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Wyszukujesz frazę "Multiple myeloma" wg kryterium: Temat


Wyświetlanie 1-5 z 5
Tytuł:
The massive nodular cutaneous and soft tissues lesions of the right shoulder and the arm as the extramedullary manifestation of the advanced stage of multiple myeloma
Autorzy:
Drobiecki, Arkadiusz
Pasiarski, Marcin
Stelmach-Gołdyś, Agnieszka
Garus, Bartosz
Powiązania:
https://bibliotekanauki.pl/articles/773404.pdf
Data publikacji:
2017
Wydawca:
Medical Education
Tematy:
cutaneous involvement
multiple myeloma
Opis:
Cutaneous and soft tissue involvement is a very rare manifestation of multiple myeloma. We are describing a woman with the huge multiple plasma cells infiltrations of the soft tissues and the skin of the right shoulder and the arm that had occurred 2.5 years after the diagnosis of multiple myeloma. In the case of the described patient there is a distinct correlation between the appearance of the nodular lesions in soft tissues and the underlying osteolytic changes found in the skeleton. We assumed that the fracture of the right humerus in the past was the beginning of the plasma cells dissemination in the adherent tissues. The skin changes in our patient appeared in the advanced stage of multiple myeloma. There was only transient improvement of cutaneous changes after the chemotherapy, despite the complete remission of the underlying disease in the bone marrow. Despite of the intensive treatment (chemotherapy, radiotherapy) the patient died 7 months after the first appearance of the skin changes.
Źródło:
OncoReview; 2017, 7, 4; 180-183
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Multiple myeloma – cancer among elderly people
Autorzy:
Januszewska, Joanna
Świderska-Kołacz, Grażyna
Zmorzyński, Szymon
Powiązania:
https://bibliotekanauki.pl/articles/472516.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie
Tematy:
multiple myeloma
etiology of multiple myeloma
epidemiology
prognostic factors
genetic mutations
chromosomal abberration
Źródło:
Annales Universitatis Paedagogicae Cracoviensis. Studia ad Didacticam Biologiae Pertinentia; 2016, VI; 52-61
2083-7267
2450-3487
Pojawia się w:
Annales Universitatis Paedagogicae Cracoviensis. Studia ad Didacticam Biologiae Pertinentia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
IgM multiple myeloma: diagnostic difficulties and results of bortezomib treatment – case report
Autorzy:
Machowicz, Rafał
Skwierawska, Kamila
Mądry, Krzysztof
Górka, Michał
Żurawska, Jagoda
Kacprzyk, Piotr
Waszczuk-Gajda, Anna
Dwilewicz-Trojaczek, Jadwiga
Powiązania:
https://bibliotekanauki.pl/articles/773502.pdf
Data publikacji:
2014
Wydawca:
Medical Education
Tematy:
IgM
Waldenström’s macroglobulinemia
bortezomib
multiple myeloma
Opis:
The IgM paraprotein secretion is most frequently associated with Waldenström’s macroglobulinemia. In very rare cases it may also occur in multiple myeloma. The diagnostic and therapeutic process of a 84 year old male suffering from IgM multiple myeloma is described, including difficulties in establishing this diagnosis. Due to infectious complications, after the first cycle of melphalan– prednisone–bortezomib treatment, melphalan was stopped, subsequently, bortezomib and prednisone doses were also reduced. Two treatment interruptions have occurred. Despite reduced treatment intensity, the patient was in very good partial remission, while the toxicity profile was acceptable. IgM multiple myeloma should be included in the differential diagnosis of IgM paraproteinemia, also when osteolytic lesions and translocation 11:14 are not detected. Bortezomib-based therapy can be effective in elderly patients (also in those suffering from cardiac insufficiency), even when dose reduction is required.
Źródło:
OncoReview; 2014, 4, 4; A160-A164
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Targeting the hypoxia pathway in malignant plasma cells by using 17-allylamino-17-demethoxygeldanamycin
Autorzy:
Kocemba-Pilarczyk, Kinga
Ostrowska, Barbara
Trojan, Sonia
Aslan, Ecce
Kusior, Dorota
Lasota, Małgorzata
Lenouvel, Claire
Dulińska-Litewka, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1038530.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Multiple myeloma
HIF-1
hypoxia
17-AAG
Opis:
Multiple myeloma (MM) is characterized as a clonal expansion of malignant plasma cells in the bone marrow, which is often associated with pancytopenia and osteolytic bone disease. Interestingly, myeloma-infiltrated bone marrow is considered to be hypoxic, providing selection pressure for a developing tumour. Since HSP90 was shown to participate in stabilization of the subunit of the key transcription factor HIF-1, which controls the hypoxic response, the aim of this study was to investigate the influence of a HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG), on MM cells cultured under low oxygenation conditions. We confirmed that 17-AAG inhibits hypoxic induction of the HIF-1 target genes in malignant plasma cells and demonstrate the concentration range of severe hypoxia-specific cytotoxicity. Next, we selected the malignant plasma cells under severe hypoxia/re-oxygenation culture conditions in the presence or absence of 17-AAG and subsequently, the cells which survived were further expanded and analyzed. Interestingly, we have noticed significant changes in the survival and the response to anti-MM drugs between the parental cell lines and those selected in cyclic severe hypoxia in the presence and absence of 17-AAG. Importantly, we also observed that the lack of oxygen itself, irrespectively of HIF-1 inhibition, is the main/pivotal factor driving the selection process in the experiments presented here.
Źródło:
Acta Biochimica Polonica; 2018, 65, 1; 101-109
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The efficacy of combination therapy with lenalidomide and dexamethasone in the treatment of relapsed multiple myeloma
Autorzy:
Szudy-Szczyrek, A.
Legiec, W.
Mańko, J.
Gmyz, K.
Szczyrek, M.
Hus, M.
Powiązania:
https://bibliotekanauki.pl/articles/2052439.pdf
Data publikacji:
2015
Wydawca:
Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:
multiple myeloma
immunomodulatory drugs
maintenance therapy
lenalidomide
Opis:
Multiple myeloma is a neoplastic disease which is characterised by proliferation of monoclonal plasmocytes in the bone marrow. It is the second most common hematologic cancer and it represents 1% of all cancer deaths. Despite enormous development in multiple myeloma biology and treatment over the last 30 years - it is still incurable disease with a median survival of 50 – 55 months. Currently, one of the most important goals in the treatment of multiple myeloma is to achieve long-term control of the disease, without negative impact on the patient’s quality of life. Thanks to therapeutic regimens based on new immunomodulatory drugs, this aim seems to be achievable. In this paper we present the case of a female patient living with multiple myeloma for 14 years. Initially patient was treated with standard VAD (vincristine, doxorubicin, dexamethasone) chemotherapy regimen. After a nearly complete remission of the disease, autotransplantation of hematopoietic cells was performed. One year after transplantation there was a relapse of the disease. In the treatment of relapse it was decided to use scheme based on lenalidomide and dexamethasone. After 4th cycle of treatment, a complete remission was achieved. So far, the patient received 149 cycles. In the evaluation of minimal residual disease still maintains a state of complete remission maintains. During over 12 years of treatment no complications in grade 3 and 4 of the CTCAE v.4 was observed. Currently the patient is 58 years old, she still receives lenalidomide and leads moderately active life.
Źródło:
Health Problems of Civilization; 2015, 09, 2; 50-54
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-5 z 5

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