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    Wyświetlanie 1-8 z 8
    Tytuł:
    Relationship of adiponectin, leptin, visfatin and IGF-1 in cow’s venous blood and venous cord blood with calf birth weight
    Autorzy:
    Shen, L.
    Zhu, Y.
    Xiao, J.
    Deng, J.
    Peng, G.
    Zuo, Z.
    Yu, S.
    Ma, X.
    Zhong, Z.
    Ren, Z.
    Zhou, Z.
    Liu, H.
    Zong, X.
    Cao, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087491.pdf
    Data publikacji:
    2019
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    adiponectin
    leptin
    IGF-1
    birth weights
    cow
    Źródło:
    Polish Journal of Veterinary Sciences; 2019, 3; 541-548
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prevalence of neoplasms in patients with acromegaly – the need for a national registry
    Autorzy:
    Matyjaszek-Matuszek, B.
    Obel, E.
    Lewicki, M.
    Kowalczyk-Bołtuć, J.
    Smoleń, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/2081765.pdf
    Data publikacji:
    2018
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    cancer
    acromegaly
    registry
    IGF-1
    GH
    neoplasms
    Opis:
    Introduction. Acromegaly is an endocrine disorder caused predominantly by pituitary adenoma leading to autonomic oversecretion of growth hormone and secondary elevation of insulin-like growth factor 1 (IGF-1). Consequently, there are both theoretical and experimental grounds for establishing a correlation between this disorder and the higher incidence of neoplasms. Objective. The aim of the study is to evaluate the incidence and types of neoplasms among patients with acromegaly. Materials and method. The study included 67 patients with acromegaly, aged between 24 and 75±18.8 years, 46 women (68.7%) and 21 men (31.3%), BMI: 30.7±5.7 kg/m2, age at diagnosis 49.1±12.5 years, with the medians of GH and IGF-1 levels at diagnosis of 11.3 ng/ml and 663.8 ng/ml, respectively. A retrospective analysis of medical records with particular regard to physical examination, medical history, laboratory and imaging tests was performed. Results. Fifty-one patients (76.1%) suffered from at least one neoplasm, among whom 48 patients (71.6%) had benign proliferations, whereas malignant neoplasms (larynx, endometrial and colon cancers) were found in only three patients (4.5%). Conclusions. Benign neoplasms were found in majority of patients with acromegaly (71.6%) most notably: nodular goiter and colon polyps; malignant lesions were rare (4.5%). Only every fifth patient suffered from no neoplastic proliferations. No correlations between the studied parameters and the incidence of neoplasms were found, most likely due to the small number of patients. This is the reason for proposing the creating of the first national register of incidences of neoplasms among acromegalic patients.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2018, 25, 3; 559-561
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The effect of prolonged hanging test to grip strength, changes in muscle mass and imunoekspresi IGF-1r in bicep muscle of mice (Swiss Webster)
    Autorzy:
    Fadhilah, Fitry
    Hassan, Abdul Hadi
    Herman, Herry
    Lesmana, Ronny
    Ihsan, Bagus Muhammd
    Powiązania:
    https://bibliotekanauki.pl/articles/1164127.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Grip strength
    igf-1r
    muscle mass
    Opis:
    Resistance training increases strength and stamina without enlarging muscle. Jaras ifg1 responsible for the proliferation and differentiation of muscle tissue in response to the exercise. Post-allocation of adaptation 36 research subjects were randomly allocated to the control group and the test. The purpose of this study to determine the effect of prolonged hanging test of grip strength, muscle mass changes and IGF-1r imunoekspresi the bicep muscles of mice. The uniqueness differences in physiological mechanisms increase the strength after resistance exercise through changes in the dynamics of unknown IGF1 receptors , so this time we did the study increased expression of IGF1 receptors (Igf1r) after resistance exercise, using new method is prolonged hanging test. Grip strength, muscle mass and score imunoekspresi igf1r in bicep muscles will be tested in the mice model (Swiss webster) using pre and posttest design. Examination of grip strength, muscle mass, muscle fiber cross-sectional diameter and imunoekspresi IGF-1r have done at day 28 in the Laboratory of Pathology in Dr. Hasan Sadikin Hospital, Bandung. Our results showed there were effect of prolonged hanging test to grip strength in the final test on mice and igf1r Imunoekspresi on mice. This research concluded that resistance exercise using hanging prolonged test increases grip strength and receptor expression igf1r without increasing muscle mass or muscle fiber cross-sectional diameter.
    Źródło:
    World Scientific News; 2018, 108; 215-223
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    IGF-I: from diagnostic to triple-helix gene therapy of solid tumors.
