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
heart rate
autonomic dysfunction
cardiovascular risk.
Źródło:
Family Medicine & Primary Care Review; 2018, 1; 87-90
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The evaluation of hemostatic dysfunctionand disseminated intravascular coagulationin dairy cows with abomasal displacement
Autorzy:
Maden, M.
Yildiz, R.
Çöl, R.
Arican, M.
Ider, M.
Garip, M.
Tras, B.
Powiązania:
https://bibliotekanauki.pl/articles/2087648.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
DIC
hemostatic dysfunction
LDA
RDA
dairy cow
Źródło:
Polish Journal of Veterinary Sciences; 2018, 21, 4; 769-778
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oxidative stress and antioxidants markers in individuals with thyroid hormones dysfunction
Autorzy:
Omon, Emmanuel Akokhamen
Ajay, Olawale David
Powiązania:
https://bibliotekanauki.pl/articles/29520465.pdf
Data publikacji:
2023-12-31
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
antioxidants
dysfunction
malondialdehyde
oxidative stress
thyroid hormone
Opis:
Introduction and aim. Thyroid hormone abnormalities have been associated with oxidative changes in human beings. The aim of the study was to evaluate the oxidative stress marker and antioxidants status in individuals with thyroid hormone dysfunction in Ekiti State. Material and methods. A total of eighty samples were recruited in this study comprising forty subjects with thyroid hormones dysfunction and forty apparently healthy controls. Malondialdehyde (MDA), reduced glutathione (GSH) and catalase were determined spectrophotometerically. Results. MDA was non-significantly higher (p>0.05) in subjects (4.33±0.84 nmol/mL) compared with control (4.12±0.63 nmol/mL), catalase was non-significantly higher (p>0.05) in subjects (199.36±20.21 µm/mL) compared with control (181.55±16.61 µm/mL), while GSH was significantly lower (p<0.05) in subjects (79.31±10.12 µmol/mL) compared with control (127.21±7.29 µmol/mL). Conclusion. It can be concluded that the increase in the reactive oxygen species accompanied with impairment of the antioxidant system occurs in patients with thyroid hormone dysfunction. Hypothyroidism and hyperthyroidism induces disequilibrium of the oxidative/anti-oxidative balance that can lead to subsequent development of inflammation and associated diseases.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 4; 768-775
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Indications for sexology consultation in women after surgical treatment due to breast cancer
Autorzy:
Streb, J.
Jabłonski, M.J.
Słowik, A.
Babczyk, D.
Jach, R.
Powiązania:
https://bibliotekanauki.pl/articles/2083232.pdf
Data publikacji:
2019
Wydawca:
Instytut Medycyny Wsi
Tematy:
mastectomy
sexual health
sexual dysfunction
desire
orgasm
Opis:
Introduction and objectives. Surgical treatment due to brest cancer have an impact on women sexuality. There is a need for research about effective indications for sexology consultation in women after such treatment. The aim of this study is to determine the indications for sexology consultation in women after surgical treatment for breast cancer. Materials and method. We tested 42 women patients diagnosed with breast cancer who had undergone mastectomy 3 months before the study. 3 months after the surgery the women were surveyed using the Polish version of FSFI assessing sexual functioning in women. The result of PL-FSFI were compared with the control group. Results. It was found that the mean score of PL-FSFI in the study group 3 months after the surgery was 13.33 points (score range: 1.2–31.7; median 8.3 points) with a statistically significant difference in terms of areas: desire, arousal, lubrication and orgasm in favour of the control group. The total score of PL-FSFI was significantly lower in women after mastectomy than in women after breast-conserving surgery. It has been shown that sexually active women in whom the surgery concerned the right breast (on the side of the dominant hand) scored lower on the scale “sexual functioning” of QLQ-BR-23 than women with surgery of the left breast, with this difference being statistically significant. There was a statistically significant correlation between the baseline performance status on the Zubrod scale and the scales: desire, lubrication and satisfaction of PL-FSFI. Living in a small town proved to be statistically significant for predicting a lower risk of sexual dysfunction among the surveyed women. Conclusions. The women who underwent surgery due to breast cancer had a higher risk of sexual dysfunction compared to the general population. Higher risk of sexual dysfunction especially concerns women after mastectomy, those who underwent breast surgery on the side of the dominant hand, and those with a worse preoperative overall level of functioning of ≥ 1 point on the Zubrod scale. A lower risk of disorders was observed in women living in smaller towns. The above factors indicate the advisability for sexology consultation in women with breast cancer.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 2; 379-384
