Temat: camptothecin - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Polyester-camptothecin conjugates for controlled release
Autorzy:: Sobczak, M.
Olędzka, E.
Kuras, M.
Luchowska, U.
Świniarska, L.
Wyrębiak, R.
Nałęcz-Jawecki, G.
Powiązania:: https://bibliotekanauki.pl/articles/284000.pdf
Data publikacji:: 2016
Wydawca:: Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:: polyesters
camptothecin
alkaloids
Źródło:: Engineering of Biomaterials; 2016, 19, 138; 45
1429-7248
Pojawia się w:: Engineering of Biomaterials
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: CAMPTOTHECIN INHIBITS MIGRATION, INVASION AND CLONOGENIC PROPERTY OF LIVER CANCER CELLS BY MODULATING MICRORNA EXPRESSION
Autorzy:: Liu, Zhenzhong
Wu, Song
Li, Xiaoqian
Powiązania:: https://bibliotekanauki.pl/articles/895460.pdf
Data publikacji:: 2020-04-29
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Tematy:: Hepatocellular Carcinoma
cell proliferation
cell cycle
Camptothecin
miRNA
Opis:: Camptothecin (CPT), an alkaloid natural product, extracted from Camptotheca acuminata bark, has been reported to have potential antitumor activity in diverse cancers. MicroRNAs (MiRNAs) are a class of short, non-coding RNAs that plays a crucial role in the normal physiology by attenuating translation. Here, we showed that the CPT modulates the expression of miRNAs in hepatocellular carcinoma cells (HCC). Microarray analysis reveals that CPT modulates the expression of as many as 39 miRNAs in HCC cells (Huh7), 27 miRNAs were downregulated whereas 12 miRNAs were upregulated. miR-16 is the key miRNA upregulated by CPT and targets key prosurvival proteins (MMP-2, MMP-9 and cyclin D1). Our results demonstrate that CPT is inhibiting cell viability of HCC cells significantly when compared with the untreated cells. Wound healing and colony formation assay confirm inhibition of cell migration and clonogenic property of Huh7 cells respectively, upon the dose-dependent treatment of CPT. Furthermore, the Boyden chamber assay analysis revealed a significant inhibition of number of invasive cells in CPT treated cells with comparison to untreated Huh7 cells. Mechanistically, CPT upregulates miR-16 expression which targets MMP-2, MMP-9, cyclin D1 downregulation and subsequently upregulates the expression of E-cadherin, TIMP1, p21, and p27, thereby inhibits cell migration, invasion and clonogenic property of HCC cells. In summary, CPT treatment in Huh7 cells decreases cell viability and upregulates miR-16 expression, which results in inhibition of cell migration, invasion and clonogenic property of cells, by decreasing MMP-2, MMP-9, cyclin D1 and increasing the expression of cell cycle-regulated proteins p21 and p27.
Źródło:: Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 295-304
0001-6837
2353-5288
Pojawia się w:: Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Defective Brca2 influences topoisomerase I activity in mammalian cells*.
Autorzy:: Rahden-Staroń, Iwonna
Szumiło, Maria
Grosicka, Emilia
Kraakman - van der Zwet, Maria
Zdzienicka, Małgorzata
Powiązania:: https://bibliotekanauki.pl/articles/1043656.pdf
Data publikacji:: 2003
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: camptothecin
V-C8 mutant
topoisomerase I
Brca2 gene
Opis:: The Chinese hamster cell mutant V-C8 is defective in the Brca2 gene (Kraakman-van der Zwet et al., 2002, Cell Biol.; 22: 669). Here we report that V-C8 cells were 10-fold more sensitive to camptothecin, an inhibitor of topoisomerase I, than the parental V79 cells. The level of the relaxation activity of topoisomerase I in nuclear extracts was also lower (4-fold) in V-C8 than V79 cells, in spite of the fact that the level of the topoisomerase I protein was the same in these cells. The survival of V-C8 cells in the presence of camptothecin, the sensitivity of V-C8 topoisomerase I to camptothecin, and the level of the relaxation activity in V-C8 nuclear extract were almost completely restored by transfection of V-C8 cells with the murine Brca2 gene or by the transfer of human chromosome 13 providing the BRCA2 gene. These results indicate that the observed changes in the topoisomerase I activity in V-C8 are due to the defective function of the Brca2 gene.
Źródło:: Acta Biochimica Polonica; 2003, 50, 1; 139-144
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Phytochemical and pharmacological aspects of Nothapodytes nimmoniana. An overview
Profil fitochemiczny i farmakologiczny Nothapodytes nimmoniana. Przegląd
Autorzy:: Khan, N.
Tamboli, E.T.
Sharma, V.K.
Kumar, S.
