Temat: cell migration - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Regulation of β1 integrin expression in endothelial cells by chimeric tRNAVal ribozyme
Autorzy:: Papiewska-Pająk, Izabela
Antoszczyk, Sławomir
Powiązania:: https://bibliotekanauki.pl/articles/1041244.pdf
Data publikacji:: 2006
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: integrins
cell migration
β1 integrin subunit
hammerhead ribozyme
Opis:: To downregulate expression of the β1 integrin subunit in endothelial cells, plasmid encoding the ribozyme cassette containing hammerhead ribozyme flanked at the 5' terminus by tRNAVal and at the 3' terminus by constitutive transport element sequences was constructed. When used to transfect immortalized human endothelial cell line EA.hy 926, it selectively blocked the synthesis of the β1 integrin subunit and thus inhibited migration and proliferation of the cells. Thus, this construct may be a valuable tool to control the proangiogenic phenotype of stimulated endothelial cells.
Źródło:: Acta Biochimica Polonica; 2006, 53, 2; 311-316
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Synthesis and anticancer activity evaluation of some new derivatives of 2-(4-benzoyl-1-piperazinyl)-quinoline and 2-(4-cinnamoyl-1-piperazinyl)-quinoline.
Autorzy:: Kubica, Krzysztof P.
Taciak, Przemyslaw P.
Czajkowska, Agnieszka
Sztokfisz-Ignasiak, Alicja
Wyrebiak, Rafal
Podsadni, Piotr
Mlynarczuk-Bialy, Izabela
Malejczyk, Jacek
Mazurek, Aleksander P.
Powiązania:: https://bibliotekanauki.pl/articles/895388.pdf
Data publikacji:: 2018-08-31
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Tematy:: anticancer activity
cytotoxicity assay
2-quinoline
cell migration assay
Opis:: In this study we designed and synthesized twenty new derivatives of 2-(4-benzoyl-1-piperazinyl)-quinoline and 2-(4-cinnamoyl-1-piperazinyl)-quinoline with potential anticancer activity. The structures of synthesized compounds were confirmed by 1H and 13C NMR spectroscopy and MS spectrometry. The activity of novel compounds was evaluated in the cell viability assay as well as in the wound healing assay. Presented data show that examined substances have anticancer activity in cell culture. Seven compounds which showed a high rate of cell growth inhibition were selected for further studies. Three of them strongly reduced growth of B16F10 cells. The novel compounds constitute a good base for further studies and optimization of structure for new therapeutically effective anti-cancerous drugs.
Źródło:: Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 4; 891-901
0001-6837
2353-5288
Pojawia się w:: Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: The role of microtubules in electrotaxis of rat Walker carcinosarcoma WC256 cells
Autorzy:: Krecioch, Izabela
Madeja, Zbigniew
Lasota, Slawomir
Zimolag, Eliza
Sroka, Jolanta
Powiązania:: https://bibliotekanauki.pl/articles/1038967.pdf
Data publikacji:: 2015
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: rat Walker carcinosarcoma WC256 cells
electrotaxis
directional cell migration
microtubules
Opis:: The endogenous electric field may provide an important signal for directional cell migration during cancer metastasis but the mechanism of cell electrotaxis is poorly understood. It was postulated that microtubules play a central role in the polarization and directional migration of several types of cells. In this paper we investigated the role of microtubules in electrotaxis of rat Walker carcinosarcoma WC256 cells. We found that colchicine-stimulated disassembly of microtubules caused the formation of blebs instead of lamellipodia at the front of about 45% of cells. Most of the remaining cells contracted and became rounded or transformed into non-polar cells. Depolymerization of microtubules in both subpopulations of cells reduced the directionality of cell migration to about 50% of the control, but bleb- forming cells migrated much more efficiently than lamellipodia-forming cells. The analysis of microtubules architecture in the presence of an endogenous electric field showed that there is no relationship between the direction of migration and the polarization of microtubules. These results suggest that microtubules are not indispensable for electrotaxis of WC256 cells, however they may improve the directionality of cell migration.
Źródło:: Acta Biochimica Polonica; 2015, 62, 3; 401-406
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Synthesis and anticancer activity evaluation of novel derivatives of 7-amino-4-methylquinolin-2(1H)-one
Autorzy:: Kubica, Krzysztof P.
Taciak, Przemyslaw P.
Czajkowska, Agnieszka
Sztokfisz-Ignasiak, Alicja
Wyrebiak, Rafal
Mlynarczuk-Bialy, Izabela
Malejczyk, Jacek
Mazurek, Aleksander P.
Powiązania:: https://bibliotekanauki.pl/articles/895717.pdf
Data publikacji:: 2018-08-31
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Tematy:: anticancer activity
cytotoxicity assay
cell migration assay
quinolin-2(1H)-one
Opis:: In this study we designed and synthesized sixteen new derivatives of 7-amino-4-methylquinolin-2(1H)-one with potential anticancer activity. The structures of synthesized compounds were confirmed by 1H and 13C NMR. The activity of novel substances was evaluated by cell viability assay and wound healing assay. In vitro tests for series of sixteen novel compounds were performed. The results showed that examined compounds are selective for cancer cells, but their activity for various types of cancer is different. Three of new compounds presented ability to inhibit cells migration. The novel compounds constitute a good starting point for further studies and optimization of structure for new therapeutically effective anti-cancerous drugs. Seven compounds, which showed the highest rate of cell inhibition, were selected for further studies.
Źródło:: Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 4; 903-910
0001-6837
2353-5288
Pojawia się w:: Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Polyamines and cell migration
Autorzy:: McCormack, S.A.
Johnson, L.R.
Powiązania:: https://bibliotekanauki.pl/articles/70020.pdf
Data publikacji:: 2001
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: cytoskeleton
spermine
polyamine
ornithine decarboxylase
microtubule
cell migration
actin polymerization
putrescine
spermidine
Źródło:: Journal of Physiology and Pharmacology; 2001, 52, 3
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: ATP-induced Ca2plus-signalling enhances rat gastric microvascular endothelial cell migration
Autorzy:: Ehring, G.R.
Szabo, I.L.
Jones, M.K.
Sarfeh, I.J.
Tarnawski, A.S.
Powiązania:: https://bibliotekanauki.pl/articles/70926.pdf
Data publikacji:: 2000
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: gastric endothelial cell
migration
ulcer healing
angiogenesis
microvasculature
calcium signalling
rat
Źródło:: Journal of Physiology and Pharmacology; 2000, 51, 4,2
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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