    Autorzy:
    Trojan, Ladislas
    Kopinski, Piotr
    Wei, Ming
    Ly, Adama
    Glogowska, Aleksandra
    Czarny, Jolanta
    Shevelev, Alexander
    Przewlocki, Ryszard
    Henin, Dominique
    Trojan, Jerzy
    Powiązania:
    https://bibliotekanauki.pl/articles/1043704.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    glioblastoma
    tumors
    antisense
    triple-helix
    IGF-I
    gene therapy
    Opis:
    Alterations in the expression of growth factors and their receptors are associated with the growth and development of human tumors. One such growth factor is IGF-I (insulin-like growth factor I ), a 70-amino-acid polypeptide expressed in many tissues, including brain. IGF-I is also expressed at high levels in some nervous system-derived tumors, especially in glioblastoma. When using IGF-I as a diagnostic marker, 17 different tumors are considered as expressing the IGF-I gene. Malignant glioma, the most common human brain cancer, is usually fatal. Average survival is less than one year. Our strategy of gene therapy for the treatment of gliomas and other solid tumors is based on: 1) diagnostic using IGF-I gene expression as a differential marker, and 2) application of "triple-helix anti-IGF-I " therapy. In the latter approach, tumor cells are transfected with a vector, which encodes an oligoribonucleotide - an RNA strand containing oligopurine sequence which might be capable of forming a triple helix with an oligopurine and/or oligopyrimidine sequence of the promotor of IGF-I gene (RNA-IGF-I DNA triple helix). Human tumor cells transfected in vitro become down-regulated in the production of IGF-I and present immunogenic (MHC-I and B7 expression) and apoptotic characteristics. Similar results were obtained when IGF-I antisense strategy was applied. In both strategies the transfected cells reimplanted in vivo lose tumorigenicity and elicit tumor specific immunity which leads to elimination of established tumors.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 4; 979-990
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Maximal oxygen uptake is associated with allele -202 A of insulin-like growth factor binding protein-3 (IGFBP3) promoter polymorphism and (CA)n tandem repeats of insulin-like growth factor IGF1 in Caucasians from Poland
    Autorzy:
    Gronek, Piotr
    Holdys, Joanna
    Kryściak, Jakub
    Wieliński, Dariusz
    Słomski, Ryszard
    Powiązania:
    https://bibliotekanauki.pl/articles/1039282.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    IGF1
    IGFBP3
    athletic performance
    genetic polymorphism
    energy efficiency
    Opis:
    Physical fitness is a trait determined by multiple genes, and its genetic basis is modified by numerous environmental factors. The present study examines the effects of the (CA)n tandem repeats polymorphism in IGFI gene and SNP Alw21I restriction site -202 A>C polymorphism in IGF1BP3 on VO2max - a physiological index of aerobic capacity of high heritability. The study sample consisted of 239 (154 male and 85 female) students of the University School of Physical Education in Poznań and athletes practicing various sports, including members of the Polish national team. An association was found between -202 A/C polymorphism of IGFBP3 gene with VO2max in men. Higher VO2max values were attained by men with CC genotype, especially male athletes practicing endurance sports and sports featuring energy metabolism of aerobic/anaerobic character. A statistically significant influence of allele 188 and genotype 188/188 of tandem repeats (CA)n polymorphism of IGF1 gene on VO2max was found in women. Also, lower values of maximal oxygen uptake were noted in individuals with allele 186 or genotype 186/186, and higher VO2max values in athletes with allele 194.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 2; 245-252
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The role of activation of insulin-like growth factors in colorectal cancer
    Autorzy:
    Walkiewicz, Katarzyna
    Nowakowska-Zajdel, Ewa
    Strzelczyk, Joanna
    Walczak, Michał
    Copija, Angelika
    Janion, Karolina
    Muc-Wierzgoń, Małgorzata
    Powiązania:
    https://bibliotekanauki.pl/articles/1062926.pdf
    Data publikacji:
    2017
    Wydawca:
    Medical Education
    Tematy:
    IGF-receptors
    colorectal cancer
    insulin-like growth factors
    metabolic disorders
    Opis:
    Co-occurrence of metabolic disorders is a recognized risk factor for the development of colorectal cancer which is currently the leading cause of morbidity due to malignant neoplasms in the world. The pathogenesis of colorectal cancer is not well understood yet. Among the postulated neoplastic mechanisms is the activation of insulin-like growth factors, with both epidemiological and clinical observations of their role. In this paper, the authors synthesize the current knowledge about the importance of activation of insulin-like growth factors in the development of colorectal cancer.