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
BIOMARKERS OF VISUAL PERCEPTION DYSFUNCTION IN AUTISM: PROGRESS AND DIRECTIONS IN EEG RESEARCH
Autorzy:
Feroz, Farah Shahnaz
Shahbodin, Faaizah
Munir, -
Riza, Lala Septem
Rasim, -
Che Ku Mohd, Che Ku Nuraini
Jano, Zanariah
Mohamad, Siti Nurul Mahfuzah
Powiązania:
https://bibliotekanauki.pl/articles/2138171.pdf
Data publikacji:
2022-04-04
Wydawca:
Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
Tematy:
visual perception dysfunction
biomarkers
autism
EEG
ERPs
Opis:
As the world moves towards the Fourth Industrial Revolution, there is a need for formulations of neurophysiological biomarkers that ensure the accuracy of the diagnosis of visual perception dysfunction in individuals with Autism Spectrum Disorder (ASD). Biomarkers of visual perception dysfunction in ASD using EEG complements behavioral methods of diagnosis and allows for a more direct assessment of the dysfunction, identifying rapid, implicit neural processes that are not revealed through behavioral measures alone. This paper aims to review the neural biomarkers of the five domains of visual perception dysfunction (visual discrimination (VD), visual spatial relations (VSR), visual form constancy (VFC), visual memory (VM) and visual closure (VC)) in individuals with ASD. This paper shall help researchers gain new insight into the current trends and progress in EEG methods in ASD and discover gaps in the subject literature. A systematic literature search on PubMed was conducted to report findings of EEG studies that:1) assessed the severity levels in patients with ASD and 2) investigated the neural biomarkers of visual perception dysfunction in ASD. Spectral analysis, functional connectivity analysis and event-related potential (ERP) are useful in modern medicine to identify the biomarkers that distinguish the levels of the severity of visual perception dysfunction in ASD.
Źródło:
Acta Neuropsychologica; 2022, 20(1); 115-127
1730-7503
2084-4298
Pojawia się w:
Acta Neuropsychologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Combination therapy of tadalafil and pentoxifylline in severe erectile dysfunction; a prospective randomized trial
Autorzy:
Kumar, Santosh
Roat, Rajesh
Agrawal, Swat
Jayant, Kumar
Mavuduru, Ravimohan
Kumar, Shrawan
Powiązania:
https://bibliotekanauki.pl/articles/1394362.pdf
Data publikacji:
2015
Wydawca:
Index Copernicus International
Tematy:
erectile dysfunction
PDE5 inhibitors
Tadalafil
Pentoxyfilline
Opis:
The aim of the study was to assess efficacy of Tadalafil alone versus Tadalafil plus Pentoxifylline in the treatment of erectile dysfunction by using self administered IIEF-5 questionnaire. Material and methods. Two hundred and thirty seven patients presenting with ED at andrology OPD were evaluated for ED by a self administered IIEF (International Index of Erectile Function) questionnaire. Patients were systematically randomized by computer generated random table into two groups groups namely, group A: Tadalafil only group, group B: combination of Tadalafil + Pentoxifylline. All the patients were re-assessed by IIEF-5 questionnaire after 8 weeks of medical therapy. Statistical analysis was performed using student’s unpaired t-test, paired t-test, chi square test. pvalue < 0.05 was considered statistically significant. Results. Two hundred and thirty seven patients were included in the present study, in group A: 92 patients (78.6%) showed improvement in their IIEF score after 8 weeks of tadalafil treatment. While in group B, overall 104 patients(86.6%) showed improvement after combination of Tadalafil and Pentoxifylline. There was a statistically significant difference of percentage change in IIEF score was seen in group B (group A 90.7±15.2%, group B 95.6±13.4%; p value – 0.014). We found this difference even more statistically significant in patients with severe ED (group A 72.7±47.2%, group B 132.3±54.3%; p value – 0.000). There was no significant difference in between the two groups with regards to occurrence of side effects. Conclusions. Both tadalafil and combination of Tadalafil + Pentoxifylline improve erectile function in patients of ED. Patients with severe ED showed much significant improvement in erectile function with combination therapy.
