Temat: alcoholic liver cirrhosis - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Afamin and adropin in patients with alcohol-induced liver cirrhosis
Autorzy:: Prystupa, A.
Kiciński, P.
Luchowska-Kocot, D.
Sak, J.
Prystupa, T.
Chen, K.-H.
Chen, Y.-H.
Panasiuk, L.
Załuska, W.
Powiązania:: https://bibliotekanauki.pl/articles/2081906.pdf
Data publikacji:: 2018
Wydawca:: Instytut Medycyny Wsi
Tematy:: alcoholic liver cirrhosis
Adropin
Child-Pugh score
afamin
Opis:: The aim of the study was to determine serum concentrations of afamin and adropin in patients with alcoholic liver cirrhosis and to define their correlation with the stage of disease. The study included 99 patients with alcoholic cirrhosis from the region of Lublin, (Eastern Poland). Liver cirrhosis was diagnosed based on clinical features, history of heavy alcohol consumption, laboratory tests and abdominal ultrasonography. The control group consisted of 20 healthy individuals without liver disease who did not abuse alcohol. The serum afamin and adropin concentrations were determined using ELISA kits. The concentration of afamin was found to be significantly lower in patients with compensated alcoholic liver cirrhosis, i.e. P-Ch B (85.1±40.6 μg/ml) and P-Ch C (56.4±32.3 μg/ml) individuals, compared to the control group (135.9±43.6 μg/ml); p-value was <0.01 and <0.001, respectively. As far as adropin is concerned, a reverse relationship was demonstrated: the highest concentration was found in patients with P-Ch C (11.7±5.7 ng/ml) cirrhosis. Furthermore, the above concentration was significantly higher compared to patients with P-Ch A cirrhosis (7.2±2.8 ng/ml; p<0.05) and controls (7.5±2.6 ng/ml; p<0.05). The concentration of afamin decreases with the severity of alcoholic liver cirrhosis, which most likely results from impaired hepatic synthesis. Otherwise, the higher the stage of disease according to the Child-Pugh score, the higher the concentration of adropin.
Źródło:: Annals of Agricultural and Environmental Medicine; 2018, 25, 3; 527-531
1232-1966
Pojawia się w:: Annals of Agricultural and Environmental Medicine
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Proinflammatory cytokines (IL-6, IL-18) and apoptotic factors (HP 53, survivin) in patients with alcoholic liver cirrhosis
Autorzy:: Prystupa, Andrzej
Kiciński, Paweł
Sak, Jarosław
Grzybowski, Andrzej
Boguszewska-Czubara, Anna
Toruń-Jurkowska, Anna
Niedziałek, Jarosław
Załuska, Wojciech
Powiązania:: https://bibliotekanauki.pl/articles/972717.pdf
Data publikacji:: 2017
Wydawca:: Instytut Medycyny Wsi
Tematy:: survivin
alcoholic liver cirrhosis
proinflammatory cytokines
apoptosis
human protein p53
Opis:: Background. Apoptosis is involved in the pathogenesis of alcoholic liver cirrhosis. Its development can be triggered by an inflammatory process. In the present study, levels of apoptotic factors – survivin human protein p53 (HP 53) and IL-6, IL-18 were determined according to the stage of liver cirrhosis. Material and methods. Seventy patients with alcoholic liver cirrhosis, treated in various hospitals of the Lublin region, Poland were included in the study. Serum levels of IL-6, IL-18, HP53 and survivin were determined by the enzyme-linked immunosorbent assay (ELISA) technique. Results. The serum level of survivin in patients with alcoholic liver cirrhosis was not statistically different from that found in the control group. The level of HP53 was significantly higher in the group of patients with alcoholic liver cirrhosis compared to the control group (16.53±22.69 vs. 0.39±1.31 U/ml; p<0.001). Likewise, the level of IL-6 was significantly higher in the group of patients with alcoholic liver cirrhosis compared to the control group (33.83±41.78 vs. 0.88 ± 0.56 pg/ml; p<0.001). Moreover, the level of IL-18 was significantly higher in the group of patients with liver cirrhosis compared to the control group (23.96±31.07 vs. 5.3±8.6 pg/ml; p<0.001). Conclusion. In conclusion, increased serum levels of IL-6 and IL-18 were demonstrated in patients with alcoholic liver cirrhosis. Moreover, the liver cirrhosis patients had elevated levels of HP53, which is a marker of apoptosis. Our results did not demonstrate the correlation between the levels of apoptosis markers (survivin, HP53) and the levels of cytokines (IL-6, IL-18) in the blood serum.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2017, 11, 1; 1-5
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Severe gynaecomastia associated with spironolactone treatment in a patient with decompensated alcoholic liver cirrhosis - case report
Autorzy:: Schab, K.
