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    Wyświetlanie 1-5 z 5
    Tytuł:
    Biological effects of molybdenum compounds in nanosized forms under in vitro and in vivo conditions
    Autorzy:
    Sobańska, Zuzanna
    Zapór, Lidia
    Szparaga, Mateusz
    Stępnik, Maciej
    Powiązania:
    https://bibliotekanauki.pl/articles/2116716.pdf
    Data publikacji:
    2020-01-17
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    in vitro
    nanoparticles
    in vivo
    molybdenum disulphide
    biological effects
    molybdenum compounds
    Opis:
    Nanoparticles of transition metal dichalcogenides, particularly of molybdenum (Mo), have gained a lot of focus due to their exceptional physicochemical properties and the growing number of technological applications. These nanoparticles are also considered as potential therapeutic tools, biosensors or drug carriers. It is crucial to thoroughly examine their biocompatibility and ensure safe usage. The aim of this review is to analyze the available data on the biological effects of different nanoforms of elemental Mo and its compounds. In the reviewed publications, different conditions were described, including different experimental models, examined nanoforms, and their used concentrations. Due to these differences, the results are rather difficult to compare. Various studies classify Mo related nanomaterials as very toxic, mildly toxic or non-toxic. Similarly, the mechanisms of toxicity proposed in some studies are different, including oxidative stress induction, physical membrane disruption or DNA damage. Quite promising, however, are the potential medical applications of MoS2 nanoparticles in therapy of cancer and Alzheimer’s disease. Further studies on biocompatibility of nanomaterials based on Mo compounds are warranted.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2020, 33, 1; 1-19
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Thermal Effects Induced in Liver Tissues by Pulsed Focused Ultrasonic Beams from Annular Array Transducer
    Autorzy:
    Kujawska, T.
    Secomski, W.
    Krawczyk, K.
    Nowicki, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/176937.pdf
    Data publikacji:
    2011
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    annular array transducer
    pulsed focused nonlinear ultrasound
    electronically moved focus
    tissue heating
    biological effects
    tissue necrosis
    Opis:
    Many therapeutic applications of pulsed focused ultrasound are based on heating of detected lesions which may be localized in tissues at different depths under the skin. In order to concentrate the acoustic energy inside tissues at desired depths a new approach using a planar multi-element annular array transducer with an electronically adjusted time-delay of excitation of its elements, was proposed. The 7-elements annular array transducer with 2.4 MHz center operating frequency and 20 mm outer diameter was produced. All its elements (central disc and 6 rings) had the same radiating area. The main purpose of this study was to investigate thermal fields induced in bovine liver in vitro by pulsed focused ultrasonic beams with various acoustic properties and electronically steered focal plane generated from the annular array transducer used. The measurements were performed for the radiating beams with the 20 mm focal depth. In order to maximize nonlinear effects introducing the important local temperature rise, the measurements have been performed in two-layer media comprising of a water layer, whose thickness was specific for the transducer used and equal to 13 mm, and the second layer of a bovine liver with a thickness of 20 mm. The thickness of the water layer was determined numerically as the axial distance where the amplitude of the second harmonics started to increase rapidly. The measurements of the temperature rise versus time were performed using a thermocouple placed inside the liver at the focus of the beam. The temperature rise induced in the bovine liver in vitro by beams with the average acoustic power of 1W, 2Wand 3Wand duty cycle of 1/5, 1/15 and 1/30, respectively, have been measured. For each beam used the exposure time needed for the local tissue heating to the temperature of 43.C (used in therapies based on ultrasonic enhancement of drug delivery or in therapies involving stimulation of immune system by enhancement of the heat shock proteins expression) and to the temperature of 56.C (used in HIFU therapies) was determined. Two sets of measurements were done for each beam considered. First, the thermocouple measurement of the temperature rise was done and next, the real-time monitoring of dynamics of growth of the necrosis area by using ultrasonic imaging technique, while the sample was exposed to the same acoustic beam. It was found that the necrosis area becomes visible in the ultrasonic image only for beams with the average acoustic power of 3 W, although after cutting the sample the thermo ablated area was visible with the naked eye even for the beams with lower acoustic power. The quantitative analysis of the obtained results allowed to determine the exposure time needed to get the necrosis area visible in the ultrasonic image.