Źródło:
Polish Journal of Surgery; 2015, 87, 8; 377-383
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of physical exercise as a component of cardiac rehabilitation on endothelial dysfunction – review of the related research
Wpływ wysiłku fizycznego w ramach rehabilitacji kardiologicznej na dysfunkcję śródbłonka – przegląd badań
Autorzy:
Domka-Jopek, Elżbieta
Lenart-Domka, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/437736.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
endothelial dysfunction
cardiac rehabilitation
dysfunkcja śródbłonka
rehabilitacja kardiologiczna
Opis:
Endothelial dysfunction means any disturbance in the vascular endothelial function. There are many data indicating that endothelial dysfunction is a source of numerous vascular diseases. Cardiac rehabilitation, especially connected with increasing physical activity, plays an important role in the prophylaxis of vascular diseases complications in patients. Physical activity causes favorable changes in the circulatory system and improves psychophysical status. It is the base of healthy life style and fundamental element of primary and secondary prevention of cardiovascular diseases. Cardiac rehabilitation after acute coronary incidents reduces total mortality and decreases the risk of next cardiac intervention. Similar beneficial effects may be observed in chronic heart failure. Some reports attempt to explain mechanisms responsible for favorable effect of rehabilitation in primary and secondary prevention of cardiovascular disease. Many authors suggest, that cardiac training improves disturbed function of endothelium in cardiac diseases (hypertension, ischemic heart disease, chronic heart failure). Improved prognosis in patients with cardiovascular diseases after cardiac rehabilitation seems to be dependent on improvement in endothelial function.
Dysfunkcja śródbłonka oznacza ubytek jakiejkolwiek z jego funkcji. Istnieje wiele danych upatrujących źródła chorób sercowo-naczyniowych w upośledzonej funkcji śródbłonka. Wśród działań mających na celu zapobieganie następstwom chorób układu krążenia istotną rolę przypisuje się rehabilitacji kardiologicznej, a zwłaszcza zwiększeniu aktywności fizycznej pacjentów. Aktywność fizyczna, wywołując korzystne zmiany fizjologiczne w czynności układu krążenia, redukując czynniki ryzyka chorób serca, poprawiając stan psychofizyczny pacjentów stała się podstawą zdrowego stylu życia oraz fundamentalnym elementem prewencji pierwotnej i wtórnej chorób układu krążenia. Zastosowanie rehabilitacji kardiologicznej u chorych po przebyciu ostrych incydentów wieńcowych redukuje śmiertelność całkowitą oraz zmniejsza ryzyko kolejnych interwencji kardiologicznych. Podobnie korzystne efekty widoczne są w przewlekłej niewydolności serca. W ostatnich latach pojawiło się szereg doniesień próbujących wytłumaczyć mechanizmy odpowiedzialne za pozytywny efekt rehabilitacji pacjentów z chorobami sercowo-naczyniowymi. Wielu autorów potwierdza, że kompleksowa rehabilitacja kardiologiczna, trening fizyczny przywraca zaburzoną funkcję śródbłonka w chorobach układu krążenia. Efekt ten jest widoczny w nadciśnieniu tętniczym, chorobie niedokrwiennej serca, przewlekłej niewydolności serca. Wydaje się, że poprawa rokowania zauważalna po zastosowaniu rehabilitacji kardiologicznej może być zależna od poprawy funkcji śródbłonka.