Prystupa, A.
Mulawka, D.
Mulawka, P.
Powiązania:: https://bibliotekanauki.pl/articles/3042.pdf
Data publikacji:: 2015
Wydawca:: Instytut Medycyny Wsi
Tematy:: gynaecomastia
spironolactone
treatment
patient
alcoholic disease
liver cirrhosis
Opis:: Gynaecomastia is uni- or bilateral breast enlargement in males associated with benign hyperplasia of the glandular, fibrous and adipose tissue resulting from oestrogen-androgen imbalance. Asymptomatic gynaecomastia is a common finding in healthy male adults and does not have to be treated, while symptomatic gynaecomastia might be the symptoma of many pathological conditions and requires meticulous diagnosis and therapeutic management. The commonest causes of gynaecomastia in the Polish population include liver cirrhosis and drugs used to treat its complications. The current study presents the case of severe painless gynaecomastia in a patient with decompensated alcoholic liver cirrhosis, treated with spironolactone because of ascites. Breast enlargement assessed a IIb according to the Simon’s Scale or III according to the Cordova-Moschella classification, developed slowly over the two-year period of low-dose spironolactone therapy The course and dynamics of disease are described and the main mechanisms leading to its development discussed. The importance of effective treatment of patients with severe gynecomastia is emphasized as the disease may result in significant psychosocial problems.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2015, 09, 1
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Spontaneous large hematoma of rectus abdominis muscle as complication of plasma coagulation disorders in 32-year-old man with terminal liver cirrhosis
Samoistny duży krwiak mięśnia prostego brzucha jako powikłanie osoczowych zaburzeń krzepnięcia u 32-letniego mężczyzny z marskością wątroby w stadium terminalnym
Autorzy:: Jakubiak, Grzegorz K.
Pietrzak, Mikołaj
Stanek, Agata
Cieślar, Grzegorz
Powiązania:: https://bibliotekanauki.pl/articles/52376303.pdf
Data publikacji:: 2024-10-29
Wydawca:: Śląski Uniwersytet Medyczny w Katowicach
Tematy:: liver cirrhosis
alcoholic liver disease
hemorrhagic diathesis
hematoma
marskość wątroby
alkoholowa choroba wątroby
skaza krwotoczna
krwiak
Opis:: Liver cirrhosis and its complications constitute one of the most important causes of hospitalization in internal medicine departments. Liver cirrhosis is not a homogeneous disease entity, but is the final stage of many different liver diseases, and the most important causes leading to the development of liver cirrhosis are alcoholic liver disease and viral hepatitis. One of the typical complications of liver cirrhosis are symptoms of bleeding diathesis. The most common bleeding complication in patients with liver cirrhosis is bleeding from the upper gastrointestinal tract. The aim of this publication is to present a case report of a 32-year-old man in the terminal stage, hospitalized due to decompensated alcoholic cirrhosis of the liver, who during hospitalization developed a spontaneous large hematoma in the rectus abdominis muscle on the left side. The presented case report shows that in the care of patients with decompensated liver cirrhosis, vigilance must be maintained to recognize bleeding complications, including those with an atypical clinical course.
Marskość wątroby oraz jej powikłania stanowią jedną z najważniejszych przyczyn hospitalizacji na oddziałach internistycznych. Marskość wątroby nie stanowi jednorodnej jednostki chorobowej, lecz jest końcowym stadium wielu różnych chorób wątroby, a najważniejszymi przyczynami prowadzącymi do jej rozwoju są alkoholowa choroba wątroby oraz wirusowe zapalenia wątroby. Jednym z typowych powikłań marskości wątroby są objawy skazy krwotocznej. Najczęstszym powikłaniem krwotocznym u chorych z marskością wątroby jest krwawienie z górnego odcinka przewodu pokarmowego. Celem niniejszej pracy jest przedstawienie opisu przypadku 32-letniego mężczyzny w stadium terminalnym, hospitalizowanego z powodu niewyrównanej alkoholowej marskości wątroby, u którego w trakcie hospitalizacji wystąpił samoistny duży krwiak w obrębie mięśnia prostego brzucha po stronie lewej. Opisany przypadek pokazuje, że w opiece nad chorymi z niewyrównaną marskością wątroby należy zachowywać czujność pod kątem rozpoznania powikłań krwotocznych, również takich o nietypowym przebiegu klinicznym.
Źródło:: Annales Academiae Medicae Silesiensis; 2024, 78; 282-286
1734-025X
Pojawia się w:: Annales Academiae Medicae Silesiensis
Dostawca treści:: Biblioteka Nauki

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