Temat: clinical trial - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Sample size in clinical trials – challenges and approaches
Autorzy:: Tomski, Andrzej
Gorzawska, Barbara
Powiązania:: https://bibliotekanauki.pl/articles/2204289.pdf
Data publikacji:: 2023-05-31
Wydawca:: Główny Urząd Statystyczny
Tematy:: sample size
clinical trial
Monte Carlo methods
stochastic simulations
Opis:: Sample size estimation is a necessary and crucial step in clinical trial research. Statistical requirements, limited patient availability and high financial risk of a clinical trial necessitate the proper calculation of this measure. The aim of this paper is to discuss the reasons why the estimation of the sample size is important and, based on the obtained results, to show how this process may be completed in selected cases. Stochastic simulations based on the Monte Carlo methods approach are applied. Therefore, new challenges facing this area of research are mentioned.
Źródło:: Przegląd Statystyczny; 2022, 69, 4; 20-28
0033-2372
Pojawia się w:: Przegląd Statystyczny
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Unification of Medical Legal Norms and Criminal Liability in the Context of Globalization of Clinical Research
Autorzy:: Karpushyna, Maria
Veresha, Roman
Powiązania:: https://bibliotekanauki.pl/articles/28407956.pdf
Data publikacji:: 2023-06-30
Wydawca:: Wydawnictwo Adam Marszałek
Tematy:: medical worker
innovative development
criminal liability
clinical trial protocol
globalization
unification
personal data
Opis:: The relevance of the article is attributed to the swift evolution of the social and state system. With the advancement of the political, economic, and social dimensions of existence, there is a growing need to consider public opinion and enhance public legal awareness in the medical domain. The purpose of the study is to apply correlation analysis in comparing legal sciences and medical sciences, combining them, and subsequently utilizing applied legal dialectics within the realm of medical law knowledge. To achieve this goal, dialectical and logical methods, as well as general scientific methods such as observation and generalization, were employed. Globalization processes are supranational in nature, and under conditions of driving factors are subject to constant development. The medical field is not an exception and is influenced by other sciences, including legal doctrine, informatics, and economics. Clinical research in the medical field is subject to international influence and development, unification and legal regulation. Internationalization processes are making innovative adjustments to the development of medical science, introducing advancements such as artificial intelligence, personalized medicine, predictive medicine, preventive medicine, participatory medicine, and precision medicine. Consequently, personalized patient data is designated as sensitive and necessitates additional legal regulation. Additional attention is paid to the issue of criminal liability of medical workers as special subjects of professional activity. The results of research are reflected in the established search routes of the possibility of improving legal awareness of medical personnel in the context of practical professional activity. Such practical ways can serve as: the creation of informative material of legal content, adapted to the understanding of persons who are not specialists in the field of law, instead, they are professionals of high intellectual level of medical services. The practical importance of the results of creating information and legal content of the medical industry can be reflected in the results of advanced training by medical personnel, in addition, in the elements of self-education of doctors – researchers, private doctors – specialists, etc. Analytical study of the statistical informative material of the medical industry is reflected in legislative and normative legal acts, taken into account in the case law of the national level, taking into account the decisions of the European Court of Human Rights.
Źródło:: Copernicus Political and Legal Studies; 2023, 2, 2; 110-118
2720-6998
Pojawia się w:: Copernicus Political and Legal Studies
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Odds -theorem and monotonicity
Optymalne zatrzymywanie w oparciu o algorytm ilorazu szans a monotoniczność wartości problemu
Autorzy:: Bruss, F. Thomas
Powiązania:: https://bibliotekanauki.pl/articles/953406.pdf
Data publikacji:: 2019
Wydawca:: Polskie Towarzystwo Matematyczne
Tematy:: Odds-algorithm
Secretary problem
Selection criteria
Multiple stopping problems
Group interviews
Games
Clinical trial
Prophet inequality
Opis:: Given a finite sequence of events and a well-defined notion of events being interesting, the Odds-theorem (Bruss(2000)) gives an online strategy to stop on the last interesting event. This strategy is optimal for independent events, and it is obtained in a straightforward way by an algorithm which is optimal itself (odds-algorithm). Here we study questions in how far the optimal value mirrors monotonicity properties of the underlying sequence of probabilities of events. We make these questions precise, motivate them, and then give complete answers. The motivation is enhanced by certain problems where it seems desirable to apply the odds-algorithm but where a lack of information does not allow to do so without incorporating sequential estimation. In view of this goal, the notion of a plug-in odds-algorithm is introduced. Several applications are included.
Źródło:: Mathematica Applicanda; 2019, 47, 1
1730-2668
2299-4009
Pojawia się w:: Mathematica Applicanda
Dostawca treści:: Biblioteka Nauki

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