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Wyszukujesz frazę "colorectal neoplasms" wg kryterium: Temat


Wyświetlanie 1-3 z 3
Tytuł:
Increasing deaths from colorectal cancer in Poland - insights for optimising colorectal cancer screening in society and space
Autorzy:
Czaderny, K.
Powiązania:
https://bibliotekanauki.pl/articles/2082987.pdf
Data publikacji:
2019
Wydawca:
Instytut Medycyny Wsi
Tematy:
colorectal neoplasms
mortality
colonoscopy
mass screening
screening acceptance
self-selection
Opis:
Introduction and objective. With respect to the increasing numbers of deaths due to colorectal cancer in Poland, the aim of the study was to investigate socio-demographic characteristics which influence colorectal cancer screening acceptance and to assess spatial variation of colorectal cancer mortality. Materials and method. An age-period-cohort model was estimated to assess mortality trends in colorectal cancer in Poland. A geographical analysis was performed by spatial regression. Factors influencing participation in colorectal cancer screening were identified using structural equation modelling. Results. In 2014 in Poland, 6.4 thousand men and 5.0 thousand women died due to colorectal cancer. In total, by 2030 this number is expected to rise to nearly 14.4 thousand. Observed spatial clustering of age-adjusted colorectal cancer mortality is associated with spatial variation in tobacco use, employment in industry, and consumption of red meat. Patient- physician communication, advanced age, and healthy diet are the most important predictors of colorectal cancer screening acceptance. Tobacco and alcohol users are not more likely to participate in colorectal cancer screening, adjusting for other variables. Conclusions. Self-selection of patients who follow healthy diet means that individuals at higher risk of colorectal cancer are less likely to participate in colorectal cancer screening. Therefore, screening should be more targeted. According to the structural equation modelling results, the phenomenon of ‘no-show’ for screening can be mitigated by patient-physician communication. The inhabitants of the Greater Poland region are at the highest risk of dying due to colorectal cancer, which may have public health policy implications.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 1; 125-132
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Association of XRCC6 C1310G and LIG4 T9I polymorphisms of NHEJ DNA repair pathway with risk of colorectal cancer in the Polish population
Autorzy:
Balinska, Kinga
Wilk, Damian
Filipek, Beata
Mik, Michal
Zelga, Piotr
Skubel, Pawel
Dziki, Łukasz
Dziki, Adam
Mucha, Bartosz
Kabziński, Jacek
Majsterek, Ireneusz
Powiązania:
https://bibliotekanauki.pl/articles/1391955.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
Colorectal Neoplasms/genetics
DNA-Binding Proteins/genetics
Genetic Predisposition to Disease/genetics
Genotype
Polymorphism
Single Nucleotide
Opis:
Introduction: Colorectal cancer is the second most common cancer worldwide. DNA double strand breaks (DSBs) are the most dangerous lesions which can lead to carcinogenesis. Nonhomologous end joining (NHEJ) is an important pathway, that allows for recovering DNA by direct end joining. The XRCC6 and LIG4 genes encode respectively Ku70 protein and human ATP-dependent DNA ligase, which are the components of the NHEJ repair pathway. The aim of our study was to evaluate the influence of XRCC6 C1310G and LIG4 T9I genes polymorphisms on colorectal cancer risk among Polish population. Materials and method: Genotyping was performed using TaqMan probes based on analysis of PCR products amplified in Real Time PCR. The research has been carried out on the material obtained from 100 patients with colorectal cancer and 100 cancer-free individuals who were age and sex-matched as a control group. The results were developed using the chi – squer test and odds ratio (OR). Results: Odd ratio analysis indicates reduced risk of colorectal cancer for LIG4 T9I polymorphism in heterozygotus model C/T (OR= 0.2717 95% CI= 0.1247-0,5918) and homozygous model T/T (OR= 0.3593 95% CI= 0.1394-0.9266). Similar situation we observed for XRCC6 C1310G gene polymorphism, which indicated on heterozygotus variant C/G (OR= 0.1181 95% CI= 0.0145-0.964) and homozygotus variant G/G (OR= 0.0972 95% CI= 0.0097-0.9713) to decrease the risk of colorectal cancer. Conslusions: Our research revealed XRCC6 C1310G and LIG4 T9I polymorphisms are associated with diminished risk of colorectal cancer. However, to confirm obtained results, a further investigations should be carried out.
Źródło:
Polish Journal of Surgery; 2019, 91, 3; 15-20
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Surgical treatment of extra-appendiceal colorectal neuroendocrine tumors.
Autorzy:
Maryański, Jan
Cyran-Chlebicka, Agata
Szczepankiewicz, Benedykt
Cebulski, Włodzimierz
Słodkowski, Maciej
Wroński, Marek
Powiązania:
https://bibliotekanauki.pl/articles/1392639.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
colorectal neuroendocrine tumor
gastrointestinal neoplasms
colorectal surgery
Opis:
Background: Extra-appendiceal colorectal neuroendocrine tumors are rare neoplasms with variable biological behavior. Materials and Methods: The study group consisted of 15 patients with an extra-appendiceal colorectal neuroendocrine tumor who underwent surgical resection (M/F=3:12, mean age=62.9 years). Lower-grade neuroendocrine tumors (NET G1-G2) and neuroendocrine carcinomas were recognized in 5 and 10 patients, respectively. Data were evaluated retrospectively with regard to clinical and pathologic characteristics and outcomes. Results: The median age of the patients with lower-grade NETs was significantly lower than that in patients with NECs (53 yrs vs. 68 yrs, p=0.03). NETs G1-G2 were significantly smaller than neuroendocrine carcinomas (4.0 cm vs. 6.4 cm, p=0.02). There were no differences between lower-grade NETs and NECs with regard to tumor location, local infiltration, rate of nodal involvement, and distant metastases. All the patients underwent open segmental resection of the colon or rectum. Complete resection was achieved in 3 of 5 patients from the lower-grade NET group, and in 5 of 10 patients in the NEC group (p=1.0). The overall survival was significantly better for lower-grade NETs tumors (p=0.005). The median survival was 4.8 months in the NEC group. The median survival in the lower-grade NET group was not achieved after a median follow-up of 69 months. Three-year overall survival was at a level of 100% for lower-grade NETs, and only 27% for NECs. Conclusion: Lower-grade neuroendocrine tumors seem to exhibit comparable potential for dissemination as neuroendocrine carcinomas, however, prognostic implications of metastases are distinct.
Źródło:
Polish Journal of Surgery; 2018, 90, 3; 7-12
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-3 z 3

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