    Źródło:
    OncoReview; 2017, 7, 3; 116-120
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The effects of adenoidectomy of serum insulin-like growth factor-1 (IGF-1) and ghrelin in hypertrophied adenoids in children with otitis media with effusion
    Autorzy:
    Żelazowska-Rutkowska, Beata
    Jacewicz, Klaudia
    Kasprzycka, Edwina
    Skotnicka, Bożena
    Cylwik, Bogdan
    Powiązania:
    https://bibliotekanauki.pl/articles/1397400.pdf
    Data publikacji:
    2020
    Wydawca:
    Index Copernicus International
    Tematy:
    ghrelin
    hypertrophied adenoid
    insulin-like growth factor-1 (IGF-1)
    Opis:
    Aim: The aim of the current study was to assess the serum levels of insulin-like growth factor-1 (IGF-1) and ghrelin in hypertrophied adenoids in children suffering with or without otitis media with effusion before and after adenoidectomy. Material and methods: Serum IGF-1 and ghrelin concentrations were measured with specific enzyme-linked immunoassay (ELISA) methods. The study was carried out in 20 children with otitis media with effusion. The reference group comprised 24 children with hypertrophied adenoid, while control group included 19 children. Results: This mean values of IGF-1 in children with otitis media with effusion and children with hypertrophied adenoid before adenoidectomy were significantly lower than those found in healthy children. Serum levels of IGF-1 were higher after adenoidectomy. There was a significant difference of serum ghrelin levels between both examined groups and the control group. Conclusion: Our results suggest that adenoidectomy in children with hypertrophied adenoids and in children with otitis media with effusion significantly increases the level of IGF-1 in serum compared to before surgery through the effect of the GH-IGF-1 axis, which could contribute to children’s growth.
    Źródło:
    Polish Journal of Otolaryngology; 2020, 74, 4; 13-17
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Polymorphism of insulin like growth factor IGF-1 in position 211 in national sheep breeds with carped wool compared to Polish Merino and European Muflon (Ovis aries musimon)
    Polimorfizm genu czynnika insulinopodobnego IGF-1 w pozycji 211 u krajowych owiec o wełnie mieszanej w porównaniu do merynosa polskiego i muflona europejskiego (Ovis aries musimon)
    Autorzy:
    Niznikowski, R.
    Czub, G.
    Glowacz, K.
    Swiatek, M.
    Slezak, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2867.pdf
    Data publikacji:
    2013
    Wydawca:
    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie. Wydawnictwo Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie
    Tematy:
    polymorphism
    insulin-like growth factor
    IGF1 protein
    national breed
    sheep
    animal breed
    carped wool
    Polish Merino breed
    Ovis aries musimon
    European mouflon
    allele
    genotype
    distribution
    Opis:
    Research was carried out on 1,684 sheep (1,093 F and 591 M) originating from European Mouflon (Ovis aries musimon), its hybrids with Polish heat sheep and four sheep breeds that are characterized by a mixed wool compared to Polish Merino. All animals were subjected to gene identification factor insulin-IGF-1, in the assessment of allele C and T. In conclusion it should be noted that in the 7 examined breed groups sheep showed no polymorphism alleles and genotypes of insulin-like factor gene IGF-1, limiting its scope to determine the C allele and genotype CC. This result indicates the need for further research in this area in "culture" sheep imported and adapted to Polish conditions and the production environment.
    Polimorfizm genu czynnika insulinopodobnego IGF-1 w pozycji 211 u krajowych owiec o wełnie mieszanej w porównaniu do merynosa polskiego i muflona europejskiego (Ovis aries musimon). Badania przeprowadzono na materiale 1684 owiec (1093 samic i 591 samców) pochodzących od muflona europejskiego (Ovis aries musimon), jego mieszańców z wrzosówką oraz czterech ras owiec charakteryzujących się okrywą wełnistą mieszaną porównywanych do merynosa polskiego. Wszystkie zwierzęta poddane były identyfikacji genu czynnika insulinopodobnego IGF-1, w zakresie oceny występowania alleli C i T. Podsumowując, należy stwierdzić, iż u badanych 7 grup rasowych owiec nie wykazano polimorfizmu występowania alleli i genotypów genu czynnika insulinopodobnego IGF-1, ograniczając jego zakres do ustalenie jedynie do allelu C i genotypu CC. Wynik ten wskazuje na potrzeby przeprowadzenia dalszych badań z tego zakresu u owiec kulturalnych pochodzących z importu i adaptowanych w polskich warunkach środowiska produkcyjnego.
    Źródło:
    Annals of Warsaw University of Life Sciences - SGGW. Animal Science; 2013, 52
    1898-8830
    Pojawia się w:
    Annals of Warsaw University of Life Sciences - SGGW. Animal Science
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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