Powiązania:: https://bibliotekanauki.pl/articles/72676.pdf
Data publikacji:: 2013
Wydawca:: Instytut Włókien Naturalnych i Roślin Zielarskich
Tematy:: phytochemistry
pharmacology
Nothapodytes nimmoniana
Icacinaceae
camptothecin
medicinal property
human disease
treatment
Opis:: Nothapodytes nimmoniana (J. Graham) (Icacinaceae), commonly known as Amruta is found in India particularly in Maharashtra, Goa, Kerala, Assam, Jammu and Kashmir as well as Tamilnadu areas. It is an important medicinal plant, the major source of a potent alkaloid, namely camptothecin, of a wide spectrum of pharmacological activities like anti-cancer, anti-HIV, antimalarial, antibacterial, anti-oxidant, anti-inflammatory, anti-fungal and also applied in the treatment of anaemia. Camptothecin is still not synthesized, therefore, its production entirely depends on natural sources. N. nimmoniana is one such plant which yields contain camptothecin in significantly high amount. The plant is gaining international recognition due to its diversified medicinal uses. It is subjected to excessive harvest. It has been categorized as a vulnerable and endangered plant. The present review encompasses the phytochemical, analytical, pharmacological, biotechnological, and other specific aspects of N. nimmoniana.
Nothapodytes nimmoniana (J. Graham) (Icacinaceae), powszechnie znana jako Amruta, rośnie w Indiach, szczególnie w prowincjach Maharashtra, Goa, Kerala, Assam, Dżammu i Kaszmir, a także na niektórych obszarach Tamilnadu. Jest jedną z ważnych roślin leczniczych, głównym źródłem silnego alkaloidu, kamptotecyny, mającej szerokie spektrum działania: przeciwnowotworowe, anty-HIV, antymalaryczne, antybakteryjne, przeciwutleniające, przeciwzapalne, przeciwgrzybicze. Znajduje również zastosowanie w leczeniu anemii. Jak dotąd kamptotecyna nie została zsyntetyzowana, dlatego jej produkcja całkowicie zależy od źródeł naturalnych. N. nimmoniana jest jedną z roślin zawierających duże ilości kamptotecyny. Zyskała ona międzynarodowe uznanie dzięki szerokiemu spektrum zastosowań, co powoduje zwiększenie jej eksploatacji. Z tego powodu została uznana za gatunek zagrożony. Poniższy przegląd obejmuje badania fitochemiczne, analityczne, farmakologiczne, biotechnologiczne i inne prowadzone nad gatunkiem N. nimmoniana.
Źródło:: Herba Polonica; 2013, 59, 1
0018-0599
Pojawia się w:: Herba Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Qualitative and quantitative evaluation of secondary metabolites of different plant extracts of Nothapodytes foetida (Wight) Sleumer an important endangered medicinal tree
Autorzy:: Bai, D. Sunitha
Suvarchala, V.
Pavani, Ch.
Chaithanya, G.
Spoorthi, V.
Shasthree, T.
Powiązania:: https://bibliotekanauki.pl/articles/1839343.pdf
Data publikacji:: 2021
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:: Camptothecin
phytochemicals
alkaloids
flavonoids
glycosides
tannins
phenols
triterpenoids
saponins
Nothapodytes foetida
Opis:: The present study of phytochemical screening has revealed valuable information about the chemical constituents of Nothapodytes foetida. Phytochemical analysis of leaves, stem, bark and root extracts of Nothapodytes foetida was performed using different solvent systems such as chloroform, butanol, hexane, methanol and acetonitrile for the presence of different phytochemicals with standard procedures. The phytochemical screening (both qualitative and quantitative) of variousplant extracts of Nothapodytes foetida revealed the presence of different phytoconstituents such as alkaloids, flavonoids, glycosides, tannins, phenols and triterpenoids. Among all the solvents tested, methanol, butanol and chloroform extract of leaf, stem, bark and root showed high concentration of all phytoconstituents compared to hexane and acetonitrile solvent extracts. The total quantity of secondary metabolites was evaluated by using the standard procedures and the line of regression and the regression coefficient estimated from the calibration curve of various standards. The highest quantity of phytoconstituent present in the plant extracts was identified to be alkaloids. The alkaloid content of leaf was evaluated to be 66.11±0.47, whereas stem possess 56.27±0.38, bark 59.02±0.17 and root 62.34±0.27 mg AE/gm of extracts and subsequent high amounts of phytoconstituents identified was flavonoids, tannins, phenols and saponins. Phytochemical screening of Nothapodytes foetidaused in the medical field for the design of new drugs.
Źródło:: World Scientific News; 2021, 162; 43-59
2392-2192
Pojawia się w:: World Scientific News
Dostawca treści:: Biblioteka Nauki

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