Źródło:
Medical Review; 2016, 3; 311 + 323
2450-6761
Pojawia się w:
Medical Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Transjugular Intrahepatic Portosystemic Shunt in patients after orthotopic liver transplantation (OLTx) due to life threatening gastrointestinal hemorrhage. A single-center experience based on three cases and literature review
Autorzy:
Januszewicz, Magdalena
Włodarczyk-Pruszyńska, Inga
Milczarek, Krzysztof
Rowińska-Berman, Katarzyna
Zieniewicz, Krzysztof
Wróblewski, Tadeusz
Rowiński, Olgierd
Powiązania:
https://bibliotekanauki.pl/articles/1392272.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
Transjugular Portasystemic Shunt
variceal bleeding
OLTx
graft dysfunction
Opis:
Background: Transjugular intrahepatic portosystemic shunt system (TIPS) is a well-recognized method of treatment of symptomatic portal hypertension in patients awaiting liver transplantation. The effectiveness of TIPS treatment in patients after liver transplantation is still not fully established. Indications for both groups of patients, with and without liver graft, are similar and include bleeding from gastrointestinal varices, ascites, pleural effusion, and Budd-Chiari syndrome. Feasibility of TIPS in emergency treatment in patients after OLTx due to life-threatening hemorrhage is not well described. Materials and methods: Patients, after OLTx performed using classical, non-piggyback technique had severe hemorrhages from gastrointestinal varices due to lost graft function. Patients were in an unstable condition, required blood transfusions on admittance and monitoring in Intensive Care Unit. TIPS were implanted urgently, after unsuccessful endoscopic treatment, as a life-saving procedure. Results: In all cases, the procedure was successfully completed. The bleeding did not reoccur during the postoperative course. Conclusion: TIPS procedure appears to be justified as a bridge to a planned retransplantation, or as a treatment of choice in patients disqualified from retransplantation. Emergency performance of the TIPS procedure as a treatment for acute variceal bleeding should still be considered individually for each patient and only as a procedure leading to further treatment.
Źródło:
Polish Journal of Surgery; 2019, 91, 2; 38-44
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The phenomena of social pathology among minors within the period of 1999-2012 as a result of family dysfunction
Zjawiska patologii społecznej wśród nieletnich w latach 1999–2012 jako wynik dysfunkcji rodziny
Autorzy:
Gosztyła, Małgorzata
Powiązania:
https://bibliotekanauki.pl/articles/526766.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Opolski. Instytut Nauk o Zdrowiu
Tematy:
dysfunction,
modern family,
juvenile crime
patologia,
nieletni,
dysfunkcja
Opis:
Over the last decade, the crime rate among young people has been rising, which may be caused by the growing dysfunctionality of the family. The aim of this work is to show the range of juvenile crime in recent years and the way in which the dysfunctionality of the family influences this phenomenon. To analyze the phenomenon of juvenile crime, the statistics of the Regional Police Headquarters in Opole in years 1999–2012 have been used. The analysis of the statistics has shown that over these years, the crime rate among young people has been rising and in 2012 it reaches 8.4% of all crimes. It is becoming apparent that the dysfunctionality of modern family influences the development of crime among young people. Modern dysfunctionality is not understood merely as orphanhood or half-orphanhood but more as a deep crisis of educational family values. What has been disturbed is the structure of families without considering it just at the level of parents’ physical presence at home but at the level of bonds, goals, norms which family should bring while shaping a young person, citizen and which it currently develops.
W ostatniej dekadzie wzrasta poziom przestępczości wśród młodych ludzi, co może być spowodowane narastającą dys- funkcjonalnością rodziny. Celem niniejszej pracy jest wskazanie zakresu przestępczości nieletnich w ostatnich latach i wpływu, jaki na to zjawisko ma dysfunkcjonalność współczesnej rodziny. Do analizy zjawiska przestępczości wśród nieletnich wykorzystano statystyki Komendy Wojewódzkiej Policji z lat 1999–2012. Z analizy danych statystycznych wynika, że w wybranym okresie wzrasta poziom przestępczości wśród młodych ludzi, który w roku 2012 sięga 8,4% wszystkich przestępstw. Widoczne staje się, że dysfunkcjonalność współczesnej rodziny ma wpływ na rozwój przestępczości wśród młodych ludzi. Przedstawione dane pokazują, jak bardzo negatywny wpływ ma rozkład rodziny i jej wartości wśród młodych ludzi. Współczesna dysfunkcjonalność nie jest już rozumiana jako sieroctwo czy półsieroctwo, ale jako głęboki kryzys wartości wychowawczych rodziny. Zaburzona została struktura rodzin, nie rozpatrując już tego zjawiska na poziomie fizycznej obecności rodziców w domu, ale na poziomie więzi, celów i norm, jakie współczesna rodzina powinna wnosić i kształtować w młodym człowieku, obywatelu, a jakie obecnie rozwija.