    Źródło:
    Archives of Acoustics; 2011, 36, 4; 937-944
    0137-5075
    Pojawia się w:
    Archives of Acoustics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analogs of diadenosine tetraphosphate (Ap4A).
    Autorzy:
    Guranowski, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/1043366.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    dinucleoside polyphosphates
    Ap4A
    biological effects of Ap4A analogs
    Ap4A analogs
    diadenosine tetraphosphate
    Opis:
    This review summarizes our knowledge of analogs and derivatives of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A), the most extensively studied member of the dinucleoside 5',5'''-P1,Pn-polyphosphate (NpnN) family. After a short discussion of enzymes that may be responsible for the accumulation and degradation of Np4N's in the cell, this review focuses on chemically and/or enzymatically produced analogs and their practical applications. Particular attention is paid to compounds that have aided the study of enzymes involved in the metabolism of Ap4A (Np4N'). Certain Ap4A analogs were alternative substrates of Ap4A-degrading enzymes and/or acted as enzyme inhibitors, some other helped to establish enzyme mechanisms, increased the sensitivity of certain enzyme assays or produced stable enzyme:ligand complexes for structural analysis.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 4; 947-972
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Hops as a source of biologically active compounds
    Autorzy:
    Przybyś, Marcin
    Skomra, Urszula
    Powiązania:
    https://bibliotekanauki.pl/articles/2148099.pdf
    Data publikacji:
    2020-12-30
    Wydawca:
    Instytut Uprawy Nawożenia i Gleboznawstwa – Państwowy Instytut Badawczy
    Tematy:
    hop
    biological activities
    antioxidative effects
    anti-microbial effects
    anticarcinogenic effects
    Opis:
    In recent years, hop, commonly known as the plant used for the production of beer, has attracted increasing interest in the pharmaceutical and cosmetic industries. Secondary me-tabolites found in hop, such as bitter acids, polyphenols or essen-tial oils, exhibit anti-cancer, anti-inflammatory and antibacterial properties. Moreover, numerous studies confirm estrogenic activ-ity, the ability to lower blood glucose levels and sedative effects of the plant. The paper discusses secondary metabolites in hops divided into groups depending on their chemical structure. Ad-ditionally, the biological activity of the metabolites is presented herein. The prospects of using hops for purposes other than brew-ing are also demonstrated.
    Źródło:
    Polish Journal of Agronomy; 2020, 43; 83-102
    2081-2787
    Pojawia się w:
    Polish Journal of Agronomy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Safety of nuclear power
    Autorzy:
    Strupczewski, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/147940.pdf
    Data publikacji:
    2005
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    low radiation doses
    LNT
    hormesis
    epidemiological studies
    biological defense mechanism
    Chernobyl effects
    Opis:
    The main questions related to nuclear power development concern effects of small radiation doses typical for the operation of nuclear power plants (NPPs) and hazards of NPP accidents. The last decade has brought many results of large scale epidemiological studies indicating that there are no detrimental effects of low radiation doses. On the contrary, many results indicate that among the people receiving increased radiation doses the frequency of cancer mortality is reduced. The review shows that such results are obtained in the studies of people living in high background radiation areas, of workers exposed to ionizing radiation and of patients exposed to radiation for diagnostic purposes. The latest studies in molecular biology suggest an explanation for possible beneficial effects of low radiation doses. This is reflected in the statements of several scientific bodies and international organizations, although the official regulations remain unchanged. The other important issue is the safety of NPPs in case of accidents. Reasons for the Chernobyl accident are shown not to be applicable to the reactors planned for Poland and the effects of Chernobyl are shown to be much smaller than feared in original estimates after the accident. Polish NPPs will satisfy the requirements of EU utilities and will provide safety for the population even in case of hypothetical severe accidents. Nevertheless, discussion with antinuclear organizations must be expected, although the recent examples of changing attitudes of leading ecological authorities show that nuclear power is gaining recognition as a clean and environmentally friendly source of energy.
    Źródło:
    Nukleonika; 2005, 50,suppl.3; 59-66
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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