Źródło:
Puls Uczelni; 2015, 1; 37-40
2080-2021
Pojawia się w:
Puls Uczelni
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
USE OF VALPROIC ACID FOR THE TREATMENT OF NEUROPSYCHIATRIC SYMPTOMS IN ACQUIRED BRAIN INJURIES
Autorzy:
Bidzan, Leszek
Powiązania:
https://bibliotekanauki.pl/articles/2137936.pdf
Data publikacji:
2020-09-09
Wydawca:
Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
Tematy:
treatment; valproic acid
cognitive dysfunction
emotional disorders
aggression
Opis:
Acquired brain injuries are often accompanied by a series of neuropsychiatric disorders. A wide range of pharmacological agents are used to treat neuropsychiatric symptoms. However, a more indepth review of the agents used indicates that there are in fact relatively few procedures recommended for use. Anticonvulsants including valproic acid, are of particular interest. This research aimed to assess the efficacy and safety of valproic acid, as based on a naturalistic observation of patients with various forms of acquired brain injury and who had displayed neuropsychiatric symptoms. The study group consisted of individuals (N = 43) who were treated with valproic acid as the first choice of drug. Both the initial dose and its size during further treatment, as well as the treatment method, were determined based on medical indications. The mental state of the patients was assessed twice: at the time of enrolment for the study and after 12 months. The Cohen-Mansfield Agitation Inventory (CMAI) was used for the assessment. In addition, the degree of cognitive dysfunction was assessed during the baseline study using the MMSE scale. Eventually, 24 individuals were accepted for statistical analysis. They were re-examined after 12 months and took only valproic acid during that period. 24 out of 43 individuals qualified for the study completed the 12-month observation period. 11 respondents were excluded from the study due to their inappropriate tolerance. The reported side effects were of a temporary nature (except for hair loss) and of a mild or moderate intensity. It was observed that aggressive and impulsive behaviours were significantly reduced in the study group. The positive therapeutic effect concerned all categories in the CMAI scale, except for verbal aggression. The therapeutic effect of the valproic acid was varied depending on the degree of cognitive impairments. Statistical significance for higher MMSE scores was obtained only for the category of non-aggressive verbal disorders. On the other hand, in the case of lower MMSE scores a significant reduction was observed both in the categories of non-aggressive and aggressive physical behaviours, as well as for the overall CMAI scale result. The results obtained seem to indicate a satisfactory efficacy and acceptable tolerance of valproic acid in the treatment of the neuropsychiatric symptoms accompanying acquired brain injuries.
Źródło:
Acta Neuropsychologica; 2020, 18(3); 357-366
1730-7503
2084-4298
Pojawia się w:
Acta Neuropsychologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Acute coronary syndrome in patients with concomitant neoplastic disease and chemotherapy. Is clinical distinctness possible?
Autorzy:
Ciszewski, Andrzej
Dąbrowski, Maciej
Bęćkowski, Maciej
Powiązania:
https://bibliotekanauki.pl/articles/1065261.pdf
Data publikacji:
2015
Wydawca:
Medical Education
Tematy:
acute coronary syndrome
chemotherapy
coronary thrombosis
endothelial dysfunction
Opis:
We present 2 cases of acute coronary syndrome in patients with concomitant neoplastic disease during chemotherapy. In both patients, we found unusual angiographic image which showed that despite the presence of very large thrombi, there were no or hardly any atherosclerotic lesions in the vessel occlusion site. Aspiration thrombectomy was successfully performed in both cases to restore coronary flow and in the second patient, two bare metal stents were also implanted. After the patients were discharged from hospital, we decided to add enoxaparin to the routine dual antiplatelet therapy of both of them. So far, no guidelines have been developed on how to manage patients with acute coronary syndrome and concomitant neoplastic diseases while on chemotherapy.
Źródło:
OncoReview; 2015, 5, 3; A100-102
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 58

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies